The method of treatment of diseases of the posterior segment of the human eye method endonasal electrophoresis and installation for its implementation

 

(57) Abstract:

The invention relates to physical therapy and ophthalmology, and is intended for the treatment of diseases in the posterior segment of the eye. The medicinal substance method nasal electrophoresis is delivered to the lesion by means of one or two active electrodes with turondale introduced into the patient's nostril, and two indifferent electrodes, one of which is located in the Central area of the forehead and the other in the temporal region. The procedure is carried out for 15 - 20 min with intermediate off the supply of electric current for 2 to 3 minutes after every 5 to 6 minutes. Installation for implementing the method contains a power source of direct current, one or two of the active electrode with turondale moistened with a solution of a medicinal substance for subsequent introduction into the patient's nostril, and two indifferent electrode mounted on the bandage covering the frontal part of the head with the possibility of longitudinal movement. One of the indifferent electrode is placed in the frontal area and the other in the temporal region from the side of the affected eye. When the treatment of an eye use one active electrode and two indifferent, and when Le is the loop, branches which are parallel with a gap relative to each other, each indifferent electrode is made in the form of a rectangular box-shaped housing with internal end-to-end groove for placement of a bandage and a round plate attached to one of the outer sides of the wall of the casing, and the casing is made of a dielectric material, a plate of conductive material current, power source DC is connected to the plate. The method allows to increase the permeability gematologicheskogo barrier and create a depot of drug substances in the structures of the eye. 2 S. and 4 C.p. f-crystals, 3 ill.

The invention relates to the field of medicine and more specifically to physical therapy in ophthalmology, and can be used for eye treatment method nasal electrophoresis.

It is known that by electrophoresis medicinal substance can be introduced into the tissues of the eye in sufficient for the expressed therapeutic effect of the number without any damaging effect on the fabric. This method differs from podklyucheniya injection. The medicinal substance can be summed up by the receptors of the patient's eyes or to its receptor zone is ome, in some cases it is more delayed by the tissues of the eye (deposited in them). The absorption of the drug, administered by electrophoresis, comes amid intensifying the processes of metabolism in the tissues of the eye under the action of the galvanic current. The medicinal substance is introduced in a state of electrical activity, has a more pronounced pharmacological effect (see Cirucci L. E. physical therapy in ophthalmology. - K.: Health, 1979, S. 3-4).

Using electrophoresis it is possible to make the treatment not only of the anterior eye and diseases of the posterior (cut) eyes, to which access is difficult.

A known method of electrophoresis posterior segment of the eye using a nasal electrophoresis (endopore), based on the existence of close anatomical and physiological connections between the posterior segment of the eye and the hypothalamic-pituitary region, including the input of medicinal substances from the nasal cavity by injecting active electrodes (electrodes connected to the positive pole of the DC source), covered by turondale moistened with a solution of a medicinal substance, and the indifferent electrode (electrode connected to the negative pole)of oresa contains the energy source of direct current, two of the active electrode connected to the positive pole of the source and covered with turondale moistened with a solution of a medicinal substance for subsequent introduction into the nostrils, and the indifferent electrode connected to the negative pole and secured to the head in the occipital part of it. The installation also includes a rim secured to the patient's head around the frontal part and serving to secure the active electrodes (see Questions balneology, physiotherapy and physical culture. - M. : Medicine, so 5, S. 462, 1964).

When performing nasal electrophoresis by well-known methods of drug substance passes into the brain, bypassing the blood-brain barrier.

Object of the invention is to bring the drug to the posterior segment of the eye with minimal concentration, as well as to create a depot of drug substances in the structures of the eye and to increase the permeability of gematologicheskogo barrier when exposed to electric current.

The above results are achieved due to the fact that the power line current goes through the eye, bypassing the brain, i.e., is a local therapeutic effects of medicinal substances.

The claimed invention alsobeen active electrode, a in Fig. 3 cross-section of the indifferent electrode.

Installation for the implementation of the nasal electrophoresis posterior eye segment contains a power source DC 1 (e.g., "Thread-1"), one or two of the active electrode 2 connected to the positive pole of the source 1 and covered with turondale 3, the rim is fixed on the front of the head and is made in the form of a tape bandages 4, and at least two indifferent electrodes, each of which is made in the form of a rectangular box-shaped housing 5 with internal end-to-end groove for placing bandages 4 and a circular plate 6 attached to one of the outer sides of the housing wall 5, the latter is made of a dielectric material, such as plastic, and the plate 6 is made of a material that conducts electric current, for example of stainless steel, while the power source of direct current 1 is connected to the plate 6. One of the indifferent electrode is located in the Central part of bandages 4, for subsequent installation in the Central part of the forehead, and the other or others at a distance laterally from the first to provide further installed in the temple or both temples, and indifferent electrodes, Zakia, taking into account individual peculiarities of the shape of the patient's head, while the electrode 2 is made in the form of a flattened loop, branch 7 which are parallel with the gap 8 relative to each other. The electrode 2 may be made of stainless wire, such as stainless steel or titanium. The dimensions of the electrodes 2 should provide their input turondale 3 (diameter 1.5 cm) into the nostrils and the protrusion of them toround 3 and the electrodes 2. The pads 3 are made of cotton or gauze, which is inserted into the gap 8 and covers the branches 7 of the loop electrode 2 and may be using this gap 8 easily and firmly fixed that eliminates the potential for the exposure of the electrode, which may cause burns of the mucous membrane of the nose. To avoid contact with the patient's body protruding part of the active electrode 2, it is isolated by tube 9 made of synthetic material.

The proposed method of treatment includes a supply of a solution of a medicinal substance from the nasal cavity (nostrils) of the patient in the region of the affected area of the posterior segment of the eye through the impact of the constant electric current supplied to one or two active electrodes and the indifferent electrode, and an active electrode or electrodes cover toround fferently electrode fixed on his head, thus the supply of medicinal substances provide through at least two indifferent electrodes, one of which is placed in the Central region of the forehead and the other in the temporal region. In the treatment of both eyes in the second temporal region impose additional indifferent electrode. The treatment procedure is carried out for 15-20 minutes with intermediate shut off electrical power for 2-3 minutes after every 5-6 minutes. This electric "swinging" gives the effect of inertial promotion of a solution of a drug and its accumulation in the posterior segment of the eye.

In the treatment of both eyes use two active electrode 2 inserted into both nostrils of the patient, and three indifferent electrode, one of which is placed in the Central region of the forehead, and the other two in the field of both temples.

When treating one eye on the frontal part of the head of the patient in a sitting position, dressings 4 and fixed to the housing 5 of the two indifferent electrodes, by placing the round plates directed toward the patient's head, moistened with water or saline strip, made for example of flannel, folded in several layers, preparaing eyes, followed by fixation bandage 4 in any known manner, for example by textile fasteners (Velcro). Turunda 3 active electrode 2 is impregnated with a solution of a medicinal substance and tightly inserted into a nostril of the patient closest to the affected eye, if necessary, fixing on the upper lip of the patient, for example, by means of a spacer and an adhesive plaster or use the attachment to the headband 4. The electrodes are connected to respective poles of a source 1 (if they have not been connected previously) and electrical current is applied with the parameters of the order of 1 mA and 60-80 In, with the power line current and the medicinal substance pass directly through gematologicheskii barrier, providing the desired therapeutic effect.

The proposed method can be used as absorbable therapy in the treatment of hemorrhages in the retina and hemorrhages in the vitreous body.

As a medicinal substance use preparations of enzymes, in particular collalysin (collagenase), enter 50 units. The drug in powder form dissolved in water for injection at room temperature. Ampoule 1000 units dissolved in 10 milliliters, and 500 units in 5 ml of water and is of trophoresis, includes a supply of a solution of a medicinal substance to the affected area through the impact of the constant electric current supplied to one or two active electrodes and the indifferent electrode, and an active electrode or electrodes are covered with turondale, which is impregnated with a solution of a medicinal substance and injected into the patient's nose, and the indifferent electrode is fixed on the patient's head, wherein the supply of medicinal substances provide by fixing on a patient's head, the second indifferent electrode, and one of the indifferent electrode is placed in the Central region of the forehead and the other in the temporal region.

2. The method according to p. 1, characterized in that the second temporal region impose additional indifferent electrode.

3. The method according to p. 1 or 2, characterized in that the procedure is carried out for 15 - 20 min with intermediate switching-off of electric current for 2 to 3 minutes after every 5 to 6 minutes.

4. Installation for the implementation of the nasal electrophoresis posterior segment of the human eye, containing the power source of direct current, one or two of the active electrode connected to its polojitelnie in the nose of the patient, the indifferent electrode connected to the negative pole and fixed on the head and the rim, covering the frontal part of the head, characterized in that the plant is equipped with at least one additional indifferent electrode, and the rim is made in the form of a bandage, an indifferent electrode mounted on the armband with the possibility of longitudinal movement for electrophoresis of the posterior eye segment, one of them is located in the Central part of the dressing for later installation in the Central region of the forehead, and the other - side first to ensure subsequent installation in the temple or temples, while the active electrode is made in the form of a flattened loop, branches which are located in parallel with a gap relative to each other, and every indifferent electrode is made in the form of a rectangular box-shaped housing with internal end-to-end groove for placement of a bandage and a round plate attached to one of the outer sides of the wall of the casing, and the casing is made of a dielectric material, and the plate of material, conductive, and the electrical power source DC is connected to the plate.

5. Installation according to p. 4, characterized in that chiawawa steel.

 

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