Method and product for treatment of iodine deficiency

 

(57) Abstract:

The invention relates to medicine, in particular to endocrinology and preventive medicine, and for the treatment of iodine deficiency in the body. For this purpose, we propose a method of introducing a drug, an organic food substances, in particular food proteins, and/or hydrolysates, and/or peptides from food proteins, iodinated amino acid residues tyrosine and/or histidine included in the composition of these substances, and/or iodinated histidine and tyrosine. In the preparation of the drug iodination carry out chemical and/or biotechnological means, excluding the occurrence of hormonal activity T3, T4. The method allows for the thyroid gland with iodine at physiological neurohumoral control. 2 C. and 24 C.p. f-crystals.

The invention relates to medicine, in particular to the treatment of iodine deficiency, which causes formation /synthesis/ thyroid hormone, which leads to the development of goiter disease.

There is a method of treatment of iodine deficiency, including the preparation of iodine-containing elements and their introduction into the body of a biological object /person / animal/,/, see P. the treatment of iodine deficiency, includes interconnected operations preparation of iodine-containing elements and the introduction of iodine-containing elements in the body of a biological object /see Popular medical encyclopedia. M: Soviet encyclopedia, 1968, S. 306-307/.

The disadvantages of the known methods of treatment of iodine deficiency are relatively narrow features, the relatively low efficiency of treatment, and the impossibility of differentiation treatment.

The purpose of the invention is improving the efficiency and differentiation of treatment and increase functionality.

This is achieved by the fact that the preparation of the iodine-containing elements carried out with the exception of hormonal activity of the protein preparation, as raw material for the manufacture of iodine-containing items used in food proteins, while dietary protein modifies on tyrosinase and/or amino acid his-tag residues of chemical and/or biotechnological methods, and the introduction of iodine-containing elements perform in a free and/or bound state.

It is advisable that as iodine-containing elements use the hydrolysate and/or peptides from food proteins.

It is useful that aderrasi elements take egg albumin.

It is useful to have as iodine-containing elements using dairy whey proteins.

It is advisable that as iodine-containing elements using dairy whey proteins.

It is useful to have as iodine-containing elements serum albumin blood.

It is advisable that as iodine-containing elements take haemoglobin proteins.

It is useful to have as iodine-containing elements with vegetable proteins, and/or animal proteins and/or proteins of microbial origin.

It is advisable that as iodine-containing elements use a mixture of proteins.

It is useful to have as iodine-containing items used chloramine-T.

It is advisable that as iodine-containing items used chloride iodide.

It is useful to have as iodine-containing items used itetrachloro.

It is advisable that as iodine-containing items used chloride of iodine.

It is useful to iodine-containing items used in the form of dosage forms - powders, tablets, capsules, pills, medicines.

Tselesoobraznim objects.

Useful for the preparation of iodine-containing elements was performed using the free Teresina.

It is advisable that the preparation of the iodine-containing elements was carried out with the use of free histidine.

Useful for the preparation of iodine-containing elements was carried out using a mixture of free tyrosine and histidine.

It is advisable that the preparation of the iodine-containing elements was performed using the free thyronine.

It is useful to biotechnological modification of food proteins and their hydrolysates, peptides, free amino acids was performed enzymatically.

It is advisable to biotechnological modification was carried out in the animal organism of interest.

It is useful to biotechnological modification was carried out using immobilized enzyme milk lactationtease.

It is advisable to enzymatic iodination was performed using lactationtease.

Useful for enzymatic iodination was performed using vegetable peroxidase.

It is advisable to enzymatic iodination produce from ispolzovaniem of the invention, namely

- the criterion of the presence of steps, since the preparation of the iodine-containing elements carried out with the exception of hormonal activity of the protein preparation,

- criterion procedure for performing actions such as iodine-containing elements use the hydrolysate and/or peptides from food proteins,

- test mode, since the introduction of iodine-containing elements perform in a free and/or bound state,

- the criterion of the use of substances as raw materials for the manufacture of iodine-containing items used in food proteins, while dietary protein modifies on tyrosinase and/or amino acid his-tag residues of chemical and/or biotechnological methods,

Treatment of iodine deficiency includes interconnected operations training iodine-containing elements and the introduction of iodine-containing elements in the body of a biological object, the preparation of the iodine-containing elements carried out with the exception of hormonal activity of the protein preparation, as raw material for the manufacture of iodine-containing items used in food proteins, while dietary protein modifies on tyrosinase and/or his-tag nepalnet in free and/or bound state, as iodine-containing elements use the hydrolysate and/or peptides from food proteins, whereas the iodine-containing elements use casein, and/or take egg albumin, and/or use milk whey proteins, and/or use milk whey proteins, and/or serum albumin blood, and/or take haemoglobin proteins, and/or vegetable proteins, and/or animal proteins and/or proteins of microbial origin, and/or a mixture of proteins that as iodine-containing items used chloramine-T, and/or used chloride, iodide and/or iodine-containing items used itetrachloro, and/or iodine that iodine-containing items used in the form of dosage forms - powders, or tablets, or capsules, or pills, or medicines that iodine-containing elements was obtained by extraction from animal and/or vegetable and/or microbiological objects, the preparation of iodine-containing elements was performed using the free Teresina, and/or free histidine, and/or using a mixture of free tyrosine and histidine, and/or using the free thyronine, that biotechnological modification of food proteins, their gidlunds in the body animals objects or using immobilized enzyme milk lactationtease that enzymatic iodination was performed using lactationtease and/or using vegetable peroxidase, and/or using chloroperoxidase.

The method of treatment is as follows. First get iodine-containing elements representing any food protein containing a free state the tyrosine and/or his-tag amino acid residues, with the same purpose can be used for protein hydrolysates, peptides, free amino acids - tyrosine and/or histidine, which then tyrosinosis and/or amino acid his-tag residues, chemical and/or biotechnological means, the latter carry out enzymatic or directly in living objects - force increasing the degree of iodization get their products /of milk, eggs, etc./, used methods iodization should avoid hormonal activity /T-4, T-3/, after which include iodine-containing elements in drugs in the free or bound state and then injected iodine-containing drugs in the human body, or an animal, in razlagateesa proteins /peptides/ with the liberation of free iodine amino acids /monoiodotyrosine, diyodtirosin, logisticon/, the latter are easily absorbed in the intestine and absorbs any tissue of the body /in contrast to, for example, input from potassium iodide/.

Dehalogenase liver otscheplaut bound iodine from these amino acids, releasing ion of iodine in the bloodstream gradually, as needed, this way the exception of the pulsed nature of the growth ion concentration of iodine in the blood that occurs when the consumption of potassium iodide, which ensures gentle operation of the thyroid gland, analogous to the release of the body bound iodine in the composition of the amino acids involved dehalogenase thyroid gland. Liver cells contain enzymes that can modify iodine-containing amino acids, excluding them from participation in the metabolism of iodine.

The modification of the iodine-containing amino acids by glycosylation, sulfation, paranirvana help remove them from the body through the kidneys.

The balance of processes dehalogenase and modification of the iodine-containing acids helps to ensure the thyroid gland with iodine in quantities adequate to consume, put these processes under natural neurohumoral control.

This forms the military preparations, containing iodine in organic form with the presence or absence of hormone activity.

1. Treatment of iodine deficiency, including the introduction into the organism of organically bound iodine, characterized in that use food proteins, and/or a hydrolyzate and/or peptides from food proteins, iodinated amino acid residues tyrosine and/or histidine included in the composition of these substances, and/or iodinated histidine and tyrosine, while iodination carry out chemical and/or biotechnological means, excluding the occurrence of hormonal activity T3T4.

2. The method according to p. 1, characterized in that the raw material for iodine-containing elements use the hydrolysate and/or peptides from food proteins.

3. The method according to p. 1, characterized in that the raw material for iodine-containing elements use casein.

4. The method according to p. 1, characterized in that the raw material for iodine-containing elements take egg albumin.

5. The method according to p. 1, characterized in that the raw material for iodine-containing elements using dairy whey proteins.

6. The method according to p. 1, characterized in that the raw material for iodine-containing element is to iodine-containing elements take haemoglobin proteins.

8. The method according to p. 1, characterized in that the raw material for iodine-containing elements with vegetable proteins, and/or animal proteins and/or proteins of microbial origin.

9. The method according to p. 1, characterized in that the raw material for iodine-containing elements use a mixture of proteins.

10. The method according to p. 1, characterized in that for obtaining iodine-containing elements using chloramine-T.

11. The method according to p. 1, characterized in that for obtaining iodine-containing elements use chloride of iodine.

12. The method according to p. 1, characterized in that for obtaining iodine-containing elements use ittihaad.

13. The method according to p. 1, characterized in that for obtaining iodine-containing elements use iodine.

14. The method according to p. 1, wherein the iodine-containing items used in the form of dosage forms: powders, tablets, capsules, pills, medicines.

15. The method according to p. 1, wherein the iodine-containing elements get their extraction from animal and/or vegetable and/or microbiological objects.

16. The method according to p. 1, characterized in that the preparation of the iodine-containing elements carried out using svoistva with the use of free histidine.

18. The method according to p. 1, characterized in that the preparation of the iodine-containing elements carried out using a mixture of free tyrosine and histidine.

19. The method according to p. 1, characterized in that the preparation of the iodine-containing elements is performed with the use of free thyronine.

20. The method according to p. 1, characterized in that the biotechnological modification through iodization of food proteins and their hydrolysates, peptides, free amino acids carried out enzymatically.

21. The method according to p. 1, characterized in that the biotechnological modification by the iodination is carried out in the body of living objects.

22. The method according to p. 1, characterized in that the biotechnological modification by the iodination is performed with the use of immobilized enzyme milk lactationtease.

23. The method according to p. 1, characterized in that the enzymatic iodination is carried out using the lactate peroxidase.

24. The method according to p. 1, characterized in that the enzymatic iodination is carried out using plant peroxidase.

25. The method according to p. 1, characterized in that the enzymatic iodination is carried out using chloroperoxidase.

 

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