Method for the prevention and treatment of environmentally dependent syndrome lesion of the blood of children

 

(57) Abstract:

The invention relates to medicine, namely to Pediatrics. It is proposed to appoint to the background correcting diet chelators in combination with massage, exercise therapy, sauna and water treatments, then make an appointment ascorbic acid, vitamins a, E and adaptogenic drugs within 4 weeks. The method allows to eliminate the toxic side effects of specific drugs, to increase the length of remission.

The invention relates to medicine and can be used in pediatric patients for the prevention and treatment of environmentally caused diseases of the blood system in children, in particular, anemic syndrome.

The method can also be used for the treatment of adult population, mainly women of childbearing age.

This pathology is particularly widespread in children living in areas with adverse environmental conditions, due to the high sensitivity of the child's body during the whole growth period, immaturity protective-adaptive mechanisms, elevated metabolic processes, as well as children whose mothers during pregnancy was neblagopriyatna the response to the blood of children is a biological marker of anthropogenic pollution.

Known methods of treatment of this syndrome lesion of the blood of children as iron deficiency anemia through iron supplementation in combination with multivitamins (see E. I. Mosyagina. Anemia in children, M., 1969; Guidance for local pediatrist. Uzbekistan. Medicine, 1986, S. 366; RF patent N 2012334, class A 61 K 31/295, 1994).

However, the known treatment is not effective enough, as it causes serious adverse reactions of the body. This is due, firstly, poor tolerability of the input oral iron preparations, causing toxic and dyspeptic symptoms. On the other hand, since the iron contained in food, is poorly absorbed by the child's body (as in children 2-14 years absorbed only about 25% of the administered dose of iron), it is necessary to increase the treatment time, which also reduces the effectiveness of the treatment (see F. E., Feinstein. Diseases of the blood system, Tashkent, Medicine, 1987, S. 327).

There is a method of treatment of anemia only purpose of a balanced diet, containing foods iron (see, for example, N. And. Kalinicheva. Anemia in children. M, Medicine, 1983, S. 85).

However, this method of treatment is ineffective because of poor digestibility child Organismo the I method for the prevention and treatment of syndrome of defeat the blood of children, including the selection of children for treatment according to the results of clinical and laboratory diagnosis, and preventive and therapeutic measures by assigning ascorbic acid on the background of correcting the diet. While ascorbic acid before taking pre-irradiated by laser, is administered to the patient orally 2 times a day, and after taking the drug, additional irradiation of the projection of the cubital vein (see RF patent N 2101043, class A 61 N 5/06 A 61 K 31/375, 1998).

However, this known method is not effective enough due to the fact that it does not allow the correction syndrome lesion of the blood, due to the presence of toxic chemical agents, since the introduction of ascorbic acid occurs against a constant presence in the body of chemical toxic agents that can disrupt blood and leucopoiesis. Moreover, the method is complex for widespread use because of technical equipment (laser system).

The aim of the invention is to increase the effectiveness of treatment through the creation of optimal conditions in the body to normalize hemo - and leucopoiesis at maximum antigen sparing of the body, as well as eliminating the need to use this selection of children for treatment according to the results of clinical and laboratory diagnosis, and preventive and therapeutic measures by assigning ascorbic acid, what's new is that before carrying out remedial measures have been selected to ensure children spend medico-chemical study of biological environments of the organism to toxic agents, and the identification of ecologically dependent syndrome lesion of blood in the complex of therapeutic measures include receiving chelators in combination with massage, physical therapy and thermotherapy for two weeks, and then assign the reception antioxidant complex (vitamins A, E, C) with simultaneous admission adaptogenic drugs within one month, and receive chelators, anti-oxidant complex and adaptogenic drugs conducted against the backdrop of correcting the diet. After treatment is again carried out medico-chemical study of biological environments of the organism to toxic agents, and clinical and laboratory examination according to standard indicators, the results of which decide about treatment termination upon receipt of a positive effect, or on the appointment of additional specific therapy in the form of receiving specific drugs if not pronounced positive effect.

The proposed set of essential to recognize the pathological changes of hematological parameters, when the deviation is caused by the presence in the body of chemical toxic agents, which eliminates adverse reactions to these specific drugs and to ensure maximum antigen sparing effect on the body, and this, in turn, allows to extend the scope of application of the proposed method.

Due to the fact that we selected based on the results of clinical and laboratory diagnosis with symptoms of blood before treatment measures conduct medico-chemical study of the biological environment of the organism (for metals in the hair, urine; organic compounds in the urine), provides the data to detect in biological environments, the presence of these toxic agents, which is the priority of environmental factors in the areas of residence, and to compare the contents of the prescribed toxic agents with milestones, then reliably establish the dependence of the lesion of blood from environmental factors and find the complex of therapeutic measures for each child, taking into account medical history and individual characteristics adequately chemical factors of anthropogenic load.

Due to the fact, cheersrobnew within two weeks, provides removal and maximum reduction of excess amounts of alien toxic chemical substances and their metabolic products in the body of the child. Receiving chelators with simultaneous massages, physical therapy and thermotherapy (sauna, contrast shower) increases the efficiency of removing toxic agents from the body.

A prerequisite of this method is the assignment antioxidant complex (vitamins A, E, C) and drug-adaptogens only after the removal of toxic agents that contribute to the most effective impact of this treatment on the body. Welcome antioxidant complex with simultaneous taking adaptogenic drugs within one month helps to normalize the redox processes, to stimulate the metabolic processes and compensatory-adaptive reactions of the organism of the child at the maximum antigen sparing.

Conduct after treatment re-medico-chemical studies of biological environments and clinical-laboratory examination allows in obtaining positive results to make a conclusion about the end of the treatment, or to schedule dopolnitelc.

Thus, the proposed set of essential features can significantly improve the effectiveness of the treatment of syndrome lesion of the blood in children caused by environmental factors, without the use of a specific therapy at the maximum antigen sparing of the body that allows you to expand the scope of treatment, and eliminates the need to apply complex technical equipment makes the proposed method more economical.

The method is as follows.

After the establishment of the child according to the results of clinical and laboratory diagnosis and physical examination signs of a lesion of the blood system conduct:

- medico-chemical study of biological environments of the body (hair, urine) for their content of heavy metals (lead, mercury, arsenic, organic compounds (benzene, its amino - and nitro-derivatives, aromatic hydrocarbons),

- compare the contents of the identified toxic chemical agents such benchmarks;

- then diagnose specific pathological and pre-pathological changes caused by environmental factors territories;

- modelowania, clinical and laboratory research with regard to history and individual characteristics of the organism, which includes:

first reception sorbents (activated carbon, karbacher, carblog, polifan, Polisorb) with simultaneous massage (General or the chest and head), physical therapy and thermotherapy (sauna, followed by washing the body) within two weeks,

then assign the reception antioxidant complex (vitamins A, E, C) with simultaneous admission adaptogenic drugs (tincture of ginseng extract, Siberian ginseng, schisandra tincture, etc. in conventional dosages in one month,

- the complex of therapeutic measures conducted against the backdrop of correcting diet (foods that contain dietary fiber, pectin for detoxification of the body, enriched with vitamins);

after the end of treatment again conduct medico-chemical study of biological environments of the body (hair, urine) on the content of toxic chemical agents, and clinical and laboratory examination,

and when getting positive results take the decision to end treatment,

or appoint additional specific therapy in the form of reception of the specific the

Example 1. Child A., born in 1989. Living in ecologically unfavorable territory of the Perm region for 9 years. He entered the rehabilitation treatment in the hospital 19.01.98, with a diagnosis of chronic tonsillitis, astheno-vegetative syndrome. When enrolling a child were filed complaints: weakness, drowsiness, restless sleep. Objectively drew attention to the pale skin and visible mucous membranes, periorbital shadows, skin dryness, slight displacement of the boundaries of the relative dullness of the heart to the left, increasing the size of the liver. Lymph nodes and spleen are not enlarged. The survey:

1. Clinical laboratory diagnostics:

complete blood count: hemoglobin - 112 g/DM3; erythrocytes - 3,4 1012DM3; leucocytes - 4,2 109/DM3; stab neutrophils - 5%; segmented neutrophils - 51%; lymphocytes - 29%; reticulocytes - 0,3%; platelet - 150 109DM3.

Set the low content of hemoglobin, erythrocytes, lymphocytopenia, stab shift to the left, reticulocytopenia.

2. Medico-chemical diagnosis: the determination of organic compounds in the urine (benzene, toluene, xylene, P> (in brackets - control):

Benzene - 0,00084 (0,0)

Ethylbenzene - 0,00052 (0,0)

Toluene - is 0.0002 (0,0)

Xylene - 0,0 (0,0)

Phenol - 0,45 (0,28 0,048)

A higher content in the urine of benzene, ethylbenzene, toluene and phenol compared to control.

On the basis of complaints, physical examination, clinical laboratory, medical and chemical diagnostics diagnosed environmentally caused anemic syndrome. The child assigned corrective diet, against which the child took carblog 7.5 g per reception as a suspension in water 3 times a day for 2 hours before meals for 2 weeks. There was also a General body massage and thermotherapy (sauna, followed by washing the body), 2 times a week and physical therapy (physical therapy) daily for 45 minutes. After that, the child took "Aevit" 1 capsule 1 time per day in combination with ascorbic acid (1 drop 3 times a day) and ginseng extract 10 drops 2 times a day after meals for 4 weeks.

After completing the course of treatment is objectively established: the skin and visible mucous physiological colour disappeared periorbital shadows, dry skin. The size of the liver within the physiological norm. Lymph nodes and the - 118 g/DM3; erythrocytes - 3,8 1012/DM3; leucocytes - 6,1 109/DM; stab neutrophils -1%; segmented neutrophils - 52%; lymphocytes - 36%; reticulocytes - 0,6%; platelet - 190 109/DM3< / BR>
2. Medico-chemical diagnostics: benzene is 0.0001 mg/DM3; ethylbenzene - 0,0 mg/DM3; toluene - 0,0 mg/DM3the xylene - 0,0 mg/DM3; phenol - 0.27 mg/DM3.

Hematological indices satisfactory, toxic chemical substances almost on the level of control. Recurrence in the subsequent six months was not observed.

Example 2. Child B., born in 1992. Living in ecologically unfavorable territory of the Perm region since birth. He entered the rehabilitation treatment in the hospital 11.10.97, with a preliminary diagnosis: syndrome of vegetative-vascular dystonia. When enrolling a child were filed complaints: dizziness, fatigue, headache, pain in the abdomen. Objectively established signs of chronic intoxication include pale skin, reduced muscle tone, metropolitane. Cardio-vascular system identified the muting of heart sounds. Border of the liver and pancreas jelly is VI: hemoglobin - 115 g/DM3; erythrocytes - 3,6 1012/DM3; reticulocytes - 7,0%; iron serum - 30,6 µmol/DM3.

2. Medico-chemical diagnosis: determination of lead content in hair, urine as priority environmental chemical factors in the areas of residence (in parentheses - control): lead: hair of 10.25 (4,33 0,8) µg/DM3the urine of 0.50 (0,310,04) mg/DM3.

Set to exceed the lead content in hair of 2.4 times in urine - 1.5 times compared to control.

On the basis of complaints, physical examination, clinical laboratory, medical and chemical diagnostics diagnosed environmentally caused anemic syndrome (I degree). The child assigned correcting the diet, on the background of which was carried out taking Politeama 0,5 g per reception as a suspension in water 3 times a day for 2 hours before meals for two weeks. There was a chest massage and physical therapy every day for 45 minutes. After receiving enterosorbent child took "Aevit" to 1 tablet 1 time per day in combination with ascorbic acid (1 drop 3 times a day) and the infusion of lemongrass, 6 drops 2 times a day after meals for four weeks.

After the end of treatment was objectivanalysis, the vesicular breathing, muffled heart sounds, the size of the liver in normal limits. Pancreas and lymph nodes are not enlarged.

1. Clinical laboratory diagnostics: CBC: hemoglobin - 116 g/DM3; erythrocytes - 4,2 1012/DM3; reticulocytes to 2.0%; iron serum - 22 µmol/DM3.

2. Medico-chemical diagnosis: lead: hair of 4.38 mg/DM3; urine 0.35 mg/DM3.

Hematological indices satisfactory, the lead content corresponds to the benchmark, recurrence in the next 6 months were observed.

As can be seen from the above data, the inventive method for the prevention and treatment of environmentally dependent defeat the blood of children is more effective in comparison with the known and has a number of advantages:

1. Eliminates the introduction of drugs specific treatment and their toxic side effects on the body.

2. The complexity of the method allows to increase the length of remission.

3. Can be used in both residential and outpatient settings.

The method was tested in the hospital Perm NICKY children's environmental pathology in children from 5 to 10 years. Politicalsystem chemical toxic agents, including the selection of children for treatment according to the results of clinical and laboratory diagnosis, correcting the diet, intake of ascorbic acid, wherein before carrying out the complex of therapeutic measures in selected for the treatment of children is conducted additionally medical-chemical study of biological environments on their content of toxic chemical agents, and then assign chelators in combination with General massage or massage the chest and head, physical therapy, sauna and water treatments for two weeks, after which along with ascorbic acid appoint antioxidant complex of vitamins a, and E and adaptogenic drugs for four weeks.

 

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