(57) Abstract:The invention relates to medicine, namely to devices for functional diagnostics, and can be used for studies of Central and peripheral blood circulation. The technical result is to increase the accuracy of diagnosis. The device comprises a generator of sinusoidal current, the current electrodes a lowpass filter and two channels, each of which includes two potentiometric electrode and cascaded amplifier high frequency, detector and amplifier peoplesmart. In each of the channels introduced the device of the sample-hold circuit comparison and analog myCitadel, and the amplifier output peoplesmart connected to one input of the analog vicites and to a storage input of the sample-hold, the output of which is connected to the input of the low pass filter and a comparison circuit connected with the control input of the sample-and-hold. 1 Il. The invention relates to medicine, namely to devices for functional diagnostics, and can be used for studies of Central and peripheral blood circulation.The closest In for blood flow studies by tetrapolar impedance measurement method . The device comprises a generator of sinusoidal current with frequency of 40 kHz, the current from which is fed to the sensed area of the body via the current electrodes, common to both channels. Measurement of impedances are two identical channels, each of which contains two potentiometric electrode and cascaded amplifier of high frequency, linear detector, amplifier peoplesmart, passive high-pass filter, which represents a differentiating RC-circuit to filter the DC component of the signal, and an active lowpass filter, which is the output of "REO".The principal disadvantage of this device are made by the high-pass filter distortion is manifested in the change in the shape (morphology) curve rogramme and, accordingly, the low accuracy of the measurement of its amplitude characteristics that reduce the quality of diagnostics. Increasing the filter time constant T - RC to a value of 3 seconds reduces insertion errors, but delays the setting time curve rogramme about "zero", isoelectric level up to 12-15 seconds, which makes it almost impossible to work with the device. Reduction of the time constant less than 2-3 seconds reduces torenia two contradictory conditions: undistorted transmission possibly the lowest frequencies and the rapid establishment of a curve rogramme about isoelectric level.The technical result of the invention is to improve the measurement accuracy and, accordingly, the quality of diagnosis due to the fact that rogramme has no distortion starting with almost zero frequency and the time of its establishment near the zero level is hundredths of seconds.The technical result is achieved due to the fact that the device comprises a generator of sinusoidal current, which is loaded on the current electrodes common to the two channels, each of which includes two potentiometric electrode and cascaded amplifier of high frequency, linear detector, amplifier peoplesmart, and active lowpass filter, which is the output of "REO". The new device is that in each of the channels in series with the amplifier peoplesmart instead of the high-pass filter introduced the device of the sample-hold circuit comparison and analog myCitadel, and the amplifier output peoplesmart connected to one input of the analog vicites and to a storage input of the sample - hold, the output of which is submitted to another input of the analog myCitadel, the output of which is connected to the input of the lowpass filter and the comparison circuit, the second circuit device.It comprises a generator 1 sinusoidal high frequency voltage, the output of which is connected to the pair of electrodes 2, called current. The other two pairs of electrodes 3, called potentiometric connected to the inputs of two channels, each of which contains cascaded amplifiers 4 high frequency detectors 5 and the amplifier 6 plethysmogram, the outputs of which are connected sample - hold 7, the comparison circuit 8 and the analog myCitadel 9, the outputs of which are connected to filters 10 of the lower frequencies, which is the output terminal for curve rogramme (outputs "REO").The device operates as follows.The patient superimposed electrodes 2 and 3 by the method of tetrapolar rheography. When applying the excitation current generated by the generator 1, by volume conductor, which is formed by the body of the patient, the potentiometric electrodes 3 creates a potential difference proportional to the total electrical resistance (impedance) volume conduction. Amplifiers 4 high frequency each of the channels amplify the voltage drop, and the output of the detectors 5 appears a voltage proportional to the base impedances of the respective areas of teoi pulse wave of blood and respiratory wave of the patient. The voltage outputs of the amplifiers 6 plethysmogram remembered devices sample-hold 7 and "shift" level output voltage analog vychitala 9, which allows to maintain the voltage at the input filter 10 of the lower frequencies in the linear area. In the care of these stresses beyond linear zones, fire of the comparison circuit 8, in a device of the sample-hold 7 writes the new value of the shear stress and curve rogramme returns to the center line zone on isoelectric level. Thus, when the lower frequency bandwidth is practically zero, there is an automatic compensation of the DC component of the input signal, and the settling time curve rogramme about isoelectric value is 10-15 milliseconds.During medical tests peoplesmart, confirmed the absence of frequency and phase distortion rogramme starting with frequencies of the order of thousandths Hz when the speed setting curve rogramme in the linear zone of the recording device within hundredths of a second, resulting in increased accuracy of measurements became possible undistorted registration of changes of blood flow cent. M. I. Gurevich and other Impedance realtystore. Kyiv. Naukova Dumka, 1982, S. 103, Fig. 59. Peoplesmart comprising a generator of sinusoidal high frequency voltage, the output of which is connected to the pair of current electrodes, a lowpass filter and two channels, each of which has two input terminals connected to respective pairs of potentiometric electrodes, and connected in series amplifier high frequency, detector, and amplifier peoplesmart, characterized in that each of the channels introduced the device of the sample-hold circuit comparison and analog myCitadel, and the amplifier output peoplesmart connected to one input of the analog vicites and entrance to a storage device of the sample-hold the output of which is connected with another input of the analog myCitadel, the output of which is connected to the input of the lowpass filter and the comparison circuit, also connected with the control input of the sample-and-hold.
SUBSTANCE: method involves recording rheogram from feet and legs lifted and fixed at an angle of 45є. Then, rheogram is recorded on inhaling from legs directed vertically downward. Functional blood circulation reserve index is calculated as product of results of dividing and subtracting rheographic indices recorded under conditions of lifted and lowered extremities that means under conditions of functional venous system relief and venous hypertension, respectively.
EFFECT: enhanced effectiveness in recognizing patient group suffering from severe lower extremities ischemia.
FIELD: medicine; medical engineering.
SUBSTANCE: method involves doing multi-channel recording of electroencephalogram and carrying out functional tests. Recording and storing rheoencephalograms is carried out additionally with multi-channel recording of electroencephalogram synchronously and in real time mode in carotid and vertebral arteries. Electroencephalograms and rheoencephalograms are visualized in single window with single time axis. Functional brain state is evaluated from synchronous changes of electroencephalograms, rheoencephalograms and electrocardiograms in response to functional test. The device has electrode unit 1 for recording bioelectric brain activity signals, electrode unit 2 for recording electric cardiac activity signals, current and potential electrode unit 3 for recording rheosignals, leads commutator 4, current rheosignal oscillator 5, synchronous rheosignal detector 6, multi-channel bioelectric brain activity signals amplifier 7, electrophysiological signal amplifier 8, demultiplexer 9, multi-channel rheosignal amplifier 10, multi-channel analog-to-digital converter 11, micro-computer 12 having galvanically isolated input/output port and personal computer 13 of standard configuration.
EFFECT: enhanced effectiveness of differential diagnosis-making.
11 cl, 6 dwg
FIELD: medicine; medical engineering.
SUBSTANCE: method involves irradiating blood-carrying tissue area under control with luminous flow, receiving scattered luminous flow modulated with blood filling changes in blood vessels and capillaries of blood-carrying tissue and forming electric signal of pulse wave. Deviation signal of light-emitting and light-receiving transducers of optoelectronic converter relative to blood-carrying tissue area under control based on difference between the current and preceding values of impedance signal on the area under control. The signal being observed, prohibition signal is produced on pulse wave electric signal passage for excluding errors caused by motion artifacts from its following processing. The device has optoelectronic converter having light-emitting and light-receiving transducers and unit for producing pulse wave signal, which input is connected to light-receiving transducer output. Unit for forming deviation signal has two measuring electrodes connected to separate comparator inputs which output being deviation signal former output, is connected to control input of key. Information input of the key is connected to pulse wave signal former output.
EFFECT: improved noise immunity.
3 cl, 3 dwg
FIELD: medicine; medical engineering.
SUBSTANCE: method involves recording multichannel electroencephalogram, electrocardiogram record and carrying out functional test and computer analysis of electrophysiological signals synchronously with multichannel record of electroencephalogram and electrocardiogram in real time mode. Superslow brain activity is recorded, carotid and spinal artery pools rheoelectroencephalogram is recorded and photopletysmogram of fingers and/or toes is built and subelectrode resistance of electrodes for recording bioelectrical cerebral activity is measured. Physiological values of bioelectrical cerebral activity are calculated and visualized in integrated cardiac cycle time scale as absolute and relative values of alpha-activity, pathological slow wave activity in delta and theta wave bandwidth. Cerebral metabolism activity dynamics level values are calculated and visualized at constant potential level. Heart beat rate is determined from electrocardiogram, pulsating blood-filling of cerebral blood vessels are determined from rheological indices data. Peripheral blood vessel resistance level, peripheral blood vessel tonus are determined as peripheral photoplethysmogram pulsation amplitude, large blood vessel tonus is determined from pulse wave propagation time data beginning from Q-tooth signal of electrocardiogram to the beginning of systolic wave of peripheral photoplethysmogram. Postcapillary venular blood vessels tonus is determined from constant photoplethysmogram component. Functional brain state is determined from dynamic changes of physiological values before during and after the functional test. Device for evaluating functional brain state has in series connected multichannel analog-to-digital converter, microcomputer having galvanically isolated input/output ports and PC of standard configuration and electrode unit for reading bioelectric cerebral activity signals connected to multichannel bioelectric cerebral activity signals amplifier. Current and potential electrode unit for recording rheosignals, multichannel rheosignals amplifier, current rheosignals generator and synchronous rheosignals detector are available. The device additionally has two-frequency high precision current generator, master input of which is connected to microcomputer. The first output group is connected to working electrodes and the second one is connected to reference electrodes of electrode unit for reading bioelectrical cerebral activity signals. Lead switch is available with its first input group being connected to potential electrodes of current and potential electrodes unit for recording rheosignals. The second group of inputs is connected to outputs of current rheosignals oscillator. The first group of outputs is connected to current electrodes of current and potential electrodes unit for recording rheosignals. The second group of outputs is connected to inputs of synchronous detector of rheosignals. Demultiplexer input is connected to output of synchronous detector of rheosignals and its outputs are connected to multichannel rheosignals amplifier inputs. Outputs of multichannel bioelectrical cerebral activity signals amplifier, multichannel rheosignals amplifier and electrophysiological signal amplifier are connected to corresponding inputs of multichannel analog-to-digital converter. Microcomputer outputs are connected to control input of lead switch, control input of multichannel demultiplexer, control input of multichannel analog-to-digital converter and synchronization inputs of current rheosignals oscillator and synchronous detector of rheosignals. To measure subelectrode resistance, a signal from narrow bandwidth current generator of frequency f1 exceeding the upper frequency fup of signals under recording is supplied. A signal from narrow bandwidth current generator of frequency f2≠ f1>fup is supplied to reference electrode. Voltages are selected and measured at output of each amplifier with frequencies of f1, f2 - Uf1 and Uf2 using narrow bandwidth filtering. Subelectrode resistance of each working electrode is determined from formula Zj=Ujf1 :(Jf1xKj), where Zj is the subelectrode resistance of j-th electrode, Ujf1 is the voltage at output from j-th amplifier with frequency of f1, Kj is the amplification coefficient of the j-th amplifier. Subelectrode resistance of reference electrode is determined from formula ZA=Ujf2 :(Jf2xKj), where ZA is the subelectrode resistance of reference electrode, Ujf2 is the voltage at output from j-th amplifier with frequency of f2, Jf2 is the voltage of narrow bandwidth current oscillator with frequency of f2.
EFFECT: wide range of functional applications.
15 cl, 10 dwg
FIELD: medicine, surgery.
SUBSTANCE: one should evaluate clinical state of a patient and as objective parameters one should calculate rheological and brachio-malleolar indices, detect fractional tension of oxygen in capillary blood. At observing clinical improvement accompanied by increased rheological and brachio-malleolar indices by more than 0.1, increased blood saturation with oxygen by more than 10 mm mercury column one should state upon a "good" therapeutic effect. At detecting clinical improvement accompanied by the increase of either one or several objective parameters, or if dynamics of these values is not available - effect should be considered as a "satisfactory" one. At kept ischemic pain at rest without decrease of its intensity, impossibility to keep a limb in horizontal position for a long period of time, the absence of positive dynamics of trophic disorders, at kept ischemic edema and at no alterations in objective parameters - should be determined as "no dynamics". In case of enhanced ischemic pain and edema of foot, at progressing necrotic alterations in foot - one should detect "deterioration" of patient's state. The method increases the number of diagnostic means.
EFFECT: higher accuracy of evaluation.
1 ex, 1 tbl
SUBSTANCE: method involves recording peripheral differential upper extremity blood vessel rheogram and phonocardiogram in synchronous way. The second phonocardiogram beginning and the deepest rheogram points are detected. Pulse way propagation time reduction being found, arterial bloodstream tone growth conclusions are drawn.
EFFECT: high reliability of the results.
18 dwg, 3 tbl
FIELD: medicine, neurology.
SUBSTANCE: a patient should be in initial position when his/her sight is directed towards the ceiling and in 3-5 min it is necessary to register a background rheoencephalogram, then a patient should fix the sight at a pointer's tip being at the distance of about 30 cm against the bridge of nose along the middle line, then the sight should be directed into marginal position due to shifting pointer to the left. Then the sight should be returned into initial position and 3 min later it is necessary to register rheoencephalogram of vertebro-basilar circulation, calculate rheographic index (RI), coefficient for RI ratio on returning the sight from left-hand marginal position into initial one (k2) and at k2>1.098 from the left and (or) k2>1.085 from the right one should detect alteration in vertebro-basilar circulation by reflector mechanism. The method excludes biomechanical impact in stimulating proprioceptive receptors of muscular-ligamentous system under stretching.
EFFECT: higher accuracy and reliability of detection.
2 ex, 2 tbl
FIELD: medicine, resuscitation.
SUBSTANCE: one should detect cerebral perfusion pressure (CPP), intracranial pressure (ICP), values for blood saturation with oxygen in radial artery and jugular vein bulb (SaO2, SjO2), additionally one should study lactate level in jugular vein bulb and radial artery, calculate venous-arterial difference according to lactate (▵lactate), cardiac ejection (CE) due to thermodilution and hemoglobin level. Values for cerebral oxygen transport function should be calculated by the following formulas: mĎO2 = 0.15 x CE x CaO2 x 10; mVO2 = 015 x CE x (CaO2 - CjO2) x 10; CaO2 = 1.3 x Hb x SaO2; CjO2 = 1.3 x Hb x SjO2. In case of noninvasive detection - due to pulsoxymetry one should measure peripheral saturation (SpO2), due to parainfrared spectroscopy - cerebral oxygenation (rSO2) and cardiac ejection due to tetrapolar rheovasography (CEr), detect and calculate the values of cerebral oxygen transport system according to the following formulas: mĎO2 = 0.15 x CEr x CaO2 x 10; mVO2 = 0.15 x CEr x (CaO2 - CjO2) x 10; CaO2 = 1.3 x Hb x SpO2; CjO2 = 1.3 x Hb x rSO2. At the value of mĎO2 86-186 ml/min and more, MVO2 33 - 73 ml/min, ▵lactate below 0.4 mM/l one should evaluate cerebral oxygen transport system to be normal and the absence of cerebral metabolic disorders. At mĎO2 values below 86 ml/min, mVO2 being 33-73 ml/minO2, ▵lactate below 0.4 mM/l one should state upon compensated cerebral oxygen transport system and the absence of metabolic disorders. At mĎO2 being below 86 ml/min, mVO2 below 33 mM/l, ▵lactate below 0.4 mM/l one should conclude upon cerebral oxygen transport system to be subcompensated at decreased metabolism. At the values of mĎO2 being 86-186 ml/min and more, MVO2 below 33 ml/min, ▵lactate below 0.4 mM/l one should establish subcompensated cerebral oxygen transport system at decreased metabolism. At values of lactate being above 0.4 mM/l and any values of mĎO2 and mVO2 one should point out the state of decompensation in cerebral oxygen transport system and its metabolism. The innovation enables to diagnose disorders and decrease the risk for the development of secondary complications.
EFFECT: higher efficiency and accuracy of evaluation.
1 cl, 3 ex, 1 tbl
SUBSTANCE: method involves setting a patient in vertical posture with stabilogram and rheoencephalogram being concurrently recorded with frontomastoid and accipitomastoid leads being used retaining head position with stressed neck extensor muscles state and head position with relaxed neck extensor muscles state. Stabilogram parameters characterizing vertical posture stability and rheographic index of each of four brain basins. When combining better filling of cerebral basins with blood and higher standing stability, training is carried out in keeping head positions allowing better filling of cerebral basins. If better filling of cerebral basins with blood follows with no increased standing stability, the trainings are carried out in keeping head position with stressed neck extensor muscles state. The training sessions are given twice a day for 15 min during two weeks.
EFFECT: enhanced effectiveness of treatment.
2 cl, 3 tbl
SUBSTANCE: method involves determining pulsating arterial blood flow parameters. To do it, measuring electrodes are applied in main liver body mass location zone. Electrode-to-electrode distance is additionally measured and hepatic index is calculated from formula HI=ρ*L2*Ad*ET*HBR/Z2*1000*S, where HI is the hepatic index (l/min/m2), ρ is the constant reflecting volume blood resistance (150 Ohm cm), L is electrode-to-electrode distance (cm), Z is the base impedance (Ohm), Ad is the differential rheogram amplitude (Ohm/s), ET is blood expulsion time (s), HBR is heart beat rate per 1 min, S is the body surface (m2), 1000 is the coefficient for converting to liters. HI value being greater than 0.225 l/min/m2, porto-portal and/or porto-central hepatic fibrosis is diagnosed.
EFFECT: wide range of functional applications.