The method of obtaining alginate material having wound healing properties

 

(57) Abstract:

The invention relates to medicine and can be used for the production of alginate materials intended for the treatment of wounds, burns, ulcers, etc., This is achieved by the fact that the solution of sodium alginate was added with stirring a crosslinking agent and polyethylene oxide mol.m. 400 in the amount of 10-30 wt. % of alginate, and the resulting mixture is then freeze-dried. The objective of the invention is the creation of a material of high elasticity, resistant to transportation and storage. 2 C.p. f-crystals, 1 table.

The invention relates to the production of alginate material intended for use in medicine as a coating for the treatment of wounds, burns, ulcers, etc.

There are many ways to obtain alginate materials with good biocompatibility and wound healing properties, are widely used in medicine.

However, the known alginate materials have low mechanical strength in combination with fragility, often break, crumble during transportation, storage and use, which makes their application difficult.

Known elastic modification of alginate materials with pomesteen (U.S. Pat. USA N 5.684.051, NCI 514/777, 1997).

However, this method is quite lengthy, multi-step, labor-intensive and is designed for medical devices in the form of tubes, such as stents, catheters, cannulas, drainage, etc.

Closest to the proposed invention to the technical essence and the achieved result is a method of obtaining alginate material (A. C. USSR N 658148, C 08 J 9/16, 1979), which involves mixing an aqueous solution of sodium alginate with gluconate and/or calcium lactate and subsequent freeze drying. Porous alginate material obtained by the above method, does not have a sufficiently high elasticity, which in combination with low strength requires receiving material with a minimum thickness of 10 mm is Such a relatively large thickness of the material makes dressing inconvenient and difficult to transport and storage. In addition, the process of freeze drying and cutting of the material he often cracks, resulting in waste in the process of getting a wound healing material is 10 - 15%.

The purpose of this technical solution is to provide a method for obtaining alginate material with high elasticity for CLASS="ptx2">

This is achieved by the fact that the original solution of sodium alginate was added with stirring a crosslinking agent and polyethylene oxide (PEO) mol. m 400 in the amount of 10-30 wt.% from the alginate, and the mixture is then freeze-dried. As a cross-linking agent according to the present method can be used aqueous suspension of gluconate or calcium lactate with a particle size of 50-30 μm, and turrilites.

At the stage of mixing the starting components in the reaction mixture can be added various additives such as antibacterial agents, proteolytic enzymes, antioxidants, stimulants regeneration of wounds of different etiology and other medications that promote the healing of wounds and burns.

The totality of all evidence leads to the creation of a method of producing alginate materials with high elasticity, reduced thickness, resistant to transportation and storage.

Example 1 (the content of PEO - 10%)

In a bowl of water with a volume of 1 l with stirring, poured 5.0 g of sodium alginate and leave for 12 hours, again mix. Then injected aqueous suspension containing 0.5 g of polyethylene oxide (mol. m 400 (PEO - 400) and 1.63 g of calcium gluconate. Prigotovlennuyu on the set sizes, packaged and sterilized radiation way from 15 to 25 kGy. The product is a sheet of porous material with a thickness of 2 to 6 mm characteristics of the material presented in the table.

Example 2 (the content of PEO - 20% of alginate)

Analogously to example 1 to 5.0 g of sodium alginate was added 1 g of PEO and 1.63 g of calcium lactate. Properties of the obtained material is presented in the table.

Example 3 (the content of PEO - 30% of alginate)

Analogously to example 1 to 5.0 g of sodium alginate was added with stirring to 1.5 g of PEO-400 and 1.63 g of calcium gluconate.

Example 4 (the content of PEO - 20% of alginate and cross-linking agent terrintino)

Analogously to example 1 to 5.0 g of sodium alginate was added with stirring 1.0 g PEO-400 and 0.35 g of terrilian.

Example 5 (antibacterial agent)

In a bowl of water with a rotating stirrer fall asleep 5.0 g of sodium alginate and leave for 12 hours, then poured 0.24 g furatsilina, stirred for 20 minutes Then when mixing the injected aqueous suspension containing 1.63 g of calcium gluconate, and 1.00 g of polyethylene oxide (mol. m 400 (PEO-400). Further according to the example 1. The product is a sheet of porous material yellow, odorless, thickness of 2-6 mm

The introduction of PEO in a number below 10 and above 30% reduces the elasticity of the alginate material.

Properties of the obtained materials are presented in the table. Elasticity was estimated by the deflection value at the time of destruction. The loading rate of the samples was 20 mm/min Distance between supports was equal to 30 mm

From the data given in the table, it follows that in comparison with the known method proposed allows to increase the elasticity of the material is approximately 1.8 times, sharply reduces the amount of waste in the process of freeze drying and cutting of material (up to 2%). In addition, the proposed method allows to reduce the thickness of the coating 10 to 2-6 mm, which makes dressing more convenient and economical.

The addition of PEO increases the resistance of coatings to transportation and storage.

The present technical solution can be used for the production of wound-healing coatings for the treatment of wounds, burns, ulcers, etc.

living agent with subsequent freeze-drying the resulting product, characterized in that it further injected polyethylene oxide (mol.m. 400 in the amount of 10 to 30 wt.% from the alginate.

2. The method according to p. 1, characterized in that as the cross-linking agent added aqueous suspension of gluconate or calcium lactate or terrilian.

3. The method according to PP.1 and 2, characterized in that the reaction mixture is additionally injected drug additives: Pensacola, furatsilin, mafenide acetate or mixtures thereof in the amount of 0.5 - 5%.

 

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