Device for evaluation of pathological changes in the systemic activity of the brain

 

(57) Abstract:

The invention relates to the field of medicine and is intended to determine the state of the human brain and detection of pathological changes in its system activity. Device for evaluation of pathological changes in the systemic activity of the brain includes a set of sensors placed on a person's head, and/or plug-in to deep electrodes, and/or have at some distance from the head, multi-channel amplifier sensor signals, such as EEG, with the number of channels corresponding to the number of sensors, the power signal conversion, such as conversion from continuous form to the discrete unit of measurement statistical relationships between processes, the unit of measurement of the dimension of the display process corresponding to the aggregate statistical properties of the relationship between the measured processes, the evaluation unit coordinates and/or values of the radius-vectors of the displayed processes, block visualization of the spatial distribution of the radius-vectors of the displayed processes, such as a plotter or graphics display, a storage device, the unit of measurement differences parametertypes activity of a brain of the patient, block making tests and synchronization unit. The device allows you to accurately identify the extent and nature of sustainable pathological abnormalities of the systemic activity of the human brain, to determine their localization and the nature of the violations, to quantify the degree of pathological abnormalities associated with any of the tests or with any changes of the functional state of the brain. 5 C. p. F.-ly, 1 Il.

The invention relates to the field of medicine and is intended to determine the state of the human brain and detection of pathological changes in its system activity.

For the assessment of novelty and inventive step of the second independent object of the claimed solution consider a number of known technical devices of similar purpose.

A device for evaluation of pathological changes in the system of activity of a brain of the person representing the correlator equipped with electrodes placed on the patient's head and connected with the signal amplifier and an operational unit for the quantitative determination of the degree of correlation of the form of EEG waves within a certain time, recorded in two neighboring points of the patient's head, and the graphic is to changes in system activity of the human brain, includes a set of sensors placed on a person's head and/or plug-in to deep electrodes, multi-channel amplifier of the sensor signals with the number of channels corresponding to the number of sensors, the block synchronous signal conversion from continuous form to the discrete unit of statistical processing of the obtained data and the block surround playback, see patent US 4736751, And 61 In 5/04.

By the greatest number of similar features and achieved when using the result of this technical solution chosen for the prototype of the present invention.

The disadvantages of the prototype, which does not allow us to achieve our goal, is that the prototype does not provide a quantitative and qualitative assessment of pathological changes in the systemic activity of the brain.

Object of the invention is to reliably detect the extent and nature of sustainable pathological abnormalities of the systemic activity of the human brain, with the ability to set their localization and the nature of the violations, to quantify the degree of pathological deviations and abnormalities associated with any of the tests or with any changes of the functional state of the brain.

According to the invention the device for the assessment of pathological changes in the systemic activity of the brain, comprising a set of sensors that measure various vital processes of the brain, imposed on the person's head and/or plug-in to deep electrodes, and/or have at some distance from the head, multi-channel amplifier sensor signals, such as EEG, with the number of channels corresponding to the number of sensors, the power signal transformation, reflecting the vital processes of the brain, for example, conversion of signals from the continuous form in discrete unit of measurement statistical relationships between processes, characterized by it contains a computing unit coordinates and/or values of the radius-vectors of the displayed processes, storage device, the block visualization of the spatial distribution of the radius-vectors of the displayed processes, for example, a plotter or graphics display, while the outputs of all sensors are connected to the inputs multi-channel amplifier signals of sensors whose outputs are connected to inputs of power conversion signals, reflecting the vital processes of the brain, the outputs of which are connected with inputs of block I of the coordinates and/or values of the radius-vectors of the displayed processes, the outputs of which are connected to the input of the block visualization of the spatial distribution of the radius-vectors of the displayed processes, and multi-channel amplifier of the sensor signals, the power signal transformation unit statistical measurement of the relationship between processes and the computing unit coordinates and/or values of the radius-vectors of the displayed processes interconnected with the storage device.

This is a set of essential features that provide technical result in all cases to which the requested amount of legal protection.

In addition, the claimed solution has optional features that characterize its special cases, the specific form of its material embodiment or special conditions of its use, namely:

- the device can be equipped with an additional unit determining the dimensionality of the space display process corresponding to the aggregate statistical properties of the relationship between the displayed processes, included between the unit of measure of the statistical relationship between processes and computing unit coordinates and/or values of the radius-vectors of the display processesto can be equipped with an additional unit of measurement differences between the parameters of the spatial distributions of the radius-vectors of the displayed processes, the inlet of which is connected to the outputs of the unit of measure of the statistical relationship between the processes of the block definition of the dimension of the displayed processes and computing unit coordinates and/or values of the radius-vectors of the displayed processes, besides the unit of measurement differences between the parameters of the spatial distributions of the radius-vectors of the displayed processes interconnected with the storage device,

- the device can be equipped with an additional unit of rendering differences in the integrative activity of the brain of the patient, whose input is connected to the output of the measuring unit of the differences of the parameters of the spatial distributions of the radius-vectors of the displayed processes, in addition to the unit of rendering differences in the integrative activity of the brain interconnected with the storage device,

- the device can be equipped with an additional unit of presentation of tests, connected to the output of the storage device,

- the device may be further provided with a synchronization unit, the outputs of which are connected to all other blocks of the device.

The applicant has not identified the sources containing information about technical solutions, identical to this image the significant features of the invention (in conjunction with signs, specified in the restrictive part of the formula) achieved an important new properties of the object. In the proposed technical solution is achieved the possibility of direct observation of the structure of the system of interaction between processes of different parts of the brain and its current changes in pathology in systemic activity of the brain.

The applicant is not aware of any publication that would contain information about the impact of the distinctive features of invention technical result achieved. In this regard, according to the applicant, it is possible to draw a conclusion on the conformity of the proposed technical solution the criterion of "inventive step".

The invention is illustrated in the drawing, which presents a block diagram of the claimed device.

Device for evaluation of pathological changes in the systemic activity of the brain includes a set of sensors 1, imposed on the person's head and/or plug-in to deep electrodes, and/or have at some distance from the head, multi-channel amplifier 2 of the sensor signals, such as EEG, with the number of channels corresponding to the number of sensors 1, block 3 signal conversion, such as converting INIA dimensional space display process, the corresponding aggregate statistical properties of the relationship between the measured processes, unit 6, calculate the coordinates and/or values of the radius-vectors of the displayed processes, block 7 visualization of the spatial distribution of the radius-vectors of the displayed processes, for example, a plotter or graphics display, a storage device 8, block 9 measuring differences of parameters of the spatial distributions of the radius-vectors of the displayed processes, block 10 visualization of differences in the integrative activity of the brain of the patient, unit 11 of presentation of tests and synchronization unit 12.

The device operates as follows.

On the head of the patient to impose, and/or inserted, and/or set at some distance from the head sensors 1, registering the various processes of vital activity of a brain of the patient, for example, bioelectrochemically, magnetic and thermal processes. Multi-channel amplifier 2 amplifies the signals of the sensors 1, unit 3 converts the signals reflecting the vital processes of the brain, for example, from continuous form to the discrete. In unit 4 are measured and the conversion of the aggregate of the values of the statistical relationship between these processes, PR is the processes.

If necessary, in block 4 can be made of the statistical measurement of the relationship between processes using vzaimozachetnykh or coherent estimation methods, as well as symbolic, covariance, regression, vsaimnoponimanie, structural and methods using optical conversion processes.

Unit 5 permits necessary to determine the minimum dimension of the space, the corresponding aggregate statistical properties of the relationship between the measured processes. Block 6 is the calculation of the coordinates and/or values of the radius-vectors corresponding to the individual processes. Unit 7 performs the construction of mappings sets the radius-vector of the process at any convenient for visual perception of the shape considering the magnitude of the statistical relationships that are displayed in the form of values of the pairwise angles between the radius vector, taking into account the inverse relationship between the magnitude of the cosine of the angle between the radius vector and the value of a statistical relationship between the relevant processes.

Evaluation of pathological changes in the systemic activity of the brain produced by visual comparison of the spatial distribution glad the s in the spatial distribution of the radius-vectors and sensors judge pathology in systemic activity of the brain of the patient.

Evaluation of pathological changes in the systemic activity of the brain produced by visual and quantitative comparisons of the distribution of the radius-vectors with the distribution of the radius-vectors, typical of clinically healthy subjects.

The assessment of pathological changes in the systemic activity of the brain produced by visual and quantitative comparisons of the distribution of the radius-vectors with the distribution of the radius-vectors previously obtained from the same patient and stored in the storage device 8. This allows us to objectively assess the results of treatment.

The assessment of functional changes in the systemic activity of the brain produced by visual and quantitative comparisons of the distribution of the radius-vectors with the distribution of the radius-vectors, obtained from the same patient in the initial state and stored in the storage device 8. This allows us to assess changes in the functional status of the patient due to fatigue, medication, extreme conditions, in the natural state or hypnotic sleep and altered States of consciousness.

To assess changes in system activity of the brain plenty perform test tasks, shown with block 11, the distribution of the radius-vectors, obtained from the same patient in the initial state.

This allows you to evaluate the changes of systemic activity of the brain in mental and carrier of human activity, to conduct proficiency testing, tracking links mental abilities of the person with the spatial organization of systemic activity of his brain.

Quantitative comparison of the distribution of the radius-vectors can be performed in block 9 by measuring the sign and magnitude of the angular deviations of registered radius vectors from the norm of their location or value and/or variance values of the modules registered radii-vectors from their normative values, with the magnitude and sign of the angular deviations of the radius-vectors is judged on the presence and nature of pathological disorders systemic interaction of brain processes, and the deviations of the values of the modules of the radius-vectors is judged on purely local, focal, changes in the systemic activity of the brain. This allows the unit 10 to receive cards of differences in integrative systematic activities of various departments of a brain of the patient, Thu the integrative activity of different brain regions from normative.

Unit 9 also allows by comparing the minimum dimensions of the space identified in the patient in block 5, with the dimension of the space, the corresponding aggregate statistical properties of the linkages between the processes in clinically healthy subjects, to detect complex shape distortion of the normative patterns of spatial Association between the measured processes.

The synchronization unit 12 ensures consistent operation of all elements of the claimed device.

The main and most important advantage of the claimed device is simple and rapid detection of abnormalities in the systemic activity of the brain, effectively diagnose the extent and nature of the pathology and to monitor the results of treatment.

The claimed device allows you to:

- directly during the registration period to see on the display the distribution of the radius-vectors of the brain signals in a particular patient,

- the deviation of their location from regulatory effectively and quickly visually and quantitatively assess the severity of pathological changes and their nature,

- to assess their stabilin is/BR> - to identify purely local, focal changes and their localization,

to find the complex form of the distortion patterns of spatial Association processes,

- continuously qualitatively and quantitatively to assess the effectiveness of the treatment in its dynamics,

- to assess changes in the functional status of the patient due to fatigue, medication, extreme conditions, in the natural state or hypnotic sleep and altered States of consciousness,

- to determine the severity of local and inter-regional differences in the activity of different parts of the brain when a patient by a variety of test tasks,

to assess changes of systemic activity of the brain in mental and carrier of human activity, to conduct proficiency testing, tracking links mental abilities of the person with the spatial organization of systemic activity of his brain.

The industrial applicability of the claimed technical solution is confirmed by the successful results of experimental verification of the claimed device, all the blocks which are realized by the known methods using known wyposazenia statistical correlations between brain processes 4 can be performed using well-known in the field of electronics technical means, implementing different methods of mathematical analysis of the statistical relationship processes (correlation, coherence, as well as symbolic, covariance, regression, vsaimnoponimanie, crossspectral, structural and methods using optical conversion processes, and so on ). All these methods are known in the field of statistics, spectral analysis, or the analysis of random processes.

Unit 5 definition of the dimension of the displayed processes can be performed using well-known in the field of electronics technical tools that implement the methods of linear algebra and multivariate statistics.

Unit 6 calculate the coordinates and/or values of the radius-vectors of the displayed processes can be performed using well-known in the field of electronics technical tools that implement different methods of factor and component analyses, and methods of extreme groups of parameters, correlation Pleiades, multidimensional scaling.

Unit 7 visualization of the spatial distribution of the radius-vectors is implemented, for example, in the form of a plotter, graphic display, representing the necessary information or in tricoordinate="ptx2">

All of the above causes, according to the applicant, whether the claimed technical solution the criterion of "industrial applicability".

1. Device for evaluation of pathological changes in the systemic activity of the brain, comprising a set of sensors that measure various vital processes of the brain, imposed on the person's head and/or plug-in to deep electrodes, and/or have at some distance from the head, multi-channel amplifier sensor signals, such as EEG, with the number of channels corresponding to the number of sensors, the power signal transformation, reflecting the vital processes of the brain, such as the conversion of signals from the continuous form in discrete unit of measurement of the static relationships between processes, characterized in that it contains a computing unit coordinates and/or values of the radius-vectors of the displayed processes, storage device, the block visualization of the spatial distribution of the radius-vectors of the displayed processes, such as a plotter or graphics display, while the outputs of all sensors are connected to the inputs multi-channel amplifier of the sensor signals, the outputs of which are connected with the input from the input unit of measurement statistical relationships between processes, the outputs of which are connected with inputs of the computing unit coordinates and/or values of the radius-vectors of the displayed processes whose outputs are connected to the input of the block visualization of the spatial distribution of the radius-vectors of the displayed processes, and multi-channel amplifier of the sensor signals, the power signal transformation unit statistical measurement of the relationship between processes and the computing unit coordinates and/or values of the radius-vectors of the displayed processes interconnected with the storage device.

2. The device according to p. 1, wherein the device is further provided with a block for determining the dimension of the display process corresponding to the aggregate statistical properties of the relationship between the displayed processes, included between the unit of measure of the statistical relationship between processes and computing unit coordinates and/or values of the radius-vectors of the displayed processes, the block determining the dimensionality of the space interconnected with the storage device.

3. The device according to PP. 1 and 2, characterized in that the device is further provided with a unit for measuring differences of parameters of spatial distributed the relationships between processes, unit definition of the dimension of the displayed processes and computing unit coordinates and/or values of the radius-vectors of the displayed processes, in addition, the unit of measurement differences between the parameters of the spatial distributions of the radius-vectors of the displayed processes interconnected with the storage device.

4. The device according to PP. 1-3, characterized in that the device is equipped with an additional unit of rendering differences in the integrative activity of the brain of the patient, whose input is connected to the output of the measuring unit of the differences of the parameters of the spatial distributions of the radius-vectors of the displayed processes, in addition, the block visualization of differences in the integrative activity of the brain interconnected with the storage device.

5. The device according to PP. 1-4, characterized in that the device is equipped with an additional unit of presentation of tests, connected to the output of the storage device.

6. The device according to PP. 1-5, characterized in that the device is further provided with a synchronization unit, the outputs of which are connected to all other blocks of the device.

 

Same patents:
The invention relates to medicine, in particular to clinical neurophysiology, and can be used to identify contraindications for electrical stimulation in children and adolescents (7 - 18 years) without epileptiform brain activity

The invention relates to medicine, in particular for neurology and Pediatrics
The invention relates to medicine, in particular to methods of correction of the physiological state of the human body with the use of electromyostimulation his Central nervous system

The invention relates to medicine, namely to Nephrology, neurosurgery, and may find application in the study of structural and functional brain changes

The invention relates to medicine, namely to psychiatry and neurology
The invention relates to medicine, in particular to the field of medical and psycho-physiological diagnostics, and for diagnosing the degree of psycho-physiological maladjustment in patients with primary chronic cerebrovascular pathology
The invention relates to medicine, in particular to methods of objective diagnostics of disorders of sleep a night person

The invention relates to the field of diagnosis of acute CNS, namely to research methods diphtheria polyneuropathy (SFD) in children, and is intended for forecasting of the current cash flow with timely therapeutic correction
The invention relates to medicine, namely to addiction

FIELD: medicine, neurology, psychopathology, neurosurgery, neurophysiology, experimental neurobiology.

SUBSTANCE: one should simultaneously register electroencephalogram (EEG) to detect the level of constant potential (LCP). At LCP negativization and increased EEG power one should detect depolarizational activation of neurons and enhanced metabolism. At LCP negativization and decreased EEG power - depolarized inhibition of neurons and metabolism suppression. At LCP positivation and increased EEG power - either repolarized or hyperpolarized activation of neurons and enhanced metabolism. At LCP positivation and decreased EEG power - hyperpolarized suppression of neurons and decreased metabolism of nervous tissue. The method enables to correctly detect therapeutic tactics due to simultaneous LCP and EEG registration that enables to differentiate transition from one functional and metabolic state into another.

EFFECT: higher accuracy of diagnostics.

5 dwg, 1 ex, 1 tbl

FIELD: medicine, neurology.

SUBSTANCE: one should establish neurological status, bioelectric cerebral activity, availability of perinatal and ORL pathology in patients, establish their gradations and numerical values followed by calculation of prognostic coefficients F1 and F2 by the following formulas: F1=-31,42+1,49·a1-2,44·a2+0,2·а3+1,63·a4+0,62·а5+3,75·a6+1,8·а7-3,23·a8-0,8·а9-1,32·а10+3,26·а11+8,92·a12-2,0·a13+3,88·а14+1,79·a15+0,83·a16-2,78·a17; F2=-27,58+1,43·a1+3,31·а2+0,08·а3+3,05·а4-0,27·а5+2,69·а6+3,11·а7-6,47·a8-6,55·a9+1,99·а10+5,25·а11+7,07·a12-0,47·a13+0,13·a14+4,04·a15-1,0·a16-1,14·а17, correspondingly, where a1 - patient's age, a2 - studying either at the hospital or polyclinic, a3 - duration of stationary treatment (in days), a4 - unconscious period, a5 - terms of hospitalization since the moment of light close craniocerebral trauma, a6 - smoking, a7 - alcohol misuse, a8 - arterial hypertension, a9 - amnesia, a10 - close craniocerebral trauma in anamnesis, a11 - psychoemotional tension, a12 - meteolability, a13 - cervical osteochondrosis, a14 - ORL pathology, a15 - availability of perinatal trauma in anamnesis with pronounced hypertension-hydrocephalic syndrome, a16 - availability of paroxysmal activity, a17 - availability and manifestation value of dysfunction of diencephalic structures. At F1 ≥ F2 on should predict the development of remote aftereffects in young people due to evaluating premorbid background of a patients at the moment of trauma.

EFFECT: higher reliability of prediction.

2 ex, 1 tbl

FIELD: medicine; medical engineering.

SUBSTANCE: method involves doing multi-channel recording of electroencephalogram and carrying out functional tests. Recording and storing rheoencephalograms is carried out additionally with multi-channel recording of electroencephalogram synchronously and in real time mode in carotid and vertebral arteries. Electroencephalograms and rheoencephalograms are visualized in single window with single time axis. Functional brain state is evaluated from synchronous changes of electroencephalograms, rheoencephalograms and electrocardiograms in response to functional test. The device has electrode unit 1 for recording bioelectric brain activity signals, electrode unit 2 for recording electric cardiac activity signals, current and potential electrode unit 3 for recording rheosignals, leads commutator 4, current rheosignal oscillator 5, synchronous rheosignal detector 6, multi-channel bioelectric brain activity signals amplifier 7, electrophysiological signal amplifier 8, demultiplexer 9, multi-channel rheosignal amplifier 10, multi-channel analog-to-digital converter 11, micro-computer 12 having galvanically isolated input/output port and personal computer 13 of standard configuration.

EFFECT: enhanced effectiveness of differential diagnosis-making.

11 cl, 6 dwg

FIELD: medicine; medical engineering.

SUBSTANCE: method involves recording multichannel electroencephalogram, electrocardiogram record and carrying out functional test and computer analysis of electrophysiological signals synchronously with multichannel record of electroencephalogram and electrocardiogram in real time mode. Superslow brain activity is recorded, carotid and spinal artery pools rheoelectroencephalogram is recorded and photopletysmogram of fingers and/or toes is built and subelectrode resistance of electrodes for recording bioelectrical cerebral activity is measured. Physiological values of bioelectrical cerebral activity are calculated and visualized in integrated cardiac cycle time scale as absolute and relative values of alpha-activity, pathological slow wave activity in delta and theta wave bandwidth. Cerebral metabolism activity dynamics level values are calculated and visualized at constant potential level. Heart beat rate is determined from electrocardiogram, pulsating blood-filling of cerebral blood vessels are determined from rheological indices data. Peripheral blood vessel resistance level, peripheral blood vessel tonus are determined as peripheral photoplethysmogram pulsation amplitude, large blood vessel tonus is determined from pulse wave propagation time data beginning from Q-tooth signal of electrocardiogram to the beginning of systolic wave of peripheral photoplethysmogram. Postcapillary venular blood vessels tonus is determined from constant photoplethysmogram component. Functional brain state is determined from dynamic changes of physiological values before during and after the functional test. Device for evaluating functional brain state has in series connected multichannel analog-to-digital converter, microcomputer having galvanically isolated input/output ports and PC of standard configuration and electrode unit for reading bioelectric cerebral activity signals connected to multichannel bioelectric cerebral activity signals amplifier. Current and potential electrode unit for recording rheosignals, multichannel rheosignals amplifier, current rheosignals generator and synchronous rheosignals detector are available. The device additionally has two-frequency high precision current generator, master input of which is connected to microcomputer. The first output group is connected to working electrodes and the second one is connected to reference electrodes of electrode unit for reading bioelectrical cerebral activity signals. Lead switch is available with its first input group being connected to potential electrodes of current and potential electrodes unit for recording rheosignals. The second group of inputs is connected to outputs of current rheosignals oscillator. The first group of outputs is connected to current electrodes of current and potential electrodes unit for recording rheosignals. The second group of outputs is connected to inputs of synchronous detector of rheosignals. Demultiplexer input is connected to output of synchronous detector of rheosignals and its outputs are connected to multichannel rheosignals amplifier inputs. Outputs of multichannel bioelectrical cerebral activity signals amplifier, multichannel rheosignals amplifier and electrophysiological signal amplifier are connected to corresponding inputs of multichannel analog-to-digital converter. Microcomputer outputs are connected to control input of lead switch, control input of multichannel demultiplexer, control input of multichannel analog-to-digital converter and synchronization inputs of current rheosignals oscillator and synchronous detector of rheosignals. To measure subelectrode resistance, a signal from narrow bandwidth current generator of frequency f1 exceeding the upper frequency fup of signals under recording is supplied. A signal from narrow bandwidth current generator of frequency f2≠ f1>fup is supplied to reference electrode. Voltages are selected and measured at output of each amplifier with frequencies of f1, f2 - Uf1 and Uf2 using narrow bandwidth filtering. Subelectrode resistance of each working electrode is determined from formula Zj=Ujf1 :(Jf1xKj), where Zj is the subelectrode resistance of j-th electrode, Ujf1 is the voltage at output from j-th amplifier with frequency of f1, Kj is the amplification coefficient of the j-th amplifier. Subelectrode resistance of reference electrode is determined from formula ZA=Ujf2 :(Jf2xKj), where ZA is the subelectrode resistance of reference electrode, Ujf2 is the voltage at output from j-th amplifier with frequency of f2, Jf2 is the voltage of narrow bandwidth current oscillator with frequency of f2.

EFFECT: wide range of functional applications.

15 cl, 10 dwg

FIELD: medicine, psychiatry.

SUBSTANCE: one should conduct EEG-testing to detect total value of the indices of spectral power or percentage spectral power of delta- and teta-rhythms due to spectrometric technique in frontal, parietal, central and temporal areas both before and during emotional-negative loading when visual emotionally negative stimuli are presented followed by their imaginary reproduction. In case of higher indices to visual stimuli being above 15% against the background one should diagnose epilepsy. The method enables to increase the number of diagnostic means, increase accuracy and objectivity in predicting epilepsy with polymorphic paroxysms at dissociation of clinical and EEG-values.

EFFECT: higher efficiency of diagnostics.

1 ex, 1 tbl

FIELD: medicine, neurophysiology.

SUBSTANCE: one should carry out EEG survey to detect spectrometrically the index of full range if alpha-rhythm both before and after therapy. Moreover, power index of full range of alpha-rhythm and the index of 9-10 Hz-strip's spectral power should be detected in occipital cerebral areas. One should calculate the value of the ratio of the index of 9-10 Hz-strip's spectral power to the index of full range of alpha-rhythm and at the increase of this value by 20% against the background it is possible to evaluate positive result of therapy. The method increases the number of diagnostic means applied in evaluating therapeutic efficiency in the field of neurophysiology.

EFFECT: higher efficiency of evaluation.

1 ex

FIELD: medicine, neurology.

SUBSTANCE: method involves carrying out the standard vascular and nootropic therapy. Diazepam is administrated under EEG control with the infusion rate that is calculated by the following formula: y = 0.0015x - 0.025 wherein y is the rate of diazepam administration, mg/h; x is an average EEG amplitude, mcV. Method provides enhancing the effectiveness of treatment of patients. Invention can be used for treatment of patients in critical severe period of ischemic insult.

EFFECT: enhanced effectiveness of treatment.

2 tbl, 1 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: method involves selecting signals showing patient consciousness level and following evoked auditory potentials as responses to repeating acoustic stimuli, applying autoregression model with exogenous input signal and calculating AAI index showing anesthesia depth next to it.

EFFECT: quick tracing of unconscious to conscious state and vice versa; high accuracy of measurements.

9 cl, 3 dwg

FIELD: medicine; experimental and medicinal physiology.

SUBSTANCE: device can be used for controlling changes in functional condition of central nervous system. Device has receiving electrodes, unit for reading electroencephalograms out, analog-to-digital converter and inductor. Low noise amplifier, narrow band filter linear array which can be program-tuned, sample and store unit, online memory, microcontroller provided with controlled permanent storage, liquid-crystal indicator provided with external control unit are introduced into device additionally. Receiving electrodes are fastened to top part of patient's head. Outputs of electrodes are connected with narrow band filters linear array through electroencephalograph. Output of linear array is connected with input of input unit which has output connected with input of analog-to-digital converter. First bus of analog-to-digital converter is connected with online storage. Recording/reading bus of microcontroller is connected with control input of input unit and its starting bus is connected with address input of online storage. Third control bus is connected with narrow band filters linear array. Second control bus is connected with liquid-crystal indicator. Output bus is connected with inductor. External control (keyboard) of first control bus is connected with microcontroller. Output of online storage is connected with data input of microcontroller through 12-digit second data bus. Efficiency of influence is improved due to getting specific directed influence being based onto general technological transparency of processing of human brain's signals and strictly specific influence based on the condition of better stimulation.

EFFECT: increased efficiency.

3 cl, 1 dwg, 1 tbl

FIELD: medicine, neurology, professional pathology.

SUBSTANCE: one should carry out either biochemical blood testing and electroencephalography or SMIL test, or ultrasound dopplerography of the main cranial arteries, rheoencephalography (REG) to detect the volume of cerebral circulation and hypercapnic loading and their digital values. Then it is necessary to calculate diagnostic coefficients F by the following formulas: Fb/e=6.3-0.16·a1+0.12·a2-1·a3+0.2·a4, or FSMIL=9.6+0.16·a5-0.11·a6-0.14·a7+0.07·a8, or Fhem=48.6-0.04·a9+0.15·a10+13.7·a11-0.02·a12+24.7·a13, where Fb/e -diagnostic coefficient for biochemical blood testings and EEG; FSMIL - diagnostic coefficient for SMIL test; Fhem - diagnostic coefficient for hemodynamic testing; 6.3; 9.6 and 48.6 - constants; a1 - the level of vitamin C in blood; a2 - δ-index by EEG; a3 - atherogenicity index; a4 - the level of α-proteides in blood; a5 - scale 3 value by SMIL; a6 - scale K value by SMIL; a7 - scale 5 value by SMIL; a8 - scale 7 value by SMIL; a9 - the level of volumetric cerebral circulation; a10 - the value of linear circulatory rate along total carotid artery, a11 - the value of resistive index along total carotid artery; a12 - the value for the tonicity of cerebral vessels at carrying out hypercapnic sampling by REG; a13 - the value for the intensity of cerebral circulation in frontal-mastoid deviation by REG. At F value being above the constant one should diagnose toxic encephalopathy, at F value being below the constant - discirculatory encephalopathy due to applying informative values.

EFFECT: higher accuracy of diagnostics.

6 ex, 1 tbl

Up!