For the treatment of mastitis in cows

 

(57) Abstract:

The invention relates to the field of veterinary medicine, can be used as a means for treatment of mastitis in cows, as well as for treatment of surgical diseases of the skin and mucous membranes. The invention consists in that the means for the treatment of mastitis in cows, including organic iodine compound as the active substance and distilled water as solvent further comprises a hydrophilic gel base, including, for example, poloxamer or polyvinyl alcohol, a phosphate-citrate buffer and glycerol. As an active substance selected iodopolyvinylpyrrolidone with the following content of components wt.%: iodopolyvinylpyrrolidone 1-10; poloxamer or polyvinyl alcohol 5-20; phosphate-citrate buffer of 0.3-2.0; glycerin 25-50 distilled water - the rest. The invention solves the problem of the increase in the content of active substance and its rapid and uniform distribution in the breast due to the gel base. In addition, when carrying out the invention is enhanced antibacterial, antifungicide, anti-inflammatory, wound healing and other effects, reduced the number of OST is. C.p. f-crystals, 2 tab.

The invention relates to the field of veterinary medicine, can be used as a means for treatment of mastitis in cows, as well as for treatment of surgical diseases of the skin and mucous membranes.

Known means Pedersen A. the product contains the antibiotic erythromycin, the dye Indigo Carmine and the basis of representing a homogeneous viscous liquid dark blue color (see Veterinary drugs: a Handbook. Comp. Malanin L. P. and others; Ed. by A. Tretyakov D. - M. Agropromizdat, 1988, S. 194-195).

Known also means Mastison a, B and E. They contain antibiotics and sulfonamides in various combinations and are oil suspension (see Goncharov, B. N., Karpov C. A., Yakimchuk, I. L. Prevention and treatment of mastitis in animals. -M Rosselchozizdat, 1987, S. 43-44).

The disadvantages of the known technical solutions should be attributed to the poor solubility of antibiotics and sulfonamides in oil, as well as their low content that does not provide the necessary antibacterial concentrations and achieve anti-inflammatory effect. In addition, these active substances have no effect on the fungi and protozoa. Used drugs in kachestve in the cavity of the breast and rapid excretion.

The closest tool adopted for the prototype is Latin (see Interim guidance on the application of Latina for the treatment of mastitis in cows during the 1994-1995), approved by the veterinary Department of the Ministry of agriculture of the Russian Federation 17.02.94 year). Latin - medical preparation, which includes triode 1,3-diethylbenzamide and polyvinylpyrrolidone. The drug is a fine crystalline powder, soluble in water.

The disadvantages of the drug include: insufficient number of free iodine, it is a significant irritant effect on the mucous membranes of the mammary gland, and that he has a simultaneous effect on the pathological focus, and water based does not provide the penetration of active substances in the upper areas of the breast.

The invention solves the problem of the increase in the content of active substance and its rapid and uniform distribution in the breast due to the gel base. In addition, when carrying out the invention is enhanced antibacterial, antifungicide, anti-inflammatory, wound healing and other effects, decreases the amount of residual effects and side effects, in particular, is virtually absent of restaration cows, including organic iodine compound as the active substance and distilled water as solvent further comprises a hydrophilic gel base containing, for example, poloxamer or polyvinyl alcohol, a phosphate-citrate buffer(pH 3.5-7) and glycerin. As an active substance selected iodopolyvinylpyrrolidone in the following components (wt. %):

Iodopolyvinylpyrrolidone - 1 - 10

Poloxamer or polyvinyl alcohol - 5 - 20

Phosphate-citrate buffer - 0,3 - 2,0

Glycerin - 25 - 50

Distilled water - rest

The proposed structure allows to extend the scope of the invention, in particular, it can be used for treatment of surgical diseases of the skin and mucous membranes.

The claimed composition is produced by dissolving poloxamer (polyvinylalcohol alcohol), glycerin, iodopolyvinylpyrrolidone and buffer in the estimated amount of water while heating and stirring for 30-40 minutes (see table. 1).

Gel base may contain instead of poloxamer PVA, experiments have shown that therapeutic properties of the drug are not changed. The formed gel filled through a special dispenser in plastic Luer silp is RIC) in the various forms of mastitis 2 times a day until clinical recovery of the animal. Tests of funds held in comparison with the known compounds - Mastiano and Masterexam (PL. 2).

Timing recovery in an average decrease in serous mastitis 0.7 to 0.9 days, in catarrhal - 0.6 to 1.9, with fibrinous - 1.3, septic - 3.1 - 4.2 and in subclinical - 0.9 - 1.3 days. The percentage of shares with complete loss of milk production decreases with serous 12.9 - 17,9, in catarrhal 14.5 - 16,7, fibrinous 4.5 and 4.9, and purulent mastitis 3.1 to 7.9%. The overall efficiency of the treatment of various forms of mastitis increased by an average of 13.7 at 16.0%. Thus, studies have shown that Septopal has a higher therapeutic efficacy in mastitis cows compared with the known compounds. The advantage of Septogelt is to increase therapeutic efficacy by increasing the content of active substances, rapid and uniform distribution in the breast due to the gel base, and strengthening antibacterial, antifungal, anti-inflammatory and other effects that reduce the amount of residual effects and side effects.

In addition to the treatment of mastitis in cows, Septopal tested as antiseptics the spent funds held in comparison with the known compounds - Syntomycin emulsion and Streptocidum ointment.

When using Septogelt for processing fresh superficial and deep wounds after suturing the number of purulent complications decreased by 40% (up to 0.8 - 0.9%) compared with Syntomycin emulsion. When using Septogelt for the treatment of festering sutured wounds became possible reduction of recovery time to 2-3 days instead of 8 - 10 days using Streptocidum ointments and Syntomycin emulsion (recovery was considered to be the disappearance of purulent discharge and the beginning of granulation and epithelization of the wound). In addition, the timing of the complete healing of uncomplicated wounds decreased by 2-3 days, and complicated by suppuration of wounds - for 4-6 days.

1. For the treatment of mastitis in cows, including organic iodine compound as the active substance and distilled water as a solvent, characterized in that it further comprises a hydrophilic gel basis, and as an active substance selected iodopolyvinylpyrrolidone in the following components, wt%:

Iodopolyvinylpyrrolidone - 1 - 10

Hydrophilic gel-based - 30,3 - 72,0

Distilled water - Rest

2. Means on p. 1, wherein t is a 3.5 - 7) and glycerol at the following content, wt.%:

Iodopolyvinylpyrrolidone - 1 - 10

Poloxamer or polyvinyl alcohol - 5 - 20

Phosphate-citrate buffer - 0,3 - 2,0

Glycerin - 25 - 50

Distilled water - Ostalnoe

 

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SUBSTANCE: the innovation deals with manufacturing remedies to prevent wound suppuration based upon polymeric matrix and antimicrobial substance due to mixing components in solution, forming the film to obtain a powder-like medicinal form by providing the safety of antimicrobial activity of medicinal preparation. The obtained remedy is completely biodestructed in the body and requires no repeated operation on its removal after the end of tissue regeneration processes.

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1 cl, 3 ex, 1 tbl

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