A method of manufacturing a hemostatic patch

 

(57) Abstract:

The invention relates to pharmaceutical industry and can be used in medical institutions and in the home as a remedy to stop bleeding during surgical interventions, as well as in industrial and household injuries. A method of manufacturing a hemostatic patch, consisting of hygroscopic atraumatic material, for example a multilayer gauze pads applied on the locking lamblasting tape, based on the impregnation of absorbent material with a solution of antiseptic substances. According to the invention absorbent material impregnated once 1,5 - 3% solution of farakala, which is then squeezed to a moisture content of 45 to 85% and dried at a temperature of 90 - 100oC to obtain a residual moisture content of 3 to 7% and the content of paracril in the dried material in the range of 2.5 - 7%. The resulting material was cut into strips of the required width, put on the tape of the adhesive tape, the top covered with a protective layer of adhesive coating, such as siliconized paper, and subjected to radiation sterilization. For best hemostatic concentration of the working solution and the moisture content after spinning. The method allows to provide optimal content paracril in the dried strip, accelerating the process of manufacturing the dosage form of paracril in the form of a hemostatic patch. 3 C.p. f-crystals, 1 table.

The invention relates to pharmaceutical industry and can be used in medical institutions and in the home as a remedy to stop bleeding during surgical interventions, as well as in industrial and household injuries.

Effective way to stop bleeding from wounds is paracril - active local drug action as in the normal state of the blood coagulation system, and in pathological cases.

Upon contact with blood paracril binds its constituent proteins, forming an artificial clot even in the absence of fibrinogen.

Known dosage form paracril in the form of a 1% solution in ampoules of 10 ml, which moisten the gauze and apply to the wound, and wipes impregnated with a solution, then dried and sterilized (M. G. Voronkov, V. 3. Annenkov and other "Brochure Paracril", Irkutsk, East Siberian book publishing house, 1988, pp. 26 - 27).

Also known dosage form for external application in the form of adhesive tapes used for the application of medicinal substances. As such, in particular, is bactericidal plaster, which consists of a gauze pads soaked in an antiseptic solution and fixed on the fixing lakoplastyrna the ribbon. On top of the patch is covered by a protective layer with a release coating, Etc., Litvinov, G. P. Gradunova. The patches. Educational-methodical manual on technology of drugs of plant production... M, Izd-vo 1thMoscow honey. Institute named after I. M. Sechenov, 1972, pp. 22-23).

The production of bactericidal adhesive tape is that the tape adhesive tape impose a gasket consisting of 4 layers of gauze soaked in antiseptic solution and dried.

The desired ratio of drugs in the dry seal is achieved by repeated impregnation and extraction gauze pads to obtain a residual moisture content of 30-40%.

The disadvantage of this product is that it does not have hemostatic properties and the process of its manufacturer is becausei hemostatic properties, easy to use and provides accurate dosing of the drug.

To do this, use paracril as a hemostatic means in the form of adhesive tape, manufactured by type bactericidal.

To solve this problem is proposed a method of manufacturing a hemostatic patch, consisting of hygroscopic atraumatic material, for example a multilayer gauze pads applied on the locking lamblasting tape, based on the impregnation of absorbent material with a solution of antiseptic substances that have a therapeutic effect to the wound of the patient, and dried, according to the invention hygroscopic material, for example a strip of six layers of gauze, impregnated once 1,5-3% solution of farakala, which is then squeezed to a moisture content of 45-85% and dried at a temperature of 90-100oC to obtain a residual moisture content of 3-7% and the content of paracril in the dried material in the range of 2.5-7%.

The resulting material was cut into strips of the required width, put on the tape of the adhesive tape, the top covered with a protective layer with a release coating, such as siliconized paper, and subjected to radiation erased the Rila in the dried gauze should be within 3-5% and is directly proportional to the magnitude of the concentration of the working solution and the moisture content after spinning.

The content of paracril in hemostatic pads in% (y) 100 g soaked gauze is determined by the formula

< / BR>
where m is the mass of dry residue after evaporation of the test solution, in grams;

k = 0,002 - constant value;

a mass of hemostatic gasket, g;

W - moisture content styptic pads, %.

The content of paracril in hemostatic pads must be in the range of 2.5-7%.

The proposed mode parameters allow you to provide the best content paracril in the dried strip, accelerating the clotting process of the blood, and to simplify the technological process of manufacture of the dosage form of paracril in the form of a hemostatic patch. The product also has full-blown local anesthetic and antimicrobial activity against gram-positive and gram-negative bacteria. Bleeding from the small vessels stops after 1-2 minutes.

Hemostatic patch is easy to manufacture, convenient in use. In addition, there are a number of advantages: the absence of auxiliary substances, direct contact with the wound, etc.

The essence of the Anna farakala.

Example.

To clarify the influence of extraction on the amount of adsorbed paracril on a gauze pad, consisting of a 3-ply gauze tape, impregnated with a solution of paracril different concentrations, and then the tape was passed in the sting shaft, the clearance between the shafts changed arbitrarily determined humidity gauze pads after each spin, skorrelirovany graphically and received the dependency.

For the study chose solutions paracril the following concentrations: 1,5%, 2%, 3%.

The dependence of the content of paracril on the gauze from the value of the residual moisture content is presented in the table.

As can be seen from the table:

content paracril in gauze directly proportional to the amount of the residual moisture;

- better hemostatic effect of drug content paracril on the gauze 2,5-7,0%;

for each concentration of solution paracril there is a certain degree of extraction gauze, in which the content of paracril adsorbed on Marla finds the optimum values of 2.5-3.5%.

1. A method of manufacturing a hemostatic patch, consisting of hygroscopic atraumatic material, for example a multilayer gauze pads, nanosandwiches substances, providing a therapeutic effect to the wound of the patient, and dried, characterized in that the hygroscopic material, for example a strip of six layers of gauze, impregnated once 1,5 - 3% solution of farakala, which is then squeezed to a moisture content of 45 to 85% and dried at a temperature of 90 - 100oTo obtain a residual moisture content of 3 to 7% and the content of paracril in the dried material in the range of 2.5 - 7%, the resulting material is cut into strips of the required width, put on the tape of the adhesive tape, the top covered with a protective layer with a release coating, such as siliconized paper, and subjected to radiation sterilization.

2. The method according to p. 1, characterized in that to achieve a better hemostatic effect the content of paracril in the dried gauze should be within 3 - 5%.

3. The method according to p. 1, characterized in that the content of adsorbed paracril in the dried gauze directly proportional to the magnitude of the concentration of the working solution and the moisture content after spinning.

4. The method according to p. 1, characterized in that the content of paracril in hemostatic pads in percent per 100 g soaked gauze is determined by the formula

< / BR>
where m is the mass of the dry residue of Paleologos, g;

w - moisture content styptic pads %.

 

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