Method for the treatment of endometritis in cows

 

(57) Abstract:

The invention relates to veterinary gynecology and obstetrics. The method consists in the fact that simultaneously with the irradiation of the uterus with a laser beam in cows suffering from endometritis, in the interstitial space of the pelvic cavity is injected drug mixture containing one dose of novocaine 1.0 g, trypsin 0.05 g, karbaholina 0.002 g distilled water 100 ml Irradiation of the uterus laser beam is conducted daily, and the introduction of medicinal mixture every 48 h until clinical recovery. The effectiveness of the treatment is increased to 97,0-100%, the output of calves per 100 cows - 3%. 3 table.

The invention relates to veterinary gynecology and obstetrics, relates to a method of treatment of acute and chronic endometritis and can be used to reduce the fertility of breeding stock of cattle, increase the output of calves and their preservation.

In nosological profile obstetric-gynecologic diseases of cattle predominate postpartum endometritis which is recorded in 47,113,9% calving cows.

Known methods of treatment of endometritis in cows, including the use of antimicrobial agents in various socetanny and uterine (myotropic) means /1, 2, 3/. However, the treatment of endometritis by known methods is not effective due to the reduction of antimicrobial properties of chemotherapeutic drugs and a number of negative consequences from their use, in particular the accumulation of residues in animal products, distribution, allergies, etc.

As the preferred analogue of the us is considered the treatment of postpartum endometritis, including the irradiation of the uterus LLLT (low-intensity infrared laser radiation) daily for a few minutes (1-3, 2-3, 3-5 min) /4, 5/.

Due to the electoral photomodification of laser energy on the microcirculation and biochemical processes in the body, in particular enzymatic, hormonal exchanges and immune status, the use of laser therapy in veterinary practice is regarded as an extremely promising. The clinical effectiveness of laser therapy in some diseases of cattle is high enough. So, it is, for example, mastitis (subclinical and serous, catarrhal) 97,9 and 92.0%, respectively, of the vaginitis is 100%, but when endometritis is not more than 85% (chronic - 82,0%, acute - 85,0%) /4/.

The method is as follows.

After diagnosis for endometritis carry out the irradiation of the uterus through the rectum or skin for 3-5 minutes daily until clinical recovery and in addition to the interstitial space of the pelvic cavity through the point of injection in peredniene corner sciatic-pryamokishechnye holes injected drug mixture containing one dose of novocaine 1.0 g, trypsin 0.05 g, karbaholina 0.002 g, distilled water 100 ml, with an interval of 48 hours prior to clinical recovery. Irradiation of the uterus, make use of a veterinary laser therapeutic apparatus STF-3. STF-3 - small-sized portable electronic device with Autonomous power supply in a plastic case with one remote emitter (terminal). Laser diodes are located in the radiator is protected from external influences by a special coating. therapeutic effect is provided by low-intensity laser pulse radiation average power is not more than 0.3 watts, with a wavelength of 0.87 to 0.97 μm (870-970 nm) and a modulation frequency of 10 to 2000 Hz. When rectal irradiation malaut beam on the uterus, while exposing through the skin is applied to the skin between the transverse processes of the lumbar and sacral vertebrae, with a total time of irradiation field 5 minutes. Medicinal mixture is prepared immediately before use. A portion of novocaine 1.0 g dissolved in 98 ml of distilled water and sterilized by boiling. The solution was cooled to 40oWith, administered in compliance with the rules of asepsis the addition of trypsin 0.05 g and 2.0 ml of sterile 0.1% solution karbaholina. Dosage of the mixture inyeccion in the interstitial space of the pelvic cavity through the point of injection in peredniene corner sciatic-pryamokishechnye holes on one side with a syringe Janet, United rubber or plastic hose with needle Bobrov. The injection site thoroughly cleaned and disinfected. Needle Bobrov injected at an angle of 30-40oto the plane of the holes parallel to the sacral vertebrae, at a depth of 3-7 cm in the pelvic cavity and inject a medicinal mixture under medium pressure piston.

Comparative analysis of the prototype showed the presence of the claimed technical solution distinctive features of the prototype of evidence that confirms the compliance with the criterion of "novelty". The lack of data on sovokupnostei patent and scientific literature demonstrates compliance with the criterion of "inventive step". The combination of laser therapy and medicinal mixture at the claimed combination of components provides enhanced motility of the uterus, resulting in its release from the accumulated exudate, inhibiting the activity of pathogenic and conditionally pathogenic microflora in the cavity, increasing the resistance of the organism and regenerative processes in the endometrium, which is a necessary condition for effective treatment of endometritis.

The essence of the method is illustrated by examples.

Example 1. Confirmation of the feasibility of the method.

In terms of dairy farm farm "Lind" (Nizhny Novgorod region) formed 5 groups of cows, patients with purulent-catarrhal endometritis, 22 of the head in each. 4 groups of cows were subjected to laser treatment by rectal and external irradiation of the uterus in the form of monotherapy (two groups) and in combination with the introduction of the medicinal mixture in accordance with the invention (2 groups). In one group of cows was treated by the introduction of medicinal mixture in accordance with the invention, with the exception of laser irradiation of the uterus. Animals of all groups were kept in the same conditions on the same diet with clinical and gynecological examinations, ulitity presented in table 1.

As can be seen from table 1, the effectiveness of the treatment of endometritis claimed process (groups 4 and 5) 95.5-100% compared to 77.3 per cent laser (groups 1 and 2) and 81.8% of drug therapy (group 3), and the method of exposure of the uterus does not significantly affect the treatment efficiency due to the penetration depth of the laser beam to the biological tissue (up to 70 cm) and its divergence (10o50o). Preferred can be considered the irradiation of the uterus through the skin of the lumbar-sacral area due to ease of implementation.

Example 2. The rationale for effectiveness.

In cows of group 1 (laser monotherapy rectal), 3 groups (drug therapy) and 5 groups (combination of laser and drug therapy in accordance with the claimed method) before treatment and after recovery was determined by the level of resistance. The results are presented in table 2.

Table 2 shows that the number of erythrocytes, hemoglobin, total protein serum (OCS), immune proteins, indicators bactericidal, lysozyme and phagocytic activity before treatment were below the lower limits of physiological norm, suggesting a low resistance, and the number of cells above the level of faiths is azdarawlenne in all groups was accompanied by normalization of indicators of resistance. Found that in the treatment of the claimed method (group 5) normalization was much more intensive compared to laser mono and drug therapy. Thus, the level of immune proteins increased 1.13 compared to 1.07 times, and the BASS 1.39 compared to 1,24, the authors estimated the effect of activity - 1,78 compared with 1.2 (group 1) and 1.31 (group 3), and phagocytic activity - 1.45 compared to 1.15 times.

Example 3. Substantiation.

Studies were performed on cows, patients with purulent-catarrhal endometritis, which were divided into 3 groups. After confirmation of the diagnosis cows in group 1 were treated declared, cows 2 groups - basic, including injection into the interstitial space of the pelvic cavity novocaine-Furacilinum mixture containing one dose of novocaine 1.0 g, furatsilin 0.02 g distilled water 100 ml with the addition of 50 units of oxytocin every 48 hours until clinical recovery, cows 3 groups of - way, considered as the preferred analog (laser monotherapy).

All animals were kept under identical conditions on the same diet. The animals were clinical observations. The results are presented in table 3.

As can be seen from tabledriven as the preferred similar ways, when the treatment time was reduced by 5.5 and 3.5, the service period is 12.1 and 11.3 days, respectively, which increased by 3% output calves per 100 cows.

Studies have confirmed the feasibility and effectiveness of the claimed method, which provides a more rapid and complete elimination of the inflammatory process in the genital tract and increase the reproductive capacity of animals by reducing the frequency of treatments.

Sources of information taken into account

1. Rumyantsev A. I. Application of leporano, furazolidone and Ichthyol when endometritis in cows. //Issues of veterinary pharmacy and pharmacotherapy: Abstracts of the all-Union scientific-practical conference, October 1982 , Riga, 1982, S. 234-235.

2. Tkachenko, Y., Complex therapy of endometritis in cows: abstract of thesis Cand. veterinary Sciences, Voronezh, 1990, S. 24.

3. Fateev, S. Novocaine blockade obstetric-gynecologic diseases and mastitis in cows. // Veterinary medicine, 1992, 2, S. 40-43.

4. Inozemtsev B. N. , Balkovoy I. I. , Krylov So Century. and other experience in the use of laser apparatus STF-3 in veterinary practice. // Veterinary medicine, 1997, 5, S. 32-36.

5. Guidance on the application of laser the CLASS="ptx2">

Method for the treatment of endometritis in cows, including the irradiation of the uterus laser beam daily until clinical recovery, characterized in that it further in the interstitial space of the pelvic cavity is injected drug mixture containing one dose of novocaine 1.0 g, trypsin 0.05 g, karbaholina 0.002 g, distilled water 100 ml, with an interval of 48 h before clinical recovery.

 

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