Osteo membrane and method for producing an osteo membrane

 

(57) Abstract:

The invention relates to medicine, namely to dentistry. Osteo membrane contains collagen and drug - glycosaminoglycan, further comprises bone powder. Components take in a certain proportion. Get osteo membrane by mixing and drying the mixture obtained, after drying, the mixture is compacted to a thickness of 0.1 to 1.0 mm and structure. The membrane has the property directed regeneration of periodontal tissues, krovoostanavlivayuschim action. 2 S. p. f-crystals.

The invention relates to medicine, in particular to the materials used in dentistry for the treatment of periodontal disease. In the process of surgical treatment of periodontal disease using a variety of upper materials, which increase the effectiveness of the treatment.

Known collagen sponge with hydroxyapatite used as osteoplastic material for filling bone cavities and gum pockets.

[RF patent N 2034572, A 61 K 15/32, 1995]

The disadvantage of this material is its small strength and thickness of 5-9 mm, n what is Ontario.

Closest to the technical nature of the claimed invention is osteoplastic collagen membrane with chlorhexidine thickness of 0.12 mm

The method of obtaining this membrane is dried mix solutions of the components in the 30oC.

[French patent N 2591892, A 61 K 37/02, publ. 1987]

The disadvantage is that in this way we obtain a quite tough membrane, which complicates its use as a separation, closely adjacent to the tooth tissues.

The purpose of this invention is to reduce the stiffness of the material obtained with the increase in its therapeutic effect through targeted regeneration of bone tissue of the alveolar process and obtaining hemostatic, anti-inflammatory, osteoplastic material prolonged action.

This objective is achieved in that in osteo membrane containing collagen and medicine, the distinguishing feature is that it additionally contains bone powder, and as a drug mixture of glycosaminoglycan in the following ratio, wt.%:

Bone powder - 18 - 40

Glycosaminoglycan - 2-10

Drying of the mixture can be achieved through air or freeze drying, and structuring in pairs aldehydes.

Analysis of the known sources showed that the use of collagen in these materials in combination with other components does not provide properties that allow their use as separation membranes and effectively influence osteogenesis of the periodontium. Air drying or freeze drying and subsequent seal provides the necessary thickness of material, and structuring in pairs aldehydes gives the resistance of the membrane to the action of the cells and the liquid body. The composition of collagen and bone meal-glycosaminoglycan can be applied on the finished film to obtain after drying, double-layered membrane that combines separation and osteo functions.

Example 1. To 1 kg of a 1% solution of collagen at a constant stirring, 8 g of bone powder and 2 g of glycosaminoglycan. After stirring obtain a homogeneous viscous composition containing 50% collagen, 40% bone powder, 10% glycosaminoglycan. The composition is poured into the cell with a layer thickness of 5-9 is and 0.5-0.8 mm, then hold structuring in pairs formaldehyde glutaraldehyde (1:1) for 8 h and the airing of the abundance of free aldehyde. The resulting membrane is Packed in plastic containers, labeled and sterilized by irradiation with a dose of Ro 25 kGy.

Example 2. To 1 kg of an 80% aqueous solution of collagen with constant stirring add 2.25 g (18%) bone powder and 0.25 g (2%) glycosaminoglycan. After stirring obtain a homogeneous viscous composition, which is poured into the polymer of the cell with a layer thickness of 2-3 mm and subjected to air drying. The dry film is treated analogously to example 1.

Example 3. Dry-structured film is treated with 4% hydrogen peroxide solution for 1 h at room temperature, washed with water and fixed on a smooth surface. Film pour a layer of 1-2 mm composition consisting of a 1% solution of collagen - 1 kg (71%), 3 g (21%) bone powder and 1.5 g (8%) glycosaminoglycan, dried in air and the dry film process of example 1.

Example 4. A method of obtaining a film as in example 3, after which the film-the sponge is subjected to freeze-drying. Dry film-the sponge is treated further as in example 1.

Membrane osteo, polucen what periodontal deseases.

Based on the pathogenesis of the inflammatory process in the periodontal tissues of osteoplastic materials should have anti-microbial, dehydrating, necroticism, osteoplastic and analgesic effect.

In contrast to the known drugs for the treatment of periodontal disease, with narrowly targeted action, the proposed osteo membrane provides multicomponent and complex effect. This membrane has the property directed regeneration of periodontal tissues, hemostatic effect (well adsorbs blood and tissue exudates, without causing side effects). In addition, the proposed membrane possesses osteo properties, reduces the toxic effects of anti-inflammatory and osteoplastic drugs and prolong therapeutic effect of the composition.

1. Osteo membrane containing collagen and a drug, characterized in that it further comprises a bone powder, and as a drug mixture of glycosaminoglycan in the following ratio, wt.%:

Bone powder - 18 - 40

Glycosaminoglycan - 2 - 10

Collagen - Rest
trichosis fact, after drying, the mixture is compacted to a thickness of 0.1 to 1.0 mm and structure.

 

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