Balls "biosan" for the treatment of obesity of various origins and treatment of obesity of different genesis

 

(57) Abstract:

The invention relates to pharmacology and about creating convenient for intravaginal application form new, not previously used in gynecological practice antiseptic plant have antibacterial, antifungal, antiviral activity and activates the reparation of damaged mucosa. The invention lies in the fact that it is proposed to use vaginal balls "Biosan" containing Civil (product processing woody biomass of Scots pine) and cocoa butter at a certain ratio of components, and that the treatment is carried out at a dose of one ball two times a day course five days a week. In the absence of toxicity of the active substance use balls "Biosan" not contraindicated in pregnancy. 1 C.p. f-crystals, 1 table.

The invention relates to medicine, namely to pharmacology, and can be used for treatment of obesity of various origins, nonspecific bacterial vaginosis, treatment processes, caused by the herpes simplex virus and human papilloma, for healing of the cervix after conducting a de, rementeria on the above indications, can be divided into two large groups. The first group products containing Metronidazole. The second group means of natural origin: Sodium UniNet (isolated from a lichen), Novoimanin (derived from plants of Hypericum), Sangviritrin (from plants of the family of Maclay), Evkalimin (the amount of terpenoid phenolaldehyde and triterpenoids from the leaves and shoots of eucalyptus), Chlorophyllipt (a preparation containing a mixture of chlorophyll from the leaves of eucalyptus) and others.

The advantage of the tools of the first group is the particular orientation and specificity of the actions of each of antibacterial components drawback - the inability to cover the entire spectrum of pathogens pathological process, and most importantly - formation heterogeneity of bacterial populations, indirectly resulting in increased resistance and virulence of bacteria.

The second group of drugs is no different particular orientation in connection with the currently recommended by the world Health Organization syndromic approach to treatment of inflammatory processes in the genital tract more than meets these requirements to antibacterial agents. Not specific what it creates favorable preconditions for establishing between the bacterial population and the host of "state of mutual tolerance", no significant selective effect on the virulence of bacterial strains. At the same time, the means of antimicrobial activity of plant origin do not exist in the form of a convenient official forms suitable for intravaginal use.

The purpose of this invention is the creation of a suitable for intravaginal application form new, not previously used in gynecological practice antiseptic plant have antibacterial, antifungal, antiviral activity and activates the reparation of damaged mucosa.

The goal is achieved in that the tool is made in the form of vaginal balls containing Civil and cocoa butter.

Characteristics of the active substance Civil. Civil - product processing woody biomass of Scots pine, containing terpenoids and acyclic compounds normal structure. The study of these substances on the bactericidal and fungicidal activity against some strains of microorganisms and yeast-like fungi Candida showed high activity comparable to the reference fungicide "Nystatin", high activity against gram-positive the on-Intellinova virus comparable to the drug "Remantadin". Civil is a solid waxy mass, greasy to the touch, from pale yellow to light brown color with a characteristic smell. Civil not toxic, does not show allergic actions. The parameters of acute toxicity refers to hazard class 4 according to GOST 12.1.007 (dangerous substance). In the manufacture of balls above composition, they have a faint smell of cocoa butter in the proposed ratio of the components is most pronounced clinical effect in the form of antiseptic, reparative, anti-inflammatory, deodorizing action, with the least annoying local action. All components included in the composition of balls allowed to be used. In the absence of toxicity of the active substance use balls "Biosan" not contraindicated in pregnancy.

Vaginal balls are obtained as follows: active ingredient Civil mixed with cocoa butter, cook the balls containing 0.075 - 0.1 g Saviola and 1,4 - 1,425 g of cocoa butter. Store bulbs in a cool place at temperatures from +4 to +8oC. storage under these conditions for at least 1 year.

The claimed means of obtecta, local reparative and anti-inflammatory action. The increased efficiency achieved through the creation of intravaginal forms of drug substances, providing sufficient space and exhibition contact Saviola from the mucous membrane of the vagina and cervix.

A method of treating obesity of various origins using the proposed tool is as follows: the ball is injected intrawaginalno 2 times a day, morning and evening for 5 consecutive days. The lack of toxicity and low absorbability allows repeated and prolonged courses.

The effectiveness of the treatment is confirmed by the results of treatment of 105 patients with non-specific colitis, conducted at the antenatal clinics N 7, 27, 31, 40, of St. Petersburg, clinic of obstetrics and gynecology, Saint-Petersburg state medical University, women's consultations, Novgorod, and center of obstetrics, gynecology and Perinatology of the RAMP, Moscow, research Institute of obstetrics and gynecologists them. D. O. Ott RAMS. The drug patients were administered as previously described

Efficiency means of the following examples.

Example 1. Patient Fedulova Y. C. the mussels-mycoplasmal infection felt a pronounced itching in the vulva and rich "cheesy" discharge from the genital tract. During the examination the diagnosis of Acute vulvovaginal candidiasis". The diagnosis is confirmed bakteriostaticheski detection of vegetative forms of yeast-like fungus in scrapings from the mucous membrane of the vagina on the background of pronounced reaction. Treatment balls "Biosan" 1 ball twice a day intrawaginalno. By the end of the first day of treatment itching and whites decreased. Treatment the patient was well tolerated. In the control smears from vagina after 2 weeks after treatment of cells 5-15 in sight, flora rod, yeast-like fungi were not identified.

Example 2. Patient Solovieva, E. M., 75 years old, came with complaints Beli within 2 months. The age of 19. Suffering from diabetes type 2, with hungry (on empty stomach level of glycemia 9.0 mmol/l in patients receiving glibenclamide. When examined clinically and bacteriologically diagnosed vulvovaginal candidiasis. Were treated as previously described. After double injection balls noted a small itch, independently disappeared by the second day of treatment, further treatment was well tolerated. At follow-up at 4 weeks phenomena of inflammation was not detected in smears against the background of severe atrophy detected moderate if the and O. A., 26 years old, came about whiter with an unpleasant odor and itching in the vulva. In the survey method polimeraznoi chain reaction detected: M. hominis, Ureaplasma urealiticum, bakteriostaticheski - leukocyte - up to 50 field of view, gram +/-polymorphic diplococci, Trichomonas vaginalis. Conducted monotherapy balls "Biosan" 1 ball twice a day intrawaginalno. Feeling better by the second day of treatment. When viewed through 1 week after treatment, the clinical signs of inflammation subsided. In smears taken 2 weeks after the end of treatment, previously detected pathogens were not detected leukocytes 5-15 in sight.

Example 4. Nazarova L. P., 42, complaints of itching, burning, cloudy discharge from the vagina. Examined in smears of pathogens, sexually transmitted diseases, not detected, detected signs of nonspecific bacterial vaginosis. The treatment of vaginal balls "Biosan". Subjective: no itching, Beli in much smaller quantities. Bakteriostaticheski - reducing the number of key cells, leukocytes - up to 20 in the field of view. In sowing the lack of growth of bacterial flora.

Example 5. Ivashchenko N. A., 36 years. Since 1989 have received many courses cantbeli with an unpleasant odor, growing during intercourse. During the examination the diagnosis of nonspecific bacterial vaginosis. Recommended and the treatment of vaginal balls "Biosan". After treatment feel better, smell disappeared in crops from the vagina to ensure the growth of E. coli after treatment with growth there.

Information about the effectiveness of the drug obtained from 105 patients who were assigned to therapy balls "Biosan" shown in the table.

As the table shows, in almost all cases, treatment with a positive effect, without the side effects and complications.

1. Vaginal balls for treatment of obesity of different Genesis, containing the medicinal substance and a base, characterized in that, as a medicinal substance they contain civil, and as the basis of the cocoa butter with the following ratio of components, g on one ball:

Civil - 0,075-0,1

Cocoa butter - 1,4-1,425

2. A method of treating obesity of various origins by administering drugs, characterized in that as a drug use vaginal balls containing civil and cocoa butter in the following ratio of components, g on one ball:

Civil - 0,075 - times a day on the course is five days a week.

 

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