A means of having anastasiadis and antibacterial effect

 

(57) Abstract:

The invention relates to the field of medicine and concerns of drugs used in dentistry for the treatment of oral cavity and gums. The tool is a film made from the blend of hydrophobic and hydrophilic layers with the inclusion of medicines, as anesthetic and anti-bacterial substances that enhance the transport of drugs, sulfa drugs, local anesthetic drugs. The tool has the combined effect is analgesic, anti-inflammatory, disibilities and antibacterial. 8 C.p. f-crystals.

The invention relates to medicine.

In medical practice, the most common form of local anesthetic drugs are gels and aerosols.

Known topical gel containing lidocaine and chlorhexidine (Litovel, India, Directory Vidal, 1997, pages 13 - 90 and B - 311); it is used in urology before catheterisation and drainage of bladder, cystoscopy, the relief of pain of cystitis, urethritis. For the same purpose applies xylocaine jelly (2% jelly lidocaine, ASTRA, Sweden. Reference Vidal, 1997, page B - 344).

LSA for surface anesthesia during endoscopic mucous and instrumental methods of research, for the relief of pain after tonsillectomy, when esophagitis, and when dumping syndrome.

Use them very uncomfortable - when esophagitis and pharyngitis 10 ml mucous gels lidocaine held in the mouth for at least 1 minute and then swallow.

In dentistry to remove gingival deposits, curettage pathologically altered periodontal pockets during anaesthesia places vcol and other inflammatory diseases of the oral cavity, it is proposed ointment, bulcaen (Piromekain, 5% ointment in tubes Registration. medicines, Russia, 1993, page 689). The ointment is applied in a thin layer (1 g) on the painful area of the mucous membrane of the oral cavity for 2 - 5 minutes 1 to 2 times a day.

Known lidocaine - spray (EGAS, Hungary, Handbook Vidal, 1997, page B - 311) for anesthesia of mucous in dentistry and otolaryngology, dermatology, urology and others To obtain anesthesia in adults recommended 1 - 3 exposure, children dentistry - 2 exposure. The maximum single dose of 15 to 20 exposures. As shown by long-term observations in dentistry, both adults and children very often after application of the spray in the mouth occur vomiting, allergies.

The gel containing imeeetsja in dentistry for surface anesthesia and treatment of inflammatory diseases of the mouth and gums, accompanied with pain. A small amount of the drug (pea-sized) are easily rubbing, several times a day on painful and inflamed mucosa.

Analysis of existing material shows that the local anesthetic agent for use in dentistry:

(a) must be in a convenient medication form, excluding gel, ointment, mucous, and aerosol form;

b) simultaneously, these funds must contain antibacterial components, because in most cases they are used in inflammatory processes, open wounds, etc. where antibiotic therapy is necessary.

The technical task of the present invention is to expand the Arsenal of drugs, in particular the establishment of funds, with a combined effect, analgesic and antibacterial.

The tool is intended for use in dentistry: application for anesthesia and in the treatment of infectious-inflammatory diseases of the mouth and gums, burns, lesions of oral mucosa and lips, dental pain, sunburn and cracking of the lips, accompanied with pain.

indologie, dermatology, neurology, urology, and gynecology.

To solve the task the tool is a film made from the blend of hydrophobic and hydrophilic layers, while the hydrophobic layer of hydrophobic polymer or copolymer and plasticizer from polyoxyethylene derivatives sorbitan, higher fatty alcohols, acids, phenols at a ratio of 9:1, and the hydrophilic layer is made of a hydrophilic, water soluble polymer or copolymer, or salts of polymers and plasticizer polyethylene glycol 300 - 6000 D or other water-soluble organic polar and non-polar substances at a ratio of 9:1 and include anesthetic and antibacterial or antimicrobial or antiseptic agents. The film additionally contains prolonging, pH - regulating components, and components which enhance the transport of drugs.

To facilitate visual observation of the film are painted.

As anesthetic drugs it contains a single mestnoanesteziruyuschie drugs on the basis of bupivacaine, lidocaine, prilocaine, etidocaine, trimekainom, mepiwakaina, amylocaine, artikaina and procain.

As antibacterial agents were used: a) antibiotics penicillin, cephalosporins, aminoglycosides, tetracycline, macrolides, rifamycin, lincosamides, chloramphenicol and other

As an antimicrobial agent - derivatives of sulfonamides, quinolone, naphthiridine, nitrofuran etc.

As antiseptic - surfactants, cationic (Quaternary ammonium compounds), anionic, Central type, and others, such as benzalconi chloride, benzathine chloride, pyridinium chloride, chlorhexidine, polyethylene oxides; polyoxyethylene derivatives of higher fatty alcohols, acids, phenols.

As a dye for color film was used brilliant green, metagenomic blue, ethacridine and other colouring agents allowed for use in medical practice.

Example 1. Prepare a two-layer hydrophilic - hydrophobic film. In the solution casting hydrophilic layer contribute lidocaine hydrochloride and chlorhexidine ballycanal, so that in the finished film their total content is from 0.01 to 10 mg/cm2and the ratio of from 1:1 to 9:1.

The film additionally contains projectwe from 0.0003 to 0.01 mg/cm2and pH - regulating component in an amount of from 0.0005 to 0.05 mg/cm2.

In the solution casting hydrophobic layer is injected dye - brilliant green in the alcohol solution.

The thickness of the finished film is from 0.02 to 2 mm

Example 2. Analogously to example 1 to prepare a film containing lidocaine hydrochloride and benzalconi chloride. The ratio of drugs in the finished film is from 1:1 to 9:1, and the total content of from 0.01 to 10 mg/cm2.

The film thickness and the content of the additional components as in example 1.

Example 3. Analogously to example 1 to prepare a film containing lidocaine hydrochloride and lincomycine hydrochloride. The value of drugs is from 1:1 to 9:1, their total content is from 0.01 to 10 mg/cm2.

The film thickness and the content of additional drugs analogously to example 1.

Example 4. Analogously to example 1 to prepare a film containing lidocaine hydrochloride and metonidazole (or metronidazole hemisuccinate). The ratio of drugs, their total content, thickness and composition of additional drugs similar to example 1.

Example 5. Analogously to example 1 to prepare a film containing BUP content of from 0.01 to 10 mg/cm2.

The film thickness and the content of the auxiliary component is similar to example 1.

Example 6. Analogously to example 1 to prepare a film containing trimekainom and chlorhexidine digluconate. The ratio of drugs in the finished film, the total content, thickness and content of the additional components similar to example 1.

Example 7. Analogously to example 1 to prepare a film containing a mixture of two anesthetics - lidocaine and primaxin (ratio 1:10 to 10:1 in the film) in combination with chlorhexidine-digluconate. The total amount of drugs in the film is from 0.01 to 10 mg/cm2. The film thickness and the content of the auxiliary component is similar to example 1.

Example 8. Preparing a film from a mixture of two anesthetics, as in example 7, in combination with various antibiotics. The content of the components and physical properties similar to example 7.

1. The tool that has anesthetic and antibacterial effect, characterized in that it is a biopolymer film made from the blend of hydrophobic and hydrophilic layers, while the hydrophobic layer is made of a hydrophobic polymer or copolymer and plastify the research Institute 9 : 1, and the hydrophilic layer is made of a hydrophilic water-soluble polymer or copolymer, or salts of polymers or co-polymers and plasticizer polyethylene glycol 300 - 6000 D at a ratio of 9 : 1 and includes an anaesthetic and antibacterial or antimicrobial or antiseptic agent.

2. Means under item 1, characterized in that it additionally contains a substance, the prolonging effect of the drug, in the amount of 0.0005 - 0.05 mg/cm2PH regulating the amount of 0.0005 - 0.05 mg/cm2the substances , improving the transport of drugs, the number 0,0003 - 0.01 mg/cm2film.

3. Means under item 1, characterized in that it additionally contains a dye.

4. Means under item 1, characterized in that as antibacterial agents it contains an antibiotic selected from the group of penicillin, cephalosporins, aminoglycosides, tetracycline, macrolides, rifamycin, lincosamides, chloramphenicol.

5. Means under item 1, characterized in that it contains antimicrobial agents means selected from the group of derivatives of sulfonamides, quinolone, naphthiridine, nitrofuran.

6. Means under item 1, characterized in that as an antiseptic, SREA, selected from the group benzalconi chloride, benzathine chloride, pyridinium chloride, chlorhexidine, oxides, polyoxyethylene derivatives of higher fatty alcohols, acids, phenols.

7. Means under item 1, characterized in that as usual means it contains a single local anesthetic drug on the basis of bupivacaine, lidocaine, prilocaine, trimekainom, manivanan, amylocaine, artikaina or mixture of drugs lidocaine - trimekain, or a lidocaine - epinephrine, articaine - epinephrine, bupivacaine - epinephrine, lidocaine - prilocaine.

8. Means under item 1, characterized in that it contains lidocaine hydrochloride and chlorhexidine digluconate or lidocaine hydrochloride and benzalconi chloride or lidocaine hydrochloride and lincomycin hydrochloride or lidocaine hydrochloride and metronidazole or bupivacaine and chlorhexidine digluconate or trimekainom and chlorhexidine digluconate based on their total content in the finished film is from 0.01 to 10 mg/cm2and a ratio of 1 : 1 to 9 : 1.

9. Means under item 1, characterized in that it comprises a mixture of two anesthetic drugs lidocaine and primaxin in the ratio of 1 : 10 to 10 : 1 and chlorhexidine digluconate based with

 

Same patents:

The invention relates to the transdermal administration of drugs
The invention relates to the field of pharmaceutical technology

The invention relates to medicine and relates to a medicinal product "Oil of scaninavia", which is anti-inflammatory and antimicrobial agent and is applied topically for the treatment of various locally occurring inflammatory processes

The invention relates to a transdermal therapeutic system for the controlled delivery of estradiol or its pharmaceutically acceptable derivatives individually or in combination with gestagens, as levonorgestrel, in the skin of a human or animal, its application and how you can get
Yellow card // 2125855
The invention relates to the medical industry, for the production of irritating and distracting medium - mustard, and can be used for the preparation of dosage forms in the form of bags of cells

The invention relates to pharmaceutical industry and relates to a combined pharmaceutical preparation for contraception

The invention relates to the field of medicine and relates to transdermal drug extended action with antiosteoporotic activity

The invention relates to the field of medicine and relates to transdermal compositions and tapes or dressings for transdermal delivery
The invention relates to medicine, namely to the dentist, and can be used for the treatment of gingivitis

The invention relates to solid pharmaceutical compositions containing less than 7 wt.% oil or oily substances, a small dose of the active ingredient insoluble in water and seamless polymeric filler, capable of binding water and having an average particle size greater than 150 microns

The invention relates to solid pharmaceutical compositions containing less than 7 wt.% oil or oily substances, a small dose of the active ingredient insoluble in water and seamless polymeric filler, capable of binding water and having an average particle size greater than 150 microns

The invention relates to medicine, namely to cure stress, reduce activity and aging and method thereof

The invention relates to the transdermal administration of drugs

The invention relates to the transdermal administration of drugs

The invention relates to the field of pharmacy and relates to dosage forms of derivatives of 5-intorimidazole

The invention relates to medicine, namely dentistry
Up!