Drug to relieve alcohol withdrawal syndrome

 

(57) Abstract:

The invention relates to medicine and relates to a means for relief of alcohol withdrawal syndrome. The invention consists in that the means for the relief of alcohol withdrawal syndrome includes water, salt, additives, caffeine and vitamins. As salt additives used balanced salt mixture containing salts of sodium, potassium, calcium and magnesium at a ratio of components. The invention provides in a short period of normalization of the disturbed functions of the body as in patients with alcoholism and those without alcohol dependence. table 2.

The invention relates to medicine, specifically to addiction, and relates to nutritional supplements for relief of withdrawal syndrome.

Known occurrence subjectively unpleasant mental and physical state to another day after a massive alcohol consumption. This condition is linked to a violation of water-elektrodnogo balance, intoxication breakdown products of alcohol. In narcology state after acute alcohol intoxication is classified as alcohol withdrawal (postintoksikatinom) syndrome, is subject aktivni.

In folk medicine it is known the use of salt solutions ("cabbage brine"), strong tea and coffee making facilities in order to relieve alcohol withdrawal syndrome. Known to use 20 drops of the tincture of peppermint in a glass of cold water, when this is facilitated by the General condition, decrease headaches (,z, Menendian. Collection on traditional medicine and alternative treatments. M., "Technicos", 1991. C. 220-221).

The disadvantage of these tools is that not considered pathogenic mechanisms leading to painful psychosomatic condition, namely the decrease in plasma magnesium ions (which leads to increased irritability, anxiety and other symptoms of Central nervous system (CNS); the decrease in plasma potassium ions (which leads to the violation of contractility, tremor, and other muscle disorders); pathological redistribution of potassium and sodium ions inside and outside the cell (which leads to swelling, feeling of thirst and reduce the amount of urine); as well as congestion of the liver and kidneys alcohol and the decay products (acetaldehyde, acetic acid and others); enhanced enzyme system is profilaktiki, treatment of alcohol intoxication and alcohol withdrawal syndrome, which contains succinic acid (0.1-0.3 g) and citric acid (0,025-0,85 g). This song should be taken 3-5 times a day at the rate of 3-5 mg/kg body weight (RF Patent 2039556, MCI: A 61 K 31/19, publ. 20.07.95 year). This composition can be used in a domestic environment. It stimulates metabolism, has anti-toxic effect caused by increased excretion of alcohol.

However, the above composition is most appropriate to use to development postintoksikatinom alcohol syndrome, because in a state of alcohol withdrawal syndrome intensification of the process of elimination of alcohol is not relevant.

Known protivooskolochnaja composition based on biological material that contains, along with citric and succinic acids more than 80 different natural components (Application of UK N 2198041, MCI: A 61 K 31/195, publ. 1987). This composition is used as biologically active additives in the manufacture of alcoholic and non-alcoholic beverages, has a toxic effect and reduces the consumption of alcohol.

However, this additive has wysokosci company Miles, contains (per 1 tablet) as the active principle of acetylsalicylic acid in the amount of 0,324 g and as auxiliary substances 0,965 g of citric acid and 1,625 g of sodium bicarbonate (Leaflet to medicine Alka-Seltzer, the firm Miles, England). The drug is used during acute alcohol intoxication.

However, this drug can be used only sporadically, when household consumption of alcohol. Prolonged use of the drug Alka-Seltzer for detoxification, which regularly require patients with alcoholism, leads, due to the presence of the drug aspirin, severe effects: diarrhoeal phenomenon, changes in the gastric mucosa, violations functions of the nervous system and the processes of gemokoagulyatsii.

It is known the use of infusion of nettle as a means possessing alcohol activity (Patent of the Russian Federation 2011382, MCI: A 61 K 35/78, publ. 30.04.94 year). The tool reduces alcohol intoxication.

However, infusion of nettle does not have a sufficiently strong effect in addressing the impact of acute and chronic alcohol intoxication.

You know the tool ARCOTEL" for the treatment of alcohol dependent the grass and inflorescences of maška yellow 15-25; rhizomes of Rhaponticum sorrowing 8-15; herb centaury 8-15; grass bearberry 8-15; inflorescences tansy 8-15; herb wormwood 8-15; grass coltsfoot European 5-10 (RF Patent 2040271, MCI: A 61 K 35/78, publ. 27.07.95 year).

However, the tool ARCOTEL" is used for the treatment of alcoholism, but has not expressed watersplashes and detoxifying effect.

Known witnessi collection "Trilepton", containing (wt.%): herb thyme - 2,0; grass cudweed herb brown - 18,0; St. John's wort herb - 18,0; hips - 18,0; peppermint leaves - 4,0; herb oregano - 4,0; rhizomes with roots of Rhaponticum sorrowing - 36,0 (RF Patent 2129008, MCI: A 61 K 35/78, publ. 20.04.99 year).

However, the collection is used for sober individuals who use alcohol, but has not expressed a detoxifying effect.

The prototype (the closest analogue) of the proposed structure is a means to relieve alcohol withdrawal syndrome, including sodium chloride (3,0-7,0) g, glucose, fructose or sucrose (10,0-15,0 g, citric acid (2,0-6,0) g, ascorbic acid (1.0 to 4.0) g, 96% ethanol (8,0-25,0) g and the rest is water to 1 liter (RF Patent 2086237, MCI: A 61 K 31/045, publ. 1997). It is preferable to use the above tool to interrupt drunken detoxication action. Improving subjective feelings, this tool can not in a short term to normalize the disturbed functions of the body. In addition, this tool can only be used for relief of alcohol withdrawal syndrome in patients with alcoholism, because it contains ethanol, which causes revulsion in persons with alcohol dependence.

The aim of the invention is the creation of funds with high organoleptic and detoxification properties, providing in the short term normalization of the disturbed functions of the body during alcohol withdrawal syndrome among patients with alcoholism and those without alcohol dependence.

This objective is achieved in that the means of control of alcohol withdrawal syndrome, including ascorbic acid, sodium chloride and water, it also contains thiamine chloride, magnesium ascorbate, potassium chloride, potassium bromide, potassium iodide, calcium lactate and caffeine, in the following ratio of components, g/l:

Ascorbic acid - 02,-03

Thiamine chloride - 0,06-0,1

Magnesium ascorbate - 0,5-0,7

Potassium chloride - 1,0-1,5

Potassium bromide - 0,3-0,5

Potassium iodide is 0, the Aki offer tools are it further comprises a salt of thiamine chloride, magnesium ascorbate, potassium chloride, potassium bromide, potassium iodide, calcium lactate and caffeine in the following ratio of components, g/l:

Ascorbic acid - 0,2 - 0,3

Thiamine chloride - 0,06 - 0,1

Magnesium ascorbate - 0,5 - 0,7

Potassium chloride - 1,0 - 1,5

Potassium bromide - 0,3 - 0,5

Potassium iodide - 0,1 - 0,2

Calcium lactate - 0,5 - 0,7

The sodium chloride - to 3.0 - 3.5

Caffeine - 0,1 - 0,2

Water, l - Up to 1

The proposed tool takes into account the pathogenetic mechanisms leading to painful psychosomatic condition after taking large doses of alcohol: increased irritability and anxiety; violation of contractility, muscle disorders; headache, swelling and the sensation of thirst.

To remove postintoksikatinom syndrome in acute alcoholic intoxication proposed tool provides:

- increased levels of plasma magnesium ions, which reduces irritability, excitability, i.e., eliminates the symptoms of the Central nervous system;

- the increase in the concentration of potassium ions, which leads to normalization contractility, eliminates tremor and other mysen the t swelling and thirst, reduces the load on the liver and kidneys, it normalizes the activity of enzyme systems.

When alcoholism violated the exchange of potassium, calcium and located in the proposed tool, potassium salts and calcium Supplement them. In addition, the presence of the drug ions of potassium, magnesium faster nausea withdrawal status in patients with alcoholism and those without alcohol dependence.

Caffeine stimulates the Central nervous system and has a cardiotonic effect.

Bromide of potassium helps to restore the balance between the processes of excitation and inhibition in violation of their correlation.

That is, the proposed remedy for this composition and ratio of components, which has a high organoleptic and detoxification properties.

All components of the proposed funds are used in pharmacy for internal use or used in the food industry.

The tool is prepared as follows.

Take 0.25 g of ascorbic acid; 0.08 g of thiamine chloride; 0.6 g of magnesium ascorbate; 1,25 g of potassium chloride; 0.4 g of potassium bromide; 0.15 g of potassium iodide; 0.6 g of calcium lactate; 3.25 g of sodium chloride; 0.15 g of caffeine, pour 993,onenow may be the maximum or minimum according to the formula of the invention depending on the severity of alcohol intoxication.

The tool is recommended for edema postintoksikatinom syndrome in acute alcohol intoxication.

The resulting solution is taken orally 2-3 hours Composition can be used in the presence of household drinking early stages of alcoholism. It is not toxic and does not cause side effects.

In addition, the proposed tool is recommended for use by persons suffering from alcoholism, but often forced to drink alcohol.

The proposed composition of the 38 patients received the second stage of alcoholism, were on inpatient treatment for alcohol withdrawal syndrome (AAS) and mild to moderate severity. The composition was administered in accordance with we offer dosage (up to 1000 ml per day) as monotherapy in mild severity and complex on the background of traditional psychopharmacological treatment of alcohol withdrawal syndrome with moderate severity (sedative tranquilizers, nootropics, brain).

In 1/3 of the observations was the combination of the proposed composition with neuroleptics (tizertsin, neuleptil, sonapaks), due to the severity of the patient's condition (form abstine the particular influence of concomitant therapy on the efficacy of treatment the dosage of compositions, used in combination with the composition did not change throughout the course of treatment. Control therapeutic group (2) consisted of 30 patients with alcoholism, standardized to the main therapeutic group age, stage of alcoholism, which have been treated by the method of the prototype.

Information about therapeutic efficacy of the composition shown in table 1. Analyzed primarily pharmacological effect of the drug on the clinical dynamics of cerebral, gastrointestinal, cardiovascular and myofascial toxicogenic effects of ethanol in the structure of the AAS. Attention was also drawn to normativities aspects of drug action in the correction of affective disorders.

In the structure of affective disorders in AAS patients astenodepressivnyh manifestations. Vector nonmotivational correction of composition in our study was projected primarily on asthenic component of depressive disorders (72,2% efficiency), to a much lesser extent on anxiety-phobic manifestations (50,0%). When mild astenodepressivnyh disorders in patients preferred was traditional psychopharmacotherapy travelstore bingodrome moderate severity, you must specify its distinct vegetal stabilizing effect. Of the clinical manifestations of cerebral toxicogenic effects of ethanol greatest trapnest to the composition found Serebryanicheskaya disorders. therapeutic effect of the composition have been reported with the relief of these disorders on the third, in most cases, on 6th-7th day of deprivation of alcohol. It is important to emphasize that the application of the composition is not aggravated discoordinating-ataxic symptoms toxicogenic effects of alcohol in the structure of the AAS. Applying a composition for correction dissomnic disorders, as research has shown to be useful when combined appointment with drugs hypnotics for use potentiation.

Clinically obvious effect has been noted in the study of its impact on the intensity of the ideational component of the pathological craving for ethanol. So, in 68% of cases accelerated compared to control reduction of the pathological craving for alcohol during withdrawal of the state, and in 47% of cases were observed weakening of the desire for alcohol in post-abstinent condition, and in these observations, patients were not aware (to avoid suggestive effect on the nature of the actions assigned to them in the preparation and treatment of 20 patients, suffering from social drinking, which appealed for help to the Department of addictive States Institute on the next day after alcohol intoxication. Clinical testing showed excellent and good results. Significant improvement in the psychosomatic condition was noted in all patients during the first 1.5-2 h of treatment. Stoped symptoms of intoxication, increased diuresis, disappeared unpleasant sensations in the heart area, improved mood, appetite and overall health. All patients (20 people) was proposed test SAN (health, activity, mood) before treatment and after 3 h after treatment proposed by the staff. The results are shown in table 2.

Thus, the results of the study of clinical effectiveness of the composition in the relief of alcohol withdrawal syndrome in patients with the second stage of alcoholism revealed vegetal stabilizing, normativities, analgesic effects of its therapeutic action. The clinical manifestations of toxicogenic effects of ethanol in the structure of AAS most pronounced sensitivity to the drug have cerebral (cephalgia, dizziness), cardiovascular (cardialgia) and myofascial (muscle discoleration manifestations of abstinence (otherwise referred to as symptoms of somatic ailments are especially susceptible to foreign exchange effect of the composition was cerebral (stenocardiceskie) disorder (51,2% efficiency). Among affective disorders greatest trapnest to the composition during alcohol withdrawal syndrome have astenodepressivnyh manifestations (indirect effect).

The proposed composition is not toxic and does not cause side effects. Clinical studies have shown good tolerability of the drink, complications and side effects were noted. This composition can be prepared in the pharmacy.

Industrial applicability. The proposed composition for the relief of alcohol withdrawal syndrome can be prepared as pharmaceutical companies and pharmacies, with the appropriate equipment.

Drug to relieve alcohol withdrawal syndrome, containing ascorbic acid, sodium chloride and water, characterized in that it additionally contains thiamine chloride, magnesium ascorbate, potassium chloride, potassium bromide, potassium iodide, calcium lactate and caffeine in the following ratio of components, g/l:

Ascorbic acid - 0,2 - 0,3

Thiamine chloride - 0,06 - 0,1

Magnesium ascorbate - 0,5 - 0,7

Potassium chloride - 1,0 - 1,5

Potassium bromide - 0,3 - 0,5

Potassium iodide - 0,1 - 0,2

Calcium lactate - 0,5 - 0,7

The sodium chloride - to 3.0 - 3.5

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