Ointment for the treatment of pyodermia

 

(57) Abstract:

The invention relates to medicine. Ointment for the treatment of pyodermia characterized by the fact that includes drug and ointment-based, integrated product isolated from the cytoplasm of Staphylococcus aureus and consisting of nucleic acids (30-34%), protein (40-45%), polysaccharides (13-17%) and lipids (5-6%). The tool contains, G.: complex drug isolated from the cytoplasm of Staphylococcus aureus, 0.1 to 0.6; lanolin 45,0; olive oil 15,0; glycerol 10.0 g; boric acid 2,0; distilled water to 100.0. The ointment provides active penetration of the drug into the skin, which enhances therapeutic effect and reduces the treatment time. table 1.

The invention relates to medicine and veterinary medicine, namely, to methods of treatment of pyodermia.

Known ointment containing drug gentamicin sulfate ointment and a basis in the ratio (g) of 0.1: 99,9 respectively, used for the treatment of pyodermia (M. D. Mashkovsky "Drugs", M.: Medicine, 1993, so 2, page 288) prototype.

However, the known ointment has a nonspecific effect and requires long-term use.

The aim of the invention is the reduction of terms of treatment is the effect on the agent.

"Somethin" is a drug selected from the cytoplasm of S. aureus strain B-243. To highlight drug use daily microbial culture grown on agar of Hottinger. To obtain the "Tomatina" microbial mass of Staphylococcus containing 1 ml 250 billion microbial cells are subjected to degradation in the mechanical disintegrator (L-17) using the beads Bollotini N 11. After removal of intact microbial cells and cell walls by centrifugation (at 8000-10000 rpm, 30 min) get cytoplasmic fraction. Electron microscopic examination shows complete absence of intact cells and cell walls in the cytoplasm.

The chemical composition of the cytoplasm: protein (58-60%), nucleic acids (11-13%), reducing sugar (11-13%), lipids (9-10%). In immunoelectrophoresis cytoplasm forms with homologous serum 7 bands of precipitation, electrophoresis in polyacrylamide gel is divided into 19 components.

Example 1. "Somethin" separated from the cytoplasm sequentially by acid precipitation at pH 3.5, followed by presidenial at pH 4.5. To remove protein impurities are trypsinization for 4 hours, allowing you to remove from the drug for more than 60% protein. Chemical forese "Somethin" forms with the serum to the cytoplasm 3 bands of precipitation, during electrophoresis in polyacrylamide gel is divided into 9 components. The drug cialiswhat against saline for 24 hours ( d=0,045 mm, Visking dialysis tubing "SERVA"), and then freeze-dried. Gelfiltration drug on Sephadex g-75 determines that the output curve has two asymmetric peak, and the peak fraction 1 is identical to the original trypsinization fraction chemical composition, immunogenicity and serological activity. Fraction 2 peak poorly immunogenic and serologically inactive.

Thus "Somethin composition is complex, including substance nucleic nature, protein, polysaccharides and lipids, soluble in saline solution, pH 7,0-7,8.

Research on animals shows that the immunity created "Sonatina", is peculiar, because it creates a protection only against Staphylococcus. The basic mechanism of the immune system caused by the activation of intracellular digestion phagocytosing staphylococci. In the abdominal cavity immunized and infected animals are observed sudden influx of leukocytes and continuous decrease in the number of living microbes. Along with this process Somethin" is an activator T-help is sicnosti "Sonatina" in the research center of Toxicology and hygienic regulation of biopreparations (NICTSP). Installed the complete absence of sensibilizatsii body substance "Sonatina" when applied to skin.

Example 2. Ointment for the treatment of skin diseases staphylococcal etiology as follows. For preparation of ointment bases to lanolin add distilled water in the ratio 2:1 and heated in a water bath to melt. Lanolin is cooled to a temperature of 40oC, and unbound water is removed, then the lanolin carefully stir by mechanical means. Add olive oil, boric acid, Somethin" with glycerin, distilled water. The mixture is ground to obtain a homogeneous mass.

To prepare 100 g of an ointment containing 0.1-0.6% of "Sonatina", take the ingredients in the following amounts:

"Somethin" - 0,1-0,6

Lanolin - 45,0

Olive oil - 15,0

Glycerin - 10,0

Boric acid and 2.0

Distilled water To 100.0

The method of treatment of pyodermia using "Sonatina study in the experiment on animals. Use of adult dogs of both sexes.

Example 3. Under observation taken 5 animal groups in three dogs in each breed: German shepherd, Airedale Terrier, Scottish Sheepdog, Chow Chow, Cocker Spaniel, French in concentrations of 0.1%, of 0.3% and 0.6%. The fourth group of control (animals put ointment base without "Sonatina"). Dogs of the fifth group to compare the effectiveness of the treatment applied is 0.1% gentamitsinovoy ointment. The average results of the treatment are shown in the table. All animals observed (fit the clinical picture, including the following elements: alopecia, erythema, infiltration of tissues, swelling, pustular rash, peeling, purulent crusts. With the affected areas of the skin of all dogs are sown staphylococci belonging to the species S. aureus, S. epedermidis, S. intermedius, and Str.pyogenes.

After processing the surface of the skin of 0.05% chlorhexidine on the affected areas impose a cloth impregnated with ointment containing "Somethin in concentrations of 0.1%, 0.3% and 0.6 per cent, with the subsequent imposition of aseptic dressings. Ligation is performed daily. The results of treatment of pyodermia presented in the table.

As can be seen, treatment with an ointment containing different concentrations of "Sonatina", lead to a positive effect. Redness and swelling in the lesions reduced by treatment with 0.1% somethingwas ointment over night, in the treatment of 0.3% ointment after 0.5 days and 0.6% ointment in a 0.6 days, and 0,1% gentamitsinovoy ointment on the fourth of sososo in the treatment of 0.1% somethingwas ointment for 5 days, of 0.3%and-0.6% ointment on the 4th day, and 0,1% gentamitsinovoy ointment on the 8th day. Treatment somethingwas ointment in different concentrations leads to the purification of the crusts on the 4th day, and 0,1% gentamitsinovoy ointment on the 7th day. On the 5th day appears pale-pink leather (starts epithelialization of affected areas) using a 0.3%and-0.6% somethingwas ointment. Complete healing of the affected skin surface occurs on the 8th day in the treatment of 0.1% somethingwas ointment and on the 7th day in the treatment of 0.3%and-0.6% somethingwas ointment. Treatment with 0.1% gentamitsinovoy ointment leads to complete recovery within 12 days.

Dogs in the control group, which is applied on the affected skin ointment base without "Sonatina", therapeutic effect is not observed.

The treatment results show the advantages of the proposed method of treatment of pyodermia ointment containing 0.1-0.6% of "Sonatina", compared with the 0.1% gentamitsinovoy ointment. Treatment of pyodermia the proposed method (with an ointment containing 0.1-0.6% of "Sonatina") is more effective than treatment with 0.1% gentamitsinovoy ointment, as the treatment time is reduced to 5 days.

Thus, therapeutic effect of the ointment is achieved due to the specific impact Sonatina" on the protective properties of composable active penetration of the drug into the skin, what enhances and accelerates its therapeutic effect.

The proposed ointment containing "Somethin", has no side effects on the body of the dog.

Ointment for the treatment of pyoderma, including drug and ointment base, characterized in that as a drug it contains a complex drug, isolated from the cytoplasm of Staphylococcus aureus and ointment base contains lanolin, olive oil, glycerin, boric acid and distilled water in the following ratio of components, g:

The integrated product isolated from the cytoplasm of Staphylococcus aureus - 0,1 - 0,6

Lanolin - 45,0

Olive oil - 15,0

Glycerin - 10,0

Boric acid and 2.0

Distilled water Up to 100.0

 

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