Ointment for the treatment of skin diseases

 

(57) Abstract:

The invention relates to medicine, in particular to composite medicines used to treat skin diseases. The invention lies in the fact that in the known ointment for the treatment of skin diseases containing the active ingredients and the fat basis, as the active ingredients enter the vitamins a, D, E, salicylic acid, salol, a fresh-water sponge and zinc oxide, and as a fatty basis - pork interior fat, lanolin and petrolatum in a given mass ratio. The invention provides a creams for effective treatment of such skin conditions as acne, boils, bruises, and so on, is highly stable, has good quality, characterized by complete harmlessness.

The invention relates to a composition medicines outdoor applications and is used in medicine for treatment of skin diseases and blood-vascular system.

Known medicinal substance group of steroidal and nonsteroidal anti-inflammatory drugs (Basic and clinical pharmacology. Under the editorship of B. Katzung. TRANS. from English. SPb. Nevsky dialect, 1998). However, numerous ointments, vklyuchyeny sensitivity, local reactions, and so on).

Known ointment Airol Rosh containing fat-based and vitamin A as the active substance (tretinoin, all-TRANS-retinoic acid), which has exfoliating, stimulating mitotic activity of the cells of the skin effect and used mainly for the treatment of common acne (C. I. Dahl, Handbook of drugs in Russia. CJSC "Attraversare", 1998).

However, this drug does not have a pronounced anti-inflammatory and antiallergic effect, and also has some contraindications to the use of (acute inflammatory lesions of the skin, burns, pregnancy). The drug should be used with caution in patients whose work is associated with prolonged exposure to the sun, as well as persons who by inheritance, characterized by high sensitivity to light and have a tendency to skin lesions when exposed to sunlight.

The present invention is to develop creams for effective treatment of skin diseases such as acne, inflammatory and blood-vascular skin lesions - bruises, boils, etc.

To solve this problem in the composition of the claimed composition is again - pork interior fat, lanolin and petrolatum, compatible in their physico-chemical properties in the same drug in the form of ointment.

The inventive composition has the following ingredients mass ratio: vitamin A:vitamin D:vitamin E:salicylic acid:salol:the fresh-water sponge:zinc oxide: lard:lanolin:vaseline 1:1:1:12:12:25:25:50:50:50.

High effectiveness of the proposed drug for the treatment of the above conditions is achieved by the joint action of three vitamins: vitamin A increases cell proliferation in the epidermis inhibits keratinization, enhances immune response, vitamin D also has a positive effect on the immune system and helps to rejuvenate the connective tissue of the skin; vitamin E enhances the protective properties of the skin, has an antioxidant effect; in addition, the fresh-water sponge contributes to a rush of blood to the skin surface and thus accelerates the healing process, and salol, salicylic acid, in turn, are antiseptic, anesthetic and anti-inflammatory drugs in the treatment of skin diseases involving inflammation.

Zinc oxide is introduced into the composition as a pigment in white.

the illnesses.

The ointment is manufactured as follows. Pre-melt and press the pork interior fat. Petrolatum and lanolin is melted at a temperature of respectively 37 - 50oC and 36-42oC. Then a fat basis while stirring consistently add cooked powdered ingredients and solutions of vitamins A, D, e, beat the mixture at room temperature until the formation of fluffy smooth. Ready ointment Packed in receptacles of a capacity not exceeding 50 g with a tight-fitting lid.

The resulting ointment is a composition of gray. The ointment is highly stable, has good quality, characterized by complete harmlessness. Contraindicated ointment only if the Allergy symptoms are specifically used on a fresh-water sponge and the tendency of the skin to increased hair growth.

Biological value and quality ointments do not depend on age. It is preferable to keep the ointment in a cool place.

Example 1. Patient Vdovin N. A., 1974 R. Complaints on the oiliness of the skin, multiple inflamed elements on the skin with purulent content, swelling of the skin. The diagnosis of acne. The patient is assigned rubbing the claimed ointment daily teeta occurred in 1-1,5 months.

Example 2. Patient Samokhina centuries, 1980, p. Complaints about oily skin, acne, separate large inflamed elements. The diagnosis of acne. The patient is assigned rubbing ointment once daily in the evening for five days. On the sixth day the patient's condition improved significantly. Full recovery after 3 to 4 weeks.

Example 3. Patient Andreeva L. N., 1960 R. Complaints inflammation in the right cheek. When seen on the skin of the right cheek found one filled element red-bluish color size 1.5 x 2 cm Diagnosis: a boil. The patient is assigned rubbing ointment into the area of inflammation twice a day for six days in a strong circular motion clockwise. On the seventh day the patient arrived at the reception. The size of the boil decreased to 0.5 x 0.5 see Full cure after 8-10 days.

Ointment for the treatment of skin diseases containing the active ingredients and the fat basis, wherein as the active ingredients enter the vitamins A, D, E, salicylic acid, salol, a fresh-water sponge and zinc oxide, and as a fatty basis - pork interior fat, lanolin and vaseline at the following weight ratio: vitamin A : vitamin D : vitamin E : salicylic acid : salol : the fresh-water sponge : ACS

 

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FIELD: agriculture, animal husbandry, organic chemistry.

SUBSTANCE: antiseptic ointment comprises cationic surface-active substance, lower glycols, polyethylene glycols, water and ethylene glycol monophenolic ester and higher polyethylene glycols taken in the definite ratio of components. As cationic surface-active substance ointment comprises N-alkyl-N-alkoxycarbonylmethylhexahydroazipinium chloride or alkyldimethylbenzylammonium chloride, or cetylpyridinium bromide, or cetylpyridinium chloride, or 1,2-ethylenebis-(N-methylcarbdecyloxymethyl)ammonium dichloride, or ethylhexadecyldimethylammonium chloride, or chlorhexidine; as lower glycol ointment comprises 1,2-propylene glycol or polyethylene glycol-300, or polyethylene glycol-400; as higher polyethylene glycol ointment comprises polyethylene glycol-1500 or polyethylene glycol-3000, or polyethylene glycol-4000, or polyethylene glycol-6000. Ointment elicits the high antibacterial activity, broad spectrum of bactericidal effect and low irritating effect with respect to udder skin. Invention can be used for sanitary-hygienic treatment of udder of lactating cows for prophylaxis and rapid healing external damages of udder and nipples (arising cracks), prophylaxis of mastitis, enhancing milk purity by microbiological indices.

EFFECT: valuable antiseptic properties of ointment.

2 cl, 1 tbl, 22 ex

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