(57) Abstract:The invention relates to medicine, in particular to ophthalmology. Developed formula with antiseptic properties including antiseptic substance Miramistin, isotonic solution of sodium chloride or isotonic sodium chloride solution with high viscosity. The increase in viscosity is achieved by the introduction of gel - various modifications of cellulose (preferably hydroxyethylcellulose). Experimental studies showed no toxic effect of the claimed composition on mucous membranes of the eyes and the body of animals, as well as its high efficiency in the treatment of experimental purulent conjunctivitis. The composition provides treatment of infectious eye lesions. 2 S. and 3 C.p. f-crystals, 2 tab. The invention relates to medicine and can be used in ophthalmology for the treatment of infectious eye lesions.Known ocular antibacterial drugs, akacin (Register of medicines, M. , "radar-2000", 1999, S. 742), wetback (ibid, S. 742), sulfatsil sodium (ibid, S. 686), ciprolet (ibid, S. 767). The disadvantages of these drugs is absent or weakly expressed antifungal allergicheskie reactions and conjunctival hyperemia. The drug oftan Go (ibid, S. 1012) is effective in viral (HSV) keratitis, but has no effect on bacterial flora, causes headache, allergic reactions and contact dermatitis of the eyelids.Closest to the claimed effect is drug sofradex (ibid, S. 1003), which exhibits antibacterial, anti-inflammatory, antiallergic and antipruritic action, does not cause irritation, burning, dermatitis. The main disadvantage of it is contraindicated in viral (herpes) or fungal eye infections, as well as purulent lesions.The aim of the present invention is to expand the range of drugs for the treatment of infectious lesions of the eye and the creation of the drug complex action on bacteria, fungi and viruses.This goal is achieved by the use of a composition comprising an effective amount of Miramistin in the pharmaceutical diluent in the following ratio of components (wt.%):
Miramistin - 0,005 - 0,10
the diluent 100
The diluent used conventional isotonic solution of sodium chloride (IRHN) or a solution of increased viscosity due to the introduction of the option is R> IRN 100
Of the known cellulose derivatives, forming solutions, gels, preferably the use of hydroxyethyl cellulose in an amount of 0.2 - 0.4 wt.%.Currently, Miramistin allowed to be used in a 0.01% aqueous solution as a means of preventing sexually transmitted diseases (VFS 42-2048-91). It has a wide antimicrobial spectrum of activity, leading simultaneously to the death of gram-positive and gram-negative bacteria, fungi and viruses (herpes, HIV, influenza) [Vasilyev, T. C. et al. Antibacterial activity and clinical efficacy of a new antiseptic drug Miramistin. Antibiotics and chemotherapy, 1993, T. 38, N 8-9, S. 61-63; Krivoruchenko Y. L. et al. The study of anti-HIV activity Miramistin. Questions of Virology, 1994, No. 6, S. 267-269]. But the introduction of this solution into the conjunctival SAC sometimes causes burning, redness, mucous, tears, resulting in leaching of the drug from the eye and reduces therapeutic effect.The use of the claimed composition (LC), including the Miramistin and IRHN normal or high viscosity helps to avoid these disadvantages and to prolong therapeutic effect by creating for some time, tonasket therapeutic solutions in otorhinolaryngological practice described [MU. Preparation, quality control and application of otorinolaringologii herbal remedies high viscosity. Kursk, GWIPP "Kursk", 1996]. As a thickener use oksipropilmetiltselljuloza (VFS 42-187-73), methylcellulose (TU 6-01-717-72) or sodium carboxymethylcellulose (VFS 42-892 - 80) in an amount of from 0.5 to 1%.In the present technical solution is proposed to use in addition hydroxyethyl cellulose, thereby reducing the concentration of the gel-to 0.2 - 0.4 wt.%.The study of the toxic effects of the proposed structure on the animal organism.The influence of CS on the mucous membrane of the eye was studied on rabbits and Guinea pigs by putting them in the eyes of the drug 3 times a day for 30 days. Irritant effects were assessed using the methods of Draize and Ogura.The data obtained showed that the AP did not cause all experimental animals used in experiments, irritating effect on the mucous membranes of the eye (score on a scale of Draize - 0, according to the classification Ogura - group a). No irritating effect was observed when instillation into the eyes of rabbits as normal solutions, and solutions of high viscosity.Postmortem and histological the Chania introducing them in the eye CS no visible pathological changes found.Thus, the obtained data show that the AP has no irritant effect on the mucous membranes of the eyes of experimental animals.Study of the effect of the inventive compounds on inflammatory process of the cornea.The experiment was carried out on rabbits of the chinchilla breed weighing 2 to 2.5 kg of Purulent-inflammation of the cornea caused by the introduction into the cornea suspension of the daily culture of Staphylococcus aureus strain 209 P. 2-4 days on the cornea was found ulcers the size of 3 x 6 mm with purulent discharge at the bottom. In addition, the observed phenomena of the inflammatory reactions: conjunctivitis, blepharospasm and otherAll rabbits were divided into 5 groups according to the types of treatment effect: group 1A - the claimed composition in three options; group 2 - prototype (sofradex); group 3 - INCH (PL. 1).All animals were buried medications daily, 3 times a day till complete cure. The inspection was carried out daily, carried out the bacteriological crops.The results of studies that illustrate the use of the claimed composition in experiments on rabbits, are presented in table. 2.As can be seen from " the end of the observations. In group 1A faster began and ended resorption of purulent infiltration, on average, 5 days, compared with group 2. In addition, from table. 2 shows that the concentration of Miramistin below 0.005 wt.% does not give significant advantages in comparison with the prototype. It was also noted that the concentration of Miramistin 0.2 wt. % IRN (composition 1 g, PL. 1) in some cases caused eye irritation.From the above data we can conclude that the optimum ratio of components within, claimed in the claims. The inventive ophthalmic antiseptic harmless to the body and is highly effective for the treatment of inflammatory lesions of the eye. 1. The use of Miramistin as an antiseptic for the treatment of infectious eye lesions.2. Eye antiseptic composition comprising an antiseptic substance in a pharmaceutical diluent, characterized in that as an antiseptic substances it contains Miramistin in the effective number in the following ratio, wt.%:
Miramistin - 0,005 - 0,1
The diluent 100
3. Eye antiseptic composition according to p. 2, characterized in that as rastriya high viscosity.4. Eye antiseptic composition according to PP.2 and 3, characterized in that for increasing the viscosity of the it contains gelling products modified cellulose in the following ratio, wt.%:
Modified cellulose - 0,2 - 1,0
Isotonic solution of sodium chloride Up to 100
5. Eye antiseptic composition according to PP.2 to 4, characterized in that as the gel-it contains hydroxyethyl cellulose in the following ratio, wt.%:
Hydroxyethylcellulose - 0,2 - 0,4
Isotonic solution of sodium chloride Up to 100
FIELD: agriculture, animal husbandry, organic chemistry.
SUBSTANCE: antiseptic ointment comprises cationic surface-active substance, lower glycols, polyethylene glycols, water and ethylene glycol monophenolic ester and higher polyethylene glycols taken in the definite ratio of components. As cationic surface-active substance ointment comprises N-alkyl-N-alkoxycarbonylmethylhexahydroazipinium chloride or alkyldimethylbenzylammonium chloride, or cetylpyridinium bromide, or cetylpyridinium chloride, or 1,2-ethylenebis-(N-methylcarbdecyloxymethyl)ammonium dichloride, or ethylhexadecyldimethylammonium chloride, or chlorhexidine; as lower glycol ointment comprises 1,2-propylene glycol or polyethylene glycol-300, or polyethylene glycol-400; as higher polyethylene glycol ointment comprises polyethylene glycol-1500 or polyethylene glycol-3000, or polyethylene glycol-4000, or polyethylene glycol-6000. Ointment elicits the high antibacterial activity, broad spectrum of bactericidal effect and low irritating effect with respect to udder skin. Invention can be used for sanitary-hygienic treatment of udder of lactating cows for prophylaxis and rapid healing external damages of udder and nipples (arising cracks), prophylaxis of mastitis, enhancing milk purity by microbiological indices.
EFFECT: valuable antiseptic properties of ointment.
2 cl, 1 tbl, 22 ex
SUBSTANCE: the present innovation deals with cosmetic preparation for taking care of skin, in particular. The suggested antibacterial gel consists of either hydroxypropylcellulose or hydroxyethylcellulose, propylene glycol or diethylene glycol compound, polyguanidine or its synergistic mixture with quaternary ammonium compound, chitosan, oxyethylated ether of sorbitane, polyvinyl pyrrolidone at molecular weight ranged 10000 - 40000 or copolymer of polyvinylpyrrolidone, trilon-B - sodium salt of ethylene diamintetraacetic acid, perfumery composition, vitamin constituent and water. The present innovation provides increased regenerating formula of skin and its enhanced barrier function, improves homogeneity of the composition mentioned and its stability.
EFFECT: higher efficiency of application.
5 cl, 4 ex, 3 tbl
FIELD: organic synthesis.
SUBSTANCE: invention provides group of novel antiviral nitrogen-containing compounds, in particular adamantane derivatives having general formula:
, wherein R represents chlorine or ethyl.
EFFECT: increased choice of biologically active compounds suitable for use in medicine as antiherpetic agents.
2 cl, 6 tbl, 3 ex
SUBSTANCE: the suggested disinfectant contains glutaric aldehyde, didecyldimethylammonium chloride, ethoxylated alcohol, propylene glycol and water at certain ratios. The method to treat objects, those of medicinal indications, among them, deals with treating an object with the above-mentioned disinfectant followed by keeping disinfectant on the object during the time and at temperature to provide disinfection and/or sterilization of the object followed by washing disinfectant off. The present innovation provides hermetic nature of elements and connective elements of flexible and rigid endoscopes, soldered and glued sites in the course of disinfection.
EFFECT: higher efficiency of application.
10 cl, 3 ex
FIELD: medicine, pharmacy.
SUBSTANCE: invention proposes an agent for removing the post-narcosis depression after combined anesthetic assistances with applying sedative and narcotic preparations. As such agent the preparation "Reamberin" is used based on succinic acid that is a natural metabolite in human body. The preparation provides reducing time for adequate spontaneous breathing and awaking time by 1.5-fold and the absence of complications and negative adverse responses.
EFFECT: valuable properties of agent.
4 dwg, 3 ex
FIELD: organic chemistry.
SUBSTANCE: invention relates to compounds of the general formula: wherein R means ethyl or benzyl; X means chlorine atom (Cl) or bromine atom (Br). Invention provides preparing quaternary ammonium compounds eliciting fungicide, bactericidal and surface-active properties.
EFFECT: valuable properties of compounds.
2 tbl, 4 ex
FIELD: medicine, gynecology, contraceptives, pharmaceutical chemistry.
SUBSTANCE: invention proposes vaginal suppository comprising benzalconium chloride, benzoic acid, purified water and the preparation vitespol taken in the definite content of components. Invention provides the reliable inhibition of fungal microflora being especially against fungus Candida albicans and the absence of irritation and symptoms in vagina drying. Invention can be used as an individual agent for prophylaxis of undesirable pregnancy.
EFFECT: valuable properties of suppository.
FIELD: medicine, pharmacology, pharmacy.
SUBSTANCE: invention relates to a medicinal agent eliciting with the anti-tumor and immunomodulating effect. Agent comprises tetramethyl, pentamethyl or hexamethyl derivative of tri-p-aminotriphenylchloromethane or their mixture with dextrin. Agent elicits enhanced activity and reduced adverse effect.
EFFECT: valuable medicinal properties of agent.
13 cl, 1 tbl, 11 ex
FIELD: medicine, urology.
SUBSTANCE: the present innovation deals with means for external application. The suggested gel-like preparation contains hydroxyethylcellulose polymer as a gel foundation, lidocaine hydrochloride, an antiseptic component - benzalconium chloride (50%), gentamycin and water. The remedy is nontoxic and easy in application, it demonstrates no unfavorable side irritating action being of high penetrating capacity of active components.
EFFECT: higher efficiency of application.
1 cl, 1 dwg, 7 ex
SUBSTANCE: the present innovation deals with disinfecting sanitary-technical equipment, means for taking care of patients, articles of medicinal indication and, also, for pre-sterilization purification and disinfection of medicinal equipment. The suggested disinfectant contains the mixture of quaternary salts of ammonium and tertiary amines at the ratio ranged 10:1 to 1:10, correspondingly. The preparation is active in area of pH being 4-9. Concentration of working solutions - 0.05-0.1% for gram-positive and gram-negative microorganisms and 0.5-1% for microbacteria of tuberculosis and viruses including viruses of hepatitis and HIV-infection. The innovation provides increased activity referring to gram-positive and gram-negative microorganisms, tuberculosis microorganisms among them, being of high virucidal activity.
EFFECT: higher efficiency of disinfection.
1 cl, 2 ex, 2 tbl