The treatment method algomenorrhea in adolescent girls

 

(57) Abstract:

The invention relates to medicine, in particular to the gynecologist, and for the treatment of oligomenorrhea in adolescent girls. The method includes the introduction antispasmodic, analgesic drugs, vitamins. Additionally impose eubiotic biosporin - 2 doses 2 times a day for 7 days in the first phase of the menstrual cycle. The method leads to normalization of immune status, menstrual cycle, disappearance of pain.

The present invention relates to medicine, namely to gynecology.

The increasing aggressiveness of the environment, due to the high anthropogenic load adversely affects the health of the population, reproductive function and quality of the gene pool. Chemical substances penetrate into the body, metabolized and become even more aggressive substances, xenobiotics that cause disorders of the endocrine, immune and other systems (Zubrzycka L. B., 1996; Musaeva L. L., 1998; Shapovalov, A. E., 1998).

Special attention should be paid to the deterioration of the immune background of the entire population, but this was more pronounced among women and children. In adolescent girls with oligomenorrhea ummunoregulatory function of the T-link-type T-SD-lymphopenia, in combination with the General T - lymphopenia, increased levels of circulating blood T-lymphocytes, which have the receptor CD8, we found a decrease of the synthesis of serum immunoglobulins of all 3 classes a, M, G), which makes the actual search for drugs for non-specific immunotherapy in treatment of this contingent patients.

Art

Analogs of this invention are described in domestic and foreign literature methods for the treatment of various forms of algomenorrhea.

This group of methods include the following:

1) treatment of oligomenorrhea, including antispasmodic and analgesic means: but, silos, baralgin, spazmatron, sevadal, analgin, tramadol. Simultaneously assigned sedatives (Valerian, motherwort, hops and other) after 3-4 hours during the pain attack in adolescent girls (Gurkin Y. A., 1998).

2) For the treatment of oligomenorrhea using drugs that suppress the synthesis of prostaglandins: naprosyn 250 mg 2-3 times daily, indomethacin 25 mg 3 times, brufen 200 mg 3 times, acetylsalicylic acid 200 mg 4-6 times the vitamin C 300 mg / day for 3 days (Bodjagina Century. And., Smetnik B. N., Tumilovich L., 1990).

3) In the treatment of Aligator bellaston, bellaid, lenbert) (Krupko-Bolsova Y. A., Kornilov, A. I., Ryskina H. A., 1990).

The prototype of the present invention is the method of complex therapy with the inclusion of immunomodulators for various forms of algomenorrhea on the background of endometriosis and inflammatory processes in the genital organs.

1. In the traditional scheme of anti-inflammatory therapy in chronic diseases of the genital organs was introduced probiotic bifidus-bacterin-Forte scheme 5 doses at once 3 times a day 30 minutes before meals, dose rate 180-210 doses (Serov C. N., Ilyenko L. N., Popova O. K., Nenkov C. F., 1996). It is shown that oral administration of capsules with bifidum-Forte provides correction of dysbiotic disorders of the gastrointestinal tract, vaginal microflora and antiendotoxin immunity. Bifidumbacterin refers to the eubiotics resident bacteria. It is proved that immunokorrigiruyuschy properties are more pronounced in eubiotics on the basis of non-resident bacteria, in particular, such as drug biosporin (Smirnov centuries, Reznik, S. R., Volynets A. K., 1988).

2. In the complex therapy of endometriosis included immunomodulator levamisole in the form of tablets decaris as follows: 20 mg per day for 3 consecutive days with a break vitalities cells, modulates the action of suppressor lymphocytes, increases the production of lymphokines, activates natural killer cells, like the action of thymic hormone thymosin he promotes maturation of undifferentiated precursors of T-lymphocytes. But the drug has severe side effects, which include cytopenia, agranulocytosis, skin ulcers, gastro-intestinal disorders.

Thus, there are currently a number of drugs for the correction of disorders in the immune homeostasis in pain syndrome on the background of gynecological pathology. The use of these drugs has a number of disadvantages and the risk of significant complications.

The aim of the invention is the improvement of immunological parameters in girls suffering from algomenorrhea.

The invention

In the complex therapy of algomenorrhea, including antispasmodics, analgesics and vitamins, in addition enter eubiotic biosporin, which has an immunomodulatory effect. Drug bioperin is a microbial mass of live bacilli B. Subtillis and B. Lichniformis significantly different physiological and biochemical properties, which, in particular, determines their ability to adapt in slovaca. Immunomodulation occurs through induction of the synthesis of endogenous interferon stimulating the activity of blood leukocytes, synthesis of immunoglobulins.

The method is as follows:

Girls suffering from algomenorrhea, prescribe a comprehensive treatment regimen.

1) folic acid 1 tablet 3 times a day 1 to day 15 of the menstrual cycle;

2) vitamin C 300 mg 3 times a day 16 day cycle before menstruation;

3) vitamin E - 1 capsule 1 time per day during the second phase of the cycle;

4) medicine Pavlov - 1 tablespoon 3 times a day during the week before menstruation;

5) no-Spa or papaverine - 1 tablet 3 times a day during the week before menstruation;

6) alpha-tocopherol 50 mg 2 times a day during the week before menstruation;

7) biosporin - 2 doses 2 times a day for 7 days in the 1st phase of the cycle.

Example 1. Okunev, K., 16 years old, suffers from algomenorrhea since menarche. A history of frequent viral infections, chronic tonsillitis. About algomenorrhea examined and treated by a gynecologist at the place of residence, the effect of therapy was not. After examination in our clinic anatomical changes in the internal genital organs not found. The patient who was ovalis some parameters of immunity, namely: to ensure the content of T-"helpers" - 16-0,28109/l; after treatment, the content of T-"helpers" - 53-0,9109/l; the concentration of antibodies before treatment - IgM - 150 g/l; IgG - 1500 g/l; IgA - 150 g/l; after treatment - IgM - 175 g/l; IgG - 1625 g/l; IgA-195 g/l In bacterial seeding vaginal flora was dominated by lactobacilli.

Example 2. Evdokimov A., 16 years old, suffers from algomenorrhea 14 years, two years after the onset of menarche. Somatic history burdened by disease of the gastrointestinal tract. About oligomenorrhea was treated at the children's gynecologist at the place of residence, the effect of the treatment was not. When applying the proposed scheme is normalized menstrual cycle, decreased pain, improved immune status, namely: to ensure the content of T-"helpers" - 39-0,46109/l; after treatment, the content of T-"helpers" - 46-0,71109/l; the concentration of antibodies before treatment - IgM - 160 g/l; IgG - 1700 g/l; IgA - 116 g/l; after treatment of IgM - 275 g/l; IgG - 2500 g/l; IgA - 230 g/l In bacterial seeding content of the vaginal microflora was not found.

Thus, the introduction of Bioperine in complex treatment regimen can significantly improve the immunological and clinical parameters.

Secondly, bioperin immunoregulatory effect on the function of T-link the immune system. In patients with reduced blood levels of T cells (CD4 cells), the drug helps to normalize their levels in the blood.

Thirdly, bioperin has immunostimulatory effects on the synthesis of serum immunoglobulins of all 3 classes (a, M, G). The concentration of IgM and IgG under the influence of therapy has increased by more than 10%. The level of IgA after applying Bioperine increased by 35.5%.

In spontaneous and stimulated versions of NBT-test significant stimulation reaction.

In addition, adolescent girls with oligomenorrhea on the background of the treatment with Bioperine normal menstrual cycle, decreases pain, bacteriological picture of vaginal contents dominated by lacto - and bifidobacteria.

This method of treatment has no contraindications and can be recommended for wide use in gynecological practice.

Sources of information

1. Avetisova L. R. Algoma E. M.//Bulletin of the obstetrician-gynecologist. - 1994. - N 3. - S. 24-29.

3. Gurkin Y. A. adolescent Gynecology. - St.-Petersburg, 1998.

4. Zubrzycka L. B. Immune complexes in the placenta and serum as biological indicators of environmental and other adverse effects on the pregnant woman: author. dis. Dr. Biol. Sciences. - M., 1996. - 35 S.

5. Krupko-Bolsova Y. A., Kornilov, A. I., Ryskina H. A. pathology of the sexual development of girls and young women. - Kiev, 1990.

6. Musaeva L. L., Eroshenko B. R., Monastic O. A. Influence of environmental factors on pregnancy, " Vestn. Grew up with. Assoc. akush.-gin. - 1996. - N 2. - S. 38-41.

7. Serov C. N., Ilyenko L. N., Popova O. K., Nenkov C. F.//Journal. - 1996. N 3. - S. 75-77.

8. Startseva N. In. Endometriosis as a new disease. - Perm, 1997.

9. Trufakin C. A. , Shurygina A. C., Dergachev T. I., Litvinenko, I. //Immunology. - 1999. N 2. - S. 49-50.

10. Shapovalov, A. E. the Role of natural factors in shaping human health/Environmental problems in Pediatrics. M., 1998. - S. 72-82.

The treatment method algomenorrhea in adolescent girls through a comprehensive therapy, including antispasmodics, seddiki and vitamins, characterized in that it further treatment regimen is administered eubiotic biosporin - 2 doses of the

 

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