Fungicidal composition and method of combating fungal diseases

 

(57) Abstract:

The invention relates to agriculture, namely, to fungicidal compositions based on derivatives of peritonectomy and to a method of combating fungal diseases, and can be used to increase the yield of sunflower. The composition contains as a fungicide 6-methyl-3-oxo-4-chloro-1H-furo[3,4-C] pyridine in the amount of 20-25 wt. % target and Supplement the rest. The composition can be used for processing of sunflower seed or processing plants. The technical result is an increase in antifungal activity. 2 S. p. f-crystals, 2 tab.

The invention relates to chemical means of protection of plants, particularly to fungicidal compositions and method of combating fungal diseases.

Among the fungicides used for seed crops, including sunflower, against the causative agents of placevine (Botrytis cinerea, Sclerotinia sclerotium, Fusarium spp, Mm), known to be derived as - Rovral (Rhone-Poulenc, France) and oxazolidinones patterns - Ronilan (BASF, Germany).

Recently (Handbook of plant protection and agrochemicals, M.: Izd-vo Agrorus. - 1998. - S. 208) became known drugs such as Sincerity foreign and therefore expensive in Russia.

Known nitrogen - and chlorinated remedy sunflower from rot (A. C. 2042327 A 01 N 43/653, 03.05.91, bull. N 24, 95). The downside of it is a large dose of the active substance (D. C.) to 50 kg/t of seed material and the active substance is a complex mixture of two complex organic derivatives-1,4-benzodioxepine triazole structures.

The closest analogue (prototype) for the claimed invention is a fungicidal composition, method of protecting seed and germinating from them plants of this song, including the quality of nutrient content derived nitrogenous heterocycle - triazole with different substituents, including chlorine, and also includes the second component is a known fungicide (import). The second component - import fungicide - makes the song costly. In addition, the synthesis of triazole derivative and the creation of its preparative forms require a large range of organic reagents and solvents - ether, tetrahydrofuran, etelaat, dimethylsulfoxide, etc. that also increases the cost of it and makes it inaccessible. Possible loss of expensive solvents increase the cost of the final product. Toxicity, as well as the fire and the Yu and ventilation.

The disadvantage of this composition could be attributed to relatively high doses of the drug, up to 6 kg/ton of seeds, and that it is recommended only for the protection of seeds and growing of these plants in the early stages of development (U.S. Pat. 2035140 A 01 N 43/653, 13.06.90, Bull. N 14, 95).

The present invention solves the problem of increasing the yield of sunflower, as well as the expansion of the range of fungicidal means and methods of combating fungal diseases of crops. The aim of the invention is the enhancement of antifungal activity.

The technical result is achieved by the fact that the known fungicidal composition comprising its active component and the target additives according to the invention, as activitiesthese component contains 6-methyl-3-oxo-4-chloro-1H-furo[3,4-C] pyridine of formula I in the amount of 20-25 wt.%, targeted supplements - the rest.

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The technical result is also achieved by the fact that in the known method of combating fungal diseases by seed treatment fungicide composition comprising the active component and the target additives according to the invention, use of a composition containing as activitiesthese component connection 6-methyl-3-is or 2.0 kg/ha at processing plants in the growing season.

Comparative analysis of the proposed technical solutions with the prototype allows us to conclude that the claimed fungicidal composition and method of combating fungal diseases differ from the prototype in that the claimed fungicidal composition, which process the seeds before sowing of the plants of vegetation to combat fungal diseases, as activitiesthese component contains a derivative of peritonectomy - harjedalen (HPL) - compound of formula I in a quantity in the composition and with a certain rate of its consumption in the processing of its seeds, and plant vegetation. Thus, the claimed technical solution to meet the patentability criteria of "Novelty."

Exploring the level of technology in the process of conducting a patent search all kinds of information, public printing, we found that the proposed technical solution - fungicidal composition and method of combating fungal diseases for the specialist does not obviously follow from the known current level of technology.

Used as activitiesthese component in the fungicidal compositions of the chemical compound harjedalen (HPL) swissitalian were identified fungicidal effect of this chemical compound, its correlation with the target additives in the composition and doses of application to combat fungal diseases by seed treatment and plant vegetation fungicidal composition. Therefore, we can conclude that the compliance group of the claimed invention related to a single inventive concept, the patentability criterion of "inventive step".

The proposed technical solution fit the patentability criterion of "industrial applicability" because they can be used in agriculture. This will be described below means and methods by which you can implement the claimed inventions, as they are characterized in the claims.

The invention is illustrated by the following examples.

Example 1. Getting 6-methyl-3-oxo-4-chloro-1H-furo[3,4-C]pyridine, i.e. harjedalen (HPL) used in the inventive composition as a fungicide.

Harjedalen (HPL) - known chemical compound as an intermediate in the synthesis of new organic compounds. It is produced by chlorination of the well-known 6-methyl-3,4-dioxo-1H-furo[3,4-C]pyridine (compound II)

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in the environment of phosphorus oxychloride in the presence of the five-acid hydrolysis is converted into the source reagent II for the synthesis of compound I (J. Amer .Chem. Soc. 1944, N 12, p. 1092-1094).

This chemical compound I - harjedalen (HPL) used in the inventive compositions as active component (fungicide), together with targeted supplements is made in the formulations of the compositions that are used in biological experiments to combat fungal diseases of plants, such as solutions, emulsions, suspensions, powders, pastes, in shell, seed, etc., These composite products are prepared by known methods, for example, by mixing the active substance with filler: solvent or solid carrier. If the solvent is water, it is possible to use organic solvents as auxiliary substances. As liquid solvents are mainly used: aromatic is benzene, toluene, alcohols and glycols, ethers, esters, acetone and other ketones, DMSO, DMF, water. Prior use of solvents is necessary to create the emulsion form of the drug or in the form of a homogeneous solution. As solid carriers used kaolin, alumina, talc, silicates.

The preparations can contain enhance the adhesion of a substance, such as, for example, carboxylates, natural or synthetic phospholipids. In addition, they can contain colorants, such as inorganic dyes, azo dyes, etc.

The preparations can also contain other known active substances such as fungicides, insecticides, herbicides, and fertilizers and plant growth regulators.

The compositions can be applied as ready-to-use solutions, emulsifiable concentrates, emulsions, suspensions. For the treatment of seed material is preferable in terms of technological process and the ecology of the method of inlaying of seeds.

Example 2. Preparation of fungicidal compositions for seed treatment.

The composition for seed treatment is obtained on the basis HPL and special additives. Targeted supplements are film-forming substance, in particular phosphatidyl concentrate (FC) - waste production of sunflower oil (THE 10-04-02-59-89), as well as alkali and water. The purpose of the FC - ensuring effective coverage, kept D. C. on the surface of the seed. To create a homogeneous solution of FC in water requires the presence of alkali, because FC is dissolved in an alkaline environment. The content of alkali in the composition in amounts of from 0.25 to 0.40% of its mass is yens (U.S. Pat. RF 2124291 C A 01 N 43/90, 97, bull. 1, 1999).

The proposed composition was prepared by mixing D. C. (HPL) and special additives. For processing, for example, 1 ton of seeds take 1000 g FC and with stirring a mixture consisting of 500 ml of water and 30 g of KOH. In the obtained solution was added with stirring 2000 HPL in powder form. All mix thoroughly and add 6470 ml of water, i.e. the amount of water to the total weight amounted to 10 litres

Example 3. Preparation of a fungicidal composition for treatment of plants for the growing season.

Composition for treatment of plants in vegetation were prepared on the basis of HPL and other special additives. To obtain compositions in the form of an emulsion as the target additives used solvent, for example ethanol and water was taken 2,0 kg HPL and dissolved it in 2.0 l of ethanol, the resulting solution was poured into 400 liters of water and the resulting composition was treated plants on the area of 1 hectare Replacement standard other solvent, in particular dimethylsulfoxide (DMSO) or dimethylformamide (DMF), allows to obtain a new preparative form of the composition solution, which process plants and emulsion.

Example 4. Testing the claimed compositions and method of preventing g the deposits held in conditions of small-plot of the experience of sunflower varieties Berezansky against ash rot and Phomopsis. The size of plots 49 m2the repetition of experiences 4x. Before sowing, seeds were treated with the inventive composition, and to compare the currently known fungicides against Phomopsis and rot of sunflower: drug Vincita (D. C. flutriafol + thiabendazole) and standard-anilana. The reason for this is that flutriafol is a derivative of triazole, as well as the prototype. The flow rate of the composition 10 l/t of seed (table. 1).

In the period 2-4 pairs of leaves were selected plant to determine the in vitro infection by a complex of pathogens: ash, white rot, Phomopsis and other diseases.

As can be seen from table 1, the inventive composition on the effect on the suppression of Phomopsis and ash rot of sunflower exceeds standard - Ronilan and Vincit. Its application on ash rot reduces the incidence by 42.6% relative to untreated seeds. The effectiveness of the actions above ronilan 25%.

By their influence on the degree of affection of sunflower diseases, the compositions and method of combating fungal diseases exceed actions recommended for use against Phomopsis system drug Vincita (Seneca) and the more Ronilan (PL. gladiali on the field on infectious background in terms of experience of small plot on the sunflower (variety Flagship) against Phomopsis. The size of plots 28 m2the repetition of experiments 4-fold. The first processing by spraying the plants is carried out in phases - the "beginning of flowering" second - phase "late flowering" offer preparative form according to example 3, at a dose of 2 kg/ha according to the current matter.

Based on tables 1 and 2 it follows that the compositions can be used for treating seeds, and for the treatment of vegetating plants.

The single processing plant in the vegetation the proposed composition provides a decrease in the electric Phomopsis stems 8.3% baskets - by 10.4% compared to control 1 (no treatment), as well as an increase in yield on 0,84 kg/ha Twice the processing plant composition reduces the defeat of Phomopsis baskets by 18.7% compared to the control and increases the yield of 1.83 kg/ha (10.0%) and oil content on 8,65%.

The analysis of tables 1 and 2 showed the effectiveness of the inventive COMPOSITION and METHOD of combating fungal diseases in different varieties of sunflower with different techniques.

Technical efficiency from the use of the claimed group of the invention is to reduce the complexity of obtaining certainly the ptx2">

1. Fungicidal composition for combating fungal diseases, including its active component and the target additives, characterized in that as activitiesthese component it contains the compound 6-methyl-3-hydroxy-4-chloro-1H-furo[3,4-C]pyridine of the formula I

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in 20 - 25 wt.%, targeted supplements - the rest.

2. A method of combating fungal diseases by seed treatment and plant fungicidal composition containing its active component and the target additives, characterized in that the composition use composition under item 1 at a dose of 2.0 - 2.5 kg/t of seeds or 2.0 kg/ha by processing plants in the growing season.

 

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6 tbl, 4 ex

FIELD: organic chemistry, chemical technology, herbicides.

SUBSTANCE: invention describes a method for preparing compounds of the formula (I):

wherein each R1, R2, R3 means independently of one another (C-C6)-alkyl; R can represent also pyridyl; R4 and R5 in common with nitrogen atoms to which they are joined form unsaturated 5-8-membered heterocyclic ring that can be broken by oxygen atom; G means hydrogen atom. Method involves interaction of compound of the formula (II):

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(IVa)

or (IVb) ,

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9 cl, 12 ex

FIELD: organic chemistry, herbicides, agriculture.

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wherein R1 means (C1-C4)-alkyl; R2 means (C1-C4)-alkyl; R3 means hydrogen atom; X and Y mean (C1-C4)-alkoxy-group; (B) represents one or two herbicides taken among the group of compounds or their acceptable forms: alachlor, metolachlor, acetochlor, dimetenamide, atrazine, cyanasin, metribusin, fluthiamide, nicosulfuron, rimsulfuron, primisulfuron, pendimetalin, sulcotrion, dicamba, mesotrion, isoxachlortol, metosulam, anilofos, fenoxaprop-ethyl, setoxydim, diclofop-methyl, MCPA, bromoxynil, pyridat, clopyralid, iodosulfuron-methyl, ethoxysulfuron, amidosulfuron, gluphosinat-amminium, isopropylammonium-glyphosate, imasetapir wherein components (A) and (B) are taken in the effective doses. Also, invention describes a method for control of weeds by using above indicated herbicide composition. Invention provides the development of the synergistic herbicide composition eliciting high activity.

EFFECT: improved method for control, valuable properties of composition.

6 cl, 26 tbl, 3 ex

FIELD: agriculture, plant science, plant protection.

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EFFECT: higher efficiency of plant protection.

3 cl, 4 ex, 4 tbl

FIELD: organic chemistry, agriculture, herbicide composition.

SUBSTANCE: invention relates to herbicide composition, containing conventional inert additives and mixture of a) herbicidically effective amount of substance satisfying the formula I [in formula R1 and R3 are the same or different C1-C4-alkyl; R4 and R5 together form groups of formulae: -C-R6(R7)-O-C-R8(R9)-C-R10(R11)-C-R12(R13)-(Z1), -C-R14(R15)-C-R16(R17)-O-C-R18(R19)-C-R20(R21)-(Z2), or -C-R22(R23)-C-R24(R25)-C-R26(R27)-O-C-R28(R29)-(Z3), wherein each R6-R29 is hydrogen; G is hydrogen or -C(X2)-X3-R31; X2 and X3 independently are oxygen; R31 is C1-C10-alkyl]; b) herbicidic synergic amount of at least one herbicide selected from group containing sulfonylureas, phenoxyacetic acids, as well as florsulam, tralcoxidim, klodinafol-propargil, phenoxaprop-P-ethyl, trifluramine, pendimethaline, picolinafen, etc. Composition also may contain safety effective amount of protective agent, such as chloquintocet-mexyl and additive (e.g., mineral oil or C8-C22-fat acid alkyl esters) in amount of 0-2 mass %. Also disclosed is method for selective controlling of weeds and grassy plants in cultural plants by treatment of cultural plants, seeds or seedlings thereof, or vegetation area thereof with claimed composition.

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5 cl, 11 tbl, 7 ex

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7 cl, 3 tbl, 8 ex

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5 cl, 63 tbl, 12 ex

FIELD: organic chemistry, agriculture.

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12 cl, 23 ex, 23 tbl

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EFFECT: compounds effective against agriculture spineless depredators.

22 cl, 13 tbl, 1 dwg, 24 ex

FIELD: organic chemistry, herbicides, agriculture.

SUBSTANCE: invention describes a composition showing the selective effect and comprising as conventional inert adjuvants and the following mixture as an active component: a) effective amount of compound of the formula (I): as a herbicide wherein each R1 and R3 means independently of one another (C1-C4)-alkyl; R4 and R5 mean the group: -C-R14(R15)-C-R16(R17)-O-R18(R19)-C-R20(R21)-(Z2) wherein R14, R15, R16, R17, R18, R19, R20 and R21 mean hydrogen atom; G means hydrogen atom, -C(X1)-R30, alkaline metal cation, earth-alkaline metal cation, sulfonium or ammonium cation; X1 means oxygen atom; R30 means hydrogen atom, (C1-C10)-alkyl, and salts and diastereomers of compounds of the formula (I) under condition that R1 and R3 don't methyl group simultaneously; b) effective amount of protective agent (antidote) for prevention of hazard effect of herbicide wherein antidote is taken among the group comprising clochintocet, clochintocet with alkaline metal cation, earth-alkaline metal cation, sulfonium or ammonium cation, clochintocet-mexil, mefenpir, mefenpir with alkaline metal cation, earth-alkaline metal cation, sulfonium or ammonium cation and mefenpir-diethyl, and c) additive comprising (C8-C22)-saturated acids alkyl ester or emulsified vegetable oil, or mineral oil taken in the amount 0.01-2% as measured to the spraying mixture mass. Also, invention describes a method for selective control of weed and grassy plants in cultural plant plantings that involves using the abovementioned composition for treatment. Invention provides the selective effect in control of weed and grassy plants, in particular, in cereals crops plantings.

EFFECT: improved control method, valuable agricultural properties of composition.

3 cl, 8 tbl, 2 ex

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