The use of dhea in the treatment of delays adrenarche

 

(57) Abstract:

The invention relates to medicine. A method of treatment delays adrenarche using DHEA. The method provides normalization of hormone levels until age norms, while there is a strong effect.

The invention relates to the field of medicine and relates to drug treatment of patients with delay of adrenarche, due to insufficient production of androgens by the adrenal cortex.

Activation of androgen adrenal function in prepubertal period or adrenarche is a physiological mechanism preceding and contributing to the normal development of puberty.

Decreased production of adrenal androgens in the cortical layer of the adrenal gland is a common condition and leads to a delay in sexual development.

Information about treatment with dehydroepiandrosterone delays adrenarche in the known literary sources are not available.

The aim of the invention is to identify the possibility of using DHEA for the treatment of delays adrenarche.

The prototype method is presented in the article Dehydroepiandroster8, V 45, pp.1011-1015. In it the authors prescribe DHEA adolescents 15-18 years of age with obesity sublingually twice a day for 40 mg for 8 weeks.

Based on this methodology, we developed a method of treatment delays adrenarche.

The essence of the proposed method is as follows: when the delay of adrenarche sublingual assigned alcoholic solution of DHEA at a dose of 25 mg 2 times a day (morning and evening) to normalize the levels of DHEA and DHEA sulfate (DHEA-S).

The effectiveness of the proposed method was confirmed in stationary conditions on volunteers and with the consent of their parents. The experiment involved 14 boys and girls aged 9 to 10 years with a decrease in the secretion of DHEA and DHEA From the adrenal glands, alerted its new form of medical treatment. They received sublingual alcohol solution degidroepiandrosterona in the dosage of 25 mg in the morning and evening to normalize the levels of DHEA and DHEA-s in basal blood continuously for 3 months.

Control surveys hormonal status after 6 and 12 months 12 was normalized secretion of DHEA and DHEA-S, increasing to normal levels is the first drug treatment delay adrenarche, manifested by decreased secretion of DHEA and DHEA-S, has enabled us to implement it in daily practice since 1996.

To date, the national Center for Human Reproduction by this technique have been treated for more than 40 patients. Liaising with 26 patients and their parents, we can talk about more than 80% of the success of the treatment. A new treatment has provided a lasting effect for a period of not less than 3 years (time of observation).

Example 1. The boy's parents L. 10 years, the history N 1847, addressed to the Center 23.5.96 with complaints about lag in physical development of the child from their peers. In the examination Center: height 140 cm, weight 33 kg, absent pubic and axillary hair growth, we found a decrease in the basal level of LH - 1,3 IU/l, FSH 0.6 U/l, T of 1.1 nmol/l DHEA - 320 nmol/l DHEA-With 10 nmol/L. Child was assigned therapy DHEA 25 mg daily 2 times a day for 5 months. During the control study at the end of treatment was determined by the increase to age-related norms level of LH, FSH, T, DHEA, DHEA-S, the appearance of axillary and pubic body hair growth, growth increased to 144 cm, weight 38 kg

Subsequent observation of the patient showed normal puberty.

ski development of the child from their peers. When surveyed in the Centre we found a decrease in the basal level of LH 1,2 U/l, FSH 0,5 IU/l, DHEA - 270 nmol/l DHEA-4.7 nmol/l, reduced growth and body weight. The child was assigned therapy DHEA 25 mg 2 times a day every day for 10 months. During the control study, basal levels of DHEA and DHEA-compliance is determined by the levels of hormones age norms, there is an increase in growth and body weight.

Puberty in subsequent proceeded without features.

Example 3. The boy's parents L. 10 years, the history N 1754, addressed to the Center with complaints of lag in physical development of the child from their peers. In the examination Center: height 142 cm, weight 38 kg, we found a decrease in basal levels of DHEA - 474 nmol/l DHEA-3.8 nmol/L. Child was assigned therapy DHEA 25 mg daily 2 times a day for 5 months. Treatment was accompanied by the appearance of axillary and pubic body hair growth, increased growth and body weight. During the control study, basal levels of DHEA and DHEA-s through 3 months, 6 months compliance is determined by the levels of hormones age norms, there was an increase in growth and body weight at puberty was proceeding without deviation.

Pramodini). Analysis of patent scientific-practical medical literature has shown that information about the use of DHEA for the treatment of delays adrenarche missing. On this basis, the applicant considers that the proposed method of treatment delays adrenarche meets the requirements of the invention.

Treatment delays adrenarche, characterized in that is used for this alcoholic solution of DHEA sublingual dosage 25 mg 2 times a day to normalize levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate.

 

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