Medical-preventive cosmetic gel silver

 

(57) Abstract:

The invention relates to medicine and cosmetic industry and relates to curative and preventive cosmetic. The invention lies in the fact that gel cleanser "Silver" contains a lipid component in the form of phospholipid microcapsules, where the fat-soluble ingredients and particles of colloidal silver to form the membrane, and are water-soluble in the internal volume of these microcapsules, which are distributed in a gel base. The invention provides a tool with low content of fat phase with a concentration of alcohol of not more than 2-3% and expands the Arsenal of tools that do not cause allergic and irritant reactions.

The invention relates to cosmetics and hygiene products, perfumes and cosmetics industries, as well as to medicine, namely, creams and remedies for the prevention and treatment of papular-pustular forms of acne mild severity and pustular skin lesions of bacterial etiology.

Due to the fact that one of the factors for the emergence and development of these skin diseases is the multiplication of pathogenic microorganisms, for arealnykh funds. The use of these drugs is often associated with various side effects: prolonged use is the emergence of resistant microorganisms, development of dysbacteriosis (Pastushenkov " L. C., Lesnaya group, E. E. Farmacoterapia the basics of herbal medicine, part II, St. Petersburg, 1995, S. 61).

Known formulations of creams cosmetic and therapeutic ointments, lotions, elixirs, detergents, etc., which included bactericidal substances, in particular silver, sulfur, zinc salts, lead, chromium and other Microbicide activity against wide range of microorganisms, gram-negative and gram-positive and chlamydia, have preparations containing silver (Krasilnikov A. P. Handbook of antiseptic.- Minsk: High school, 1995, 91, 109; Handbook of drugs used in medical practice in the USSR/edited by M. A. Klyuyev.- M.: Medicine, 1989).

The presence of silver provides anti-inflammatory and astringent effect, contributes to the normalization of metabolic processes in skin cells. The unique properties of silver are widely used, as evidenced by the number of inventions (patents of the Russian Federation N 2146516, MKI6A 61 K 7/48, BI N 8, 2000; N 2093139 MKI6A 61 K 7/00, e means, contains protein components, natural extracts, oils and wax, are a breeding ground for bacteria. Emulsion particles such creams have a certain degree of penetration through the skin barrier. The active substance of such compositions, in particular silver, are freely exposed to the processes of degradation of, or used with anticoagulants protein and chemical nature.

Preparation of solutions of protargol or colloid requires certain skills and provides for the storage of these drugs under certain conditions. The use of lotion or soap does not provide the locality of the impact, the high content of alcohol or surfactants (from 20 to 96%) has a hard effect on the skin, greasy basis creams (20-80% lipid phase) inhibit the respiratory processes of the skin cells. When pustular skin lesions should local bactericidal action that doesn't clog skin pores, normalizes lipid and salt metabolism, has anti-inflammatory properties, is easy to apply and absorbs quickly.

The urgency of this problem involves the search for and development of new drugs and forms for the prevention and Le is laticastelli indicators, do not cause side effects.

Known drug - ointment Sulfargin (Sulfargin) - based sulfathiazole of silver with a broad spectrum antimicrobial action has side effects that are manifested in the skin allergic reactions, irritation at the application site, the burning sensation and dyspeptic problems (Reference Vidal, 1998 E-148). Affects the skin and the use of silver in an unprotected form (solution, not a colloid).

Stronger effects have gels and balms with antibiotics and chemical antibiotics and bacteriophages, but which must be applied by a doctor and under his control.

The closest to the technical nature of the claimed object is a remedy for skin care containing protein from blood plasma from 0.01 to 10, the fatty component 20-80, an aqueous solution of mineral salts - the rest as distributed (RF patent N 2027431, MKI6A 61 K 7/48, BI N 3, 1995).

The disadvantage of this tool is its high content of fatty phase, preventing the respiratory processes of the skin cells, the presence of protein components that provoke allergic reactions, as well as the fact that silver is in the completed cosmetic products with low content of fatty phase, with the alcohol concentration is not more than 2-3%, in order to avoid hard impact on skin cells, but with a bactericidal anti-inflammatory effect, and in which the silver is in a bioavailable form.

The technical result of the invention consists in expanding Arsenal of health care resources for the integrated treatment and prevention of inflammatory skin diseases that do not cause allergic and irritant reactions that are compatible with traditional methods of treatment and prevention, and are capable of local application.

The above technical result is achieved by the fact that medical-preventive cosmetic gel "Silver" contains a lipid component with additives, and the lipid component is presented in the form of phospholipid microcapsules, where the fat-soluble ingredients and the silver particles to form the membrane, and are water-soluble in the internal volume of these microcapsules, and the stability and uniformity of distribution of the microcapsules is fixed gel basis in the following ratio, wt.%:

Lecithin - 1,5

Sesame oil - 0,50

Vodopyanova extract of Bidens - 1,0

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Essential oil tea tree - 0,42

Rosemary essential oil - 0,18

Essential oil of Jasmine - 0.02

Methylene blue to 0.0004

Colloidal silver - 0.003

The carbopol - 0,4

Glycerin - 2,0

Triethanolamine - 0,5

Katon - 0,06

Water - the Rest

Medical-preventive cosmetic gel "Silver" contains phospholipid microcapsules (single-layer vesicles or microcontainer), wrapped them in a certain way included target bactericidal additives: microparticles colloidal silver, essential oils manardi, tea tree, rosemary, Jasmine, and the internal volume of such microcapsules filled with extracts series, clover, alfalfa, and a solution of methylene blue.

The proposed tool allows you to use mutually reinforcing and complementary properties of natural bacteriocins and bacteriostatic.

The stability of the structure of lipid microcapsules is provided by introducing them in a gel base. In addition, gel-based allows you to use the drug locally, it does not cause hypoxia of the cells and provides extra hydration.

For the first time as antimicrobial, anti-inflammatory, the particle colloidal silver and essential oils of monarda and other targeted supplements, embedded in the membrane bilayer phospholipid vesicles. The inclusion of biologically active ingredients in lipid vesicles allows them targeted transport in the cell structure. Targeted transport reduces the applied dose of the active ingredients from 2 to 50 times without losing their effectiveness, and to ensure their prolonged action. The concentration of the active substances was calculated on the basis of considerations of medical safety for skin cells, bactericidal effect on microorganisms, provoking an inflammatory disease of the sebaceous ducts and sebaceous glands, and taking into account the properties of the microcapsules. Incorporation of substances in microcapsules, the size of which ranges from 20 to 150 nm, preserves their properties within 12 months. Sizes, lay-up and architectonics (the location of the involved particles of silver) phospholipid vesicles was assessed by electron microscopy.

The product has the appearance of a translucent gel with a bluish tint. The gel is intended for the prevention and treatment of papular-pustular forms of acne mild severity and pustular skin lesions of bacterial etiology.

The applicant received hygiene saluces risk to health in connection with its General toxicity and no allergenic effect on the human body.

In use of the present medical-preventive cosmetic gel "Silver" is inflammation relief of mild severity and prevention of pustular inflammation due to the antibacterial, anti-inflammatory, moisturizing action of this tool.

The tool has a pronounced prophylactic effect when teenage acne and therapeutic effect in papular-pustular form of acne on the background of oily seborrhea. In the process of applying the gel marked substations effect, reduction of erythema, infiltration, edema and regression pustular eruptions.

Example 1.

The lipid component is presented in the form of phospholipid microcapsules, the membrane forming lipid-soluble ingredients and particles of silver. Water-soluble ingredients are in the internal volume of the microcapsules. The concentration of curative-preventive cosmetic gel "Silver" below, wt.%:

Lecithin - 1,5

Sesame oil - 0,50

Vodopyanova extract of Bidens - 1,0

Vodopyanova extract of clover - 0,5

Vodopyanova extract alfalfa - 0,5

The ether magazine - 0.02

Methylene blue to 0.0004

Colloidal silver - 0.003

The carbopol - 0,4

Glycerin - 2,0

Triethanolamine - 0,5

Katon - 0,06

Water - the Rest

Example 2. The medical-prophylactic gel "Silver". Treatment-and-prophylactic means in the form of gel contains a lipid component, which is a phospholipid microcapsules, membranes which contain fat - soluble ingredients such as lecithin, sesame oil, essential oils manardi, tea tree, Jasmine and particle colloidal silver. Water-soluble - Vodopyanova extracts series, clover, alfalfa, and methylene blue are located in the internal volume of the microcapsules. Phospholipid microcapsules distributed in a gel base containing carbopol, glycerin, triethanolamine, Katon, water.

The medical-preventive means in the form of a gel, wt.%:

Lecithin - 1,5

Sesame oil - 0,50

Vodopyanova extract of Bidens - 1,0

Vodopyanova extract of clover - 0,5

Vodopyanova extract alfalfa - 0,5

Essential oil of monarda - 0,12

Essential oil tea tree - 0,42

Rosemary essential oil - 0,18

Essential oil of Jasmine - 0.02

Methylene blue to 0.0004
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Water - the Rest

Receiving therapeutic-prophylactic gel microcapsules is carried out by introducing into a gel based microcapsules loaded with biologically active substances (BAS) bactericidal action. Microcapsules with bactericidal substances formed by the method of ultra-high-speed dispersion, when the lipid and aqueous phase are mixed inside a special camera. The process is carried out without vacuum at room temperature. All ingredients are chosen in optimal proportions, violation of which leads to loss of effectiveness of preventive and curative cosmetics gel.

Treatment-and-prophylactic means in the form of a gel containing lipid component with additives, wherein the lipid component is a phospholipid microcapsules, membranes which contain fat - soluble ingredients such as lecithin, sesame oil, essential oils manardi, tea tree, Jasmine and particle colloidal silver and water-soluble - Vodopyanova extracts series, clover, alfalfa, and methylene blue are located in the internal volume of the microcapsules, which are distributed in a gel base containing carbopol, glycerin, triethanolamine, ka is portovoi extract series - 1,0

Vodopyanova extract of clover - 0,5

Vodopyanova extract alfalfa - 0,5

Essential oil manage - 0,12

Essential oil tea tree - 0,42

Rosemary essential oil - 0,18

Essential oil of Jasmine - 0.02

Methylene blue to 0.0004

Colloidal silver - 0.003

The carbopol - 0,4

Glycerin - 2,0

Triethanolamine - 0,5

Katon - 0,06

Water - The Rest

 

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