A method of treatment of disorders of the central nervous system

 

(57) Abstract:

The invention relates to medicine and can be used for the treatment of neuroses and neurosis-like disorders. In the treatment of neurotic States with vascular symptoms in patients produce xenotransplantation donor embryonic brain tissue. While using cloth septum laboratory mammal in the amount of 15 - 25 mg, which is distant implanted under the skin in the area of 5th - 6th intercostal space. The method allows to increase the effectiveness of the treatment.

The invention relates to medicine, namely to xenoplanets embryonic brain tissue, and can be used for the treatment of neuroses and neurosis-like disorders.

There is a method of treatment of disorders of the Central nervous system by the implant recipient donor embryonic brain tissue (see Bystrong I. P. , Tellin Century A. Structural basis of correction of the disturbed functions marrow transplantation disallowance embryonic nervous tissue. Physiological journal. Sechenov, I. 81, No. 4, 1995, S. 91 - 94). This method is characterized by sufficient complexity that limits its functional in edenia is a method of treatment of disorders of the Central nervous system by xenotransplantation recipient donor embryonic brain tissue (see Saveliev, S. C., Lebedev Century. Century. and other Transplantation distal and xenogeneic neural tissue in Parkinson's disease, the journal "Bulletin of experimental biology and medicine. M.: Nauka, 1994, No. 4, S. 369 - 371). To restore the patient's brain using a mix of human fetal and xenogenic tissue that gives the most significant results in the treatment of parkinsonism, but in other cases, such a combination may not be effective.

The invention is directed to the creation of simple to implement, effective treatment of disorders of the Central nervous system of patients with neuroses and neurosis-like disorders, by implantation of embryonic brain tissue, excluding the manifestation of undesirable side effects.

The solution of this problem is provided by the fact that in the method of treatment of disorders of the Central nervous system by xenotransplantation recipient donor embryonic brain tissue, according to the invention in the treatment of neurotic States with vascular dystonia for implantation using cloth septum laboratory mammal in the amount of 15-25 mg that distant implanted under the skin in the area of 5-6 intercostal space.

The choice is of transplantati embryonic brain laboratory mammals enables activation of the process of General and selective adaptation and compensation of the deficit of endogenous biological regulators. While subcutaneous xenoplanets, the effect of which on the brain occurs due to the rising peripheral afferention and the possibility of passing directly produced substances in the hypothalamus, easy to implement, avoids side effects and complications in the brain (overgrowth of the graft, scarring, and so on).

In addition, the transplant when implementing the inventive method the native version can be used within 6 hours (from donor to recipient) after the extraction of the fetal brain laboratory mammal that does not require special conditions of handling and storage. It must be emphasized that when distant xenoplanets, according to the invention, eliminates the threat of genetic modifications, transfer of especially dangerous infections (AIDS, viral hepatit and so on).

The claimed method provides the most significant results in the treatment of neurosis and is implemented as follows.

Example 1. Patient X-a, 35 years of age, was treated with a diagnosis of hysterical neurosis with vascular paroxysms. Upon admission to the hospital complained of headaches, shortness of breath, numbness of the tongue, tearfulness, razdrajayut: groomed, friendly, easily comes into contact, speaking quickly, very worried, the complaint sets forth brightly. Emphasizes the feeling of hopelessness, however, easily switched to other topics, is keen to talk about sophistication to your tastes, saddened by loss of life status, optimism. Wosaam, believes in the healing.

In neurological and somatic status changes it is not revealed. Clinical analysis of urine, blood, etc. within normal limits.

In the psychological examination using techniques SAN, personal and reactive anxiety by Spielberg revealed a high level of reactive (49 points) and personal (53 points) anxiety, and the results of the SAN objectively confirmed the subjective complaints of the patient. Data EEG also showed high levels of anxiety (diffuse-spindle with the passage in the frontal sections interspersed with areas desynchronizing activity "fragments" -spindles). Data REG were characteristic of dystonia mixed venous dystonia, high functional lability of vascular reactivity. Blood pressure: systolic - 125 - 140, diastolic - 65 - 90 mm RT.article.

Installed nariida distant xenoplanets. Surgery proceeded as follows: in region 5 - 6th intercostal space of the patient under local anesthesia in the conditions of asepsis made the cut length of 1 cm, topfarm formed pocket (the tunnel), which is subcutaneously implanted 20 mg embryonic septum laboratory mammal, then put 1 stitch that secures the wound edges, then put a sterile cloth with Creole at the edges. After 7 days was off the seam.

In 6 days according to the patient came "the state of comfort", "gone the need for additional treatment." Objectively: the patient became calm, Santanna, decreased blood pressure on the 12 mm RT.art., diastolic 5 mm RT.article compared to the background (140/90 mm RT.article). Marked improvement in mental status, smooth background mood, less pronounced autonomic seizures. After 30 days in the outpatient setting resulted in a second distant xenoplanets embryonic septum with the aforementioned method.

The psychosomatic condition of the patient improved significantly, normalized sleep, affective sphere, became less pronounced autonomic seizures, stabilized blood pressure, strengthened faith in in the th status: smooth background mood, normalization of sleep, stabilized blood pressure, are rare, erased, abortifacient autonomic seizures; disappeared complaints of abdominal pain, headaches, numbness of the tongue; it was noted persistent improvement of health, increased purposeful activity, the desire to get to work and return to the family. Objectively: the patient was outgoing, friendly, noted emotional balance, disappeared crying. This was combined with the improved performance SAN, personal (49 points) and reactive (47 points) anxiety. In the electrical activity of the brain was noted sync-rhythm in the rear and a regular rhythm in the frontal departments. Indicators REG showed improvement of the blood and improving venous outflow. Blood pressure ranged: systolic - 115 - 120, diastolic - 80 - 85 mm RT.article Objectively, the patient was in a state of recovery.

A method of treatment of disorders of the Central nervous system by xenotransplantation recipient donor embryonic brain tissue, characterized in that in the treatment of neurotic States, with vascular symptoms for implantation using cloth septum is rd.

 

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