The method of treatment of rheumatoid arthritis


(57) Abstract:

The invention relates to medicine, namely to rheumatology, and is intended for the treatment of rheumatoid arthritis. The method includes the introduction of non-steroidal anti-inflammatory drugs and ceruloplasmin, which is injected intravenously 10 times a day. 100 mg of ceruloplasmin before the introduction dissolved in 200 ml of 5% glucose or saline solution. The method allows correcting serum enzyme level of the antioxidant system and reduce endogenous intoxication in this disease. 1 C.p. f-crystals.

The invention relates to medicine, namely to rheumatology, and is intended for the treatment of rheumatoid arthritis.

Known methods of treatment of rheumatoid arthritis, in which the complex traditional treatments include pharmacological tools antioxidant, such as vitamin E and vitamin A, C, P, K and with non-steroidal anti-inflammatory drugs /1/, tocopherol at high doses (500-600 mg/day) and Essentiale-Forte oral or intravenous /2/. These methods are based on correction of the deficiency nonenzymatic element of the antioxidant system, inhibition of peroxidation OK is Musasa in patients with rheumatoid arthritis insufficiency element of the antioxidant enzymatic system, because of antioxidant enzymes in this way are not used.

Closest to the claimed is a method of treatment of rheumatoid arthritis, including the introduction of enzymatic antioxidant orgotein on the background of oral administration of non-steroidal anti-inflammatory drugs /3/. Orgotein injected intra-articular dose of 8 mg on an injection once a week). The course of treatment 4-6 injections.

The disadvantage of this method of treatment is the fact that corrects only the cellular element of the antioxidant enzymatic system of the body, because orgotein have superoxide dismutase activity, which is the main cellular antioxidant enzyme carrying out its protective action is intracellular. Serum accumulate highly aggressive superoxide radicals and toxic products of lipid peroxidation, which requires correction of serum enzyme level of the antioxidant system.

The objective of the invention is the correction of serum enzyme level of the antioxidant system. This task is solved in that in the method of treatment of rheumatoid arthritis, including the introduction of enzymatic antivimentin antioxidant use of serum ceruloplasmin, which is injected intravenously 10 times a day, to which 100 mg of ceruloplasmin ex temporae dissolved in 200 ml of 5% glucose or saline solution.

Drug "ceruloplasmin" - "Ceruloplasminum humanum placentaris" produced from waste products of the blood products. It stimulates hematopoiesis (red blade of blood), reduces toxicity and immunosuppression, binding of superoxide radicals and providing membranostabiliziruyuschee action.

Ceruloplasmin is a copper-containing enzyme alpha-globulin fraction, is the main antioxidant serum. In the serum of a healthy person contains 303 + 124 mg/l ceruloplasmin, which is the "interceptor" oxygen free radicals circulating in the blood. It protects lepidosperma patterns from the action of superoxide radicals, prevents the free lipid oxidation.

In patients with rheumatoid arthritis the content of ceruloplasmin in the serum may be normal or elevated, but even increasing the concentration of ceruloplasmin in the blood does not compensate the existing intensification of the processes of lipid peroxidation.

The introduction of full donor ceruloplasmin in patients with rheumatoid arthritis. Ten intravenous infusion of ceruloplasmin allow to improve the clinical condition of the patient, leading to a pronounced detoxifying, antioxidant and anti-anemic effect. Introduction ceruloplasmin through the day due to the fact that the effect of the introduction of the drug is not more than 48 hours.

The method is as follows. The contents of one vial of ceruloplasmin (100 mg) immediately before introduction dissolved in 200 ml of 5% glucose solution or isotonic sodium chloride solution and injected intravenously at a rate of 30 drops in one minute. The introduction of the drug carry a day in patients receiving nonsteroidal anti-inflammatory drugs (indomethacin, diclofenac, ortofen and others), the course of treatment 10 intravenous infusion.

Example 1. Patient E., 50 years of age, was treated in the Republican artrologicheskoy the centre of Sarnico with a diagnosis of rheumatoid arthritis, arthritis, HIV infection, stage 3 total activity 2, functional failure of joints 1.

At admission the patient was weakness, lethargy, stiffness in the morning for 6 hours, severe pains in the interphalangeal and metacarpophalangeal joint of the GDS for the first time, without apparent reason, pains and swelling in the wrist joints, in the small joints of the right wrist, and then in the ankle, metatarsophalangeal joints of both feet. Repeatedly was in outpatient and inpatient treatment for rheumatoid arthritis were treated: non-steroidal anti-inflammatory drugs (ortofen in table 1. 2 times a day), intra-articular injection of hormones (kenalog).

On examination: the patient is lethargic, marked pallor of the skin. Visually there is swelling, defigure left and right wrist joints, the second metacarpal-phalangeal joint of right wrist, II and IV interphalangeal joints of the left hand. Palpation tenderness in the area of the above joints. Movement in the joints is limited because of pain.

Laboratory data: complete blood count: erythrocytes 3,410", hemoglobin 91 g/l, colour index of 0.8, leukocytes 5,510', ESR 32 mm per hour, total protein, 76 g/l, SRV 2 mm, seromucoid 0,59.E., malonic dialdehyde 2.5 Ámol/l ceruloplasmin 333 mg/l, the average molecule weight 0,284.E.

The patient completed the treatment by the proposed method, including the introduction of ceruloplasmin in the background of continued therapy with nonsteroidal anti-inflammatory drugs in the same dosage as before therapy ceruloplasmin was dissolved in 200 ml of 5% glucose solution and injected intravenously at a rate of 30 drops per minute. Treatment consisted of 10 investments held through the day.

After treatment showed improvement in overall health and the clinical picture consisted in reducing lethargy, weakness, stiffness in the morning is actually absent, improved sleep and appetite, decreased the severity of joint pain (before treatment 5 points, after treatment 2 points), decreased swelling of the wrist joints. There was a positive dynamics laboratory indicators: increased number of erythrocytes to 3,910", the level of hemoglobin 114 g/l, colour index of 0.9. 2 times decreased erythrocyte sedimentation rate (16 mm per hour), Vietnam fell to 1.5 mm, seromucoid to 0.39.e, the level of malondialdehyde up to 2 Ámol/l, the level of molecules of average weight dropped to 0,268.E., the content of ceruloplasmin was equal to 335 mg/l

Thus, the patient with advanced and reasonable activity of the rheumatoid process introduction ceruloplasmin improved health, clinical status and laboratory values.

Some patients already after 2-3 injections showed a significant decrease in erythrocyte sedimentation rate, a reduction in the number of cells, a positive shift in terms of the blood formula, the increase is when he first showed swelling, pain in the small joints of both feet, then there was swelling of the left knee and small joints of both hands. Repeatedly was in hospital, where she was held the traditional course of conservative treatment, including non-steroidal anti-inflammatory drugs, intra-articular injection of hormones. At admission the patient experience pain in the right elbow, wrist, small joints of the hands, knee, ankle, small joints of both feet, as well as weakness, lethargy, stiffness in the morning till five o'clock. Objectively there is swelling, contracture of the wrist joint, right elbow, metacarpophalangeal joints of both hands, the smoothness of the contours of defigure right knee joint. Palpation is determined by tenderness along the line of the joint space, the signs of resultnode internal and external lateral ligaments, the symptom front of a drawer. In General, the analysis of blood upon receipt of erythrocytes 3,310", hemoglobin 95 g/l, colour index of 0.8, leukocytes 3,810', lymphocytes 26, ESR 65 mm/hour. In the biochemical analysis of blood flow C reactive protein 2,5; sialic acid 310; seromucoid 0,46, ceruloplasmin 310 mg/l Rheumatoid factor is adiya's, stage II, functional failure II. The patient started treatment with ceruloplasmin in the form of a course of intravenous fluids conducted through the day on the back of continued therapy with indomethacin (1 tab. 3 times a day). The contents of the vial of ceruloplasmin (100 mg) was dissolved immediately before introduction into 200 ml of saline and injected intravenously at a rate of 30 drops per minute. After three injections, the patient noted improvement in General condition, decreased intoxication symptoms: weakness, lethargy; stiffness in the morning decreased from 5 to 3 hours, the patient clearly notes the feeling of lightness in the joints after the introduction of ceruloplasmin, which was maintained for about 48 hours after the injection. After 10 injections, the patient has no symptoms of intoxication (weakness, lethargy, stiffness in the morning, decreased by approximately 60%, significantly reduced pain in joints, synovitis of the right knee joint was practically stopped. There has been a dramatic positive dynamics of indicators of the "red" blood and a positive trend in the decrease of the activity of the inflammatory process in the joints according to the General analysis of blood and reactive was more pronounced in two weeks after the start of treatment.

Thus, in addition to the antioxidant, the product has detoxifying and haemostimulating action, increasing the efficiency of treatment of rheumatoid inflammation.

The proposed method in the Republican artrologicheskoy center at Sarnico treated 45 patients reliable rheumatoid arthritis.

The proposed method of treatment has a positive effect on patients peroxidation-antioxidant imbalance and has a pronounced anti-anemic effect. The positive moment of introduction of ceruloplasmin is a significant detoxifying effect, which is manifested in the reduction of weakness, sweating, time, morning stiffness, improve sleep and appetite, normalization of body temperature. It was noted positive dynamics of the concentration of molecules of average weight - integrated biochemical test, reflecting the level of endogenous intoxication.

An additional positive aspect of the proposed method is intravenous, but not intra-articular, as in the prototype, the introduction of the drug. The latter avoids the difficulties and disadvantages inherent in intra-articular introduction, namely: does not require special training of the physician and sterile relavely method allows to achieve a pronounced therapeutic effect much faster (15-20 days), what is known (30-45 days).

In the proposed method uses the drug, derived from retroplatsentarno human blood, rather than a preparation from animal tissues.

Sources of information

1. Lobaria L. S. Denisov, L. N., Yakushev, E. O. "Antioxidant vitamins in the treatment of rheumatic diseases". The wedge. rheumatol., 1994, No. 3. C. 7-8.

2. Noskov, S. M. "Pathogenetic therapy of RA in the aspect of free-radical and lipid mechanisms of inflammation". - Abstract., Diss. Dr. med. Sciences. - Yaroslavl, 1993. - S. 50.

3. Kerimov, H. A. O., "Experimental and clinical evaluation of the effectiveness of orgotein in rheumatoid arthritis and deforming arthrosis". - Diss. Kida. the honey.Sciences., M., 1988. - N-100 /prototype/.

1. The method of treatment of rheumatoid arthritis, including the introduction of the enzymatic antioxidant drugs on the background of oral administration of non-steroidal anti-inflammatory drugs, characterized in that the enzymatic antioxidant use of serum ceruloplasmin, which is injected intravenously 10 times through the day.

2. A method of treating rheumatoid arthritis under item 1, characterized in that the intravenous injection of 100 mg Torulopsis the


Same patents:

The invention relates to surgery
The invention relates to medicine, obstetrics

The invention relates to medicine, namely to dentistry

The invention relates to medicine, namely to therapy, and can be used in the treatment of malnutrition
The invention relates to medicine, namely to methods for treating chronic polymyositis

The invention relates to medicine and is a method of treating scar-modified tissue drug "Morical"
The invention relates to medicine, namely to Oncology, and can be used in the treatment of patients with fibrose-cystic mastopathy and breast cysts
The invention relates to medicine, particularly cardiology, and for the treatment of pathology of the coronary arteries

The invention relates to medicine, namely to andrology, and can be used in the treatment of autoimmune male infertility

FIELD: medicine, pharmacology, pharmacy.

SUBSTANCE: invention relates to the agent comprising the following components: lidazum (16-32 U), proserinum 0.05% solution, 0.00025-0.0005 g; methylprednisolone succinate sodium, 0.02-0.04 g; lidocaine 10% solution, 0.05-0.1 g, and glucose 40% solution, 3-4 ml. Also, invention relates to a method for administration of agent and a method for treatment of inflammatory diseases. Invention provides expanding assortment of medicinal agents and improving the regional transport of medicinal preparations.

EFFECT: improved and valuable properties of agent.

6 cl, 5 ex

FIELD: veterinary medicine.

SUBSTANCE: poultry's diet during the first and second phases of egg yield should be supplemented with roxazym enzymatic complex at the ratio towards husk-bearing components being 0.007 - 0.009 : 20. The present innovation prevents inflammation of oviducal vagina in laying hens.

EFFECT: higher efficiency of prophylaxis.

3 ex

FIELD: medicine.

SUBSTANCE: the present innovation deals with preventing the development of hypoxia due to introducing ceruloplasmin 1 d before hypoxia. The method enables to exclude the development of allergic reactions.

EFFECT: higher efficiency of hypoxia prevention.

2 ex, 3 tbl

FIELD: medicine, gynecology.

SUBSTANCE: one should perform surgical destruction of endometrioidal heterotopias, antibioticotherapy followed by hormone-modulating therapy. Moreover, it is necessary to irradiate blood through a monofilamentous quartz light guide introduced into patient's elbow vein with the help of He-Ne laser at wave length being 628 nm at 15 min duration during the first 5 procedures and for 30 min during 2 last procedures followed by prescribing GnRH agonists for 7 d at the background of antibioticotherapy, intake of analgetics and vobenzyme beginning since the 1st postoperative day.

EFFECT: higher efficiency of therapy.

2 ex

FIELD: medicine, surgery.

SUBSTANCE: medicinal mixture consisting of 10 ml 0.25%-novocaine, 1 ml 1%-emoxypin and 64 c.u. lidase should be injected strictly subcutaneously per 1 ml for each point of injection into the center of plantar surface of nail phalanx of every toe, and for the first inter-toe space - subcutaneously in plantar and rear directions, then, after injections, it is necessary to carry out massage in area if injection with stretching and stroking movements in proximal direction for 10-15 sec, moreover curative seances should be performed every other day , the course being of 5-10 procedures, at repeating this course 3-6 mo later. The present innovation enables to activate transcapillary exchange due to pathogenetically proved impact onto surface and deep lymphatic network of inferior limbs.

EFFECT: higher efficiency of therapy.

1 cl, 2 ex

FIELD: medicine, cosmetology.

SUBSTANCE: one should introduce enzymes-containing liposomes of DNAase activity into skin and/or subcutaneous fiber, moreover, one should apply multi-layer MLV-liposomes at their size ranged 500-2000 nm at temperature of phase transition of liposomal membrane being 30-60 C, moreover, one should deliver and deposit an enzyme into intercellular space, and as enzymes with DNAase activity one should apply endo- and/or exonucleases that destroy single and/or double stranded DNA. The innovation prevents the damage of intracellular DNA of alive skin cells and/or its adnexa and/or subcutaneous fiber.

EFFECT: higher efficiency of prophylaxis and correction.

4 ex, 4 tbl

FIELD: medicine, laboratory diagnostics.

SUBSTANCE: the present innovation deals with blood testing based upon chromatographic purification of snake's venom, identification and mixing fractions that contain thrombin-like enzyme followed by isolating the target product due to chromatography upon Sepharose leveled with Tris-HCL buffer solution, moreover, snake's venom Agkistrodon halys in 0.05 M sodium chloride solution should undergo chromatography upon a column filled with Sephacryl S-300 HR, after identification and mixing fractions with thrombin-like enzyme they should be concentrated due to ultrafiltration at selecting against molecular weight of 10 Kd, the obtained solution should undergo chromatography upon a column with DEAE Sepharose FF leveled with acetate buffer solution to select and mix fractions with thrombin-like enzyme and repeatedly concentrate due to ultrafiltration, then concentrate should pass chromatography upon a column with SP Sepharose FF gel, fractions that contain the target product should be combined, diluted with distilled water up to activity of 12-15 sec in thrombin time test, then one should add saccharose, sodium azide up to 0.01% to be poured into vials and freeze dried. The method provides broadened quantity of reagents for laboratory diagnostics of disorders in the system of hemostasis. Fraction isolated out of snake's venom Agkistrodon Halys (the Russian Federation) is not inferior to that of snake's venom Bothrops atrox.

EFFECT: higher efficiency.

1 ex

FIELD: medicine, gynecology.

SUBSTANCE: intravaginally one should introduce proteolytically immobilized enzyme - imosimase at the dosage of 5 ml (300PU) and basic combined antimycotic preparation on the 1st, 5th and 10th d of therapy. The present innovation enables to decrease the number of complications during pregnancy, in the course of delivery, during puerperal and early neonatal periods due to valuable vaginal sanitation.

EFFECT: higher efficiency of therapy.

2 ex

FIELD: surgery.

SUBSTANCE: complex therapeutic mixture consisting of 32 un lidase, 4 mg dexametasone, 40 mg lidocain diluted with 6 ml of 40% glucose solution is introduced into bulk of interspinous ligament at levels C7-Th1 and Th8-Th9. Procedure is repeated 5 times with 48 h intervals.

EFFECT: achieved rapid stopping of esophagitis manifestations owing to improved lymphovenous interactions in posterior mediastinum region.

FIELD: medicine.

SUBSTANCE: method involves increasing receptor activity, that is activated with proliferating agent of peroxis, by introducing NADP+-dependent isocitrate dehydrogenase (IDPc), IDPc gene or NADPH, selecting antisense molecule inhibiting fat deposit or nitroglycerides and cholesterol production using IDPc gene, and treating metabolism disorder diseases like adiposity, hyperlipiemia or hepatic fat infiltration by introducing antisense molecule of IDPc gene or IDPc gene inhibitor like oxalomalic acid or methyl isocitric acid.

EFFECT: enhanced effectiveness of treatment; reduced NADP level in cells.

5 cl, 10 dwg