Medicinal composition for the local treatment of benign tumors and precancerous diseases of the skin

 

(57) Abstract:

The invention relates to medicine, more specifically to dermatology, and can be used for the treatment of benign tumors (adenoma, fibroma), including viral etiology (all forms of warts, molluscum contagiosum), and precancerous diseases of the skin (keratosis, keratoacanthoma, cylindroma etc). The invention consists in that the pharmaceutical composition comprises nitric acid, copper nitrate, dimethyl sulfoxide and water. Composition is prepared using conventional blending techniques. The invention provides amplification her keratoplasticheskie and antiviral activity in tissue pathological lesions, to accelerate its penetration into the tissue while reducing aggressive reactions to healthy skin, which leads to the rapid achievement of a stable treatment effect. The effectiveness of treatment in comparison with the prototype increases from 60 to 70% to 96.7%. table 1.

The invention relates to medicine, namely to dermatology, and can be used for the treatment of benign tumors (adenoma, fibroma), including viral etiology (all forms of warts, molluscum contagiosum), and precancerous diseases of the skin (keratosis, carat is and neoplastic diseases of the skin, including benign viral, pre-cancerous. These diseases can lead to disability, often recur. Existing therapeutic tools are not always fully heal these skin diseases, causing painful subjective feelings of the patients. Therefore there is a need for new more effective treatments.

Known medicinal composition (LC) for the local treatment of warts, including podophyllum, ethanol, sulfuric ether in a weight ratio of 1:5:5 (Arutyunov Century Ya Skin and venereal disease. - M.: Medicine, 1972. - S. 208, 210).

A disadvantage of the known LC is the frequent recurrence of the disease after treatment.

Also known Luke for the local treatment of benign tumors, including warts, including lactic acid, salicylic acid, resorcinol, collodion (Skripkin Y. K. Skin and venereal disease. - M.: Medicine. 1979. - S. 107).

A disadvantage of the known LC are complications such as irritation and chemical burns that occur on the skin during treatment.

Known closest to the claimed combination of essential features of LC for local leczenie nitrate of copper and lactic acid in the ratio 1:2 and 3:1 (A. St. USSR N 229744, CL. 30 H, 2/02; IPC A 61 K, 1968, bull. N 33).

The disadvantages of the known LC are low effectiveness of therapy in its application; frequent recurrences of the disease after treatment; the aggressiveness of the local effects on the skin, gives side effects such as chemical burns, ulcers, erosions; short shelf life means due to the instability of lactic acid; economiccost applications: high consumption during treatment.

The cause of the disadvantages of the known LC are weak keratoplasticheskie and antiviral properties, as well as low rate of penetration in the tissue pathological lesions and chemical aggressiveness against healthy tissues.

The basis of the invention the task by typing in the LC for the local treatment of benign tumors and precancerous diseases of the skin new ingredients and change their quantitative ratio to enhance its keratoplasticheskie and antiviral action on cells of pathological lesions, to accelerate its penetration into the tissue while reducing aggressive reactions to healthy skin, which will lead to the rapid achievement of a stable treatment effect. The effectiveness of the treatment compared to prototheria benign tumors and precancerous diseases of the skin, including copper nitrate, further comprises nitric acid, dimethyl sulfoxide (DMSO) and water in the following ratio, wt.%.

Nitric acid - 4,5 - 67,0

Nitrate copper - 1,0 - 14,5

DMSO - 1,3 - 18,0

Water - the Rest

Between the set of features of the invention and achievable technical result there is a causal relationship.

Known LK (prototype), including a mixture of nitrate of copper and lactic acid in the ratio 1:2 and 3:1, is very aggressive in terms of biological tissues. When applied to the skin leaves open long burns, abrasions and ulcers that extend the treatment time.

From literature it is known that lactic acid is cauterant and destroys biological tissue means. The use of high concentrations of lactic acid in dermatology complicated by burns, erosions, ulcers (Skripkin Y. K. , Mackillican A. L., Sharapova, Ya Skin and venereal disease. - M.: Medicine, 1997 - S. 58).

On biological action of copper nitrate (nitrate of copper, it is known that it it has a fungicidal action (Chemical dictionary/ CH. relk (prototype) in the treatment of benign tumors and precancerous diseases of the skin can be attributed to the slow penetration of the tool into the tissue deeply located tumors, as well as a weak antiviral activity, since most of these diseases has a viral nature. Therapeutic effect known LC limited keratoplasticheskie reaction on the surface of biological tissue tumors. Therefore, treatment with known Luke have to conduct long-term (20-25 days), and relapses occur very often (in 30-40% of cases). The treatment duration is negatively affected by aggressive properties known Luke since received chemical burns, abrasions and ulcers long-term heal.

DMSO is known in pharmacology as an external tool for local use in inflammatory diseases of the musculoskeletal system. DMSO has a mild antiseptic, anti-fibrinolytic action and the ability to penetrate biological membranes, including skin barriers (Mashkovsky M. D. Medicines. - M.: Medicine, 1993. - S. 222).

Nitric acid has nitrious effect on biological tissue. In addition, the protein of the skin under the action of nitric acid and nitrate of copper is subjected to denaturation, which resulted in the protein loses its biological properties (APN E. F., Literatim solvent ingredients LK.

Declare LK, as well as two known (similar to the prototype) and three experimental composition (under NN 1-3 shows three variants of the qualitative composition of the inventive LC) were tested on 100 patients aged from 5 to 57 years, with disease duration from 1 month to 5 years. The study included patients with the following diagnoses: simple warts - 19 people, plantar warts - 17, juvenile warts - 15, fibroma - 11, genital warts - 9, molluscum contagiosum - 9, senile keratosis - 8, keratoacanthoma - 7, cylindroma - 5. The formulations were applied directly to the area of the mass 1-3 times a day until its complete disappearance. The test results listed in the table.

As can be seen from the table, the inventive LC containing copper nitrate, nitric acid, DMSO and water (excluding structure provided in the prototype aggressive and unstable lactic acid), more efficiently than known cure benign tumors and precancerous diseases of the skin, resulting in a short duration of treatment and due to potentiating the action component at each other, as well as the ability of DMSO to penetrate biological membranes and transport" other ingredients LK in the tissues, machining the almost complete absence of recurrence of the disease. The exact cause of this phenomenon is unknown. May declare LK inherent in a new quality - enhanced antiviral activity. To test the proposed LC on antiviral activity is not possible because of its corrosive action on microorganisms. But such indirect evidence of antiviral activity of the claimed LK, as successful treatment of some viral diseases of the skin: bubble zoster (5 cases), recurrent herpes (8 cases), as well as unexplained rapid and effective action label: recovery of benign tumors and precancerous diseases of the skin, most of which are viral in nature (flat, youth, plantar warts, genital warts, molluscum contagiosum). Due to the new feature has been expanded range of diseases that can be cured using the proposed LC.

In addition, manifested more unexpected property claimed LK: no irritation and burns of the skin surfaces around tumors, due to which also reduces the period of treatment. Perhaps the aggressive properties of nitric acid and nitrate of copper in the inventive composition is neutralized by the mutual influence of the ingredient does not allow to obtain the necessary technical result (see table: experienced LK NN 1-3).

The essential feature of the invention is the proportion of the ingredients of the claimed LK. LK, containing less than 4.5 wt.% nitric acid, less than 1.0 wt.% nitrate of copper, less than 1.3 wt.% DMSO and over 93,2 wt.% water, because of the strong dilution practically has no therapeutic effect. And LK, containing more than 67,0 wt.% nitric acid, over a 14.5 wt.% nitrate of copper, more than 18.0 wt.% DMSO and less than 0.5 wt.% water that contains dissolved salt crystals, aggressive acts on the skin and apply it for medicinal purposes is dangerous.

Declare LK are prepared using conventional blending techniques. Purified water (about half of the prescription volume) is poured in a glass, enamel or porcelain capacity corresponding volume. The water poured copper nitrate and stirred with a glass stirrer until complete dissolution of the salt. The remaining ingredients are added one at a time with stirring, allowing each to dissolve before adding the next. After all ingredients are added, the residue is purified water is used to bring the mixture up to 100 wt.%.

For the preparation of the claimed use LK pharmacy DMSO 100% concentration produced emuu "Stirol" (Ukraine), nitrate copper brand "H. H." - Sackeim XS (Ukraine), distilled water or water purified using filters for water purification. The shelf life claimed LK is 5-7 years.

The advantages of the inventive LC compared with the prototype are highly effective therapy in its application; practical no recurrence of the disease after treatment; no negative side effects such as chemical burns, ulcers, erosions; long shelf life means; a small flow treatment.

Three specific example of the inventive compositions given in the table.

Medicinal composition for the local treatment of benign tumors and precancerous diseases of the skin, including copper nitrate, characterized in that it further comprises nitric acid, the sulfoxide and water in the following ratio, wt.%:

Nitric acid - 4,5 - 67,0

Nitrate copper - 1,0 - 14,5

Dimethyl sulfoxide - 1,3 - 18,0

Water - The Rest

 

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