The method of obtaining anti-parasite tincture
(57) Abstract:The invention relates to medicine. Perform the insistence of okoloplodnika biologically Mature walnut until the loss of the fetus from the pericarp in an aqueous solution of alcohol in a ratio of components, wt.%: the pericarp of 4 to 6, an aqueous solution of alcohol 94 - 96. The alcohol content of an aqueous solution of alcohol is not less than Ob.%. The maceration is carried out in a period of not less than 35 days. The invention reduces the time course of antiparasitic effects while maintaining efficiency, to reduce the total amount of alcohol consumed while receiving infusions. 1 C.p. f-crystals. The invention relates to medicine and can be used in the manufacture of a medicinal product and dosing of its use for getting rid of a variety of parasites, particularly helminths of different types.Art
It is known that for getting rid of worms, in particular, in the treatment of ascariasis use synthetic anthelmintic number: piperazine, nattamon, decaris, etc. (Mashkovsky M. D. Medicines, M., 1986, ch. II, sec. 372). These drugs have negative side effects as nausea, pain in the statements of the application of these drugs are organic diseases of the Central nervous system and the liver. Most synthetic drugs are accepted from 2 to 5 days.A method of obtaining funds for deworming, in particular cucurmin, including direct extraction of crushed pumpkin seeds, dual defatting with petroleum ether in a ratio of 1:1 after the separation of the syrup and the deposition of ballast methanol in a ratio of from 1:3 to 1:4 in the cold (SU 1223912, A 61 K 35/78, 15.04.86). This anthelmintic insufficient, and the use of when obtaining toxic substances does not exclude its toxic effect.There is also known a method of producing a drug that has protivosnaryadnym action, including extraction of raw materials in the form of the nut milk ripeness (EN 2136304, A 61 K 35/78, 10.09.99). As extractant used purified kerosene when the ratio of raw material and extractant from 1:0.8 to 1: 1.5 and then add the sunflower oil to the total content of fatty oils in the final product at the level of 11%. Experiments on animals have shown that the effectiveness of this drug reaches 100% at the maximum non-lethal dose for mice 19 g/kg, However, used as extractant kerosene is a significant obstacle for wide used the Tu to the described method of obtaining anti-parasite tincture is a method of obtaining anti-parasite tincture, including the infusion of raw materials on the basis of a walnut in an aqueous solution of alcohol (EN 2135200, A 61 K 35/78, 27.08.99). The method involves the use as feedstock green black walnuts. The increasing concentration of drug substance in aqueous solution of alcohol is due to the fact that 100 wt.h. walnut taken from 100 wt. 'clock to 1000 wt.h. solution of alcohol with alcohol content in the solution is from 40% vol. up to 96%. The maceration is carried out in a period of 3-21 days. High concentration solution of a medicinal product, on the one hand, increases the efficiency and, on the other hand, limits the duration of use, as when the daily average intake of 50 drops of the course duration should not exceed 1.5 months. Otherwise, a daily dose of this quantity drops highly concentrated alcohol solution may lead the patient to alcohol dependence.The invention
The present invention is to provide a method for obtaining anti-parasite tincture with improved quality characteristics.The solution of this task, you can get technical results, to be administered total amount of alcohol used when receiving a tincture, is the encoding of the body to recognize and destroy worms.These technical results are achieved by the fact that in the method of obtaining anti-parasite tincture, including the infusion of raw materials on the basis of a walnut in an aqueous solution of alcohol, as a source of raw materials used pericarp biologically Mature walnut until the loss of the fetus from the pericarp when the ratio of the components (wt.%):
The pericarp of Mature walnut - 4-6
An aqueous solution of alcohol - 94-96
moreover, the content of alcohol in an aqueous solution of alcohol is not less than 30 vol.%, and the maceration is carried out in a period of not less than 35 days.A distinctive feature of the present invention is as follows. As a source of raw materials use proper pericarp biologically Mature walnut, i.e. open pericarp. Moreover, it has been experimentally established that the effect would be achieved if the pericarp will be disrupted until the loss of the fetus. The thwarted okoloplodnika extract of the fruit, then pour oculoplasty aqueous solution of alcohol in a ratio of components, wt.%:
Approximately now selected on the basis of that the entire mass of raw materials is guaranteed to be covered with a layer of an aqueous solution of alcohol. The alcohol content in the aqueous solution of the alcohol of not less than 30 (% vol.) due to the fact that at lower alcohol concentration sharply decreases the concentration of drug in the infusion. At the time of infusion less than 35 days is not output to insist the solution all medicinal substances that form the basis of infusions.It is advisable to insist pericarp biologically Mature walnut in the number amounts to 4.76 wt.%.Information confirming the possibility of carrying out the invention
Features of the present invention are illustrated by examples.Example 1. Patient K., 43 years. Presented with severe disease of the blood - thrombocytopenia. Were treated with standard regimens for five years in Haematology departments. Therapy worsened the condition, the disease manifested brighter. Chronic hepatitis, pancreatitis, ulcer 12 duodenal ulcer (8 years), thrombocytopenia, burst vessels (bruises under the skin), fatigue, depression, fears. When diagnosing identified 6 species of worms in the liver, trichomoniasis and symbiosis of other parasites. Within six days of taking the antiparasitic naturestone alcohol at a ratio of components, wt.%:
The pericarp of Mature walnut - 4
An aqueous solution of alcohol - 96
when the content of alcohol in an aqueous solution of 60 vol.%. The maceration was carried out for 40 days. When the content of the pericarp less than 4 wt.%, the concentration of drug in the infusion insufficient for effective impact. During the first five days of taking on an empty stomach and two drops of tincture diluted in 100 ml of water. From the sixth to the eighth day or two teaspoons diluted in 50 ml of water. After the course was examined in the clinic. Conclusion - almost healthy. Six months is a preventive measure tincture. When checking the always - infected worms 0%. Healthy. Works. Disease, above, left.Example 2. Patient, 53 years. Migraine, hypertension, obesity, cholecystitis, pancreatitis, pyelonephritis. Took systematically more than ten drugs proposed operation on the heart (tachycardia). Treatment by traditional schemes within ten years brought no relief. When the primary diagnosis of helminths detected four classes - belt, round, flukes, bacterial diseases. Special attention was attracted by toxoplasmosis, and trichomoniasis, chlamydia. During the first five days of taking the tincture, scientific insisting pericarp of Mature walnut in aqueous alcoholic solution at a ratio of components, wt.%):
The pericarp of Mature walnut - 5
An aqueous solution of alcohol - 95
when the content of alcohol in an aqueous solution of 30 vol.%.The extract was diluted in 80 ml of water. On the sixth day of admission amounted to 1.5 teaspoons of tincture in 40 ml of water. After the course condition has improved - gone headaches, my blood pressure normalized, reduced weight 15 kg Patient, praised the properties of the tincture, acting as the strongest degirmenlik that creates immunity against worms.Example 3. Patient C. (10 years) - former champion in rhythmic gymnastics. Became motionless, the joints were not functioning. Treated with antibiotics, antihistamines hormones. The condition worsened. It is proposed to issue disability in childhood. The diagnosis of chlamydial oligoarthritis. When the primary diagnosis defined infecting worms four classes, including chlamydia and toxoplasmosis. During the 21st daily total Wellness course were receiving infusions on an empty stomach (from the ninth day of the General course) 3 drops in 60 ml of water. Tincture obtained by 35 daily infusion of pericarp biologically Mature walnut in an aqueous solution of alcohol in a ratio of components, wt%:
Acolop the 6 vol.%. If the number of pericarp walnut greater than 6 wt.%, the aqueous solution of alcohol may not completely cover a lot of the pericarp, which during infusion swells. The lack of alcohol leads to the possibility of oxidation of the pericarp. To obtain high-quality tinctures it is necessary that the raw material was completely covered with the alcohol, with the possibility of impregnation of the entire mass.Dose of the tincture on the sixth day amounted to 1.5 teaspoons in 120 ml of water. An additional two days taken 2 teaspoons of tincture in 120 ml of water. After General Wellness course that includes the use of anti-parasite tincture, the girl began to walk, to write, he resumed his studies in school physical education classes. The condition is satisfactory. The opinion of the parents - tincture returned the girl health.Example 4. Patient W., (22 years). Used tincture yourself. Before applying the tincture twice prooperirovanna in gynecology regarding ovarian cysts, found roundworm, Toxoplasma, Trichomonas, fungi Mycoplasma. In the first five days, the dose of the tincture was five drops in 120 ml of water, and on the sixth day - 1.5 teaspoons in 40 ml of water. The product was obtained by maceration 1 part (4,76 wt. %) receiving infusions newly formed cysts resolved. The need for surgery anymore. The opinion of the patient - tincture contributed to getting rid of parasites who created the ovarian cyst, it destroys worms brain toxoplasmosis and all of ascarides. Despite the specifics of the work (pig farm), after deworming infecting worms, fungi - 0%. 1. The method of obtaining anti-parasite tincture, including the infusion of raw materials on the basis of a walnut in an aqueous solution of alcohol, characterized in that the feedstock used pericarp biologically Mature walnut until the loss of the fetus from the pericarp when the ratio of components, wt.%:
The pericarp of Mature walnut - 4 - 6
An aqueous solution of alcohol - 94 - 96
moreover, the content of alcohol in an aqueous solution of alcohol is not less than 30 vol.%, and the maceration is carried out in a period of not less than 35 days.2. The method according to p. 1, characterized in that the feedstock used pericarp biologically Mature walnut until the loss of the fetus from the pericarp in the number amounts to 4.76 wt.%.
FIELD: medicine, cardiology, phytotherapy, pharmacy.
SUBSTANCE: invention relates to the field in development of an agent of vegetable origin used for improvement of the functional state and prophylaxis of organic alterations in cardiovascular system, in particular, atherosclerosis. The biologically active supplement used for prophylaxis of cardiovascular diseases, in particular, atherosclerosis comprises clover dry extract, haw-thorn flowers powder, ascorbic and nicotinic acids, and accessory substances taken in the definite ratio. The biologically active supplement is made in the form of tablet or capsule. No adverse responses observed in intake of the supplement. The blood cholesterol level was reduced to the normal value in 68% of patients and reducing morbidity with acute respiratory-viral infections has been noticed. In patients with ischemic heart disease with cholesterolemia the improvement of the state is noted on the background of conventional therapy: the moderate reducing the arterial pressure value in its elevation, improved in the state of health, enhanced working capacity, reduced retrosternal pains, ear noise, vertigo, headache.
EFFECT: valuable medicinal properties of supplement.
FIELD: medicine, hematology.
SUBSTANCE: invention relates to applying elm-leaf dropwort (Filipendula) above-ground part 40% alcoholic tincture as an agent stimulating erythroidal and granulocytic hemopoiesis stems in cytostatic myelorepressions. Agent promotes to effective stimulation of erythroidal and granulocytic hemopoiesis stems in cytostatic myelodepression. Invention is used for correction of disorders arising in blood system in administration of cytostatic preparations.
EFFECT: valuable medicinal properties of agent.
FIELD: organic chemistry, chemical technology, agriculture.
SUBSTANCE: invention relates to a method for preparing the preparation comprising triterpenic acid water-soluble salts and additionally added protein-containing product and vegetable raw, the source of triterpenic acids taken in the following ratio of components, wt.-%: protein-containing product, 10-17; triterpenic acid sodium salts, 4-5, and vegetable raw, the balance. Method involves mixing triterpenic acid-containing vegetable raw with the protein-containing product taken in the ratio = (9-11):(1-2), mechanical-chemical treatment of this mixture in activator device, mixing of prepared semi-finished product with sodium carbonate or sodium hydrocarbonate taken in the ratio = (92-97):(3.5-8.3) and repeated treatment in the activator device. Method involves applying flow-type ball vibration-centrifugal or ellipse-centrifugal mills as the activator device that provide the acceleration of milling bodies up to 170-250 m/c2 and time for treatment for 1.5-3 min. Invention provides simplifying the process and the complex processing waste in lumber industry.
EFFECT: improved preparing method.
6 cl, 1 tbl, 6 ex
FIELD: beauty products manufacturing.
SUBSTANCE: the present innovation deals with manufacturing cosmetic composition that contains solubilized cumic alcohol of a certain formula, glucose, ascorbic acid or compound which is split in skin up to glucose or ascorbic acid and a cosmetically acceptable carrier. Components should be taken at a certain quantitative ratio. The suggested composition improves expression of transglutaminase-1 and ceramides in skin cells and enhances absorption of glucose and ascorbic acid by cells.
EFFECT: higher efficiency.
1 cl, 5 ex, 12 tbl
FIELD: organic chemistry, natural compounds, medicine, oncology.
SUBSTANCE: invention represents new saponin mixtures used for inhibition of initiation and activation of mammalian epithelial cell in pre-malignant or malignant state, for stimulation of apoptosis of mammalian malignant cell, prophylaxis of anomalous proliferation of mammalian epithelial cell, for treatment of inflammatory and regulation of angiogenesis in mammal. These mixtures are isolated form plants of species Acacia victoriae. Also, invention relates to methods for their applying. These compounds can comprise triterpene component, such as acacic or oleanolic acid to which oligosaccharides and monoterpenoid components are joined. Mixtures and compounds elicit properties associated with regulation of apoptosis and cytotoxicity of cells and strong anti-tumor effect with respect to different tumor cells.
EFFECT: valuable medicinal properties of compositions.
43 cl, 53 tbl, 50 dwg, 44 ex
FIELD: pharmaceutical industry and technology, pharmacy.
SUBSTANCE: invention relates to a method for preparing extract based on walnuts at milkwax stage of ripeness. Method for preparing extract based on walnuts involves grinding walnuts at milkwax stage of ripeness taken with pericarps, drying to air-dry state, mixing with wild rose fruits ground and dried to air-dry state and taken in the definite ratio of components followed by treatment with aviation kerosene and stirring at room temperature. Method provides preparing extract with the higher content of biologically valuable substances and to increase the assortment of vegetable supplements.
EFFECT: improved preparing method.