A method of treating disease reiter

 

(57) Abstract:

The invention relates to medicine and can be used in dermatology for the treatment of chronic infections of the urogenital tract, namely disease Reiter. In the method of treatment of a disease Reiter, including integrated local, physical and drug therapy with antibiotics, proposed protivokomarinye antibiotic to enter lymphotropic in the Shin, with the 1st to the 5th day medicine to enter once a day, and starting from the 7th day to once every other day for a total course of 15 injections. The introduction is carried out on a methodology that provides optimum penetration and saturation of the lymphatic system antibiotic. For this antibiotic is administered in the midline posterior surface of the tibia at the junction of its upper and middle thirds angle of 45, and the antibiotic is diluted with water for injection for a total of 7-8 ml, and the rate of introduction of the drug out 1 ml in 1 minute. As antibiotic injected abaktal 400 mg per injection, or rivoal 250 mg per injection. The method provides relief of symptoms of Reuters. 2 C.p. f-crystals, 1 table.

The invention relates to medicine and can be applied in dermatology at electromega treatment in the treatment of disease Reiter, includes oral antibiotics (tetracyclines, macrolides, fluoroquinolones, rifampicin), aimed at the elimination of chlamydia and other pathogens. (Y. N.Kovalev, I. I. Ilyin. Disease Reiter.- Chelyabinsk. 1993. -S. 192-195; sexually transmitted and Skin diseases: a Handbook / edited in the treatment of disease Reiter O. L. Ivanova. -M.: Medicine, 1997. -S. 244).

The disadvantage of these methods is long and 1.5 -2-month period of treatment, large course doses of antibiotics, the development of dysbiosis and immunosuppression.

The closest is a method of treating disease Reiter, including integrated local, physical and drug therapy with antibiotics, as the last appoint oral tetracycline 2-3 grams per day (reception is divided into 4-5 doses) for 4-7 weeks, i.e. 56-147 g on the course. (Molochkov C. A., Ilyin I. I. Chronic retrogenes prostatitis. -M.: Medicine, 1998. -S. 269. ; Y. N. Kovalev, I. I. Ilyin. Disease Reiter. - Chelyabinsk. 1993. -S. 192).

The disadvantages of such regimens of antibiotic in that it is long, while developing various complications of other organs and systems (candidiasis, severe dysbiosis Kish is practical disorders; even when adequate doses protivodiareynah funds in cases of treatment failure can be as high as 30-40%, and in repeated two-month courses etiotropic therapy to be 25%.

The present invention was to remedy these disadvantages by providing a direct hit of a drug to the site of infection of the urinary tract, which allows the use of smaller course doses and in a shorter time effectively to achieve causal cure with fewer side effects.

For this purpose, the method of treatment of a disease Reiter, including integrated local, physical and drug therapy with antibiotics, proposed protivokomarinye antibiotic to enter lymphotropic in the Shin, with the 1st to the 5th day medicine to enter once a day, and starting from the 7th day once a day; the General course of 15 injections.

In addition, proposed as antibiotic use abaktal 400 mg per injection, or rivoal 250 mg per injection.

The method is as follows.

Upon confirmation of disease diagnosis Reuter conducted a comprehensive treatment, including antibiotic therapy, local therapy x-inflammatory drugs, and in the second stage of the disease and immunodepressive funds (glucocorticoids, cytotoxic drugs, drugs group hingamina and so on). In addition, a symptomatic treatment and physiotherapy.

Antibacterial therapy lymphotropic way to do this, the patient is laid on his stomach. The back surface of the tibia treated with alcohol. Strictly in the midline posterior surface of the tibia, at the junction of its middle and upper thirds, at 45ois injected into the subcutaneous tissue, the needle for the a/m drugs. First introduced 32 ED lidz dissolved in 5.0 ml of 0.25% novocaine. Then, without removing the needle, after a 5 minute break is introduced antibiotic 400 mg abaktal or 250 mg rithala diluted with water for injection to a total volume of 7-8 ml of Introduction is carried out slowly at a rate of 1 ml in 1 minute. From the 1st to the 5th day the drug is administered lymphotropic 1 time per day. Starting from the 7th day the drug is administered lymphotropic once a day. Injections in both tibia turns alternating. In the course of 15 injections.

Lymphotropic gives the antibiotics as low molecular weight compounds are completely different properties, thanks to which antibiotic drugs can easily penetrate the o concentration in the Central lymph, blood, lymph nodes, organs and tissues (in the introduction and beyond) is several times higher than that in other ways. For lymphotropic antibiotic therapy of patients with disease Reiter has very favorable anatomic prerequisites, due to the fact that part of the lymphatic vessels of the body of the prostate (inflammation mainly chlamydial etiology which is fundamental in the pathogenesis of the disease Reiter) is sent to the iliac lymph, and in the course of VAS duct and the inguinal lymph nodes; therefore, antibiotics, put lymphotropic Shin able to get into the inguinal lymph nodes, and from them through the lymphatic vessels of the spermatic cord in the lymphatic vessels and tissue of the prostate. And oral antibiotics due to anatomical features of prostate cancer - the presence of dense fibrous capsule, which even at the commencement of the inflammation in the gland increases vnutripoliticheskoi pressure - shipping medicines in gland choked on the arterioles very difficult. In women who develop the disease Reiter 10-100 times less likely than men entered the lymph is clinical infection of the urogenital tract.

The proposed method allows for the bioavailability significantly reduce the total dose rate and the concentrations of drug in the body.

The invention is illustrated by the following examples.

Example 1.

Patient, 27 years, football, history 7178. Diagnosis: the disease Reiter (chronic chlamydial urethroprostatitis, vesiculitis, chronic conjunctivitis, polyarthritis), 2 tbsp., aggravation. At admission were noted complaints of swelling in the right knee joint, pain, limited mobility in him, dragging pain in the perineum, periodic burning in the urethra, slight redness of the eyes, weakness, periodic evening rise in body temperature up to 37.5. Aggravation after sexual infection. During examination: catarrhal colliculi, posterior urethritis, litterati (ureteroscopy); in the semen asthenoteratozoospermia; title protivodiareynah immunoglobulins in the ejaculate lgG 1:32; immunomorphological skin examination revealed lgG in the reticular layer of the dermis; ECG syndrome early ventricular repolarization. The treatment by the above method using abaktal 400 mg per injection N 15. On the background of treatment, the patient noted improvement in otsustava, stop pain in joint; immediately after completion of the course was able to resume training in the field. When examining the title protivodiareynah IgG 1:8, the improvement of semen; if immunomorphological study of skin IgG in mesh layer were absent; showed normalization of the shape of the prostate. The control tests for STIs chlamydia is not found.

Example 2.

Patient P. , 31,, history 10727. Diagnosis: the disease Reiter (chronic total chlamydial urethritis, transient infiltration of the anterior urethra, catarrhal colliculi, chronic follicular prostatitis, arthritis, sacroiliac), 2 tbsp., aggravation. At admission were noted complaints of pain in the perineum, the small pains in the urethra, pain in large joints, spine, sharply movement impairing expressed weakness, weight loss of 12 kg, evening rise of temperature of the body. Earlier re-symptomatic treatments, including antibiotics effect was not given. During the examination in the General analysis of blood ESR 25 mm/h, hemoglobin 117, leucocytes 10; ECG sinus tachyarrhythmia with HR 78-98 beats in minutes a comprehensive treatment using rithala 250 mg on lease, N 15, at the above lipotropin is pokazateli blood, a significant decrease in pain in the joints, the patient was free to move independently, no pain in the perineum and smarting in the urethra, showed normalization of the shape and boundaries of the prostate. The control tests chlamydia is not revealed, leukocytosis in General smear and juice prostate was absent.

The advantage of the proposed method is that with the introduction of the antibiotic is not activated gastrointestinal tract, does not occur dyspeptic disorders. No complications from other bodies: pronounced and persistent dysbiosis, candidiasis, depression of the immune strength of the body. Achieved causal cure in 100% of cases, and in oral administration in 60-70%.

Unlike methods of introducing antibiotic specified in the application method of antibiotic therapy has not only regional effect (treatment of uretroprostatit), but expressed a General impact on the complex symptoms of the disease Reiter : polyarthritis, conjunctivitis, etc.

So, for dynamic monitoring of the immune status of the eight patients noted immunocorrective effect that was not detected in the previously used methods, which, by contrast, caused immunosuppresent manifestations of the articular component - polyarthritis - when applying the inventive method occurred on average after 2 weeks, and in other ways therapy - not earlier than 3 weeks.

In terms seriological studies after the course lymphotropic antibiotic therapy at the stated procedure were noted such positive developments as the decrease in agglutination and the lack of available previously leucospermum, whereas standard methods can be marked only the reduction of leucospermum.

After treatment at the stated procedure marked prolongation of the remission period - an average of 2 -3 months.

The table below presents a comparative analysis of the impact on the patient's body during the application of various methods of treatment of the disease Reiter.

The table shows that the results of the treatment by the proposed method are more pronounced. The obtained clinical results suggest that the proposed method: injection site at the specified rate with the breeding of antibiotic water has a therapeutic effect on chronic source of infection in the urogenital tract, but also affects the subsidence of the extent of autoimmune destruction of other organizations is the treatment time.

With regard to the foregoing, as described in the application method of treatment differs significantly from other traditional methods.

1. A method of treating disease Reiter, including integrated local, physical and drug therapy with lymphotropic introduction protivodiareynogo antibiotic in the Shin, with 1 to 5 injections daily, and starting from the 7th day to once every other day, characterized in that the antibiotic is administered in the midline posterior surface of the tibia at the junction of its upper and middle thirds angle of 45oand the antibiotic is diluted with water for injection to a total volume of 7 to 8 ml, and the rate of introduction of the drug out 1 ml of 1 min, the rate of 15 injections.

2. The method according to p. 1, characterized in that the quality of antibiotic use abaktal 400 mg per injection.

3. The method according to p. 2, characterized in that the quality of the antibiotic impose rivoal 250 mg per injection.

 

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