Drug

 

(57) Abstract:

The invention relates to medicine, namely to medicines affecting the immune system. The invention consists in the development of drug - sodium salt of 5-amino-2,3-dihydrophenazine-1,4-dione, have immunomodulatory properties as well as anti-inflammatory and antioxidant effect. The proposed remedy does not cause allergic reactions and other side effects. 3 table.

The invention relates to medicine, namely to medicines affecting the immune system.

Known drug "sodium nucleate"sodium salt of nucleic acid representing the preparation of immunomodulating actions in the form of a white or slightly yellow powder, easily soluble in water with formation opalestsiruyuschih solutions, and having the ability to stimulate migration and cooperative T and B-lymphocytes, increase the phagocytic activity of macrophages and the activity factors of nonspecific resistance (see, for example, M. D. Mashkovsky "Drugs", M, Medicine, 1985, so 2, S. 172).

However, injecting this means painful,

The closest analogue prototype is applicable as an immunomodulator, as well as having the properties of the drug's anti-inflammatory and antioxidant action of the drug is 2-amino, 1,2,3,4-tetrahydropyrazin-1,4-dione sodium salt dehydrate (see, for example, patent RF N 2113222 priority from 30.09.97 year, the IPC: A 61 K 31/04 A 61 K 31/13 representing a light-yellow easily water-soluble crystalline powder.

Introduction this medication to a patient at the weak response of cellular immunity, for example in the presence of malignant tumors, causes activation of macrophages, interleukins and other ostrofsky proteins. In inflammatory processes this immunomodulator for a few hours inhibits the activity of macrophages, but also reinforces the microbicide system cells.

This drug does not cause allergic reactions and other side effects, but long-term treatment of chronic and other diseases possibly addictive patient's body to apply to a medicinal product and the effectiveness of its action is reduced.

In this case, replacement of such a drug to another lekarska drug sodium salt of 5-amino-2,3-dihydrophenazine-1,4-dione structural formula

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have immunomodulatory properties as well as anti-inflammatory and antioxidant effect.

Known application of 5-amino-2,3-dihydrophenazine-1,4-dione, the interaction of which with an aqueous solution of caustic soda (NaOH) receive the drug as lyuminola possessing fluorescent properties (see , for example, USSR author's certificate N 130903, with priority from 21.11.59,, MKI: 12, 602, bull. N 16 1960).

The drug is a white or pale-yellow, highly water-soluble crystalline powder.

Studies have shown that the introduction of the patient as a drug of sodium salt of 5-amino-2,3-dihydrophenazine-1,4-dione with a weak reaction of cellular immunity, for example in the presence of malignant tumors, causes activation of macrophages, which is manifested by the release of their TNF (tumor necrosis factor, interleukins and other ostrofsky proteins. At the same time also specifically react to the introduction of the drug T-lymphocytes.

In inflammatory processes, this drug selectively to 4-8 hours inhibits the activity of macrophages, decreasing with the but the activation superoxidedismutase function and phagocytic activity of neutrophils, enhance microbicide system cells and kopurua inflammatory process.

These results were confirmed instrumental laboratory studies of patients by conducting blood tests when checking immunological parameters leukocyte and lymphocyte system.

Entered the drug is almost completely excreted from the body of the patient with exhaled air and urine for 20-60 minutes Its application in a wide range of doses (from 20 to 1500 mg) does not cause allergic reactions and other side effects and the mechanism and efficiency of action is similar, and in some cases even more effective immunomodulator selected as a prototype that allows you to vary these drugs in the treatment of diseases associated with the need for long-term use of drugs to avoid tolerance of the patient.

This drug can be used in the form of a powder for injection, as well as in the form of tablets oral.

The invention is confirmed by the examples.

Example 1.

Patient S., 58 y.o.

Turned 02.02.2000, Complaints about epologue, what is the residual after effects of flu, she was sick with 15.01. on 27.01.2000,

When receiving low-grade fever, dry cough, listen wheezing.

Completed the treatment of the medicinal product sodium salt of 5-amino-2,3-dihydrophenazine-1,4-dione (hereinafter Tumeric).

The first 5 days of injection Tamerica a single dose up to 300 mg per 2 ml of water for injection, and then assigned to receive Tamerica orally in the form of powder or tablets 100 mg 2 times a day, one hour after a meal.

After 3 days significantly improved the General condition of the patient, almost stopped coughing, fever disappeared.

10 days after the start of treatment, the condition is satisfactory.

The results of laboratory examinations of the patient are shown in table 1.

Example 2.

Patient I., 68 years of age.

Complaints: difficult urination, frequent urges to urinate.

Ultrasound: marked hypertrophy of the prostate.

Diagnosis: prostate adenoma 2nd degree.

Completed the treatment of 20 and 15 injection of the medicinal product 2-amino-1,2,3,4-tetrahydropyrazin-1,4-dione sodium salt dihydrate with a break between the first 20 for injection, respectively.

After the first 20 injections adenoma decreased, however, after the final 15 injection further positive dynamics is not marked.

The patient's condition is unstable.

An additional course of injections of Tamerica 10 injections of a single dose of 200 mg in 2 ml water for injection, daily for 1 injection.

The marked improvement of the General condition of the patient, urination normalized.

The results of laboratory examinations of the patient are shown in table 2.

Example No. 3.

The patient Was a 42 year.

Erysipelas of the left forearm, edema, exacerbation of psoriasis, the temperature at receipt - 39,9.

Before applying manifestations of psoriasis stoped using ointments.

Conducted by injecting Tamerica one dose of 200 mg of a drug in 2 ml of water for injection. Injections daily.

On the 4th day after the start of treatment edema and hyperemia of the forearm disappeared.

Injecting continue for 5 days with a single dose of 100 mg drug per 1 ml of water for injection.

The patient was in good condition.

There is a significant Ulu is robalino 1 tablet (100 ml), 2-3 times a day for 7-10 days.

The results of laboratory examinations of the patient are shown in table 3.

Drug with immunomodulatory properties, as well as anti-inflammatory and antioxidant effect, characterized in that it is a sodium salt of 5-amino-2,3-dihydrophenazine-1,4-dione structural formula



 

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