A method of producing glucose for use in medicine

 

(57) Abstract:

The invention relates to the production of medical solutions primarily for the preparation of the injection, various drug solutions. The method involves the dissolution of crystalline glucose in water and impact on the resulting solution ionizing radiation exposure dose 4-6 G/min and the specific dose of 0.2-0.5 G/ml, the Invention provides the improvement of the quality of the obtained solution by cleaning it from decay products of glucose.

The invention relates to the production of medical solutions and can be used in medicine and the medical industry.

A method of obtaining glucose solution in ampoules, providing for the dissolution of crystalline glucose in water for injection, add a solution of 0.26 g of sodium chloride and 0.1 G. of hydrochloric acid, filtering the resulting solution, pouring in ampoules of 10, 20, 25, 50 ml and sterilized with steam at a temperature of 100oC for 60 minutes. Get solution with the concentration of glucose 5%, 10%, 25%, 40%. (Glucose 5%, 10%, 25% or 40% for injection. State Pharmacology of the USSR - 10th ed. , -M. : Medicine, 1968, S. 335-336).

Nedostate its collapse, such as aldehydes, ketones, furans and furfural, which can have a negative impact on human health.

The closest technical solution to the invention is a method of obtaining a glucose solution, providing for the dissolution of crystalline glucose in water for injection, add a solution of 0.26 g of sodium chloride and 0.1 n hydrochloric acid solution, the processing solution activated charcoal, filtering, pouring in a bottle of 400 ml, 2 ml vials or ampules and sterilized at a temperature of 110oC for 45 minutes. (Tereshkina O. I. "New aspects of control and standardization of glucose solution for injection" Dis. Kida. formats. Sciences: 15.00.02 - Protected 18.12.90. -M. , 1990, S. 149).

The disadvantage of this method is the formation of degradation products of glucose, despite the cleaning solution activated carbon and filtering.

The technical result of the invention is to improve the efficiency of purification of glucose from the products of its disintegration and improved, thus its quality.

To achieve this result in the proposed method to obtain glucose for use in medicine, provides the radiation exposure dose 4-6 G/min and the specific dose of 0.2-0.5 G/ml

The method consists in the following.

Crystalline glucose is dissolved in water to obtain a solution of a given concentration. The resulting solution of glucose in water is exposed to ionizing radiation exposure dose 4-6 G/min and the specific dose of 0.2-0.5 G/ml

Exposure to ionizing radiation (x-ray) on the glucose solution in water leads to the partial destruction of the molecules, which are the breakdown products of glucose dissolved in water.

When using the exposure dose is less than 4 G/min, and the specific doses less than 0.2 G/ml not provided weight aqueous solution of glucose from aldehydes, furans, and most of furfurol, so as not reached the most complete breakdown of these substances. When the exposure dose of 6 Gy/min, and the specific doses greater than 0.5 G/ml is the radiation decomposition of glucose.

In the chromatography spectrometric analysis of glucose solution before and after exposure to ionizing radiation found that in solution, not exposed to ionizing radiation, contains the following ingredients:

2-isopropyl-MetLife,7 g/l), bicyclo (3.1.0), hexane-2-it, 1,5-diisopropyl (0,166 g/l), oktilovom ether somaclonal acid (0,28 mg/l). In solution exposed to ionizing radiation, detected the presence of only 5-oxymethyl-2-furfural (3.5 g/l), which is approximately 21% by weight of the substances contained in unirradiated solution.

Example. Crystalline glucose 50 g dissolved in water for injection. In the resulting solution was added 0.26 g of sodium chloride and 0.1 G. of hydrochloric acid. The resulting solution was purified activated charcoal, filtered, bottled in bottles of 400 ml and sterilized at a temperature of 110oC for 45 minutes. Sterile glucose solution treated at therapeutic x-ray apparatus (for example, RUM-17) at a voltage of 200 kW and current 15 mA ionizing (x-ray) radiation exposure dose rate of 5 Gy/min and the specific dose of 0.4 G/ml In solution exposed to ionizing radiation, detected only 5-oxymethyl-2-furfural (3,4 g/l).

In the test method, it was found that in comparison with known ways of reducing the presence of degradation products of glucose in the form of aldehydes, ketones, furans and furfural about 79% by mass.

A method of producing glucose for use in medicine, providing for the dissolution of crystalline glucose in water, wherein the resulting solution is subjected to ionizing radiation exposure dose 4-6 G/min and the specific dose of 0.2-0.5 G/ml

 

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