Antimicrobial drug for the treatment of infected wounds

 

(57) Abstract:

The invention can be used in the production of pharmaceuticals and related medication for the treatment of infected wounds, burns, trophic ulcers and pustular skin diseases. The technical result is an increase therapeutic antimicrobial action dioksidina and reduction of terms of treatment of infected wounds. The composition of antimicrobial drug for the treatment of infected wounds (wt.%): dioxidine - 4,0-5,0; novocaine - 0,3-0,5; oil fatty (stone) - 10,0-20,0; abbasian - 0,6-0,8; distilled monoglycerides - 2,0-3,0; glycerol - 4,0-5,0; Aerosil - 2,0-3,0; nipagin - 0,10-0,11; nipazol - 0,10-0,11; distilled water - up to 100.0. table 4.

The invention relates to medicine, can be used in the production of pharmaceuticals and related medication for the treatment of infected wounds, burns, trophic ulcers and pustular skin diseases.

It is known that dioxidine is a broad spectrum antibacterial drug action. For local applications, the use of 0.2% solution dioksidina and 5% ointment dioksidina /1/. However, the use of 0.2% solution dioksidina in the treatment of wounds irrational and inefficient, 5% ointment dioksidina prepared for hydro is minisheet evaporation through the sweat glands, when this Horny layer of the skin materials, reduces the resistance of the skin. Therefore, known methods of treatment of 0.2% solution dioksidina and 5% ointment dioksidina not provide a high therapeutic activity.

The purpose of the invention is the improvement of therapeutic antimicrobial action dioksidina and reduction of terms of treatment of infected wounds.

To achieve this goal in the drug entered the complex of active components, such as dioxidine, novocaine, glycerin, Aerosil in the emulsion of oil and water stabilized by abbasides, in the following ratio of components /wt.%/:

Dioxidine - 4,0-5,0

Novocaine - 0,3-0,5

Oil fatty /stone/ - 10,0-20,0

Abbasian - 0,6-0,8

Distilled monoglycerides - 2,0-3,0

Glycerin - 4,0-5,0

Aerosil - 2,0-3,0

Nipagin - 0,10-0,11

Nipazol - 0,10-0,11

Distilled water - Up to 100.0

The proposed solution allows you to create an effective, sustainable antibacterial drug.

The introduction of aubazine, bacterial polysaccharide, allows to obtain a stable emulsion system. In addition, abbasian increases the resistance of the microorganism and protective phew substances, prevents heat and gas exchange in the skin, while softening it. Aerosil dries the wound and promotes the active action of medicinal substances, to ensure rapid and complete return of medicinal substances used rational pharmaceutical form emulsion, in which, due to its special structure, medicinal substances have a high degree of dispersion, which increases the efficiency of ointments /3/.

Emulsion system such as "oil-water", which include the proposed composition, reduces dryness of the skin, improves its softness and elasticity, maintains the normal balance of the skin, reduces inflammation.

The inventive tool is obtained as follows.

Weighed medicinal substance - dioxidine, novocaine, oil oily /stone/, glycerin, distilled monoglycerides, anhydrous lanolin, Aerosil, nipagin, nipazol, water. Prepare a solution of aubazidan, for which the powder aubazidan pour distilled water and leave to swell /40 min, then heated under stirring to a temperature of 50-60oC, to complete the transition of aubazidan in the solution. In the resulting solution, aubazidan download novocaine, dioxidine, glycerin, mipagi substances the temperature of the mixture is brought to 70oC when operating the mixer add the fat fraction: a blend of distilled monoglycerides, oil oily /stone/ and dissolved in the alloy nipazol. The process of emulsification is carried out at a speed stirrer 1400-1500 rpm for 20-25 minutes, after which the resulting mixture, adding Aerosil, passed through a colloid mill, where the finished emulsion is transferred into the machine, where it is cooled at a low speed mixer /60-100/min to ambient temperature.

The invention is illustrated by the following examples.

Example 1. According to the composition of the recipe N 1 /table.1/ 0.6 g of aubazidan pour distilled water /75,9 g/ and leave for swelling /40 min/. Then include a stirrer and heated on a water bath to a temperature of 50-60oC with stirring until complete transition of aubazidan in the solution. In the resulting solution, aubazidan load 0.3 g procaine, 4.0 g dioksidina, 4.0 g of glycerin, 0.10 g nipagina and continue stirring until complete dissolution of drugs. After dissolution of drugs the temperature of the mixture is brought to 70oC when operating the mixer add pre-cooked fat fraction: alloy monoglycerides remote speed stirrer 1400-1500 rpm for 20-25 minutes, after that, not including the mixer, add 2.0 g of Aerosil and the resulting mixture passed through a colloid mill. The finished emulsion is pumped into the machine, where it is cooled at a low speed mixer /60-100/min to ambient temperature /20oC/.

Examples 2-6 carried out analogously to example 1.

The resulting ointment is an emulsion system type "oil-water" on the basis of a polysaccharide, soft consistency, easy superimposed on the wounds and high stability /observation period 24 months/.

To establish changes under different storage conditions ointment kept at temperatures 40oC, 20oC, 4oC. condition of the studied emulsion system before laying and during storage was determined by the following indicators: colloidal stability, the particle size of the dispersed phase viscosity properties as freshly prepared, and in the process of storing / 24 months/.

Studies of basic physical-chemical parameters of the system table. 2/ allow us to conclude that the claimed product has a high stability

Research on the effectiveness of saleemah-males weighing 160-220 g, which were divided into 4 groups of 21 individuals each. Model festering wounds on the back was created by a modified method granulomere bag /4/.

The animals of the 1st group /control/ no additional impact on the wound had been received. Wounds in animals of the second group were treated 1 time per day 0.2% solution dioksidina /spray/ daily until complete healing. Animals of the 3rd and 4th groups were made appliques ointment drugs on wound at a dose of 0.5 g/cm2every day, until complete wound healing: in the 3rd group - 5% dioxidea ointment on hydrophobic basis, in the 4th group of the inventive tool / part N 4, see table. 1/.

Planimetric method measured the size of the Russian Academy of Sciences, noted the time necrolysis, resorption of infiltration, granulation, start and complete epithelialization of the wound. Was carried out morphological control /light microscopy of sections stained with hematoxylin and eosin, pikrofusin, methylene blue/ reparative and regenerative processes. Microbiological study of wound was performed 1 time in 3 days according to standard procedures.

All work was carried out in accordance with the Order of the USSR Ministry of health N 755 from 12.08.77 "About the humane treatment of actally research repair and regeneration when exposed dioksidina in different dosage forms is presented in table. 3. The maximum reduction rate of complete healing of purulent wounds in comparison with the control achieved in the 4th group /23,40,8 to 14,91,3 day./, in this group the average time of necrosis and resorption of the infiltrate were shorter than in the 1st group /4,80,7 day and 6,7 0,8 days, compared with 9,90,8 day and 9,70,8 day, respectively/. The use of 5% dioxydinum hydrophobic ointments on the basis of the animals of the 3rd group also reduced the average time of necrosis and resorption of the infiltrate, the timing of complete epithelialization of the wound /see tab. 3/, but less than in the 4th group, degree. It should be noted that in animals the 4th group significantly earlier compared with all other groups, p<0,05/ started epithelialization, which is, apparently, due to the influence of the emulsion bases of type oil-in-water containing as stabilizer microbial polysaccharide abbasian.

When analyzing the results of the microbiological examination discharge of purulent wounds /see tab. 4/ it is noted that complete removal of pathogenic organisms has not been achieved either in the 1st or in the 2nd group throughout the period of wound healing, in the 3rd group full sterility RAS achieved by the 16th day, and the 4th - already by the 10th day.

Thus, the claimed means actuially effect, thus achieving a statistically significant shorter time to healing of infected wounds.

Sources of information

1. Mashkovsky M. D. Medicines. -M, Medicine. 1984.

2. Klinov I. P. Prerequisites for compilation of the biological functions of natural polysaccharides. -In the book. : Materials of the scientific. proc. Leningrad chem. Pharm. in-TA. -L., 1971. -S. 5-7.

3. Walnut C. M., Tsagareishvili, Century Media medicinal substances in ointments. - Tbilisi, "Back To Text", 1979.

4. Verai M. I., Hausman B. J., Denisov, I. N., Chumachenko P. A. // the Use of lasers in medicine. - M., 1985, vol.1/220/. -S. 21-22.

5. The order of the USSR Ministry of health N 755 from 12.08.77 "About the humane treatment of experimental animals."

Antimicrobial drug for the treatment of infected wounds, including dioxidine, characterized in that it further comprises novocaine, butter fat (stone), abbasian, distilled monoglycerides, glycerin, Aerosil, nipagin, nipazol, distilled water in a ratio of components, wt.%: dioxidine - 4,0 - 5,0; novocaine - 0,3 - 0,5; oil fatty (stone) - 10,0 - 20,0; abbasian - 0,6 - 0,8; monoglyceride distilled - 2,0 - 3,0; glycerol - 4,0 - 5,0; Aerosil - 2,0 - 3,0; nipagin - 0,10 - 0,11; nipazol - 0,10 - 0,11; water diest is

 

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