A method of treating vitiligo

 

(57) Abstract:

The invention relates to medicine, and dermatology. Assign phonophoresis with bio-complex of copper on the lesions. Additionally influence on biologically active points of the electromagnetic radiation of extremely high frequency. The power density is not more than 10 mW/cm2. After conducting 5-6 sessions designate the Autonomous electrostimulator of gastrointestinal tract. Spend endogenous electrophoresis of copper ions. The method reduces the time of treatment.

The invention relates to medicine and can be used in dermatology.

There is a method of treatment of vitiligo [1], consisting in the use of physiotherapeutic method of stimulation of melanocytes by using long wave ultraviolet irradiation in combination with photosensitizers (PUVA therapy). Treatment includes 15 sessions dosage of ultraviolet irradiation, appointed a day in combination with the use of photosensitizers. Using this method gives the effectiveness of treatment is not more than 40%, while the best results are observed in patients with limited damage and a small prescription of disease. Repigmentation occurs is possible. Note that the duration of a single course of treatment is 3 weeks, and the intervals between them 1-2 months. Thus, the usual course of treatment until the results of the ranges from 2 to 3 months excluding breaks between courses.

Thus, the disadvantages of this method of treatment primarily include low efficiency and long-term treatment. In particular, to achieve the restoration of pigmentation on the whole surface of the lesions is very difficult even when mnogocentrovom treatment. Moreover, the observed repigmentation is often unstable in nature and may gradually fade like the sun. This method of treatment of vitiligo has contraindications pathology stomach, liver, kidneys, blood and vision.

Closest to the proposed method is a method of treatment of vitiligo [2] (the prototype), which is to assign a sinusoidal modulated currents (SMC) with alternating every other day on the upper cervical sympathetic nodes and the area of the adrenal glands and phonophoresis with bio-complex of copper on the lesions. CMT normalize the activity of the sympathetic-adrenal system, stimulate the peripheral circulation and the immune system. The reason for choosing biocomplex the expression.

To conduct the ITC using the apparatus Omnipolis - 4". On the lateral surface of the neck below the mastoid processes (approximately the projection of the upper cervical sympathetic nodes) or attach plate sizes 3-4 5-6 cm2or round with a diameter of 5 cm on hand holders electrodes with hydrophilic spacers. Use the following procedure parameters: P - 1 min. III PP-2-3 min and IV PP 2-3 minutes the Third and fourth generation (III PP and IV PP respectively) is selected to calculate the welfare effects of currents on the largest possible range of fabrics. When conducting phonophoresis with bio-complex of copper intensity of exposure is selected depending on the localization of foci in the range from 0.1 - 0.2-0.4 - 0.6 W/cm2.

In this method of treatment of vitiligo for one course of treatment is 10-12 treatments listed above.

The disadvantages of this method of treatment are the long duration and low efficiency. Only 2 months in 50% of patients were observed scatter plots of repigmentation in the mouths of hair follicles, with the boundaries of lesions become blurred and fuzzy. For large lesions and long-term disease, one treatment is not enough.2 to 3 months excluding breaks between courses of treatment.

Summarizing the above, we can conclude that the existing methods of treatment of vitiligo have low efficiency, long in time and give a positive effect only after quite a long time after the end of treatment.

The problem solved by the invention is the improvement of efficiency and reduction of terms of treatment of vitiligo.

The solution of this problem is achieved by the fact that according to the method of treatment of vitiligo by assigning phonophoresis with bio-complex of copper on the lesions advanced, but at a different time, appoint EHF-therapy effects of non-thermal electromagnetic radiation of extremely high frequency and low intensity (power density not more than 10 mW/cm2) on biologically active points, after 5 to 6 sessions of physical therapy procedures prescribed Autonomous electrostimulator of gastrointestinal tract with endogenous electrophoresis of copper ions (AES GIT - si) [3] and then hold the remaining 5 - 6 treatments.

For EHF-influence choose BAHT recommended for the treatment of vitiligo, skin diseases and diseases associated with metabolic disorders. It is recommended ispolzovaniya - MS-6 (nei-Guan), RP-5 (Shang - Qiu), V-60 (kun-LUN), VG-11 (Shen-Tao), VG-20 (Bai Hui).

Recipes EHF exposure are made individually on the basis of recommended above BAHT and subject to the associated pathological manifestations. Usually in the recipe is not more than 5 - 8 BAHT, so that the total exposure time did not exceed 30 minutes

New in the proposed method of treatment of vitiligo is that advanced, but at a different time, appoint EHF-therapy effects of non-thermal electromagnetic radiation of extremely high frequency and low intensity (power density not more than 10 mW/cm2) on biologically active points, after 5 to 6 sessions of physical therapy procedures prescribed Autonomous electrostimulator of gastrointestinal tract with endogenous electrophoresis of copper ions (AES GIT - si) and then hold the remaining 5 - 6 treatments.

To choose impact BAT, the recommended treatment for vitiligo, skin diseases and diseases associated with metabolic disorders. It is recommended to use the following BATH: main - V-40 (Wei-Zhong), GI-10 (show-San-Lee), F-8 (Zui Quan), W-90 (JIU-Dian-fan), W-101 (Zhong-kui) and extra - MS-6 (nei-Guan), RP-5 (Shang-Qiu), V-60 (kun-komentowanych above the BATH and given the associated pathological manifestations. Usually in the recipe is not more than 5 - 8 BAHT, so that the total exposure time did not exceed 30 minutes

In the analyzed scientific medical and patent literature not found data distinguishing features. Thus, the invention meets the criterion of "novelty."

The set of distinctive features is not obvious from the level of technology for professionals. Thus, the technical solution meets the criteria of the invention "inventive step".

The present invention can be used in practical medicine, and therefore, it meets the criterion of "industrial applicability".

Let's consider a practical example of the use of the proposed method for the treatment of vitiligo. Patient C., male, 65 years, is ill vitiligo for more than 20 years. Lesions localized on the hands and face. Treatment: 10 sessions phonophoresis with bio-complex of copper-based cream company Mirra on lesions located on the hands, and 10 sessions of EHF-therapy. The above procedure spaced in time so that the interval between them was not less than 2 hours

To conduct phonophoresis used the device of "UST - 101". P the actions selected BAHT recommended for the treatment of vitiligo, skin diseases and diseases associated with metabolic disorders. Recipe EHF exposure includes the following BATH: W-90 (JIU-Dian-fan), W-101 (Zhong-kui), MS-6 (nei-Guan), GI-10 (show-San-Lee), F-8 (Zui Quan), V-40 (Wei-Zhong) and V-60 (kun-LUN). The exposure time for each BAT 2 minutes In odd-numbered sessions BATH right hand combined with BAT left leg, and in even-numbered sessions, on the contrary BAHT left hand combined with BAT right leg.

EHF-therapy was performed by the apparatus ACVC-01 "Ni - 1", which is manufactured serially on TU - 9444-003-07543077-97, the certificate of conformity N ROSS RU.IM 11.W.

After holding five of the above procedures, the patient is assigned to the Autonomous electrostimulator of gastrointestinal tract with endogenous electrophoresis of copper ions (AES GIT-Cu) [3]. After taking the electrostimulator-Cu held the remaining five sessions of treatments.

Used the electrostimulator-Cu made in the form of pharmaceutical capsules, consisting of two electrically isolated electrodes, forming the body of the capsule, the power source and generator of electrical impulses, is placed inside the capsule. The anode of medicinal capsules covered with a layer of copper.

With the introduction of the pacemaker in glucocare contact with the walls of the tract. The effect of electric pulses on the walls of the tract causes a response in the form of waves of peristalsis, which promotes the stimulator to the distal gastrointestinal tract.

In the process, the electrostimulator-C simultaneously with the generation of electrical impulses, causing a wave of peristalsis occurs electrochemical dissolution of copper coating of the anode contact of the stimulator, which produces copper ions, easily digestible by the body of the patient. Thus, when the stimulator is provided a metered intake of copper ions at a rate not exceeding the daily requirement of the body. The use of this stimulant in the treatment of vitiligo due to the above mentioned deficiency of copper.

We will present the results of treatment of a patient Century After the 6th session of the procedures on the face and hands of the patient in some lesions appeared multiple separate small spots of pigmentation with a diameter of about 1 mm, which is localized in the mouths of hair follicles. After 10 session there has been a steady staining of repigmentation in all lesions. One month after the end of the first course of treatment check poisony described above, after which there is a complete disappearance of depigmentation spots.

The treatment efficiency of the proposed method was evaluated in the clinic of skin diseases SSMU. Thus were obtained the following results. In 52% of patients showed stains of repigmentation directly in the process of conducting the first course of treatment. Control patients one month after the first course of treatment showed that the spots of repigmentation in the lesions appeared in 85% of all patients, which allows to make a conclusion about the high efficiency of the proposed method for the treatment of vitiligo and on the reduction of treatment time. When large areas of destruction and long-term disease for a complete cure requires a total of 2 to 3 courses of treatment.

Thus, the proposed method of treatment not only improves the effectiveness of the treatment, but significantly reduce the treatment time, as within a month after the first course of treatment observed positive results in 85% of patients.

Literature.

1. Koshevenko Y. N. Modern ideas about the clinic, pathogenesis and treatment of vitiligo. // Medicine and health care. Ser. therapy. The overview. // In: problems of optimization of sanatorium-resort treatment. - Tomsk, 1998. -S. 133-134.- the prototype.

3. RF patent N 2036671. MCI AND 61 N 1/375. The electrostimulator of gastrointestinal tract. // Agafonnikov C. F. - Appl. 11.07.89, N 471 8573/14.- Publ. 09.06.95, bull. N 16.

1. A method of treating vitiligo by assigning phonophoresis with bio-complex of copper on the lesions, characterized in that it further, but at other times, conduct of EHF-therapy effects of non-thermal electromagnetic radiation of extremely high frequency and low intensity (power density not more than 10 mW/cm2) on biologically active points, after 5 - 6 sessions procedures prescribed Autonomous electrostimulator of gastrointestinal tract with endogenous electrophoresis of copper ions and then hold the remaining 5 - 6 treatments.

2. The method according to p. 1, characterized in that the recipe for EHF-therapy include the following biologically active points: basic - V-40 (Wei-Zhong), G110 (show-San-Lee), F-8 (Zui Quan), W-90 (JIU-Dian-fan), W-101 (Zhong-kui) and extra - MS-6 (nei-Guan), RP-5 (Shang-Qiu), V-60 (kun-LUN), VG-11 (Shen-Tao), VG-20 (Bai Hui).

3. The method according to PP.1 and 2, characterized in that the recipe of EHF-therapy are thus, to sum

 

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