Biologically active additive

 

(57) Abstract:

The invention relates to the food and cosmetic industry. Biologically active additives (BAA) contains (g/l): lithium 0,005-2,08; potassium 0,004-0,38; magnesium 0,001-0,51; iron 0,001-2,10; zinc 0,001-1,24; copper 0,001-0,35; manganese 0,001-0,41; Nickel of 0.001 to 0.13; Bor 0,001-0,05; cobalt of 0.001 to 0.04; molybdenum 0,001-0,11; vanadium of 0.001 to 0.13; fluorine 0,001-0,10; iodine 0.001 to 0.01; nicotinamide 0,02-5,00; nicotinic acid 0.005-0.1; thiamine 0,004-4,0; Riboflavin of 0.003 to 0.2; calcium Pantothenate 0,001-0,5; pyridoxine of 0.002 to 0.5; ciankobalamin 0,001-0,05; calcium pangamat 0,004-5,5; sodium ascorbate 0,006-3,2; tocopherol 0,003-0,03; folic acid 0.005-0,03; retinol of 0.004 to 0.08; ergocalciferol 0,001-0,02; cholecalciferol 0,001-0,02; fitomenadion of 0.003 to 0.05; ATP acid 0.003 to 0.05; glycine 0,004-0,1; glutamic acid 0.003 to 0.1; Mexidol of 0.001 to 0.2; distilled water to 1000,0 Jr. Declared biologically active additive shows antihypoxic, hypothermic, antioxidant, antibacterial, antiviral properties, reduces the growth rate of tumor cells, shows the soothing, antidepressant, diuretic, entityrelationship properties, the volumetric rate increases coronary blood flow, increases the volume of the vascular plexus and microca is urolithiasis, normalizes the metabolism of lipids, proteins and carbohydrates, improves the metabolism of ethanol and acetaldehyde in the body, prevents and reduces their toxicity, alcohol dependence, effects of alcoholism, enhances mental and physical performance. 15 C.p. f-crystals.

The invention relates to food industry, namely, biologically active additives (BAA) restorative actions, and can be used for rational and therapeutic nutrition in a variety of extreme conditions and pathological conditions associated with the failure of essential vital minerals and vitamins to optimize the metabolism of ethanol and oxidized product of its decay - acetaldehyde (ACAG), prevention of alcoholism and its pathophysiological consequences, and can also be used in the agricultural industry for the production of feed for animals and plants foliar feeding, in cosmetics, in the manufacture of toothpastes, toilet water, nourishing creams for skin and hair shampoos.

Food production in the modern world involves improving their biological value by adding nezvychayna important in the organization of nutrition, normal growth, development and functioning of the body, improving the psycho-physiological tone, prevention, prevent premature aging and death.

Currently, to solve the above problems created various biologically active food supplements - dietary SUPPLEMENTS (DE, B2, 2060601, A 23 L 1/30, 1980; GB, A, 2113064, A 23 L 1/30, 1983; Patent N 158024, A 61 TO 33/14, 1993; EPB1, 217975, A 61 K 33/00, 1991), which are either insufficiently balanced composition of trace elements and vitamins, or they are completely absent of those or other vital components. As shown by our analysis, these additives have a fairly narrow range of effectiveness or various restrictions apply.

Known biologically active additive to food products (DE, B2, 2060601, A 23 L 1/30, 1980), containing organic salts of sodium, potassium, calcium and magnesium, which are optimized for cationic composition.

The disadvantage of this additive is a lack of vital indispensable (essential) trace elements, which significantly narrows the scope of its use for the prevention of various diseases, as well as when microelementoses (deficiency of essential trace elements).

Also the e l e C manganese, Nickel, boron, cobalt, vanadium and fluoride.

In this biologically active additive "GS" no vitamins, which significantly narrows the scope of its use in the comprehensive prevention and treatment of various diseases caused by the lack or complete absence of the relevant minerals and/or vitamins.

The closest technical solution is optimized composition of trace elements and some biologically active substances that determine its broad spectrum of action, it is biologically active additive (EN 2035880, A 23 L 1/24, 1995) containing lithium, sodium, potassium, magnesium, iron, zinc, copper, manganese, Nickel, boron, cobalt, molybdenum, vanadium, fluoride, glycerin, glycine, EDTA, tartaric acid, amber-stone acid, ascorbic acid, citric acid, and distilled water.

However, in this BAD vitamin component is represented only ascorbic acid, which is clearly insufficient, and the absence of biological media energy phosphate makroergov) even more significantly limits its application. In addition, even minimal concentrations of the individual components of the above SUPPLEMENTS in some cases can provide the th are expensive, scarce, however, has very limited indications for the use of components, such as amber-stone and tartaric acid.

Object of the invention is the creation of biologically active additives, with a broader spectrum of activity, more pronounced and prolonged tonic effect, as well as giving it a new therapeutic and preventive properties, for example, protivoallergennyh.

The essence of the invention lies in the fact that a dietary Supplement containing lithium, potassium, magnesium, iron, zinc, copper, manganese, Nickel, boron, cobalt, molybdenum, vanadium, fluoride, glycine, ascorbic acid and distilled water additionally contains iodine, nicotinamide, nicotinic acid, thiamine, Riboflavin, calcium Pantothenate, pyridoxine, ciankobalamin, calcium pangamat, tocopherol, folic acid, retinol, ergocalciferol, cholecalciferol, fitomenadion, adenosine triphosphate, glutamic acid and Mexidol in the following ratio, wt.% (g/l): lithium 0,005-2,08, potassium 0,004-0,38, magnesium 0,001-0,51, iron 0,001-2,10, zinc 0,001-1,24, copper 0,001-to 0.35, manganese 0,001-0,41, Nickel of 0.001 to 0.13, boron 0.001 to 0.05, the cobalt of 0.001 to 0.04), molybdenum 0,001-0,11, vanadium of 0.001 to 0.13, cotent 0,001-0,5, pyridoxine of 0.002 to 0.5, ciankobalamin 0,001-0,05, calcium pangamat 0,004-5,5, sodium ascorbate 0,006-3.2, tocopherol of 0.003 and 0.03, folic acid 0.005-0.03, retinol of 0.004 to 0.08, ergocalciferol 0,001-0,02, cholecalciferol 0,001-0,02, fitomenadion of 0.003 to 0.05, ATP acid (ATP) of 0.003 to 0.05, glycine 0,004-0,1, glutamic acid 0.003 to 0.1, Mexidol of 0.001-0.2 and distilled water to 1000 ml.

Depending on the field of application of biologically active additives it is possible to find the optimal composition of the components, as well as to balance their proportion.

As biologically active anions can be used citrate, gluconate, acetate, etc. and as anions in inorganic salts - chlorides, sulfates, oxides, fluorides, etc.

The use of the invention allows to obtain the following technical result.

The authors have obtained highly effective SUPPLEMENTS that manifests antihypoxic, hypothermic, antioxidant, antibacterial, antiviral properties, reduces intensivist the growth of tumor cells, shows the soothing, antidepressant, diuretic, entityrelationship properties, the volumetric rate increases coronary blood flow, increases vascular volume is ibrin, the aggregation of platelets and red blood cells, prevents thrombocytopenia during treatment with cytotoxic drugs and x-irradiation.

It is effective when the exchange arthritis, gout and kidney stones. Actively affects lipid, protein and carbohydrate metabolism. Optimizes the metabolism of ethanol and AZAG in the body, prevents or reduces their acute and chronic toxicity, alcohol dependence, short-and long-term effects of alcoholism.

The proposed additive enhances mental and physical performance, shows a pronounced tonic effect. The BAD belongs to the group of practically healthy recipes and can long be used inside specified in the annotation doses, i.e. not exceeding the physiological needs of the organism in their constituent trace elements and organic compounds.

Intra - and extracellular competitive interactions of trace elements included in the formulation of dietary SUPPLEMENTS, with their radioactive counterparts (lithium, cobalt, molybdenum, Nickel, zinc, copper and others) reduces their accumulation in the tissues and thus contributes to a more rapid elimination from the body, which ultimately reduces the total radiation dose load in terms of propilivanii and conditions deficiencies of these micronutrients, the so-called "microelementoses", including those caused by ethanol abuse.

One of the main indications for the use of dietary SUPPLEMENTS is its influence on the metabolism of ethanol in the body, the preventive effect on addicted to it and its pathogenic action AZAG.

It is well known that ethanol in the body is metabolized emitting large amounts of energy mainly in three ways. The main is acetaldehyde, which breaks down to 80-90% of exogenous alcohol. The second degree of significance (about 9%) is the path of assimilation of ethanol via microsomal etnologija system (MEOS). The rest is catalyse the oxidation of about 1%. The oxidation of ethanol MAOS and catalase do not play a significant role in alcoholic pathology and little to attract the attention of researchers (Yu M. Ostrovsky, M. N. The gardener, the Journey of ethanol metabolism and their role in the development of alcoholism. theoretical basis of the search for cures of alcoholism, a series of "Toxicology", T. 13, M, 1984, 93-150; T. J. Halej, W. O. Berndt, Handbook of Toxicology, USA, 1987; E. A. Luzhniki, Clinical toxicology, M., 1994, S. 146-147).

In the first case, the ethanol under vliianie toxic substances - acetaldehyde (ACAG), which physiologically favorable conditions (healthy body and/or limited income exogenous quality alcohol) immediately destroyed by the enzyme acetyldihydrocodeine (ACIDH). Thus, this highly toxic product of the cleavage of ethyl alcohol immediately neutralized by removal of two hydrogen atoms with the formation of acetic acid, which is utilized in the tricarboxylic acid cycle (Krebs Cycle) with the release of the final decay products of ethanol - carbon dioxide and water.

It is known that the consumption of large quantities of alcohol dramatically inhibits gluconeogenesis in the liver, resulting in rapidly decreasing the concentration of glucose in the blood. This action of ethanol in particular affects after exhausting exercise or starvation. If in the above extreme conditions people drink alcohol, your blood sugar may fall even 60 to 70 percent of normal, and the body temperature to fall by more than 2 degrees Celsius (A. Lininger, fundamentals of biochemistry, M. Mir, 1985, so 2, S. 611) that adversely affects the function of the Central nervous system. Introduction the patient in this state, a sufficient amount of glucose significantly of oblabla rediculouse to give rescued at sea or in the desert, hungry and in exhausted people liquor physiologically unreasonable and even dangerous; in such cases, in conjunction with it should be give and large quantities of carbohydrates.

Effects of alcohol intoxication are determined not so much by the toxicity of ethanol as highly pathogenic influence of the intermediate product of its decay - AZAG. On the background of acetic acid acidosis acute and chronic toxicity of AZAG on average much higher toxicity of the ethyl alcohol. Therefore, the key taxagent this pathology is ACAG and treatment should be directed primarily to the early neutralize its harmful effects on the structural and functional integrity of the nervous and other tissues, as well as the fastest splitting ACAG ACIDH and MAOS in the respective structures of the liver to carbon dioxide and water. ACAG is polytropic poison, affecting almost all organs and systems of the body.

The main elements that determine the toxic effect of AZAG are:

- "membranopovrezhdayuschih effect of the cells of the Central and peripheral nervous system, endocrine glands, immune organs, heart, liver and kidneys;

"depletion factors that Deplete AZAG", in the first acharei other;

- "calorie-gene effect, inhibiting the traditional physiological pathways of energy production due to the decomposition of glucose and lipids, and concentrated in dependence of the body from receiving energy only through one type of fuel - ethanol;

- "lethal synthesis" - with increasing delivery of exogenous ethanol broken paths and metabolizirovannom unable to effectively destroy AZAG, and with the increase of its concentration in the tissues increased proportionally and toxic effects ACAG;

- "energy crisis" - when cancelling the receipt of exogenous alcohol traditional physiological ways of obtaining energy (carbohydrate and lipid) is not able to provide the current needs of the organism in phosphate makroergov (ATP, creatinephosphate and others), which requires to maintain its operation (in severe cases, the viability of new doses of exogenous ethanol (syndrome "hangover").

Thus, a vicious cycle. In terms of alcoholic "energy crisis" (acute alcohol deficiency) of vital organs and systems of the body are unable to function normally due to the lack of preservatives energy and the failure of druidstone previous systematic intake of energy-dense and highly available for absorption type of "fuel" - ethyl alcohol. Thus, according to A. Patek, E. Toth et al. (Arch. Int. Med. 1975, 135, 1053-1057) patients with chronic alcoholism receive in the form of ethanol up to 50% of the daily calorie. Ethanol more than competes with other energy sources, primarily from carbohydrates, clearly surpassing them in terms of bioavailability. Simultaneously with the increasing dependence on alcohol fuel, increases the degree and intensity of the autointoxication of the body ("lethal synthesis") due to the inability to effectively destroy the product half-life of ethanol - AZAG.

Alcoholics, as already noted, a little eating, and generally eat little, as the bulk of the calories they get from alcohol, in which there is no vitamins and some essential minerals, as a result they may have the appropriate deficiency and the so-called "microelementoses". For example, according to T. J. Halej. W. O. Berndt (Handbook of Toxicology, USA, 1987) long-term intake of ethanol causes nutritional deficiency of vitamin B-12, folic acid, methionine, and other vital biologically active substances. According to A. Leininger (1985), typical for alcoholics deficiency of thiamine (vitamin B-1), known as the syndrome of Korsako the th, and usually requiring hospitalization disease, is not the alcohol, and the combination of lack of thiamine and a possible reduction in the activity of the thiamine-dependent enzyme - transketolase. It has been suggested, according to which mental disorders and other symptoms Korsakov syndrome could be prevented by adding thiamine to alcoholic beverages (a. Leninger, fundamentals of biochemistry, M. Mir, 1985, I. 3, S. 829). However, practically in this direction no attempts were not, because, according to public opinion, this could increase the consumption of alcoholic beverages.

Physiological breakdown of ethanol in the body is impossible without the full participation of vitamins and vital (essential) trace elements. Thus, according to A. that is, the assumption (Toxicological characteristics of ethanol. Metabolic pathways of ethanol and their role in the development of alcoholism. theoretical basis of the search for cures of alcoholism, a series of "Toxicology", T. 13, M, 1984, from 6 to 56), alcoholdehydrogenase in its structure contains zinc and ACIDH - molybdenum and they are activated by a complex of essential trace elements. When their supply accordingly decreases the activity of the above clybucca pathogenetic treatment and prevention of toxic lesions and disorders of the body, caused by the abuse of ethanol, by introducing into the composition of formulations spirits already known protective and scarce mineral and vitamin complexes appears to be the most important direction in a complex system of anti-alcohol measures.

Thus, in General, the SUPPLEMENTS can:

to increase the shelf life of products and to reduce the number of special preservatives used for these purposes;

to increase the biological value of the food to improve absorption and assimilation, to intensify their biologically active components (ingredients);

- to be therapeutic and restorative effects, i.e., to reduce morbidity, especially in extreme conditions (high physical activity, hyperthermia, stress, radiation exposure, and others), to improve the psycho-physical performance;

to inhibit the formation of free radicals, slowing the aging process and can be used primarily in geriatrics and medicine of extreme problems;

- to increase the activity of the immune system and accelerate the removal of radionuclides from the body;

to ensure the body is not melitsa; the development of alcohol dependence and pathological manifestations of chronic alcoholism.

The technical result is achieved due to the fact that the authors chosen optimally balanced composition of dietary SUPPLEMENTS, including minerals, vitamins and biologically active substances - ATP, glycine, glutamic and amber (Mexidol) acid. The formula shows that when receiving a BAD person receives essential trace elements, vitamins and some biologically active substances within their daily needs. Obviously, in conditions of insufficient intake of these substances with food and water BAD to fully compensate their deficit and cautions associated with this, the junk for the body of the consequences.

While all components in a balanced dietary SUPPLEMENTS appear new divergent biological effects, whereas individual ingredient formulations such biological activity by itself to be unable. This gives the entire mineral-vitamin complex Supplement new biological properties, potentiation and prolongation of effect, allowing lower concentrations to obtain more's reactions and increases the safety of its use.

It should be noted that the proposed tool is biologically active additive exerts its biological activity at all levels of the regulation of homeostasis: molecular, subcellular, tissue, organ, system and organism.

BAD shows antihypoxic, hypothermic, antioxidant, antibacterial, antiviral properties, reduces the growth rate of tumor cells, shows the soothing, antidepressant, diuretic, entityrelationship properties, the volumetric rate increases coronary blood flow, increases the volume of the vascular plexus and microcapillaries, improves microcirculation, prevents the conversion of fibrinogen to fibrin, the aggregation of platelets and red blood cells, prevents thrombocytopenia during treatment with cytotoxic drugs and x-irradiation. It is effective for metabolic polyarthritis, gout and kidney stones. Actively affects lipid, protein and carbohydrate metabolism. Optimizes the metabolism of ethanol and AZAG in the body, prevents or reduces alcohol dependence, reduces acute and chronic toxicity of alcohol and AZAG, short-and long-term effects of alcoholism. Offer comp is. This is due to the fact that the trace elements included in the BAA (lithium, magnesium, iron, zinc, copper, manganese, Nickel, boron, cobalt, molybdenum, vanadium, fluorine and iodine) participate in the regulation of basic metabolic processes of the body, especially in extreme and adverse human life conditions.

Introduction in the formulation of SUPPLEMENTS of potassium iodide allows more active thyroid gland to synthesize thyroid hormones, which are a powerful activator MAOS that breaks down ethanol and AZAG (M. D. Mashkovsky, Medicines, ed.13, 1997, so 2, S. 163). In dietary SUPPLEMENTS these effects are amplified.

Adding to the above additive nicotinamide (NA), which is the prosthetic group of enzymes kodegidrazy I (diphosphopyridine ABOVE) and kodegidrazy II (triphosphopyridine - NADP) and serve as the carriers of hydrogen and involved in redox processes. ON improves carbohydrate metabolism, has hypolipidemic activity (reduces total cholesterol, low-density lipoprotein and triglycerides. In dietary SUPPLEMENTS TO accelerate the dehydrogenation of ethanol, acetaldehyde and acetic acid (M. D. Mashkovsky, is illogical, but a more lasting effect. It increases the efficiency of acetaldehyde path splitting of ethanol.

Use in BAD thiamine allows you to actively affect various body functions, to interfere with the metabolism and neuro-reflexive regulation, to cause a positive effect in various pathological processes, this vitamin is involved in the regulation of the conduct of proceedings in the nervous synapses: has a moderate ganglioblokiruyuschim curariform properties, affects the processes of polarization of motor end plates. Deficiency develop neuropsychiatric disorders, for example, alcoholic Korsakov's syndrome (a. Leininger, 1985). Together with other components BAD thiamine prevents the development of alcoholic psychosis and alcoholic dementia (M. D. Mashkovsky, Medicines, ed. 13., 1997., so 2, S. 75).

Introduction in the inventive composition Riboflavin stimulates its interaction with ATP and the formation of a flavin-mononucleotide/flavinadeninnukleotid, which are involved in the transport of hydrogen and the regulation of redox processes. This vitamin has a great impact on carbohydrate, protein and fat metabolism, improves the decay atmah, the myocardium, liver and kidneys (M. D. Mashkovsky, Medicines, ed. 13, 1997, so 2, S. 78).

In the formulation of SUPPLEMENTS calcium Pantothenate being a part of coenzyme A, plays an important role in the acetylation and oxidation. It is involved in carbohydrate and fat metabolism, stimulates the formation of corticosteroids improves the physiological oxidation of ethanol and its metabolites, reduces toxicity and increases the resistance of body tissues to the so-called "secondary alcohol hypoxia" (M. D. Mashkovsky. Drugs, ed. 13, 1997, so 2, S. 93).

Pyridoxine, part of the SUPPLEMENTS necessary for normal functioning of the Central and peripheral nervous system. In the body of this vitamin: fosfauriliruetsa and is part of the enzymes involved decarboxylation and transamination of amino acids; involved in the metabolism of tryptophan, methionine, cysteine, glutamic acid and histamine. It improves lipid metabolism in atherosclerosis. It reduces or completely blocks the neurotoxic effect of alcohol and the products of its degradation (M. D. Mashkovsky, Medicines, ed. 13, 1997, so 2, S. 80).

Adding ciankobalamin in the proposed set of BAD red is optimizatsii metabolism of carbohydrates and lipids (M. D. Mashkovsky, Medicinal product. , ed. 13, 1997, so 2, S. 82). This vitamin exhibits a therapeutic effect in case of poisoning with ethanol and products of its oxidation.

Use in BAD calcium pangamate allows you to have a beneficial effect on metabolism: to improve lipid metabolism, increase oxygen uptake by the tissues, to increase the content of creatine phosphate in muscle and glycogen in the tissues, improve the body's resistance to hypoxia. (M. D. Mashkovsky, Medicines, ed. 13, 1997, so 2, S. 103). It prevents the development of alcoholic atherosclerosis and microdisperse, increases in these conditions, the functional activity of the Central nervous system and myocardium.

Sodium ascorbate in the formulation of SUPPLEMENTS plays an important role in the life of the body: it participates in the regulation of oxidation-reduction processes, carbohydrate metabolism and ethanol metabolism, blood clotting, the state of the vascular wall, regeneration of the tissues, formation of steroid hormones, and normalization of the functional state of the liver and other alcoholic intoxication, etc.

Use in BAD tocopherol, a powerful anti-oxidant funds (antioxidant) protects the structure of the organism from dejstvija other critical processes of cellular metabolism disturbed in chronic alcoholism.

Which is BAD folic acid is essential for normal development of the fetus during pregnancy, optimization of blood, especially when the blood diseases of different origin, blood loss and anemia, caused by alcohol and other intoxications and ionizing radiation.

Retinol in dietary SUPPLEMENTS is needed for optimal development and growth of the body, the normal functioning of the organs of vision, prevention of diseases and skin lesions, pulmonary and gastrointestinal diseases, kidney stones, alcoholic intoxication and liver cirrhosis.

Use in the inventive complex BAD ergocalciferol and cholecalciferol optimizes the metabolism of calcium in bone tissue, as well as in the regulation of the metabolism of phosphorus in the body, which are in chronic alcoholism.

One of the components of the BAD fitomenadion is protivogemorragicheskim or coagulation vitamin and promotes normal blood clotting. It is necessary for the normal functioning of the liver and its diseases and lesions and other alcoholic intoxication.

The introduction of et in terms of alcoholic "energy crisis" to use it for physical work the muscle tissue, functioning of the nervous system, as well as protein synthesis, urea and intermediate products of metabolism, prevent and/or mitigate the violation of these processes.

The presence of glycine is a nonessential amino acid, a Central neurotransmitter braking action in BAD improves metabolic processes in the brain, significantly reduces the craving for alcohol reduces the effects of withdrawal symptoms, depressive disorders, irritability, insomnia, and other pathological manifestations in patients with chronic alcoholism (M. D. Mashkovsky. Medicinal product. Ed. 13, Kharkov, 1997, so 2, S. 131).

Use in recipes BAD glutamic acid, a nonessential amino acid, is actively involved in the metabolic processes of the body, especially the brain and normalize them in various pathological conditions: hypoxia, stroke, poisoning, including alcohol.

Mexidol - salt of succinic acid (2-ethyl-6-methyl-3 - oksipiridina succinate) in dietary SUPPLEMENTS has strong antioxidant properties. It improves mental functions of the Central nervous system in chronic alcoholism. Reduces the toxic effects of ethanol and AZAG (M. D. Mashkovsky. Lecaro balanced number, shows original multidirectional biological potentiated and prolonged effects, allowing lower concentrations to obtain a more pronounced effect.

We conducted experimental and clinical studies have shown that the exclusion from the formulation of at least one of the components of the dietary Supplement and/or a change in the ratio of their concentration to each other leads to the disappearance of the claimed effects. None of the substances included in its composition, in particular not in itself has all the breadth and duration of action BAD. If you change the quantity of one of the ingredients of the additive, appropriate correction of all other components. The complex interaction of trace elements, vitamins and other biologically active substances can improve, to summarize and/or to increase the bioavailability, absorption and digestibility of the dietary Supplement.

The versatility of the proposed formulation and its high therapeutic and prophylactic properties allow the use of dietary SUPPLEMENTS in the food industry, for example, in the production of drinking table water, tonic and other drinks, juices, compotes, marmalades, jams, jellies, beer, wine and spirits is Lee, products made from flour, sugar, salt, sauces, flavor seasonings, with the production of animal feed; in the medical industry; in perfumery when creating new formulations of toothpastes, creams, toilet waters, lotions, shampoos, etc.

BAA gives the opportunity to create a future different for each individual at a particular extreme in his actions (or States) of the optimal formulation of therapeutic nutrition in both residential and outpatient settings.

The main marker should be considered as the lithium concentration to 2.08 g/L.

Biologically active additive is prepared as follows. To obtain 1000 ml of BAD charge (g/l): lithium 0,005-2,08, potassium 0,004-0,38, magnesium 0,001-0,51, iron 0,001-2,10, zinc 0,001-1,24, copper 0,001-to 0.35, manganese 0,001-0,41, Nickel of 0.001 to 0.13, boron 0,001-0,05, cobalt of 0.001 to 0.04), molybdenum 0,001-0,11, vanadium of 0.001 to 0.13, fluorine 0,001-0,10, iodine 0.001 to 0.01, nicotinamide 0,02-5,00, nicotinic acid 0,005-0,1, thiamine 0,004-4,0, Riboflavin of 0.003 to 0.2, calcium Pantothenate 0,001-0,5, pyridoxine of 0.002 to 0.5, ciankobalamin 0,001-0,05, calcium pangamate 0,004-5,5, sodium ascorbate 0,006-3,2, tocopherol of 0.003 and 0.03, folic acid from 0.005 to 0.03, retinol of 0.004 to 0.08, ergocalciferol 0,001-0,02, cholecalciferol 0,001-0,02, fitomendiona of 0.003 to 0.05, the isolation of water to 1000,0 ml.

The resulting liquid is thoroughly mixed at a temperature of 50-60 degrees C and Packed. Store in a tightly closed container in dark glasses without access of air and water at a temperature of 5-10 C.

Add it in a certain proportion to the food or other products (concentrates).

BAD is a transparent liquid pale - greenish color without a smell. Has slabovskyy consistency salted taste and metallic taste.

Example 1. Hot non-alcoholic drinks with tonic and curative action. To the Cup (50-100 ml) tea or coffee add 5-10 drops of the main formulations of the BAD of the following composition (g/l): Lithium 0,006-2,00; Potassium From 0.005 To 0.35; Magnesium 0,001-0,50; Iron 0,002-1,9; Zinc 0,003-1,1; Copper Of 0.002 To 0.3; Manganese 0,0015-0,35; Nickel 0,002-0,1; Bor 0,003-0,03; Cobalt 0,001-0,02; Molybdenum 0,002-0,09; vanadium 0.003 to 0.1; Fluoride Of 0.004-0.05; Iodine 0,005-0,01; Nicotinamide 0,03-4,00; Nicotinic acid 0,006-0.05; Thiamine 0,005-3,5; Riboflavin 0,003-0,1; Calcium Pantothenate 0,002-0,4; Pyridoxine 0,003-0,45; Ciankobalamin 0,002 - 0,03; Calcium pangamat of 0.005 to 5.0; sodium Ascorbate 0,008-3,0; Tocopherol 0,004-0,02; Folic acid 0,006-0,02; Retinol 0,005 - 0,05; Ergocalciferol 0,005-0,01; Cholecalciferol Of 0.003 To 0.01; Fitomenadion 0,005-0,05; Adenosine 1000,0 ml.

Example 2. Drinking table water. To 999 ml basic recipe drinking table water add 1 ml of the BAD of the following composition (g/l): Lithium 0,005-2,08; Potassium From 0.005 To 0.30; Magnesium 0,001-0,51; Iron 0,001 - 1,10; Zinc 0,001-1,24; Copper 0,001-0,25; Manganese 0,001-0,31; Nickel 0,001-0,10; Bor 0,001-0,05; Cobalt Of 0.001 To 0.04; Molybdenum 0,001-0,10; vanadium 0,001-0,10; Fluorine 0,001-0,10; Iodine 0.001 to 0.01; Nicotinamide 0,02-0,4; Nicotinic acid 0,005-0,006; Thiamine 0,004-0.8; Riboflavin Of 0.003 To 0.05; Calcium Pantothenate of 0.001 to 0.4; Pyridoxine Of 0.002 To 0.3; Ciankobalamin 0,001-0,005; Calcium pangamat of 0.004 to 1.5; sodium Ascorbate 0,006-3,2; Tocopherol Of 0.003 To 0.01; Folic acid 0,005-0,02; Retinol 0,004-0,008; Ergocalciferol 0,001-0,002; Cholecalciferol 0,001-0,002; Fitomenadion 0,003 - 0,005; ATP acid 0,003-0,005; Glycine 0,004-0,1; Glutamic acid: 0.003 to 0.1; Mexidol 0,001-0,02; Distilled water - up to 1000,0 ml.

Example 3. Tonic drinks. To 998,5 ml basic recipe soft drinks add 1.5 ml of BAD of the following composition (g/l): Lithium 0,005-1,08, Potassium From 0.005 To 0.30; Magnesium 0,001-0,41; Iron 0,001-1,6; Zinc Of 0.001 To 1.0; Copper 0,001-0,30; Manganese 0,001-0,31; Nickel 0,001-0,10; Bor Of 0.001 To 0.04; Cobalt 0,001-0,03; Molybdenum 0,001-0,10; vanadium 0,001-0,10; Fluorine Of 0.001 To 0.08; Iodine 0.001 to 0.01; Nicotinamide 0,02-5,00; Nicotinic acid 0,005-0,01; Thiamine 0,004-2,0; Riboflavin Of 0.003 To 0.2; Calcium Pantothenate 0,001-0,5; Pyridoxine: 0,002-0,5; Siankaba the 0,004-0,008; Ergocalciferol: 0.001 to 0.01; Cholecalciferol: 0.001 to 0.01; Fitomenadion: Of 0.003 To 0.05; ATP acid: 0,003-0,005; Glycine: 0,004-0,09; Glutamic acid: 0.003 to 0,09; Mexidol: of 0.001 to 0.2; distilled Water - up to 1000,0 ml.

Example 4. Fruit and/or vegetable juices. To 999,5 ml of juice, add 0.5 ml of the BAD of the following composition (g/l): Lithium 0,005-2,00; Potassium 0,004-0,30; Magnesium 0,001 - 0,50; Iron 0,001-0,09; Zinc 0,001-1,20; Copper 0,001-0,35; Manganese 0,001-0,41; Nickel 0,001-0,10; Bor: 0,001-0,04; Cobalt 0,001-0,03; Molybdenum 0,001-0,10; vanadium 0,001-0,10; Fluorine: 0,001-0,09; Iodine 0.001 to 0.01; Nicotinamide: 0,02-5,00; Nicotinic acid: 0,005-0,01; Thiamine: 0,004-4,0; Riboflavin: 0,003-0,2; Calcium Pantothenate: 0,001-0,5; Pyridoxine: 0,002-0,5; Ciankobalamin: 0,001-0,05; Calcium pangamat: 0,004-5,5; sodium Ascorbate: 0,006-3,2; Tocopherol: 0,003-0,03; Folic acid: from 0.005 to 0.03; Retinol: 0,004-0,008; Ergocalciferol: 0.001 to 0.01; Cholecalciferol: 0.001 to 0.01; Fitomenadion: Of 0.003 To 0.05; ATP acid: 0.003 to 0.05; Glycine: 0,004-0,07; Glutamic acid: 0.003 to 0.1; Mexidol: of 0.001 to 0.2; distilled Water - up to 1000,0 ml.

Example 5. Milk (fresh, condensed, and others). To 999 ml of milk add the BAD of the following composition (g/l): Lithium 0,005-1,90; Potassium 0,004-0,30; Magnesium 0,001-0,50; Iron 0,001-2,10; Zinc 0,001-1,04; Copper 0,001-0,30; Manganese 0,001-0,41; Nickel Of 0.001 To 0.13; Bor Of 0.001 To 0.04; Cobalt: 0,001-0,03; Molybdenum 0,001-0,11; vanadium 0,001 what I Pantothenate 0,001-0,45; Pyridoxine 0,002-0,45; Ciankobalamin 0,001-0,05; Calcium pangamat 0,004-5,5; sodium Ascorbate 0,006-3,2; Tocopherol 0,003-0,03; Folic acid 0,005-0,01; Retinol Of 0.004 To 0.08; Ergocalciferol 0,001-0,02; Cholecalciferol 0,001-0,02; Fitomenadion Of 0.003 To 0.05; ATP acid 0,003-0,005; Glycine 0,004-0,1; Glutamic acid of 0.003 to 0.01; Mexidol of 0.001 to 0.2; distilled Water - up to 1000,0 ml.

Example 6. Dairy products (cheese, sour cream, yogurt, butter, infant formula, ice cream and other). To 990 g milk product add SUPPLEMENTS of the following composition (g/l): Lithium 0,005-2,08; Potassium 0,004-0,30; Magnesium 0,001-0,50; Iron 0,001 - 2,00; Zinc 0,001-1,04; Copper 0,001-0,35; Manganese 0,001-0,31; Nickel 0,001-0,10; Bor 0,001-0,05; Cobalt 0,001-0,03; Molybdenum 0,001-0,10; vanadium 0,001-0,10; Fluorine 0,001-0,10; Iodine 0.001 to 0.01; Nicotinamide 0,02-5,00; Nicotinic acid 0,005-0,01; Thiamine 0,004-4,0; Riboflavin Of 0.003 To 0.2; Calcium Pantothenate 0,001-0,5; Pyridoxine Of 0.002 To 0.4; Ciankobalamin 0,001-0,05; Calcium pangamat 0,004-5,5; sodium Ascorbate 0,006-3,0; Tocopherol 0,003-0,03; Folic acid 0.005-0,009; Retinol Of 0.004 To 0.08; Ergocalciferol 0,001-0,02; Cholecalciferol 0,001-0,02; Fitomenadion Of 0.003 To 0.05; ATP acid 0,003-0,005; Glycine 0,004-0,1; Glutamic acid of 0.003 to 0.01; Mexidol of 0.001 to 0.2; Distilled water - up to 1000,0 ml.

Example 7. Beer and/or brew. To 992 ml of beer and/or kvass add is ANEC 0,001-0,40; Nickel of 0.001 to 0.13; Bor 0,001-0,05; Cobalt Of 0.001 To 0.04; Molybdenum 0,001-0,10; vanadium of 0.001 to 0.13; Fluorine 0,001-0,10; Iodine 0.001 to 0.01; Nicotinamide 0,02-4,00; Nicotinic acid 0,005-0,01; Thiamine 0,004-3,0; Riboflavin Of 0.003 To 0.2; Calcium Pantothenate of 0.001 to 0.4; Pyridoxine Of 0.002 To 0.4; Ciankobalamin 0,001-0,005; Calcium pangamat 0,004-5,0; sodium Ascorbate 0,006-1,2; Tocopherol Of 0.003 To 0.02; Folic acid 0.005-0,03; Retinol of 0.004 to 0.08; Ergocalciferol 0,001-0,02; Cholecalciferol 0,001-0,02; Fitomenadion Of 0.003 To 0.04); ATP acid 0,003-0,005; Glycine 0,004-0,1; Glutamic acid 0.003 to 0.1; Mexidol of 0.001 to 0.2; distilled Water - up to 1000,0 ml.

Example 8. Wine-vodka products. To 990 ml basic recipe wine-vodka products, add 10 ml of the BAD of the following composition (g/l): Lithium 0,005-2,00; Potassium 0,004-0,33; Magnesium 0,001-0,41; Iron 0,001-1,10; Zinc 0,001-1,14; Copper 0,001-0,30; Manganese 0,001-0,31; Nickel 0,001-0,10; Bor 0,001-0,05; Cobalt Of 0.001 To 0.04; Molybdenum 0,001-0,11; vanadium 0,001-0,10; Fluorine 0,001-0,10; Iodine 0.001 to 0.01; Nicotinamide 0,02-4,00; Nicotinic acid 0.005-0.1; Thiamine 0,004-4,0; Riboflavin Of 0.003 To 0.2; Calcium Pantothenate 0,001-0,5; Pyridoxine Of 0.002 To 0.5; Ciankobalamin 0,001-0,05; Calcium pangamat 0,004-5,5; sodium Ascorbate 0,006-3,2; Tocopherol 0,003-0,03; Folic acid 0.005-0,03; Retinol Of 0.004 To 0.08; Ergocalciferol 0,001-0,02; Cholecalciferol 0,001-0,02; Fitomenadion Of 0.003 To 0.05; ATP acid 0.003 to 0.05; Glycine is th meat (sausage, sausages, sausages, dumplings and other). To 995 g of minced meat add 5 ml of the BAD of the following composition (g/l): Lithium 0,005-2,00; Potassium 0,004-0,31; Magnesium 0,001-0,41; Iron 0,001-0,003; Zinc 0,001-0,24; Copper 0,001-0,30; Manganese 0,001-0,31; Nickel 0,001-0,10; Bor Of 0.001 To 0.04; Cobalt Of 0.001 To 0.04; Molybdenum 0,001-0,11; vanadium of 0.001 to 0.13; Fluorine: 0,001-0,10; Iodine 0.001 to 0.01; Nicotinamide 0,02-5,00; Nicotinic acid 0,005-0,01; Thiamine 0,004-4,0; Riboflavin Of 0.003 To 0.2; Calcium Pantothenate of 0.001 to 0.4; Pyridoxine Of 0.002 To 0.5; Ciankobalamin 0,001-0,005; Calcium pangamat 0,004 - 5,5; sodium Ascorbate 0,006-3,2; Tocopherol 0,003-0,03; Folic acid 0.005-0,03; Retinol Of 0.004 To 0.08; Ergocalciferol 0,001 - 0,02; Cholecalciferol 0,001-0,02; Fitomenadion 0,003-0,005; ATP acid 0,003-0,005; Glycine: 0,004-0,1; Glutamic acid 0.003 to 0.1; Mexidol of 0.001 to 0.2; Distilled water - up to 1000,0 ml.

Example 10. Feed for cattle, poultry and fish. To 994 g main feed formulas add the BAD of the following composition (g/l): Lithium 0,005-1,08; Potassium Of 0.004 To 0.21; Magnesium 0,001 - 0,41; Iron 0,001-1,10; Zinc 0,001-1,04; Copper 0,001-0,33; Manganese 0,001-0,31; Nickel 0,001-0,10; Bor Of 0.001 To 0.04; Cobalt 0,001-0,03; Molybdenum 0,001-0,10; vanadium 0,001-0,11; Fluorine 0,001-0,10; Iodine 0.001 to 0.01; Nicotinamide 0,02-5,00; Nicotinic acid 0,005-0,006; Thiamine 0,004-3,0; Riboflavin Of 0.003 To 0.2; Calcium Pantothenate 0,001-0,5; Pyridoxine Of 0.002 To 0.3; Ciankobalamin Of 0.001 To 0.04); Calcium pangamat 0,004-4,5; Ascorbate n is 01-0,02; Fitomenadion of 0.003 to 0.05; ATP acid 0,003-0,005; Glycine 0,004-0,1; Glutamic acid 0.003 to 0.1; Mexidol of 0.001 to 0.2; distilled Water - up to 1000,0 ml.

Example 11. Bakery products. To 999 test add 1 ml of the BAD of the following composition (g/l): Lithium 0,005-2,01; Potassium 0,004-0,38; Magnesium 0,001-0,51; Iron 0,001-2,10; Zinc 0,001-1,14; Copper 0,001-0,35; Manganese 0,001-0,31; Nickel Of 0.001 To 0.13; Bor 0,001-0,05; Cobalt Of 0.001 To 0.04; Molybdenum 0,001-0,10; vanadium of 0.001 to 0.13; Fluorine 0,001-0,10; Iodine 0.001 to 0.01; Nicotinamide 0,02-5,00; Nicotinic acid 0,005-0,006; Thiamine 0,004-4,0; Riboflavin Of 0.003 To 0.2; Calcium Pantothenate 0,001-0,5; Pyridoxine Of 0.002 To 0.5; Ciankobalamin 0,001-0,05; Calcium pangamat 0,004-5,5; sodium Ascorbate 0,006-3,2; Tocopherol 0,003-0,03; Folic acid 0.005-0,03; Retinol Of 0.004 To 0.08; Ergocalciferol 0,001-0,02; Cholecalciferol 0,001-0,02; Fitomenadion Of 0.003 To 0.05; ATP acid 0,003-0,005; Glycine 0,004-0,1; Glutamic acid 0.003 to 0.1; Mexidol of 0.001 to 0.2; Distilled water - up to 1000,0 ml.

Example 12. Food salt. To 998 g of salt add 2 ml of the BAD of the following composition (g/l): Lithium 0,005-2,08; Potassium 0,004-0,18; Magnesium 0,001-0,41; Iron 0,001-1,10; Zinc 0,001-1,14; Copper 0,001-0,31; Manganese 0,001-0,21; Nickel 0,001-0,03; Bor Of 0.001 To 0.04; Cobalt 0,001-0,03; Molybdenum 0,001-0,10; vanadium 0,001-0,03; Fluorine 0,001-0,10; Iodine 0.001 to 0.01; Nicotinamide 0,02-4,00; Nicotinic acid 0,005-0,01; Thiamine-5,0; Sodium ascorbate 0,006-2,2; Tocopherol: 0,003-0,02; Folic acid 0.005-0,03; Retinol Of 0.004 To 0.08; Ergocalciferol 0,001-0,02; Cholecalciferol 0,001-0,02; Fitomenadion Of 0.003 To 0.05; ATP acid 0,003-0,005; Glycine 0,004-0,1; Glutamic acid 0.003 to 0.1; Mexidol of 0.001 to 0.2; distilled Water - up to 1000,0 ml.

Example 13. Shampoos and Soaps. To 999,5 ml/g of shampoo or soap, add 0.5 ml of the BAD of the following composition (g/l): Lithium 0,005-2,08; Potassium 0,004-0,31; Magnesium 0,001-0,41; Iron 0,001-1,10; Zinc 0,001-0,24; Copper 0,001-0,35; Manganese 0,001-0,41; Nickel 0,001 - 0,10; Bor Of 0.001 To 0.04; Cobalt Of 0.001 To 0.04; Molybdenum 0,001-0,11; vanadium 0,001-0,11; Fluorine 0,001-0,09; Iodine 0.001 to 0.01; Nicotinamide 0,02-4,00; Nicotinic acid 0,005-0,01; Thiamine 0,004-3,5; Riboflavin 0,003-0,1; Calcium Pantothenate 0,001-0,3; Pyridoxine Of 0.002 To 0.4; Ciankobalamin Of 0.001 To 0.04); Calcium pangamat 0,004-3,5; sodium ascorbate 0,006-2,2; Tocopherol 0,003-0,03; Folic acid 0.005-0,03; Retinol Of 0.004 To 0.08; Ergocalciferol: 0,001-0,02; Cholecalciferol 0,001-0,02; Fitomenadion Of 0.003 To 0.05; ATP acid 0.003 to 0.004 percent; Glycine 0,004-0,1; Glutamic acid 0.003 to 0.1; Mexidol of 0.001 to 0.2; Distilled water - up to 1000,0 ml.

Example 14. Nourishing creams, perfume and lotions. To 999 ml basic recipe add 1 ml of the BAD of the following composition (g/l): Lithium 0,005-2,08; Potassium 0,004-0,31; Magnesium 0,001-0,31; Iron 0,001-1,09; Zinc 0,001-1,24; MD 0.001 to 0.01; Nicotinamide 0,02-4,50; Nicotinic acid 0,005-0,006; Thiamine 0,004-2,5; Riboflavin 0,003-0,1; Calcium Pantothenate of 0.001 to 0.4; Pyridoxine Of 0.002 To 0.2; Ciankobalamin Of 0.001 To 0.04); Calcium pangamat 0,004-3,5; sodium Ascorbate 0,006-1,2; Tocopherol 0,003-0,03; Folic acid 0,005-0,02; Retinol 0,004-0,07; Ergocalciferol 0.001 to 0.01; Cholecalciferol 0,001-0,02; Fitomenadion Of 0.003 To 0.05; ATP acid 0,003-0,005; Glycine 0,004-0,1; Glutamic acid 0,003-0,1; Mexidol 0,001-0,1; distilled Water - up to 1000,0 ml.

Example 15. Toothpastes and/or elixirs. To 998,5 g/ml toothpaste and/or elixir add 1.5 ml of BAD of the following composition (g/l): Lithium 0,005-2,08; Potassium 0,004-0,31; Magnesium 0,001-0,31; Iron 0.001 To 1.00; Zinc 0.001 To 1.00; Copper 0,001-0,23; Manganese 0,001-0,21; Nickel 0,001 - 0,10; Bor Of 0.001 To 0.04; Cobalt 0,001-0,03; Molybdenum 0,001-0,10; vanadium 0,001-0,11; Fluorine 0,001-0,10; Iodine 0.001 to 0.01; Nicotinamide 0,02-5,00; Nicotinic acid 0,005-0,006; Thiamine 0,004-3,0; Riboflavin 0,003-0,1; Calcium Pantothenate of 0.001 to 0.4; Pyridoxine Of 0.002 To 0.2; Ciankobalamin Of 0.001 To 0.04); Calcium pangamat 0,004-3,5; sodium Ascorbate 0,006-1,2; Tocopherol 0,003-0,03; Folic acid 0,005-0,02; Retinol 0,004-0,07; Ergocalciferol 0.001 to 0.01; Cholecalciferol 0,001-0,02; Fitomenadion Of 0.003 To 0.05; ATP acid 0,003-0,005; Glycine 0,004-0,1; Glutamic acid 0.003 to 0.1; Mexidol 0,001-0,1; Distilled water - up to 1000,0 ml.

Bor, cobalt, molybdenum, vanadium, fluoride, glycine, ascorbic acid and distilled water, characterized in that it further contains iodine, nicotinamide, nicotinic acid, thiamine, Riboflavin, calcium Pantothenate, pyridoxine, ciankobalamin, calcium pangamat, tocopherol, folic acid, retinol, ergocalciferol, cholecalciferol, fitomenadion, adenosine triphosphate, glutamic acid and Mexidol in the following ratio, wt.% (g/l):

Li - 0,005 - 2,08

Potassium - 0,004 - 0,38

Magnesium is 0.001 - 0,51

Iron - 0,001 - 2,10

Zinc - 0,001 - 1,24

Copper - 0,001 - 0,35

Magnenat - 0,001 - 0,41

Nickel is 0.001 to 0.13

Bor - 0,001 - 0,05

Cobalt is 0.001 - 0.04

Molybdenum - 0,001 - 0,11

Vanadium is 0.001 to 0.13

The fluorine - 0,001 - 0,10

Iodine - 0,001 - 0,01

Nicotinamide - 0,02 - 5,00

Nicotinic acid - 0,005 - 0,1

Thiamine - 0,004 - 4,0

Riboflavin - 0,003 - 0,2

Calcium Pantothenate - 0,001 - 0,5

Pyridoxine - 0,002 - 0,5

The ciankobalamin - 0,001 - 0,05

Calcium pangamat - 0,004 - 5,5

Sodium ascorbate - 0,006 - 3,2

Tocopherol - 0,003 - 0,03

Folic acid - 0,005 - 0,03

Retinol - 0,004 - 0,08

Ergocalciferol is 0.001 - 0.02

The cholecalciferol - 0,001 - 0,02

Fitomenadion is 0.003 to 0.05

Adenosinetriphosphatase - To 1000,0 ml

2. Biologically active additive under item 1, characterized in that when it is used for the production of hot non-alcoholic drinks it contains components in the following ratio, g/l: Li 0,005 - 2,00, potassium from 0.005 to 0.35, magnesium 0,001 - 0,5, iron 0,02 - 1,9, zinc 0,003 - 1,1, copper 0,02 - 0,3, manganese 0,015 - 0,35, Nickel 0,002 - 0,1, boron 0.003 to 0.03, cobalt 0,001 - 0,02, molybdenum 0,02 - 0,09, vanadium 0,03 - 0,1, fluorine 0,04 - 0,05, iodine 0,005 - 0,01, nicotinamide 0,03 - 4,00, nicotinic acid 0,006 - 0,5, thiamine 0,005 - 3,5, Riboflavin 0,003 - 0,1, calcium Pantothenate 0,002 - 0.4, pyridoxine of 0.003 - 0.45, and the ciankobalamin of 0.002 and 0.03, calcium pangamat of 0.005 to 5.0, sodium ascorbate 0,008 - 3.0, tocopherol of 0.004 to 0.02, folic acid 0,006 - 0,02, retinol 0,005 - 0,05, ergocalciferol 0,005 - 0,01, cholecalciferol of 0.003 to 0.01, fit-amination 0,005 - 0,05, ATP acid (ATP) of 0.004 to 0.04), glycine 0,006 - 0,05, glutamic acid 0,004 - 0,1, distilled water to 1000,0 ml.

3. Biologically active additive under item 1, characterized in that when it is used for the production of drinking table water it contains components in the following ratio g/l): lithium 0,005 - 2,08, potassium from 0.005 to 0.30, magnesium 0,001 - 0,51, iron 0,001 - 1,10, zinc 0,001 - 1,24; copper 0.001 to 0.25, the manganese of 0.001 - 0.31, Nickel 0,001 - 0,10, boron 0.001 to 0.05, the cobalt of 0.001 to 0.04), molybdenum 0,001 - 0,10, vanadium 0.001 to 0.10 is, the tion Pantothenate 0,001 - 0.4, pyridoxine of 0.002 to 0.3, ciankobalamin 0,001 - 0,005, calcium pangamat 0,004 - 1,5, sodium ascorbate 0,006 - 3.2, tocopherol of 0.003 to 0.01, folic acid 0,005 - 0,02, retinol 0,004 - 0,008, ergocalciferol 0,001 - 0,002, cholecalciferol 0,001 - 0,002, fit-amination 0,003 - 0,005, ATP acid 0,003 - 0,005, glycine 0,004 - 0,1, glutamic acid 0.003 to 0.1, Mexidol 0,001 - 0,02, distilled water to 1000,0 ml.

4. Biologically active additive under item 1, characterized in that when it is used for the production of tonic, refreshing and drinks it contains components in the following ratio, g/l: Li 0,006 - 1,8, potassium from 0.005 to 0.30, magnesium 0,001 - 0,41, iron 0,001 - 1,6, zinc is 0.001 - 1.0, copper 0,001 - to 0.30, manganese of 0.001 - 0.31, Nickel 0,001 - 0,10, boron 0.001 to 0.04; the cobalt 0,001 - 0,03, molybdenum 0,001 - 0,10, vanadium 0,001 - 0,10, fluorine 0,001 - 0,008, iodine 0.001 to 0.01, nicotinamide 0,02 - 5,00, nicotinic acid 0,005 - 0,01, thiamine 0,004 - 2,0, Riboflavin of 0.003 to 0.2, calcium Pantothenate 0,001 - 0,5, pyridoxine of 0.002 to 0.5, ciankobalamin 0,001 - 0,5, calcium pangamat of 0.004 to 0.5, sodium ascorbate 0,006 - 3.0, tocopherol of 0.003 and 0.03, folic acid 0.005 - 0.03, retinol 0,004 - 0,008, ergocalciferol 0.001 to 0.01, cholecalciferol 0.001 to 0.01, micromanaging of 0.003 to 0.05, ATP acid 0,003 - 0,005, glycine 0,004 - 0,09, glutamic acid 0,003 - 0,09, Mexidol of 0.001 to 0.2, the water polizovanii for the production of fruit and/or vegetable juices it contains components in the following ratio g/l): lithium 0,005 - 2,0, potassium 0,004 - 0,30, magnesium 0,001 - 0,50, iron 0,001 - 0,09, zinc 0,001 - 1,20, copper 0,001 - to 0.35, manganese 0,001 - 0,41, Nickel 0,001 - 0,10, boron 0.001 to 0.04; the cobalt 0,001 - 0,03, molybdenum 0,001 - 0,10, vanadium 0,001 - 0,10, fluorine 0,001 - 0,09, iodine 0.001 to 0.01, nicotinamide 0,02 - 5,00, nicotinic acid 0,005 - 0,01, thiamine 0,004 - 4,0, Riboflavin of 0.003 to 0.2, calcium Pantothenate 0,001 - 0,5, pyridoxine of 0.002 to 0.5, the ciankobalamin 0,001 - 0,05, calcium pangamat 0,004 - 5,5, sodium ascorbate 0,006 - 3.2, tocopherol of 0.003 and 0.03, folic acid 0.005 - 0.03, retinol 0,004 - 0,008, ergocalciferol 0.001 to 0.01, cholecalciferol 0.001 to 0.01, fitomenadion of 0.003 to 0.05, ATP acid 0.003 to 0.05, the glycine 0,004 - 0,07, glutamic acid 0.003 to 0.1, Mexidol of 0.001 to 0.2, distilled water to 1000,0 ml.

6. Biologically active additive under item 1, characterized in that when it is used for production of milk (fresh, condensed, and others) it contains components in the following ratio, g/l: Li 0,005 - 1,90, potassium 0,004 - 0,30, magnesium 0,001 - 0,50, iron 0,001 - 2,10, zinc of 0.001 to 0.04, copper 0,001 - to 0.30, manganese 0,001 - 0,41, Nickel of 0.001 to 0.13, boron 0.001 to 0.04; the cobalt 0,001 - 0,03, molybdenum 0,001 - 0,11, vanadium 0,001 - 0,10, fluorine 0,001 - 0,10, iodine 0.001 to 0.01, nicotinamide 0,02 - 5,00, nicotinic acid 0,005 - 0,006, thiamine 0,004 - 4,0, Riboflavin of 0.003 to 0.2, calcium Pantothenate 0.001 to 0.45, and pyridoxine 0,002 - 0,45, ciankobalamin 0,001 - 0,05, calcium p is Erol 0,001 - 0,02, cholecalciferol 0,001 - 0,02, fitomenadion of 0.003 to 0.05, ATP acid 0.003 to 0.05, the glycine of 0.004 - 0.1, the glutamic acid of 0.003 to 0.01, Mexidol of 0.001 to 0.2, distilled water to 1000,0 ml.

7 dietary Supplement under item 1, characterized in that when it is used for production of dairy products (cottage cheese, sour cream, yogurt, infant formula, ice cream and other) it contains components in the following ratio, g/l: Li 0,005 - 2,08, potassium 0,004 - 0,30, magnesium 0,001 - 0,50, iron 0,001 - 2,00, zinc 0,001 - 1,04, copper 0,001 - to 0.35, manganese of 0.001 - 0.31, Nickel 0,001 - 0,10, boron 0.001 to 0.05, the cobalt 0,001 - 0,03, molybdenum 0,001 - 0,10, vanadium 0,001 - 0,10, fluorine 0,001 - 0,10, iodine 0.001 to 0.01, nicotinamide 0,02 - 5,00, nicotinic acid 0,005 - 0,01, thiamine 0,004 - 4,0, Riboflavin of 0.003 to 0.2, calcium Pantothenate 0,001 - 0,5, pyridoxine of 0.002 to 0.4, ciankobalamin 0,001 - 0,05, calcium pangamat 0,004 - 5,0, sodium ascorbate 0,006 - 3.0, tocopherol of 0.003 and 0.03, folic acid 0.005 - 0,009, retinol of 0.004 to 0.08, ergocalciferol 0,001 - 0,02, cholecalciferol 0,001 - 0,02, fitomenadion of 0.003 to 0.05, ATP acid 0,003 - 0,005, glycine 0,004 - 0,1, glutamic acid of 0.003 to 0.01, Mexidol of 0.001 to 0.2, distilled water to 1000,0 ml.

8. Biologically active additive under item 1, characterized in that when it is used for the production of p, is elesa 0,001 - 2,00, zinc 0,001 - 1,24, copper 0,001 - to 0.30, manganese 0,001 - to 0.40, Nickel of 0.001 to 0.13, boron 0.001 to 0.05, the cobalt of 0.001 to 0.04), molybdenum 0,001 - 0,10, vanadium of 0.001 to 0.13, fluorine 0,001 - 0,10, iodine 0.001 to 0.01, nicotinamide 0,02 - 4,00, nicotinic acid 0,005 - 0,01, thiamine 0,004 - 3.0, Riboflavin of 0.003 to 0.2, calcium Pantothenate 0,001 - 0.4, pyridoxine of 0.002 to 0.4, ciankobalamin 0,001 - 0,005, calcium pangamat 0,004 - 5,0, sodium ascorbate 0,006 - 1,2, tocopherol of 0.003 to 0.02, folic acid 0.005 - 0.03, retinol of 0.004 to 0.08, ergocalciferol 0,001 - 0,02, cholecalciferol 0,001 - 0,02, fitomenadion of 0.003 to 0.04), ATP acid 0,003 - 0,005, glycine 0,004 - 0,1, glutamic acid 0.003 to 0.1, Mexidol of 0.001 to 0.2, distilled water to 1000,0 ml.

9. Biologically active additive under item 1, characterized in that when used for the production of wine-vodka products it contains components in the following ratio, g/l: Li 0,005 - 2,00, potassium 0,004 - 0,33, magnesium 0,001 - 0,41, iron 0,001 - 1,10, zinc 0,001 - 1,14, copper 0,001 - to 0.30, manganese of 0.001 - 0.31, Nickel 0,001 - 0,10, boron 0.001 to 0.05, the cobalt of 0.001 to 0.04), molybdenum 0,001 - 0,11, vanadium 0,001 - 0,10, fluorine 0,001 - 0,10, iodine 0.001 to 0.01, nicotinamide 0,02 - 4,00, nicotinic acid 0,005 - 0,01, thiamine 0,004 - 4,0, Riboflavin of 0.003 to 0.2, calcium Pantothenate 0,001 - 0,5, pyridoxine of 0.002 to 0.5, ciankobalamin 0,001 - 0,005, calcium pangamat 0,004 - 5,5, sodium ascorbate 0,006 - 3.2, tokovinin of 0.003 - 0,05, ATP acid 0.003 to 0.05, the glycine of 0.004 - 0.1, the glutamic acid of 0.003 - 0.1, Mexidol of 0.001 to 0.2, distilled water to 1000,0 ml.

10. Biologically active additive under item 1, characterized in that when it is used for minced meat (sausages, frankfurters, sausages, dumplings and other) it contains components in the following ratio, g/l: Li 0,005 - 2,00, potassium of 0.004 - 0.31, magnesium 0,001 - 0,41, iron 0,001 - 0,003, zinc 0,001 - 0,24, copper 0,001 - to 0.30, manganese of 0.001 - 0.31, Nickel 0,001 - 0,10, boron 0.001 to 0.04; the cobalt of 0.001 to 0.04), molybdenum 0,001 - 0,11, vanadium of 0.001 to 0.13, fluorine 0,001 - 0,10, iodine 0.001 to 0.01, nicotinamide 0,02 - 5,00, nicotinic acid 0,005 - 0,01, thiamine 0,004 - 4,0, Riboflavin of 0.003 to 0.2, calcium Pantothenate 0,001 - 0.4, pyridoxine of 0.002 to 0.5, ciankobalamin 0,001 - 0,005, calcium pangamat 0,004 - 5,5, sodium ascorbate 0,006 - 3.2, tocopherol of 0.003 and 0.03, folic acid 0.005 - 0.03, retinol of 0.004 to 0.08, ergocalciferol 0,001 - 0,02, cholecalciferol 0,001 - 0,02, fitomenadion 0,003 - 0,005, ATP acid 0,003 - 0,005, glycine 0,004 - 0,1, glutamic acid 0.003 to 0.1, Mexidol of 0.001 to 0.2, distilled water to 1000,0 ml.

11. Biologically active additive under item 1, characterized in that when it is used to produce feed for livestock, poultry and fish it contains components in the following ratio, g/l: Li 0, is 0.001 to 0,04, cobalt 0,001 - 0,03, molybdenum 0,001 - 0,10, vanadium 0,001 - 0,11, fluorine 0,001 - 0,10, iodine 0.001 to 0.01, nicotinamide 0,02 - 5,00, nicotinic acid 0,005 - 0,006, thiamine 0,004 - 3.0, Riboflavin of 0.003 to 0.2, calcium Pantothenate 0,001 - 0,5, pyridoxine of 0.002 to 0.3, ciankobalamin of 0.001 to 0.04), calcium pangamat 0,004 - 4,5, sodium ascorbate 0,006 - 1,2, tocopherol of 0.003 and 0.03, folic acid 0,005 - 0,02, retinol 0,004 - 0,07, ergocalciferol 0.001 to 0.01, cholecalciferol 0,001 - 0,02, fitomenadion of 0.003 to 0.05, ATP acid 0,003 - 0,005, glycine 0,004 - 0,1, glutamic acid 0.003 to 0.1, Mexidol of 0.001 to 0.2, distilled water to 1000,0 ml.

12. Biologically active additive under item 1, characterized in that when it is used for the production of bakery products it contains components in the following ratio, g/l: Li 0,005 - 2,01, potassium 0,004 - 0,38, magnesium 0,001 - 0,51, iron 0,001 - 2,10, zinc 0,001 - 1,14, copper 0,001 - to 0.35, manganese of 0.001 - 0.31, Nickel of 0.001 to 0.13, boron 0.001 to 0.05, the cobalt of 0.001 to 0.04), molybdenum 0,001 - 0,10, vanadium of 0.001 to 0.13, fluorine 0,001 - 0,10, iodine 0.001 to 0.01, nicotinamide 0,02 - 5,00, nicotinic acid 0,005 - 0,006, thiamine 0,004 - 4,0, Riboflavin of 0.003 to 0.2, calcium Pantothenate 0,001 - 0,5, pyridoxine of 0.002 to 0.5, ciankobalamin 0,001 - 0,05, calcium pangamat 0,004 - 5,5, sodium ascorbate 0,006 - 3.2, tocopherol of 0.003 and 0.03, folic acid 0.005 - 0.03, retinol of 0.004 to 0.08, ergocalciferol 0,001 - 0,02, the traveler acid 0.003 to 0,1, Mexidol of 0.001 to 0.2, distilled water to 1000,0 ml.

13. Biologically active additive under item 1, characterized in that when it is used for production of food of salt it contains components in the following ratio, g/l: Li 0,005 - 2,08, potassium 0,00 - 0,18, magnesium 0,001 - 0,41, iron 0,001 - 1,10, zinc 0,001 - 1,14, copper of 0.001 - 0.31, manganese 0,001 - 0,21, Nickel 0,001 - 0,03, boron 0.001 to 0.04; the cobalt 0,001 - 0,03, molybdenum 0,001 - 0,10, vanadium 0,001 - 0,03, fluorine 0,001 - 0,10, iodine 0.001 to 0.01, nicotinamide 0,02 - 4,00, nicotinic acid 0,005 - 0,01, thiamine 0,004 - 4,0, Riboflavin 0,003 - 0,1, calcium Pantothenate of 0.001 to 0.4, pyridoxine of 0.002 to 0.4, ciankobalamin 0,001 - 0,004, calcium pangamat 0,004 - 5,0, sodium ascorbate 0,006 - 2,2, tocopherol of 0.003 to 0.02, folic acid 0.005 - 0.03, retinol of 0.004 to 0.08, ergocalciferol 0,001 - 0,02, cholecalciferol 0,001 - 0,02, fitomenadion of 0.003 to 0.05, ATP acid 0,003 - 0,005, glycine 0,004 - 0,1, glutamic acid 0.003 to 0.1, the Mexidol of 0.001 to 0.2, distilled water to 1000,0 ml.

14. Biologically active additive under item 1, characterized in that when it is used for the production of shampoos and Soaps it contains components in the following ratio, g/l: Li 0,005 - 2,08, potassium of 0.004 - 0.31, magnesium 0,001 - 0,41, iron 0,001 - 1,10, zinc 0,001 - 0,24, copper 0,001 - to 0.35, manganese 0,001 - 0,41, Nickel 0,001 - 0,10, boron 0.001 to 0,0 is the lot of 0.005 - 0,01, thiamine 0,004 - 3,5, Riboflavin 0,003 - 0,1, calcium Pantothenate 0,001 - 0,3, pyridoxine of 0.002 to 0.4, ciankobalamin of 0.001 to 0.04), calcium pangamat 0,004 - 3,5, sodium ascorbate 0,006 - 2,2, tocopherol of 0.003 and 0.03, folic acid 0.005 - 0.03, retinol of 0.004 to 0.08, ergocalciferol 0,001 - 0,02, cholecalciferol 0,001 - 0,02, fitomenadion of 0.003 to 0.05, ATP acid 0.003 to 0.004 percent, glycine 0,004 - 0,1, glutamic acid 0.003 to 0.1, Mexidol of 0.001 to 0.2, distilled water until 1000,0 ml.

15. Biologically active additive under item 1, characterized in that when it is used for the production of nourishing creams, toilet water, lotion, it contains components in the following ratio, g/l: Li 0,005 - 2,08, potassium of 0.004 - 0.31, magnesium 0,001 - 0.31, iron 0,001 - 1,09, zinc 0,001 - 1,24, copper 0,001 - to 0.30, manganese 0,001 - 0,30, Nickel of 0.001 to 0.15, boron 0.001 to 0.04; the cobalt 0,001 - 0,03, molybdenum 0,001 - 0,09, vanadium 0,001 - 0,10, fluorine 0,001 - 0,09, iodine 0.001 to 0.01, nicotinamide 0,02 - 4,50, nicotinic acid 0,005 - 0,006, thiamine 0,004 - 2,5, Riboflavin 0,003 - 0,1, calcium Pantothenate of 0.001 to 0.4, pyridoxine of 0.002 to 0.2, ciankobalamin of 0.001 to 0.04), calcium pangamat 0,004 - 3,5, sodium ascorbate 0,006 - 1,2, tocopherol of 0.003 and 0.03, folic acid 0,005 - 0,02, retinol 0,004 - 0,07, ergocalciferol 0.001 to 0.01, cholecalciferol 0,001 - 0,02, fitomenadion of 0.003 to 0.05, ATP acid 0,003 - 0,005, glycine 0,004 - 0,1, guna additive under item 1, characterized in that when it is used for the production of toothpastes and/or elixirs it contains components in the following ratio, g/l: Li 0,005 - 2,08, potassium of 0.004 - 0.31, magnesium 0,001 - 0.31, iron of 0.001 to 1.00, zinc of 0.001 to 1.00, copper 0,001 - 0,23, manganese 0,001 - 0,21, Nickel 0,001 - 0,10, boron 0.001 to 0.04; the cobalt 0,001 - 0,03, molybdenum 0,001 - 0,10, vanadium 0,001 - 0,11, fluorine 0,001 - 0,10, iodine 0.001 to 0.01, nicotinamide 0,02 - 5,00, nicotinic acid 0,005 - 0,006, thiamine 0,004 - 3.0, Riboflavin 0,003 - 0,1, calcium Pantothenate of 0.001 to 0.4, pyridoxine of 0.002 to 0.2, ciankobalamin of 0.001 to 0.04), calcium pangamat 0,004 - 3,5, sodium ascorbate 0,006 - 1,2, tocopherol of 0.003 and 0.03, folic acid 0,005 - 0,02, retinol 0,004 - 0,07, ergocalciferol 0.001 to 0.01, cholecalciferol 0,001 - 0,02, fitomenadion of 0.003 to 0.05, ATP acid 0,003 - 0,005, ATP acid 0,003 - 0,005, glycine 0,004 - 0,1, glutamic acid of 0.003 - 0.1, Mexidol 0,001 - 0,1, distilled water to 1000,0 ml.

 

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< / BR>
in which X represents a hydrogen atom or halogen, (C1-C3)alkyl group, one or two (C1-C3)alkoxy group, or triptorelin group, Y is a hydrogen atom or halogen, (C1-C3)alkyl or (C1-C3)alkoxygroup, R represents a hydroxy group, a methoxy group, or a group of the General formula NR2R3in which R2and R3each independently represents a hydrogen atom, (C1-C4)alkyl group, 2-methoxyaniline group, 3-methoxyaniline group, 3-aminopropyl group, group 2-(dimethylamino)ethyl group, 3-(dimethylamino)propyl or 2-piperidine-2-retil, or R2and R3form together with the nitrogen atom to which they are connected, morpholine, pyrolidine or pieperazinove ring which may have in position 4 Deputy in the form of a methyl group or groups (1,1-dimethylmethoxy)carbonyl, in the form of free bases or salts formed by the addition of acid

The invention relates to compounds of General formula I

< / BR>
in which X represents a hydrogen atom or halogen, (C1-C3)alkyl group, one or two (C1-C3)alkoxy group, or triptorelin group, Y is a hydrogen atom or halogen, (C1-C3)alkyl or (C1-C3)alkoxygroup, R represents a hydroxy group, a methoxy group, or a group of the General formula NR2R3in which R2and R3each independently represents a hydrogen atom, (C1-C4)alkyl group, 2-methoxyaniline group, 3-methoxyaniline group, 3-aminopropyl group, group 2-(dimethylamino)ethyl group, 3-(dimethylamino)propyl or 2-piperidine-2-retil, or R2and R3form together with the nitrogen atom to which they are connected, morpholine, pyrolidine or pieperazinove ring which may have in position 4 Deputy in the form of a methyl group or groups (1,1-dimethylmethoxy)carbonyl, in the form of free bases or salts formed by the addition of acid

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< / BR>
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