Antimicrobial agent and method thereof

 

(57) Abstract:

The invention relates to medicine and, in particular, for the creation of tools to combat microorganisms. The essence of the invention lies in the fact that the proposed agent containing hydrogen peroxide, Quaternary ammonium compound, organic acid, or a mixture of two or more organic acids and urea in a certain ratio. A method of receiving funds from the abovementioned components. The resulting product has a high antimicrobial activity and stability. 2 S. and 3 C.p. f-crystals, 4 PL.

The invention relates to the field of medicine and, in particular, for the creation of tools to combat microorganisms.

Known liquid antimicrobial compositions based on a mixture of hydrogen peroxide and Quaternary ammonium compounds.

For example, a tool called "STC", produced by TU-2386-019-13164401-95, contains as AI (active ingredient) 25-38% hydrogen peroxide and 2% Quaternary ammonium compound (QAC) - alkyldimethylbenzylammonium chloride.

A tool called "Grillen" - liquid contains 9-25 wt.% of hydrogen peroxide and 18-25 wt.% N-alkanolamines the Both drugs have a broad spectrum of antimicrobial action. However, they both have some significant drawbacks:

1. Unsafe and uncomfortable in the work of both formulations based on the use of concentrated solutions of hydrogen peroxide, resulting in often cause burns, regardless of the use of protective equipment.

2. Cause irritation of the upper respiratory tract of staff.

3. Have low stability during prolonged storage and transport oxygen is liberated, which leads to increased pressure in the tanks.

4. Severely corrode instruments.

The closest in technical essence and the achieved result is powdered antimicrobial agent consisting of hydrogen peroxide, urea, dimethylbenzylamine chloride and Aerosil (U.S. Pat. RF 2083228). Despite the obvious positive result achieved in this patent, a method of obtaining disinfectants contained in it, has several disadvantages:

1. The process is multi-staged and-low-tech.

2. It turns out the preparation of heterogeneous composition.

Also known is a method of obtaining an antiseptic and disinfectant preparations on the basis of the chlorides, iodides or bromides, alkyldimethylbenzylammonium (H) and hydrogen peroxide in the P> The technical task of the present invention is the expansion of the range of antimicrobial agents, increasing their activity and stability.

Antimicrobial agent based on hydrogen peroxide and an HOUR devoid of these shortcomings. One of the ways to solve this problem is the transfer of antimicrobial agents from a liquid to a solid in powder form.

It is also proposed a method of obtaining powder of antimicrobial agents on the basis of hydrogen peroxide and HOUR.

To solve this problem is proposed antimicrobial agent containing in addition to hydrogen peroxide, H, urea and an organic acid or a mixture of two or more organic acids.

To improve the technology and obtain a homogeneous preparation process of getting a new powdered antimicrobial agent is carried out in one stage.

The proposed method in the apparatus of the mixed aqueous solution of hydrogen peroxide, aqueous solution or powder HOUR, urea and an organic acid. The organic acid is introduced in the beginning of the process or after it is completed prior to extraction of the powdered drug from the aqueous solution.

As ant, acetic, tartaric, oxalic, adipic, citric, malic, salicylic, water-soluble acid.

The composition obtained by this technology drugs in %, weight ranges:

Hydrogen peroxide - 28 - 35

HOUR AND 1.5 - 2.5

Organic acid is 0.01 - 1

Urea - Rest

The preparations obtained by the proposed method, are crystalline powder, easily compressible into tablets, easily soluble in water, stable under prolonged storage, have a prolonged effect against a wide spectrum of gram-positive and gram-negative bacteria, viruses. They can be used for processing domestic and industrial premises, hotels, cafes, bars, beauty salons, aircraft, road and rail transport, sports facilities and equipment, medical equipment, veterinary clinics, clothing, shoes.

Examples getting powdered compounds and their antimicrobial properties.

Example 1.

In the vessel while operating the stirrer was filled with 800 g of hydrogen peroxide (the content of H2O237%, pH 3), then 125 g of a 50% aqueous solution benzalconi chloride and 715 g of urea. Urea is quickly dissolved in the mixture andC and maintained at this temperature for 1 hour. Then for 10 minutes in the reactor is injected 10.6 g of acetic acid. Obtained a slightly yellowish, foamy solution is poured into a mold and cooled to -3, -5oWith under stirring. Kept at this temperature 30-35 hours.

The selection of complex suspensions carried out by vacuum filtration or by centrifugation (preferably by centrifugation). Drying is produced in a vacuum drying Cabinet at a temperature of 25-35oWith the vacuum.

Similarly prepared antimicrobial drugs with other alkyldimethylbenzylammonium chlorides, such as lauryl-, cetyl, stearyl, diisobutyldimethoxysilane-, N-alkanolamines, Diisobutyl, peroxyacetylnitrate chloride, alkyldimethylbenzylammonium chloride, alkyldimethylbenzylammonium chloride (tert-octylphenoxy), diethylbenzamide chloride, dialkyldimethyl and dioctyldimethylammonium chloride, alkyltrimethylammonium chloride.

Example 2.

Analogously to example 1, the tool is made from 850 g of hydrogen peroxide (H2O230%), 90 g dimethyldodecylamine bromide, 715 g of urea and 10.6 g of acetic acid. Selection powdery regstellende bromide, alkyltrimethylammonium bromide, satellitetelevision bromide, tetradecylbenzene bromide, cetylpyridium bromide, sterilisability (ammonium bromide) and other Quaternary ammonium compounds with different substituents of the nitrogen atom) prepared by similar technology.

Example 3.

Analogously to example 1 to prepare powdered antimicrobial agent of 340 g of hydrogen peroxide (the content of H2O235%), 120 g of a 50% aqueous solution of N-alcoholismmorecondition chloride, 240 g of urea and 4.6 g of acetic acid.

Example 4.

Analogously to example 1 to prepare powdered antimicrobial agent from 800 g of hydrogen peroxide, 125 g of catamine AB and 715 g of urea. In the liquid reaction mixture before allocating introduced 10 g of pre-prepared mixture of acetic acid and citric acid (1:1).

Example 5.

The process is carried out analogously to example 1. Before allocating the crystalline antimicrobial agent in the liquid reaction mixture was added 10 g of salicylic acid.

Example 6.

Analogously to example 1 to prepare powdered antimicrobial agent from 1000 ml of 38% hydrogen peroxide, 120 g of 50% is foreign and 10 g of formic acid.

Example 7.

Toxic and antimicrobial properties of the obtained preparations were examined on the sample powder obtained in example 1. His registered name "Okadas".

1. The "Okadas" is a crystalline powder white or light yellow color, as the active substance contains 28-34% hydrogen peroxide, and 2.0% alkyldimethylbenzylammonium chloride (catamine AB). Shelf life means in unopened manufacturer's packaging is 2 years; shelf life working solutions - 1 day.

The parameter acute toxicity when injected into the stomach "Okadas" belongs to the 3rd class of mild-hazard substances according to GOST 12.1.007-76 (LD50is 1208157 mg/kg).

When applied to the skin (LD50>2500 mg/kg) means "Okadas" belongs to the 4th class of low-hazard substances OST 12.1.007-76.

Inhalation at saturating concentrations (pair) tool "Okadas in powder form belongs to the 4th class of low-hazard substances by the degree of volatility. The tool does not pilit.

"Okadas has a marked irritant action in the form of a powder in a single effect on the skin and on the mucous membranes of the eyes (possibly corneal damage), does not have the Sensi is kaziah not have a local irritating action on the skin and eyes, 10-12% solutions cause dryness of the skin with repeated application and in case of contact with eyes causes weak irritation of mucous membranes.

2. The "Okadas" possesses antimicrobial activity against bacteria (including Mycobacterium tuberculosis), viruses (including viruses parenteral hepatitis and HIV), fungi of the genus Candida, Trichophyton, and washing properties.

Study of antimicrobial properties funds held in accordance with the methods outlined in the book "Methods of testing disinfectants to assess their safety and effectiveness", M, 1998, am 2.

As test objects experienced test surface (tile, ceramic floor tile, linoleum, wood painted), the dishes, the test cloth (calico), tests of rubber, plastics, glass etc. As the test microorganisms used Escherichia coli (strain 1257), Staphylococcus aureus (strain 906), Mycobacterium B5the Candida albicans (strain 15), hypsometry Trichophyton, poliovirus type 1 (vacc. Strain LSC 2ab). To simulate organic pollution applied inactivated horse serum in amounts of 40 and 80%, 40% fecal emulsion, 10% semolina. Neutralization means were carried out with a solution, with whom we disinfection of various objects with disinfectant solutions "Okadas" (PL. 1-4).

Powdered antimicrobial agent based on hydrogen peroxide and the HOURS can be applied for processing of surfaces in premises, rigid furniture, sanitary-technical equipment, linen, crockery, patient-care items, cleaning material, bacterial infections (including tuberculosis), viral (including parenteral hepatitis and HIV infection) etiology, candidiasis and dermatophytosis in medical institutions (hospitals), public catering enterprises, in public interest, for the disinfection of medical devices during viral infections (including parenteral hepatitis and HIV infection) etiology in hospitals.

1. Antimicrobial agent containing hydrogen peroxide and a Quaternary ammonium compound, characterized in that it further comprises urea and one or a mixture of two or more organic acids in the following ratio of ingredients, wt. %:

Hydrogen peroxide - 25-35

The Quaternary ammonium compound is 1,5-2,5

An organic acid or a mixture of two or more organic acids of 0.01-1

Urea - Rest

2. Antimicrobial agent under item 1, characterized in that the organic kislotno fact, they use organic acid selected from the group of formic, acetic, lactic, tartaric, oxalic, adipic, citric, malic, salicylic.

4. The method of obtaining antimicrobial agent by mixing hydrogen peroxide and Quaternary ammonium compounds, followed by separation of powdered drug, characterized in that it further injected urea, the mixture is heated to 40-42oC and maintained at this temperature, then introducing an organic acid or a mixture of two or more organic acids, the resulting solution is cooled to minus 3-5oWith, maintain 30-35 h, the desired product is isolated and dried at 25-35oWith the vacuum.

5. The method according to p. 4, wherein the organic acid is chosen from the group of formic, acetic, lactic, tartaric, oxalic, adipic, citric, malic, salicylic.

 

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