The way to prevent the progression of impaired glucose tolerance with the use of local essentuki mineral water type
(57) Abstract:The invention relates to medicine, in particular to endocrinology, and can be used to prevent the development of diabetes at the stage of impaired glucose tolerance with the use of local Essentuki mineral water type. Mineral water Essentuki 4 take 200-250 ml for 15-20 minutes before meals for 30 days. The method allows to normalize the blood glucose curve, to improve the early phase of insulin secretion, improve lipid metabolism. It increases the effectiveness of prevention of the disease. 11 table. The invention relates to the field of medicine in particular, to the prevention of diabetes at the stage of impaired glucose tolerance with the use of carbon dioxide chloride-hydrocarbonate sodium mineral water of medium mineralization in complex Spa therapy.As we know from literary sources, disturbed tolerance to carbohydrates occurs 2-3 times more often than overt diabetes (A., Mazowieckie, 1987; I. I. Dedov, 1992) and to prevent its development - task more promising than to achieve success in the treatment of this horizon manifest itself already of the disease.Previously we had offers is that have a normalizing effect on the disturbed carbohydrate, lipid, protein, water-salt metabolism, indicators of hormonal regulation of glycogenesis and tissue sensitivity to insulin (G M Krasnica, L. A. Botvinov. The matters. kurortol. - 1992. - N 3. - S. 21-24). Found that these mineral waters have expressed insulinotropic effect in the early preabsorption phase insulin secretion, which is a powerful sanogenetic factor (B. G. Kuznetsov et al. 1979, 1987).Research has identified all the prerequisites for the use of mineral waters as a primary prophylactic agent in patients with very early, actually diagnosed to date manifestations of disorders of carbohydrate metabolism - according to the who classification (1987) - in persons with impaired glucose tolerance (IGT) who have these disorders are diagnosed by oral glucose tolerance test (OGTT). For this stage of diabetes is characterized by reduced or absent early peak of insulin secretion and hyperinsulinemia in the postprandial period, a decrease in insulin sensitivity of tissues to the hormone, dyslipidemia.In this regard, we have proposed a method of preventing the progression of disorders of carbohydrate metabolism in individuals with IGT were prominences mineral water Essentuki N 4 in 200 ml for 15-20 minutes before meals for 30 days on the background diet (diet 9), receiving carbon-mineral baths in the course of 20 treatments. Control was a group of individuals with IGT who received identical treatment complex, but without the intake of mineral water.The method is illustrated by the following examples.1. Patient I., 29 years old were treated in the Essentuki clinic research Institute of balneology with 27.07. on 25.08.1996, Diagnosis: Obesity III senior alimentary-constitutional Genesis, stable stage, IGT. Overweight is celebrated with children's age, the greatest body weight 129 kg with height 171 see Heredity diabetes burdened by the maternal line. Upon receipt of a complaint to increased appetite, weakness, fatigue, irritability, drowsiness, shortness of breath when walking, aching pain in the heart, a tendency to constipation.During examination: body weight of 114.5 kg, height 171 cm, barely noticeable stretch marks on the abdomen and thighs. Cardiovascular system without pathology, palpation of the abdomen painless, liver and spleen are not enlarged. When conducting OGTT with a glucose load of 50 g/m2the surface of the body, revealed impaired glucose tolerance and hyperinsulinemia with lack of early phase insulin secretion (see tab. A).Lipid metabolism: odes - 480 g/l, nezhk - 1,17 mEq/ml.After the treatment with the application of the above method initial complaints disappeared, body weight decreased by 3.5 kg, normalization OGTT and reduction of hyperinsulinemia fasting and in the postprandial period, the emergence of the early peak of insulin secretion (5 and 10 min) (see tab. B).Improved lipid metabolism: total lipids 400 g/l, triglycerides - 68 mmol/l, total cholesterol of 5.5 mmol/l cholesterol 1.12 mmol/l, LDL - 420 g/l, nezhk - 1,02 mEq/ml When conducting an insulin test increased sensitivity to insulin. Given the positive dynamics of clinical symptoms, normalization OGTT, reduction of hyperinsulinemia, body mass and improve insulin sensitivity patient was discharged with significant improvement.2. Patient O., 37 years of age, was treated in the Essentuki clinic research Institute of balneology with 8.07 on 31.07.1996, Diagnosis: Obesity Art. I alimentary-constitutional Genesis, stabilant stage STG. Overweight is logged within 10 years, the last increase to 6 kg noted after delivery, the baby's weight at birth 4.5 kg, heredity diabetes is not burdened.Upon admission to the hospital was concerned about the aja system without pathology, HELL 120/80 mm RT.art., the abdomen is soft, painless on palpation, the liver and spleen are not enlarged. OGTT at the beginning of treatment (see table. C).Lipid metabolism: General lipid - 600 g/l, triglycerides - 115 mmol/l, total cholesterol - 5,72 mmol/l cholesterol is 0.99 mmol/l, LDL - 550 g/l, nezhk - 1,17 mEq/ml.After the course of Spa therapy with the use of mineral waters for the initial complaints were not disturbed in body weight lost 3.6 kg, OGTT at the end of treatment normalized the level of IRI decreased, the early phase of insulin secretion is increased (see table. D).The lipid metabolism by the end of treatment significantly improved: total lipids 520 g/l, triglycerides - 94 mmol/l, total cholesterol - 5,72 mmol/l cholesterol - 1,09 mmol/l, LDL - 480 g/l, nezhk - 1,17 mEq/ml When conducting an insulin test increased sensitivity to the hormone.The results of the treatment were assessed as a significant improvement.3. Patient S., 36 years old, was treated in the diabetes branch of the Essentuki clinic research Institute of balneology from 13.12 on 11.01.1996, the Diagnosis of Obesity II senior alimentary-constitutional Genesis, progressive stage, IGT. Increased body weight with de is P CLASS="ptx2">Upon admission to the hospital was worried about the non-permanent dry mouth, General weakness, fatigue, weight 91 kg with height 160 cm, BP 130/80 mm RT.art., cardiovascular system without pathology, abdominal palpation soft, painless, liver and spleen are not enlarged, OGTT at the beginning of treatment (see table.E).Lipid metabolism: total lipids 400 g/l, triglycerides - 70 mmol/l, total cholesterol is 5.54 mmol/l cholesterol - 0.6 mmol/l, LDL - 430 g/l, nezhk - 1,17 mEq/ml After a course of Spa treatment with the application of the described method the initial complaints were not disturbed in body weight lost 4,2 kg OGTT at the end of treatment normalized the level of IRI decreased basal to subnormal numbers, increased early phase of hormone secretion (see tab. F).Lipid metabolism: General lipid - 320 g/l, triglycerides - 60 mmol/l, total cholesterol - to 4.68 mmol/l cholesterol is 0.72 mmol/l, LDL - 400 g/l, nezhk - 1,02 mEq/ml Increased sensitivity to insulin.Given the dynamics of all indicators, drawn with significant improvement.Demonstrated clinical examples the proposed method is tested in the Essentuki clinic research Institute, resort examined 30 patients with IGT, which were cures without the use of mineral water (group II). Both groups comparable on the main clinical characteristics: sex, age, weight and height of patients (table. 1).Symptoms symptoms of pathology in both groups was low (General weakness, fatigue, irritability), the frequency of extinction neurasthenic symptoms by the end of treatment was about the same. The same applies to the average loss of body weight, which in group I was -4,1 0.5 kg, while in the second -3,8 0,4 kg Obvious advantages identified in the appointment of mineral waters patients of group I when conducting OGTT (PL. 2). As can be seen from the table, by the end of treatment in patients of the first group normalization of blood glucose curve and the absence of such dynamics in group II. The level of insulinemia significantly decreased basal to 25.3 2.4 Miu/ml, increased early-phase insulin secretion (0-20 min), before treatment it was : S (area of insulinemia) 0-20 minutes 249,8 32,1, after treatment 524,7 36,8 srvc. ed, (P=0). In the second group and glycemic insulinemic curves had only tended to improve.When conducting an insulin test, charcterized insulin sensitivity, persons I and II vtoroy. This is confirmed by comparison of the areas under the glycemic curve. In group I S for the entire study period 0 - 120 minutes was -60,25 12,5 and after treatment -147,75 19,1 srvc. units (P=O), (PL. 3), in group II, these figures remained virtually unchanged.Similar differences were revealed in relation to lipid metabolism: in individuals of group I significant shifts observed for all the studied tests (except total lipids), such dynamics in group II was not observed (table. 4).Results the overall effectiveness of treatment (table. 5) also confirm the advantage of I medical complex. The way to prevent the progression of impaired glucose tolerance, characterized in that the mineral water Essentuki N 4 take a dose of 200 ml for 15 - 20 minutes before meals for 30 days.
FIELD: medicinal microbiology, medicine, pharmacy.
SUBSTANCE: invention relates to agents used for enhancing sensitivity of microorganisms to antibacterial preparations. Invention involves applying hydrocarbonate chloride-sodium drinking mineral water "Obukhovskaya" with the total mineralization 1.8-2.2 g/l as an agent for enhancing sensitivity of microorganisms to antibacterial preparations that is used early for treatment of atopic dermatitis and as an agent for treatment of iodine-deficient states. It has been found by method using disks that mineral water "Obukhovskaya" provides enhancing sensitivity of microorganisms to such antibacterial preparations as antibiotics and specific preparations against yeast-like fungi.
EFFECT: improved and valuable agent.
6 tbl, 6 ex
SUBSTANCE: method involves administering to patients mineral water drinking from Slavianovsky source of Zheleznovodsk type at a dose of 3-5 ml per 1 kg of body mass 3 times a day 30-60 min before taking meals depending on gastric juice acidity. Carbonic acid gas baths and gynecological irrigation treatments are administered every other day at 36-38°C high temperature, exposure time of 10-15 min in 8-12 procedures long course. Physical activity is applied daily as individual dosed terraincour walks.
EFFECT: enhanced effectiveness in repairing menstrual and ovulation functions.
FIELD: medicine, phthisiology.
SUBSTANCE: at first, a patient should drink mineral water at the quantity of 200-300 ml, then 30-40 min later a patient should have breakfast, then 2 h later comes ultrasound impact for 6-8 min, then 4 h later a patient should take aqueous radon bath at concentration of 1.5 kBq/l. The cycles mentioned should be carried out every 1-2 d, at total number being 8-10. The method enables to improve the state of immunological values and, also, phenotypic parameters. Moreover, due to stimulating patient's olfactory nerve stem structures are being affected along with reticular formation and cerebral cortex with subsequent impact upon different body systems.
EFFECT: higher efficiency of correction.
2 ex, 5 tbl
FIELD: medicine, colonohydrotherapy.
SUBSTANCE: one should perform 3-5 procedures of deep intestinal purification due to its irrigating with Carlsbad salt solution and additional supply of ozone or oxygen. One should apply 1-2%-Carlsbad salt solution and perform 3-5 procedures at solution's temperature being 30-36.6 C. The method enables to carry out colonohydrotherapeutic procedures by causing no discomfort body state and affect the whole body more efficiently.
EFFECT: higher efficiency of body healing.
1 cl, 1 dwg, 2 ex, 1 tbl
FIELD: medicine, gastroenterology.
SUBSTANCE: in case of syndrome of irritated intestine with diarrhea one should apply hydrocarbonate magnesium-calcium-sodium poorly mineralized water named "Amurskaya-2" at 45 C per one/fourth glass thrice daily 40 min before meals, slowly, with small gulps for 3 wk. In case of syndrome of irritated intestine with constipations one should apply the same mineral water at 20 C per 1 glass daily 1-1.5 h before meals, quickly, with large gulps and for nocturnal intake, obligatory, for 4 wk. The method enables to achieve efficient restoration of intestinal transit and decrease the risk for the development of large-intestinal cancer.
EFFECT: higher efficiency of therapy.
FIELD: medicine, physiotherapy.
SUBSTANCE: one should introduce mineral water named "Yessentuki 17" once daily for animals with prostatitis pattern for 23-24 d along with the course of inhalations by applying essential oils with the help of a phytoaeroionizer daily for 5-6 min, about 12-14 procedures/course. One should apply essential oils of sage, lavender and mint at the ratio of 1:1:1. The method enables to normalize both lipid and carbohydrate metabolism and decrease blood content of prolactin and estradiol.
EFFECT: higher efficiency of therapy.
FIELD: medicine, gastroenterology.
SUBSTANCE: a patient should follow a diet along with the intake of cholagogue species, oats decoction and symptomatic therapy. Moreover, at postoperative period a patient should be prescribed with the intake of drinking mineral water named "Ust' Kachkinskaya 1/99" at 38-40 C at total mineralization being 8.2-8.6 g/cu. m 40-60 min before meals 5-6 times daily at total amount of 200-250 ml for 24 d. Diet is fractional, 6 times daily, calorie amount of 2800-3000 kcal and decrease of highly digestible carbohydrates up to 30 g/d. The method enables to avoid application of hepatoprotectors and antioxidants during therapy to prevent polypragmasy.
EFFECT: higher efficiency of rehabilitation.