The method of treatment of a dysbacteriosis of the intestine with increased proliferation of fungi of the genus candida

 

(57) Abstract:

The invention relates to physical therapy and is intended for treatment of a dysbacteriosis of intestines. Conduct drug therapy. Additionally carry out electrophoresis 2% zinc sulfate and 3% sodium thiosulfate for 3-electrode method. Anodes with an area of 150 cm2placed on the front surface of the abdomen in the area of the projection of the liver and pancreas. The cathode area of 150 cm2place in the field nizhnegrudnogo spine. The procedure lasts 15 to 25 min, rate 10 - 15 procedures. The method provides a stable therapeutic effect.

The invention relates to medicine, namely to Mycology, gastroenterology.

There is a method of treatment of a dysbacteriosis of the intestine with increased proliferation of fungi of the genus Candida, chosen as a prototype, by receiving antifungal agents (nystatin, levorin, nizoral) and then taking the complex of drugs aimed at restoring normal function and intestinal flora. However, this method of treatment time (up to 2 months), not in all cases gives a strong reaction, taking antifungal drugs may LASS="ptx2">

The purpose of the invention is strengthening antimycotic effect and recovery of bowel function in the earlier period, increase the immunological reactivity of the organism, preventing complications of drug therapy.

This objective is achieved in that, along with medical therapy electrophoresis 2% zinc sulfate and 3% sodium thiosulfate for the 3-electrode method. Thus the lines of force of the galvanic current passing from the positive pole (anode) to the negative (cathode), stimulate the liver, gallbladder, pancreas, duodenum 12 and the adjacent small intestine; zinc ions possessing fungicidal action, also stimulate cellular immunity, and sulfur ions are included in the composition of proteins and various bioactive compounds that allows you to achieve rapid therapeutic effect.

The proposed method of treatment is as follows. Two strip area of 150 cm2each wetted with a 2% solution of zinc sulfate and placed on the front surface of the abdomen in the area of the projection of the liver and pancreas. Forked electrode is connected to the positive terminal apparatus for electroplating "Thread-1". Another is odnom spine (in the area of Th8- Th12), the electrode is connected to the negative terminal apparatus "Thread-1". The current is calculated by physiological density, taking into account individual sensitivity is 10-15 mA. The duration of the procedure is equal to 15-25 minutes treatment consists of 10-15 treatments daily. If necessary, a second course is assigned after 3-4 months.

Example No. 1.

Patient, 44 years old, was hospitalized in the clinic of mycosis MAPO with a diagnosis of chronic bronchitis mixed etiology in the acute stage, a dysbacteriosis of an intestine with increased proliferation of fungi of the genus Candida, athlete's foot onychomycosis, chronic right-sided otitis media. At receipt of the gastro-intestinal tract, the patient complained of nausea, bloating, persistent constipation. Palpation was noted abdominal tenderness in the right pogrebennoi the field and in hypogastrium. These laboratory tests:

1. When planting feces were on the rise, 20102Candida albicans.

2. Blood count: HB-128 g/l; erythrocytes-4,61012/l; Col. pok. - 0,85; leucocytes - 4,9109/l; stab - 1%; segmented - 62%; eosinophila - 26%; monocytes - 8%; ESR - 4 mm/h.

3. Immunol the den of drug therapy in the form of taking the following drugs: mucolytics, broncholytic, nystatin 500000 UNITS 2 tablets 4 times a day for 7 days, group b vitamins within 15 days, the vitamin E within 15 days, vitamin C intramuscularly within 15 days. After the treatment, the patient noted a slight improvement of the gastrointestinal tract. Retained sensitivity to palpation in hypogastruridae area.

According to laboratory studies:

1. When planting Kala is determined by the growth 13102Candida albicans.

2. In the clinical analysis of blood notes: HB 120 g/l; erythrocytes-4,11012/l; leucocytes-6,5109/l; stab-6%; segmented-76%; lymphocytes-18%;

3. the immunological: TLF-42%; Th-22%; Ts-20%; Tact-25%; Th/Ts-1,1.

Thus, on the background of drug therapy with the use of antifungal drug that is carried out within 15 days, there is a slight clinical improvement, a slight decrease of fungi of the genus Candida in the stool with a simultaneous deterioration in the laboratory of blood and cellular immunity.

Example No. 2.

A female patient, 48 years of age, enrolled in the mycological clinic MAPO with a diagnosis of bronchial asthma in the acute stage, chronic eastcoast cerebral circulation; cystourethrocele. At admission the patient along with complaints specific to the underlying disease, were presented with complaints of the gastrointestinal tract in bloating, unstable stool, mild tenderness in the epigastric region. According to laboratory studies:

1. When planting feces was determined by the growth of 19102Candida albicans.

2. Blood count: HB-128 g/l; erythrocytes-4,51012/l; Col. pok. - 0,85; leucocytes-5,6109/l; stab-2%; segmented-69%; lymphocytes-24%; monocytes-3%; ESR-27 mm/h.

3. The immunological: TLF-34%; Th-27%; Ts-7%; Tact-31%; Th/Ts-3,85. Along with therapy of bronchial asthma (broncholytic) was treated gastrointestinal tract with the use of nystatin 500000 UNITS 2 tablets 4 times a day for 7 days, aktovegin 1 ml intramuscularly within 12 days, a course of multivitamins; underwent a course of 10 treatments electrophoresis 2% zinc sulfate and 3% sodium thiosulfate for 3-electrode method, carried out daily for 15-25 minutes At the end of therapy the patient noted significant improvement in the General state and condition of the intestinal tract: the disappearance of bloating, normalization of stool. When laboratory the definition blood test: HB-132 g/l; erythrocytes - 4,51012/l; segmented-66%; eosinophila-2%; lymphocytes-22%; monocytes-3%; ESR-8 mm/hour.

3. The immunological: TLF-40%; Th-30%; Ts-12%; Tact-31%; Th/Tsa-2.5. Thus, after 10 treatments electrophoresis 2% zinc sulfate and 3% sodium thiosulfate but 3-electrode method, the patient reported a significant clinical improvement along with improvement in cellular immunity and blood; clearly expressed high antimycotic effect.

Example No. 3.

Patient B, 33, enrolled in mycological clinic MAPO with a diagnosis of chronic colitis exacerbation; dysbacteriosis of the intestine with increased proliferation of fungi of the genus Candida and deficit bifidoflora; chronic iron deficiency anemia. At admission the patient complained of bloating, unstable stool, pain along the colon. On palpation, there was a sharp pain in hypogastruridae area. According to laboratory diagnostics mentioned:

1. When planting Kala - growth - 640102Candida albicans.

2. Blood count: HB-102 g/l; erythrocytes - 3,81012/l; Col. pok. - 0,84; leucocytes-3,4109; stab-2%; segmented-42%; eosinophils-23%; Th/Ts-5,5. Along with drug therapy (reglan table 2. 3 times a day; festal 1 tablet per day; holenzim 1 tab. 3 times a day; veraplex 20 mg 2 tab. 3 times a day; nystatin 50000 IU in table 2. 4 times a day) is carried out within 10 days, the patient underwent a course of electrophoresis 2% zinc sulfate and 3% sodium thiosulfate for 3-electrode method, consisting of 10 daily treatments for 15-25 minutes

After therapy the patient noted complete disappearance of abdominal pain, bloating; palpation of the abdomen painless in all departments. According to laboratory diagnosis:

1.Seeded Kala - growth 15102Candida albicans.

2. Blood count: HB-110 g/l; erythrocytes-3,71012/l; Col.pok.- 0,89; leucocytes-6,0109/l; stab-3%; segmented-36%; eosinophila-5%; lymphocytes-51%; monocytes-2%; ESR-6 mm/h.

3. The immunological: TLF-45%; Th-37%; Ts-12%; Tact-30%; Th/Ts-3,1. Thus, for 10 days managed to achieve significant clinical improvement, improvement of blood and cellular immunity, expressed antimycotic effect.

The proposed method, the treatment was performed in 212 patients with disbakterioza the AEB was good. Allergic reactions are not identified. Antimycotic effect and normalization of bowel function was observed in 100% of cases.

Thus, the research results showed that the method of complex treatment using electrophoresis 2% zinc sulfate and 3% sodium thiosulfate for 3-electrode technique in patients with intestinal dysbiosis with increased proliferation of fungi of the genus Candida is an effective method of treatment, contributing to more rapid clinical dynamics of the process, which has strong antifungal effect, enhancing the immunological reactivity of the organism, which allows to reduce the duration of drug therapy.

The method of treatment of a dysbacteriosis of the intestine with increased proliferation of fungi of the genus Candida by drug therapy, characterized in that it further conduct electrophoresis 2% solution of zinc sulfate and 3% sodium thiosulfate solution for 3-electrode method with the location of the positive pole (anode) with an area of 150 cm2on the front surface of the abdomen in the area of the projection of the liver and pancreas, and the negative pole (cathode) with an area of 150 cm2in the field nizhnegrudnogo Department of pozvonochnyh the

 

Same patents:

The invention relates to medicine and can be used in the treatment of gynecological diseases, namely endocervicitis
How aeroionotherapy // 2152810
The invention relates to physical therapy and veterinary medicine intended for the treatment of air ions and ions of medicinal substances

The invention relates to the field of medicine and is intended for the treatment of chronic inflammatory diseases of the abdominal organs
The invention relates to medicine, namely otolaryngology
The invention relates to medicine, gynecology

The invention relates to medicine, namely to oral and maxillofacial surgery, and may find application in the treatment of patients with uncomplicated fractures of the mandible within the dentition
The invention relates to medicine, cosmetology
The invention relates to medicine, herbal medicine

The invention relates to medicine, in particular to a system clinical application of electroporation for the treatment of humans and other mammals
The invention relates to medicine, physical therapy

The invention relates to the field of veterinary pharmacology and can be used for the prevention and treatment of hypochromic microcytic anemia

Drug // 2121347

The invention relates to new chemical compounds, complexes of 1-vinyl - 1-ethylimidazole with zinc and cobalt salts of organic and inorganic acids with the General formula given in the description text

-oxyethyl)-2-methyl-5-nitroimidazol] zinc (ii) hydrate exhibiting bacteriostatic activity" target="_blank">

The invention relates to new derivatives of metronidazole [1-(-oxyethyl)-2-methyl-5-nitroimidazol] with bacteriostatic action and finds application in medicine

The invention relates to medicine, in particular to the treatment of polielementnom in patients with clinical manifestations of zinc States

The invention relates to medicine and for the production of the antidote

FIELD: organic chemistry, medicine, dermatology.

SUBSTANCE: invention relates to zinc and aliphatic halogen-carboxylic acid salts that can be used in treatment of benign neoplasms of skin and visible mucosa tissues. Invention proposes the following formula of zinc and aliphatic halogen-carboxylic acid salts: (1): wherein R means -CHal3, -CHHal2, -CH2Hal and (2): wherein R' means Alk, hydrogen atom (H); R'' means Hal; R' means Alk; R'' means H, Alk wherein in these formulae halogen atom can be represented by fluorine atom (F), chlorine atom (Cl), bromine atom (Br) or iodine atom (J). Invention provides the development of original preparation used in treatment of benign neoplasms of skin and visible mucosa tissues with low toxicity, rapid effect, expressed therapeutic effect and eliciting good tolerance, absence of complications in treatment, healing without formation of scar tissue. The development of the preparation provides expanding assortment of agents used in treatment of such diseases.

EFFECT: enhanced and valuable properties of agents.

13 ex

FIELD: veterinary science.

SUBSTANCE: the present innovation deals with applying a multi-purpose complex preparation that contains the following components in 1 l of distilled water: sodium selenite 1.0; vitamin E/in the form of combinal E/7500 mg; succinic acid 10.0; zinc sulfate 10.0 and pharmazine 50000 U. The preparation should be introduced as intramuscular injections 45, 30, 15 d before delivery and during the day of delivery: in cows per 10-15 ml, for pigs and sheep per 5 ml, for youngsters after the birth: in calves - 5 ml, in piglets and lambs per 1-2 ml, in hens per 0.5 ml once/2 wk. The innovation is very efficient in increasing the quality and quantity of production, improving the growth and development in fetus and offspring, preventing some surgical and obstetric-gynecological pathologies.

EFFECT: higher efficiency of correction.

5 cl

FIELD: veterinary science.

SUBSTANCE: invention relates to a composition used in prophylaxis and treatment of anemia in agricultural animals and poultry that comprises a mixture of chelates of iron, copper, zinc, cobalt, sodium, calcium with ethylenediamine-N,N'-disuccinic acid in the following ratio of components, wt.-%: copper chelates with ethylenediamine-N,N'-disuccinic acid, 0.45-0.60; zinc chelates with ethylenediamine-N,N'-disuccinic acid, 1.40-1.45; cobalt chelates with ethylenediamine-N,N'-disuccinic acid, 0.075-0.08; sodium chelates with ethylenediamine-N,N'-disuccinic acid 42.0-44.0; calcium chelates with ethylenediamine-N,N'-disuccinic acid, 12.0-13.0, and iron chelates with ethylenediamine-N,N'-disuccinic acid, the balance. Agent provides enhancing the blood hemoglobin content in animals by 28% as compared with animals receiving neither anti-anemic agents and by 12% as compared with animals receiving the preparation-analog.

EFFECT: enhanced effectiveness of composition.

4 tbl, 4 ex

FIELD: pharmaceutics.

SUBSTANCE: the present innovation deals with obtaining compositions being of bactericidal, antiphlogistic, regenerating, antioxidant and antimicrobial properties at no allergic action. Wound-healing preparation (variant 1) contains: stearic acid 4.5-6.0; purified lanolin and its derivatives 3.0-6.0; vegetable oil 3.0-5.0; Vaseline 1.5-2.5; glycerol 4.0-8.0; castor oil 8.0-12.0; zinc stearate 1.0-2.5; 70%- alcoholic extract of phytospecies 2.5-3.5; extract of common John's wort grass 3.5-8.5; dog rose oil or sea buckthorn oil 2.6-6.0; Na-salts of fatty acids of wool fat 0.3-0.6; triethanolamine 0.7-1.1; anesthesin 2.0-3.0; 10%-butyric solution of propolis 0.3-1.0; boric acid 0.4-0.6; purified water - the rest. Wound-healing preparation (variant 2) contains: stearic acid 4.5-6.0; purified lanolin and its derivatives 3.0-6.0; vegetable oil 3.0-5.0; Vaseline 1.5-2.5; glycerol 4.0-8.0; castor oil 8.0-12.0; zinc stearate 1.0-2.5; 70%-alcoholic extract of phytospecies 2.5-3.5; extract of common John's wort 3.5-8.5; dog rose oil or sea buckthorn oil 2.6-6.0; Na-salts of fatty acids of wool fat 0.3-0.6; triethanolamine 0.7-1.1; anesthesin 2.0-3.0; levomycetin or gentamycine 2.0-3.0; 10%-butyric solution of propolis 0.3-1.0; boric acid 0.4-0.6; purified water - the rest. Additional introduction of the extract of common John's wort has increased antioxidant properties; 10%-butyric propolis - antioxidant and bactericidal properties, and levomycetin and gentamycine - has widened the range of antimicrobial action. Application of the preparation suggested in patients with burns and wounds revealed positive therapeutic effect without any cicatricial neoplasms and allergic action. No contraindications had been established.

EFFECT: higher efficiency of application.

4 cl, 8 ex

FIELD: medicine.

SUBSTANCE: invention relates to application of Acizol, namely bis(1-vinylimidazole) zinc diacetate as coronary active anti-ischemia and anti-arrhythmia agent. Acizol makes it possible to limit development of necrosis zone in acute myocardium ischemia, to reduce frequency of complications and fatal cases, to normalize antrioventricular and intraventricular electrical conductivity , to prevent ciliary arrythmia.

EFFECT: improved anti-ischemia and anti-arrhythmia agent.

15 tbl, 7 dwg, 6 ex

Up!