For the treatment of chronic prostatitis

 

(57) Abstract:

The invention relates to medicine, namely to urology, and relates to means for the treatment of chronic inflammatory diseases of the prostate. The invention lies in the fact that the proposed tool is made in the form of suppositories and contains pumpkin seed oil is up to 40 wt. %, thymol to 10 wt. % and lipophilic suppozitornyj basis to 100 wt. %. The invention provides a receiving means having anti-inflammatory and analgesic activity, and has a wide antimicrobial spectrum. Application of the above tools can improve the effectiveness of the treatment.

The invention relates to medicine, namely to urology, and can be used for the treatment of chronic inflammatory diseases of the prostate, in particular bacterial (infectious) prostatitis.

The main efforts of the majority of urologists aimed at finding more efficient methods for causal treatment and elimination of infection.

Known means for the treatment of bacterial prostatitis with the use of various antibiotics, including broad-spectrum antibiotics, such as semi-synthetic PE is Lina (see C. N. Tkachuk and other Chronic prostatitis, M. : Medicine, 1989, S. 147) were highly active against a large number of gram-positive and gram-negative bacteria, Rickettsia, chlamydia, and in high concentrations can act on some protozoa. However, they are not active against Proteus, Pseudomonas aeruginosa, small viruses and fungi. Therefore, the effectiveness of antibiotic therapy depends on the accuracy of establishing the etiology of chronic prostatitis.

The disadvantages of therapy with the use of antibiotics are: dampening effect of antibiotics on the immune system and spermatogenesis, the appearance is under their influence of dysbacteriosis and OTO - and nephrotoxic action of some antibiotics, allergic reactions to their introduction, especially anaphylactic shock and more.

Know the use for the treatment of chronic prostatitis non-steroidal anti-inflammatory drugs, namely indometacin (indomethacin). Indometacin assign inside depending on tolerability in a daily dose of 100 to 150 mg (3-4 hours) or in the form of rectal suppositories 0.05 g twice a day. The disadvantages of the used tools are the duration of the treatment, numerous protive tools for the treatment of chronic prostatitis in the form of rectal suppositories, containing the active substance of plant origin and lipophilic suppozitornyj basis. As the active substance known means contain lipophilic fraction melon seeds (see RF patent N 2097051, MKI a 61 K 35/78 - selected by the authors for the prototype), chopped pumpkin seeds (see RF patent N 2077889, MKI a 61 K 35/78), lipophilic fraction of the pulp of fruits of Aronia melanocarpa (see RF patent N 2112537, MKI a 61 K 35/78), lipophilic fraction of the pulp of the fruit of black currant (see RF patent N 2089211, MKI a 61 K 35/78).

Some funds have anti-inflammatory and analgesic activity, however, have a narrow antimicrobial spectrum of action. Chronic prostatitis own antibacterial activity of the prostate significantly reduced, as it penetrates pathogens through numerous excretory ducts opening onto the mucous membrane of the prostatic part of the urethra, and hematogenous and lymphogenous the introduction of infection. This anatomic-physiological features of blood supply of the prostate, is widely developed venous and arterial anastomoses contribute to subsidence in her circulating blood of microorganisms (C. A. Molotkov, I. I. Ilyin, "Hronalnyh suppositories is compulsory admission during the course of treatment with antibacterial drugs. This oral medication for chronic inflammation of the prostate gland enlarges the path of transport of the drug to the body of the lesion, leading to dose reduction of exposure and, consequently, to the increase of treatment time, and the possibility of side effects.

The problem to which the invention is directed, is to create funds in the form of rectal suppositories, the active substance which, along with anti-inflammatory and analgesic effects has a broad spectrum of antimicrobial action.

The problem is solved in that the means for the treatment of chronic prostatitis, containing lipophilic suppozitornyj based and active substance of plant origin, according to the invention, as the active substance contains pumpkin seed oil and thymol. Also, according to the invention, the tool contains pumpkin seed oil is up to 40 wt. % and thymol to 10 wt. %.

The essence of the proposed invention is that along with pumpkin seed oil, which has androgenic and anti-inflammatory, relieves pain in the prostate and facilitates urination, means codignotto in relation to the simplest and herpes virus. Experimental studies have shown that the increase in the content of thymol above 10 wt. % causes discomfort in the application (short-term pain). The increase in the content of pumpkin seed oil over 40.0 wt. % leads to the fact that suppositories are soft, which makes their introduction, and is invalid according to the article "Suppositories" GF - XI ed.

In its natural form contains thymol in thyme (cabrecom) essential oil obtained from the leaves of thyme. Aqueous 5% solution canrecover essential oil kills typhoid bacilli, colibacteria, Streptococcus and diphtheria bacterium, Staphylococcus, Bacillus kochii ("the Treatment of diseases smells", M, "Middlecountry", 1993, S. 6). Also known and antiherpetic activity of thyme essential oil (Pogorelskiy L. Century. and other Herbal medicine in the infectious disease practice, edition 1, M , Department of infectious diseases, RMAPO MOH, 1998, S. 98).

Thymol is used as an active tool, is a synthetic drug in the form of a crystalline powder with a characteristic odor and taste, easily soluble in fatty oils. The main purpose of thymol is an antihelminthic agent, also used in dental practice in the quality of the school, 1998, 120 C.). In connection with the antiseptic properties of thymol assign during diarrhea and flatulence to reduce fermentation in the gut.

The proposed remedy for the treatment of chronic prostatitis, including lipophilic suppozitornyj basis and the active ingredient, which is used as the pumpkin seed oil and thymol, has along with anti-inflammatory and analgesic properties of a wide spectrum of antimicrobial activity against such organisms as Staphylococcus, Streptococcus, herpes, Trichomonas, chlamydia. The use of the proposed tool allows you to exclude the path of transport of antibiotic - thymol to the lesion, to shorten the time of treatment and avoid side effects.

Candles were prepared in accordance with GF - XI ed. Vol. 2, 151-153 C. Art. "Suppositories" method of pouring.

The composition of suppositories: pumpkin seed oil is up to 40 wt. % (normative - technical documentation FS 42 - 3002 - 97, registration card 98/21/14 approved by the Ministry of health and approved for oral use); thymol to 10 wt. % (normative-technical documentation: FS 42 - 1010 - 75, registration card 70/864/4 approved by the Ministry of health and approved for oral use in m is popilnya suppozitornyj basis to 100 wt. %.

Candles are obtained as follows.

10 g of pumpkin seed oil is heated and the temperature is 50 - 60oC add 2.5 g of thymol in the form of a powder, then mix with a mixer. After dissolution of thymol resulting solution is poured into the molten lipophilic suppozitornyj a basis weight of 17.5 g, which use a mixture of Witepsol brand H-15 and H-33 in a ratio of 1: 1, and stirred for 30-60 minutes using a stirrer at a temperature of 50oC. After stirring until a homogeneous mass is fed to the molding suppositories. After forming receive 10 candles weighing 3 g

Candles were used for the treatment of 15 patients suffering from chronic parenchymatous nonspecific prostatitis etiology, age of patients 22 to 46 years.

Criteria for diagnosis and evaluation of treatment effectiveness have served the objective of the study, hematological and immunological tests, urine tests, secrets of the prostate gland and semen, bacteriological tests, and the results of ultrasonic, radiographic and endoscopic studies.

The control group consisted of 19 patients suffering from similar diseases, in the course of therapy is 2">

The course of treatment in the main group included the introduction of 1 candle 1 time per day. The candle is contained to 40.0 wt. % pumpkin seed oil, up to 10 wt. % thymol (0,16 - 0,22 g), the rest of lipophilic suppozitornyj basis.

During clinical trials reported good tolerability of the drug were no local or General side effects. At the same time revealed therapeutic activity of subjects of candles in chronic prostatitis, in particular their anti-inflammatory, analgesic effects, as well as a high antimicrobial effect against Staphylococcus, Streptococcus, herpes simplex virus, Trichomonas.

The subjects of the core group noted more persistent and rapid decrease or complete disappearance of pain and dysuria, decrease or complete data normalization objective research, laboratory, ultrasound and endoscopic tests.

Examples of specific use of the proposed tools in clinical practice.

Example 1. Patient S. , aged 26. Diagnosis: chronic bacterial (non-specific) lung prostate in the phase of active inflammation. The disease duration of 4.5 years. Previously held courses of standard therapy were ineffective. B is knit together 1 suppository 1 time a day for 14 days. At follow-up after 20 days there is a strong positive trend. Improving data ultrasound, palpation of the prostate, data normalization of urine, prostate secretion, semen, absence of microorganisms when bacteriologic examination of prostate secretion.

Example 2. Patient N. , 42 years. Diagnosis: chronic bacterial lung prostate, often recurrent urogenital (Mycoplasma - HSV) infection. The disease duration of 8 years. Held earlier courses of standard therapy were ineffective. The patient underwent a course of complex therapy, including biogenic stimulators, antibacterial, antiviral drugs, rectal suppositories according to the invention, which was introduced on 1 suppository 1 time a day for 14 days. At follow-up at 28 days showed complete disappearance of pain, improvement of data palpation and transducer data normalization of urine, prostate secretion. In the study of prostate secretion by polymerase chain reaction (PCR) for chlamydia, herpes simplex virus type II repeatedly for 2 months were obtained negative results.

Example 3. Sick,, 45 the gas of sinologie. The disease lasts for 7 years. The clinical picture was dominated by complaints about pain in the perineum and rectum. The treatment included vegetotherapy tools, physiotherapy UHF waves and rectal administration of suppositories according to the invention, which was administered by one candle 2 times a day for 12 days. At follow-up after 22 days showed a significant reduction in pain. Data palpation of the prostate and ultrasound revealed a clear positive trend.

Example 4. Patient N. , 29 years. Diagnosis: chronic bacterial (non-specific) urethritis, chronic lung prostate in the phase of active inflammation. Held earlier courses of standard therapy was ineffective. The patient underwent a course of treatment with rectal introduction suppositories according to the invention, which was introduced on 1 candle 1 time a day for 16 days. At follow-up, improvement was noted in the data palpation and ultrasound of the prostate, data normalization urine and semen.

Thus, suppositories containing pumpkin seed oil is up to 40 wt. % and thymol to 10 wt. %, have a pronounced therapeutic effect in chronic nonspecific prostatitis. They are safe, ke.

For the treatment of chronic prostatitis, containing lipophilic suppozitornyj basis and the active ingredient of vegetable origin, wherein the active substance contains pumpkin seed oil and thymol in the following ratio, wt. %:

The pumpkin seed oil - 40

Thymol - 10

Lipophilic suppozitornyj the basis of Up to 100

 

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