The method of treatment herpesvirus infections, including ozone therapy

 

(57) Abstract:

The invention relates to medicine, namely to skin diseases, and can be used to treat herpesvirus infections. Spend most of autohemotherapy dose of 3-9 mg/ml in the volume of a single administration of 200-400 ml to symptom exacerbation. Then on the background of continuing high autohemotherapy administered antiviral drugs. The local manifestations of ozone therapy is carried out in the form of subcutaneous obkalyvanie ozone-oxygen mixture at the periphery of the affected area, greasing "ozonid, irrigation with ozonated solution, subconjunctival injection of ozone-oxygen mixture, subcutaneous injection of ozone-oxygen mixture along the projection of the affected nerve trunks and exit points of the spinal and cranial nerves. The method provides a reduction in the frequency of relapses and disease transition in the latent phase. 1 S. and 4 C. p. F.-ly.

The invention relates to skin diseases and is intended for treatment of herpesvirus infections. The group of herpes infections, which include diseases caused by the herpes simplex viruses type I and II, zoster virus, cytomegalovirus, Epstein-Beckie viruses cause a variety of pathologies in humans, ranging from skin lesions and mucous to generalized forms with the defeat of all organs and systems of man. They can cause immune suppression, and some of them cause cancer lesions.

It is known that the cause of persistence and frequent exacerbation of herpes infections are disorders in the immune system. This is often a reduction in the number and functional state of cytotoxic lymphocytes (CD8+), natural killer cells, inhibition of interferonbeta and production of specific antibodies competent cells, and reduced phagocytic activity.

Often this infection is considered as facultative-pathogenic activity, which increases greatly with the weakening of the body in trauma, emotional overstimulation, receiving lekarstvennyh funds, etc., All this should define a comprehensive approach to treatment (A. L. Mascalese "Treatment of skin diseases" M : Medicine, 1990, S. 248).

Treatment herpesvirus infections is one of the most difficult problems of medicine. Now in their therapy uses drugs - nucleoside analogues (acyclovir, valtrex, famciclovir, and others), drugs IISI in the period of exacerbation and cause a temporary effect, don't put the disease in long-term remission, and do not lead to recovery.

The closest analogue of the proposed method is a method of the same purpose, providing local treatment areas rashes on the skin by lubricating the affected area with ozonized oil with a peroxide number of the ozonides 200-500 every 6 hours, which contributes to the resolution of the rash (EN 2008898, 15.03.1994). Insufficient use SonicStage drug only locally, because, as you know, the manifestation herpesviruses infection reflects not only the local process, but in a greater degree of violation of a General nature associated with immune processes.

Currently, for the treatment of various pathological conditions used ozone in various forms (solutions, ointments) and using different routes of administration (vnutrisosudisto, locally, in the cavity of the body).

Medical ozone as a universal stimulator, launching diverse intracellular biochemical processes in the body and participating in them can act as an active immunomodulator. In addition, the local application of ozonized solutions and ozonated oil have verizonmedia was to develop an integrated approach in the treatment of herpesviruses infection with medical ozone.

The technical result of the invention is to transition from the acute phase herpesviruses infection stage in long-term remission or complete recovery.

The technical result is achieved due to the combined multilateral effects on immune processes antiviral effect and processes of the local effect of ozone therapy, supplemented by drugs antiviral action.

In the proposed method, the overall impact on the body is realized through a large autohemotherapy to stimulate antiviral immunity and relieve symptoms of intoxication, supplemented by taking antiviral drugs. The second aspect of treatment herpesviruses infection is the reduction and elimination of local manifestations of the disease, which, depending on the localization process using subcutaneous chip ozone-oxygen mixture at the periphery of lesions or streaks of the same zone oil ozonid", irrigate mucous membranes in the affected area ozonated solution, conduct subcutaneous injection of ozone-oxygen mixture along the projection of the affected nerve trunks and exit points of the spinal and cranial nerves; realize OCCS is primaline doses and types of ozone therapy General and local actions for different types of localization process. However, in all cases with different clinical forms of lead exposure is the total exposure of the immune and antiviral direction of ozone therapy as immunokorrektiruyuschie impact and antiviral, supplemented by the effect known antiviral drugs.

The method is as follows.

In a patient with herpesviruses infection take blood from the cubital vein in the amount of 100-200 ml and placed in a special plastic bag - Remocon. At the same time there is introduced into an equal volume (100-120 cm3) ozone-oxygen mixture with ozone concentration from 3 to 9 mcg/ml, with slow stirring of the blood, anticoagulant and gas. Then make reinfuse blood (60-90 drops in 1 min), i.e. the time reinfused a given volume of blood within 20-25 minutes.

To control the speed reinfused slightly compress the outlet tube of gemikona to obtain a gas bubble with a volume of 0.5-1.0 cm-3. The gas bubble should move to Vienna slowly. At high speed reinfused or at a sufficiently high concentration of ozone, the patient noted numbness of tongue and hands. In this case, you must omit g is istratii and volume directly from valve ("Multiossigen Medikal") in syringes with a capacity of 60 cm3that have rubber tips on the piston and not leak ozone, or indirectly in the beginning in a special plastic bag ("Madison"), and then into the syringe.

Big autohemotherapy carried out in a number of 10-12 treatments with ozone concentration from 3 to 9 mcg/ml volume of a single administration of 200-240 ml, 2-3 times per week until symptoms of worsening the appearance of redness with burning, itching, painful sensations on the skin or mucous membranes, the appearance of herpetic vesicles. Then, without stopping of course great autohemotherapy, attach antiherpetic drugs - nucleoside analogues (acyclovir, famciclovir, valtrex and others ). Against the background of course carry out the purpose of antioxidants.

In the presence of herpes zoster lesions on the skin conduct subcutaneous chip zones herpes sores in the period of exacerbation on the background of large autohemotherapy or during relapse. From the first hours or on the first day of the appearance of the manifestations on the skin around on the periphery of herpetic vesicles spend every day with ozone concentration in the gas mixture from 3 to 20 μg/ml, from 0.5 to 20 ml, depending on the area affected, 1-3 days, or lubricate the affected area with oil "OIE ozone-oxygen mixture 1-2 times a week, just 5-7 times in a concentration of 0.5-1 µg/ml, volume of 0.3 ml

When herpes sores on the vulva, vagina, cervix daily sessions running irrigation with ozonated solutions with the concentration of ozone in solution 1-7 µg/ml with a volume of 300-400 ml Procedure is carried out in the normal position the patient on the gynecological chair. Using a speculum to the lesion down hollow plastic catheter, which use glass or plastic bottles through the system for intravenous drip quick drops or inkjet serves ozonated solution. The number of procedures 3-7.

When herpetic stomatitis rinsing of the oral cavity and pharynx spend ozonized solution of distilled water or ozonated physiological solution with a concentration of ozone 1-7 µg/ml, 2-3 times a day, with a volume of 200-300 ml treatment Duration 3-5 days to complete epithelialization.

With the defeat of Herpes Zoster perform subcutaneous injection of ozone-oxygen mixture along the projection of the affected nerves exit points of the spinal and cranial nerves in the period of the lesions with the aim of fast regeneration, analgesia on the background of course great automam from 10 to 100 ml, depending on the degree of destruction.

Clinical examples

1. Patient T. , 31, outpatient map 71-99. Suffering from herpes simplex labialis (HSV-1 type), in the last year of often - almost every month. Turned out of aggravation.

Assigned course great autohemotherapy with ozone concentration of 3-5 mg/ml with a frequency of 2 times per week and anexinet 1 tablet 2 times a day.

After 3 treatments the patient on his upper lip had a feeling of fullness, then redness and swelling. Applied topically, the oil ozonid" 4 times a day and valtrex 0.5 g 2 times a day for 10 days. Outpatient in the first two days of aggravation over the rim lip area of effect produced by a single subcutaneous injections of ozone-oxygen mixture in a volume of 0.5 ml with an ozone concentration of 3 µg/ml.

On the background of treatment characteristic of herpetic vesicles does not appear, the redness disappeared after 3 days. Just spent 10 sessions large autohemotherapy.

In the process of observation after a course of ozone therapy and valtrex recurrent herpes there for 16 months.

2. Patient A. , 28, outpatient map 124-98.

He complained of fatigue, occasional chills, subfigure revealed an increase in front - and zadnesheynyh, axillary lymph nodes, liver +1, see blood lymphocytosis. In the immune status of the reduction in the number of natural killer cells, and interferons.

In outpatient examination in blood and saliva revealed DNA of Epstein-Barr.

Diagnosed with a chronic viral infection of Epstein-Barr.

Assigned course great autohemotherapy with ozone concentration of 3-5 mg/ml with a frequency of 2 times per week and anexinet 1 tablet 2 times a day. Intramuscularly at the same time through the day appointed IFN 3 million ME 15.

Against the backdrop of ongoing course being sick is normalized, the lymph nodes normal size of the liver was normal.

In the study of blood and saliva after 1, 2, 3, 6 months after treatment of DNA virus Epstein-Barr not found.

Thus, the proposed method of treatment herpesvirus infections using ozone therapy in combination with antiviral drugs can get a good clinical effect, to reduce the frequency of relapses, to achieve transfer of the disease in the latent phase.

1. The method of treatment herpesvirus infections, including ozone, characterized in that spend most of autohemotherapy (BAT) in odelzhausen large autohemotherapy impose additional antiviral drugs.

2. The method according to p. 1, characterized in that in the presence of herpes zoster lesions on the skin additionally spend around on the periphery of lesions ozone-oxygen mixture at a dose of 3 to 20 ág/ml 0.5-20 ml or lubrication oil ozonid".

3. The method according to p. 1, characterized in that when the mucous membranes is conducted additionally irrigation of the affected area ozonated solution with a concentration of ozone 1-7 µg/ml.

4. The method according to p. 1, characterized in that when herpes keratitis or keratoconjunctivitis additionally spend subconjunctival injection of ozone-oxygen mixture in a dose of 0.5-1 µg/ml in a volume of 0.3 ml

5. The method according to p. 1, characterized in that the infection caused by herpes zoster, is conducted additionally subcutaneous injection of ozone-oxygen mixture along the projection of the nerve trunks and exit points of the spinal and cranial nerves dose of 3-20 mg/ml in a volume of 10-100 ml

 

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