Method of prevention of postpartum diseases of the uterus of cows
(57) Abstract:The invention relates to veterinary medicine. 20 days before calving cows intramuscularly injected with sodium Selenite, and in the first 5 days postpartum daily laser irradiation of the uterus within 3-5 minutes At this twice with an interval C injected into the interstitial space of the pelvic cavity medicinal mixture containing one dose of novocaine 1.0 g, trypsin 0.05 g, karbaholina 0.002 g, distilled water 100 ml Provided with a reduced incidence of up to 15-10% and the maximum time approximation for the involution of the genital organs to the level of the upper limits of physiological norm (20-22 days). table 2. The invention relates to veterinary medicine, in particular to the veterinary obstetrics and gynecology, relates to a method for the prevention of postpartum diseases of the uterus of cows (retention of placenta, postpartum endometritis, subinvolution of the uterus) and can be used to reduce the fertility of breeding stock of cattle, higher output, calves, their safety, and increase milk production.Postpartum diseases of the uterus of cows (postpartum endometritis, subinvolution of the uterus) are recorded at 75 to 95% and more calving cows, vesovyh puerperium diseases of the uterus are adverse factors (physical inactivity, failure to comply normalized feeding, microclimate parameters and other stresses associated with environmental degradation), which has a negative effect on the General and local resistance of animals, as well as the load on the body and stress due to the physiological state (childbearing, childbirth), which caused a sharp decrease in immunobiological reactivity.Insufficient knowledge of the etiopathogenesis of postpartum diseases in cows has led to contradictory recommendations regarding the selection tools pharmacoprophylaxis. So, are widely used hormonal preparations (FLC, extrogen, oxytocin), complexes of fat-soluble vitamins, aseptic and cauterizing solutions, antimicrobial agents and their combinations [1,2,3].Known also environmentally safe methods of prevention of postpartum diseases of cows with the use of physical resources (different types of acupuncture, magnetic field, electromagnetic field UHF, and so on), which are based not suppress or enhance the functions of the organs, and the mobilization of domestic resources of the organism [4, 5].However, the known methods have a limited efficiency for different reasons. So, when profitech membranes of the genital organs and decreases the muscle tone of the uterus; the effectiveness of antibiotics, sulfonamides, nitrofuranovye and judicative drugs small due to the limited spectrum of activity and low or lack of sensitivity of microorganisms; effective normalization of metabolism of vitamins A, C, B1and B2the use of vitamins and their complexes is possible only with simultaneous metabolism of carbohydrates, phosphorus, calcium and vitamin E; physical means, activating redox processes in tissues and metabolism, insufficient stimulate contractility of the myometrium.In some cases illustrates the use of selenium products, for example of sodium Selenite, which affects a variety of biochemical reactions: contractile activity of the myometrium, the synthesis of prostaglandines, the metabolism of thyroid hormones, and it is possible that these biological mechanisms contribute to the timely separation of the placenta and accelerate the involution of the uterus  .The effectiveness of the prevention of postpartum complications in cows increases with an integrated approach using a variety of drugs and their combinations, which implies taking into account a number of factors, in particular fiziologicheskomu substances and so on, and charting prevention in each case, resulting in prevention activities require a considerable investment of time (the difficulty the dosage of certain drugs, a repetition of the introduction) and tools (most medications roads, therefore, are not economically feasible). In addition, each drug is an additional stress.The purpose of the invention is a high - performance environmentally safe method of prevention of diseases of the uterus of cows with a high degree of reproducibility of results.This goal is achieved by an integrated use of laser irradiation of the uterus and drugs - of sodium Selenite before and medicinal mixtures containing in each dose of novocaine 1.0 g, trypsin 0.05 g, karbaholina 0.002 g, distilled water 100 ml after calving.The method is as follows.20 days prior to calving dry cows intramuscularly injected with sodium Selenite at a dose of 50 mg, and in the first days after calving carry out the irradiation of the uterus through the rectum (rectal) or through the skin (topically), daily for 5 days for 3-5 min and twice with an interval of 72 h injected into the interstitial space of the pelvic floor is a private water 100 ml.The essence of the method is illustrated by examples.Example 1. The group of dry cows 20 days prior to calving intramuscularly injected sodium Selenite at a dose of 50 mg, and in the first days after calving were irradiated rectal cancer or externally for 3-5 min daily for 5 days and twice with an interval of 72 h was injected into the interstitial space of the pelvic cavity medicinal mixture containing one dose of novocaine 1.0 g, trypsin 0.05 g, karbaholina 0.002 g distilled water 100 ml Irradiation of the uterus was performed low-intensity laser pulse radiation average power is not more than 0.3 watts, with a wavelength of 0.87 to 0.97 μm (870-970 nm) and modulation frequency of 10 to 2000 Hz with the use of veterinary laser therapeutic apparatus STP-z by rectal irradiation of the uterus emitter, previously placed in a plastic glove or package, introduced into the rectum and directed the beam to the uterus, while exposing through the skin was put on the skin between the transverse processes of the lumbar and sacral vertebrae.Medicinal mixture was prepared before the application of the sequential mixing of components: a portion of novocaine 1.0 g was dissolved in 98 ml of distilled water followed by sterilization 0.05 g and 2.0 ml of sterile 0.1% solution karbaholina. Dosage of the mixture were injected with in the interstitial space of the pelvic cavity through the point of injection in peredniene corner sciatic-pryamokishechnye holes on one side with a syringe Janet connected to a rubber hose with needle Bobrov. The injection site were thoroughly cleaned and disinfected, and the needle Bobrov was injected at an angle of 30-40oto the plane of the holes parallel to the sacral vertebrae at a depth of 3-7 seeThe effectiveness of prevention depending on the processing method of the uterus amounted to 87.5 rectal and 83.3% for exterior exposure, the timing of the involution of the genital organs is practically not depend on the method of exposure and amounted to 22.3 2,0 and 22.5 2.0 days, respectively, therefore, were close to the level of the upper limits of physiological norm.Example 2. Comparative effectiveness
Determined the effectiveness of the claimed method in comparison with known methods-analogues (with the use of sodium Selenite prior to calving, using laser irradiation of the uterus after calving) and basic way (pharmacoprophylaxis using schema: tetravit + oxytocin + sinistral) in dairy complex in winter-stall period on cows kept in the same conditions on an the us in the table. 1.From table. 1 shows that the claimed method prevented the development of postpartum diseases of the uterus in 83.4% of cows compared to 50.0 and 54.2 per cent in ways analogous to and 58.3% in the base method with a significant reduction in terms of the involution of the genital organs - 5.3 and 3.5 days compared with how peers and 3.4 days compared to the baseline method.Example 3. Rationale the effectiveness of
To substantiate the effectiveness of the claimed method in a comparative study of the level of natural resistance in cows in the postpartum period (within 10 days after calving). The results are presented in table. 2.From table. 2 shows that all the indicators of the natural resistance of the organism in groups 1, 2, 3 normalized within the physiological norm, in group 3 on the upper level, in groups 1 and 2 the lower limits of physiological norm. In animals not subjected to preventive treatment, the corresponding figures are close to the lower limits of physiological norm. Positive changes of natural resistance manifested by the activation of the processes of involution of the genital organs.The novelty of the claimed method consists in using the laser irradiation mA is the essential introduction to the interstitial space of the pelvic cavity medicinal mixture, containing one dose of novocaine 1.0 g, trypsin 0.05 g, karbaholina 0.002 g distilled water 100 ml, with an interval of 72 h for the prevention of postpartum diseases of the uterus of cows. The uncertainty of the proposed scheme, combining laser irradiation and pharmacoprophylaxis with the usage of drugs, the choice of which was based on the etiology, pathogenesis and clinical manifestations of postpartum diseases of the uterus, which allows to reduce the incidence of up to 15%, indicates the compliance of the way the criterion of "inventive step". The feasibility and effectiveness of the method is confirmed in the research and production experience.Sources of information taken into account:
1. Vlasov S. A., Nezhdanov A. G., Regulation steroidogeneza and prevention of generic and postpartum diseases in cows. Tr. Institute all-Union scientific research Institute of non-contagious diseases of animals. 1988. C. 22-24.2. Vlasov S. A., the Use of vitamin and hormonal preparations and of sodium Selenite to prevent the detention of the placenta in cows // Issues of veterinary pharmacy and pharmacotherapy: Abstracts, all-Union scientific-practical conference, October 1982. - Riga, 1982. S. 179-180.3. Nauchno. - 25 S.4. Guidance on the application of the method of acupuncture for the prevention and treatment of obstetric-gynecological diseases cows: Approved by the veterinary Department of the Ministry of agriculture of the Russian Federation 16.03.2000, M., 2000. - 19 S.5. Guidance on the use of laser devices of mark "STP" in veterinary medicine: Approved by the veterinary Department of the Ministry of agriculture of the Russian Federation 19.03.2000, M., 2000. - 3 C.6. Veterinary medicine, 1998, No. 3, S. 37-38. Method of prevention of postpartum diseases of the uterus in cows, including intramuscular injection of sodium Selenite 20 days prior to calving, characterized in that it further in the first days postpartum conducting laser irradiation of the uterus for 3-5 minutes daily for 5 days and twice with an interval of 72 h injected into the interstitial space of the pelvic cavity medicinal mixture containing one dose of novocaine 1.0 g, trypsin 0.05 g, karbaholina 0.002 g, distilled water 100 ml
SUBSTANCE: method involves carrying out hernia removal in intralaminar way. Posterior longitudinal ligament defect is covered with Tacho-Comb plate after having done disk cavity curettage. Subcutaneous fat fragment on feeding pedicle is brought to dorsal surface of radix and dural sac.
EFFECT: enhanced effectiveness of treatment; reduced risk of traumatic complications.