The method of fixation of a patient for carrying out a rotational radiotherapy horizontal therapeutic proton beam and the unit chair for the implementation of this method

 

(57) Abstract:

The invention is used in medical technology in radiation therapy for fixing in position the human body. The patient record in the chair so that his back, feet, hands and forearms, and head on the headrest was tightly fixed to the respective nodes and parts of the seat. Fixation of body parts is carried out by compression, tension and stretching of the tissues of the joints when the force moving the neighbouring parts of the body to the greatest possible number of articular joints. The chair includes seat with side supports of the pelvis, placed on a solid horizontal base plate with the foot, floating knee supports and side supports of the pelvis. On a rigid vertical rod attached to the rear edge of the plate, set backs, the fixing unit of the shoulders and a device for stretching of the spine. All nodes chairs equipped with locking sides. The invention allows metered and rigidly fix the patient in the chair when conducting rotary irradiation. 2 C. and 12 C.p. f-crystals, 3 ill.

The invention is used in medical equipment for fixing in position the human lokacionih tumors beam of ionizing radiation irradiation is carried out only when the position of the patient "lying". For this purpose, the radiation source (for remote gamma-therapy) or a waveguide (for the irradiation of the electron beam) rotate around the patient lying on the treatment table.

Therapeutic application of beams of high-energy protons (100-250 MeV) this leads to serious technical difficulties. Due to the large mass and particle energy device for rotation of the waveguide (vacuum prostonaprosto) lying around the patient (so-called GANTRY) here turn into a huge complex structures weighing 50-80-130 tons, cost 3-5 million (Fig. 1, Ponticles, 1992, 10, p. 8). For their placement requires expensive protective areas, sizes HH m and more.

The known method precision therapeutic rotary scanning exposure of large malignant tumors of multiple narrow horizontal beams of heavy charged particles (e.g. protons) high energy, in which the object of irradiation (for example, a patient, a fixed chair rotary stand) rotate the beam around the vertical axis, simultaneously adjusting the mileage of protons in the object of irradiation so that all horizontal levels of exposure Bragg peak was continuously aligned with the given point is complicated by the methods of scanning and rotational irradiation of any beams of heavy charged particles without the need to use expensive and bulky GANTRY.

However, the realization of the potential of this method of exposure is only possible when providing a rigid fixation of the patient during irradiation in a sitting position.

It is known device Medical chairs to accommodate and reproducible fixation of the patient during radiation therapy in the position of "sitting", produced by the American firm MED-TEC (Radiation Therapy Sourcebook, 1997-1998, MED-TEC, Inc., p. 25). The chair represents the latest development of the famous company, which supplies its immobilizers installation for radiation therapy in many countries, and demonstrates the modern art fixation of the patient to radiation in a sitting position. The chair consists of a flat seat, mesh back, the head restraint in the form of semicircular bowl, armrests and seat belts to secure the parts of the seat pelvis and the head of the patient.

The disadvantage of this design is the low rigidity of fixation of the patient. Given that the human body has almost 20 degrees of freedom, such a device cannot provide the accuracy and repeatability of positioning of the patient or individual parts of his body, which is necessary for precision irradiation beam of heavy charged particles. The chair has no fissile, adopting the posture coachman," to bend, to change the position of the shoulders, pushing forward or pulling back one or both of the shoulder joint, to raise or lower the chin, etc.

A device pneumoencephalographic chairs (US 4153841) mounted on an x-ray apparatus with the possibility of movement, including rotation.

The disadvantage of this design is the low accuracy of fixation of the patient to the hard elements of the armchair, which is basically obespechivaetsya flexible tie straps. Given that the human body has almost 20 degrees of freedom, such a device cannot provide accurate positioning of patients or individual parts of his body, necessary for precision irradiation beam of heavy charged particles.

The chair does not move and does not rotate relative to the radiation source. Move the chair produces only at the stage of preparation for diagnostic irradiation, after which the chair separat and using a moving x-ray tube and cassette with film perform tomografirovaniya immobile patient, fixed in a stationary chair.

The chair also may not retireval sitting in the chair of the patient around the vertical is youseo exposure of the patient stationary horizontal therapeutic beam of protons or other particles.

The technical result of the invention is that the fixation of a patient in such a way that ensures high rigidity, accuracy and reproducibility of patient positioning and separate parts of his body in the chair, required for precision irradiation beam of heavy charged particles. The method determines the exact characteristics and the order of operations required to perform such fixation. Set on a rotating stand with a vertical axis of rotation of the chair provides performance rotary scanning exposure fixed patient stationary horizontal therapeutic proton beam or other heavy particles.

The essence of the proposed method lies in the fact that the fixation of individual body parts perform consistently eliminating physiological gaps between the mating articular surfaces (i.e., "physiological gaps" or "backlash" in the greatest possible number of articular joints using an extremely hard locking elements, by compression, tension and stretching of the tissues of joints that perform forcibly moving the neighbouring parts of the body, bearing articular surface in the body, to turn part of the body that includes multiple joints (e.g., spine), in the pre-tense the carrier structure, and then fix the parts of the body in this position.

For fixing the patient in the position of the irradiation place him in the chair rotating stand with foot, seat, backrest, headrest and podocotyle. In the chair the patient is placed so that the rear surface of his back in contact with the chair, head resting on the headrest, thigh lay on the surface of the seat, the legs were lowered and the feet are on the foot.

Fixation may also be sequentially pressing the feet of a patient to stop heels, and (with the help of knee stops) by clicking on the knee joints in the lower edge of the patella so that the force had along the axis of each femur of the patient, press the pelvis of the patient's back, pressing firmly against the rear surface of the pelvis to the front surface of the lower part of the seat back. The force to be transmitted through the knee joint, the long axis of the femur and the hip joint, which allows to reduce to zero the width of the joint space, i.e., to eliminate the "physiological gaps" ("backlash") in these joints.

On the wings of the pelvis (with stops, having everyone in the vertical sectional shape of a triangle or trapezoid, facing the top down), press the buttocks of the patient to the seat.

Thereafter, the shoulder stops) maximum lowered down and drains the posterior region of the shoulder joint of the patient, eliminating the "physiological gaps" ("gaps") in the joints of the shoulder girdle and pressing them to one of the backs of the chairs.

Then do dosed spine, then firmly grasp the patient's head (clamping it between a chin rest and a head rest) and move it up and dosed with effort.

It is also possible fixation of the shoulder girdle and spine by hard capture of the patient's head and moving it up with measured force, after which the shoulder joints of the patient maximally lowered downwards, away back and fix them on the details of the armchairs.

Finally, on the penultimate stage of fixing possible the implementation of forced lordosis, i.e. quite vigorously (on the verge of pain) prohibit the back of the patient anteriorly (using rolling back). Because at this point, the pelvis of the patient, the region of the shoulder girdle and head are already fixed, the latter is nnow, practically stationary design, resembling a bow with a stretched string, where the string assumes a rigid vertical arm of the chair.

Fixation of the patient ends that immobilizes the shoulder joints, which eliminates them in the remaining physiological gaps" ("gaps") between paired articular surfaces. To do this, each forearm of the patient's arm is placed on the armrest so that it lay on the surface of the arm and elbow rested in the existing armrest elbow emphasis. Then the patient grasps the hand available on the armrest movable vertical pin, which the operator moves toward the elbow to rest up until the elbow of the patient will not be pressed to the maximum elbow fence and brush (clenched fist around the post) will not SAG maximum in the outer (lateral) side so that the line connecting the vertical axis of the shaft with the center of the elbow-rest, was lying outwards (laterally) from donnica bones of the forearm. The brush, the wrist joint and forearm form something similar to a bayonet clip, in which compressed (with external, rear side) and stretched (with inner Palmar side) of the fabric is authorized by the joint surfaces as brushes, and elbow and provides rigid fixation of the elbow and wrist of the patient, as well as his forearm. At the same time, if absolutely necessary, the patient can move the brush upwards along the retaining pin and remove the arm from the armrest (for example, to break a chin rest and to release the head during regurgitation).

Further, the arm of the chair move back and forth and up and down so that the front surface of the upper arm is located along the anterior axillary line, and the humerus was propped up from below the shoulder joint, eliminating it residual gap.

All the operations mentioned above are provided by the design of the chair.

The chair of the lock of the patient includes seat, lateral pelvis, backrest, armrests and a vertical rod on which they are installed, they can move along it, the device for fastening with brackets, bearing a head and chin rest, with the possibility of their simultaneous movement and fixation of individual body parts of the patient and the brakes.

It is also equipped with a massive horizontal base plate, a rigid vertical rod, a traction device allows the CLASS="ptx2">

On the upper surface of base plate armchairs placed seat. To the rear edge of the plate still attached directed vertically upwards rod. The front edge of the plate attached to the foot, with the possibility of changing the distance between him and the support plate, and knee supports can be moved along a line parallel to the anteroposterior axis of symmetry of the seat.

To the sides of the plate attached lateral pelvis with the possibility of changing the distance between the supports and armrests, which are rigidly connected with the side lugs of the pelvis and move with them towards the patient and from him. There is also the opportunity to move each arm parallel to itself up and down and back and forth, parallel to the anteroposterior axis of symmetry of the seat. The device stretching of the spine, the back and the fixing unit installed shoulders on the vertical rod with the possibility of movement along the rod. All nodes chairs and their component parts is equipped with brakes, locking them in any of the possible positions.

The vertical rod may have a rectangular cross-section, which eliminates the angular offset hung on the rod of the nodes of the chair.

One of the backs of the chairs are made with the possibility of moving towards sitting in the chair of the patient and from him.

The fixing unit of the shoulders of the patient consists of a back and shoulder rests, made in the form of an l-shape curved triangular or trapezoidal plates. Each plate facing narrow end down, and a broad base to the top of the back of the site with the possibility of changing the distance between the shoulder stops, and between each shoulder rest and the back of the node.

Lateral pelvis can be performed in the form of two removable flat plates parallel to each other and to the axis of symmetry of the seat. The plate can be moved towards each other above the seat surface. The plate may also have a wedge shape (or shape facing the top down flat pyramid), i.e., in vertical section, each can be oinoi rectangular flat or concave areas, which still has the rest of the elbow of the patient and the vertical pin is movable along the long axis of the pad. The armrest is mounted on the same carriage that same side, the emphasis of the pelvis, and is moved together with the latter in the direction of the patient and from it, with the added ability to move the armrest parallel to itself up and down and back and forth, parallel to the anteroposterior axis of symmetry of the seat.

The knee supports are made in the form of two semicircles connected to each other by a jumper and converted its concave rubber surface to the knees of the patient. You can adjust the height of the half-rings relative to the plane of the seat.

The foot of the chair may have a V-shaped lugs for heels of shoes of the patient and clamps made in the form of two flat half-rings connected to each other by a jumper and converted its concave rubber surface to lift the feet of the patient. You can modify the distance between the clamps and stops for heels.

Plate side lugs of the pelvis, shoulder rests, head rest, chin rest, backrest can be made of plexiglass or other hard daniellellanes the CLASS="ptx2">

In Fig. 3 shows the attachment of the patient's head and stretching of the spine.

The inventive chair has the foot 1 (Fig. 1), the seat back 2 (Fig. 1) and 2, 3, 4 (Fig. 2), the headrest 5 (Fig. 1, 3) and the armrests 6 (Fig. 1, 2), equipped with a massive horizontal base plate 7 (Fig. 1, 2), rigid vertical rod 8 (Fig. 1-3), the device stretching of the spine 9 (Fig. 1 and 2 and Fig. 3), the fixing unit of the shoulders 10 (Fig. 1, 2), movable side stops pelvis 11 (Fig. 1), knee supports 12 and the seat back 2 (Fig. 1) and 2-4 (Fig. 2) is made independent.

The base plate 7 is rigidly mounted on a rotating stand 13 (Fig. 1). On the upper surface of base plate placed seat. To the rear edge of the plate still attached directed vertically upwards rod 8 (Fig. 1-3). The front edge of the plate attached to the foot 1 (Fig. 1), with the possibility of changing the distance between him and the support plate 7, and knee supports 12, with the possibility of movement along a line parallel to the anteroposterior axis of symmetry of the seat. To the sides of the plate attached lateral pelvic 11 (Fig. 1) with the possibility of changing the distance between the supports and armrests 6 (Fig. 1, 2). Each armrest is moved together with the same (right or Les what about the armrest parallel to itself up and down and back and forth, parallel to the anteroposterior axis of symmetry of the seat.

On the vertical rod 8 (Fig. 1 - 3) installed: device stretching of the spine 9 (Fig. 1 and 2 and Fig. 3), the backrest 2 to 4 (Fig. 2) and the fixing unit of the shoulders 10 (Fig. 1, 2), with the possibility of their movement along the boom.

All nodes chairs or their parts is equipped with brakes, locking them in any of the possible positions.

Individual nodes chairs have the following design features.

Vertical rod 8 (Fig. 1-3) has a rectangular cross-section, which eliminates the angular offset hung on her sites.

The device stretching of the spine 9 (Fig. 1, 3) mounted on the rod 8 can move along a line parallel to the anteroposterior axis of symmetry of the seat and is provided (Fig. 1, 3) bracket 14 carrying the headrest 5 and chin rest 15, with the possibility of changing the distance between the last two. Chin rest 15 (Fig. 3) is rigidly fixed on the rod 16, which are attached to the brackets 14 at two points, one of them with a loop 17, and in another by means of a clamp 18 with variable power capture.

This design on the one hand allows to compensate the TOC is on the line parallel to the anteroposterior axis of symmetry of the seat) and hard to capture the head of the patient (due to a change in the distance between the headrest 5 and a chin rest 15 (Fig. 3)), and on the other, ensures the safety of the fastening head. So, if during irradiation, the patient will lose consciousness and all your weight is "up" on the chin rest 15 or wants to escape from the mount for any other reason, then head of the patient raspoliruyte at the moment when the pressure on the chin emphasis will exceed the level of the grip force of the strap 16, initially set the clamp 18. In this case, the strap 16 that carries a chin-rest, to slip from the clamp 18 and freely hung on the loop 17.

The proposed device is equipped with multiple backs 2-4 (Fig. 2) that allows you to adjust the shape of the support surface in accordance with the anatomical features of the back of the specific patient. The backrest is made of plexiglass, which provides rigidity to the supporting surface and sufficient transparency for charged particle beam.

The backrest 3 is configured to move back and forth (using screw mechanism 19 (Fig. 1)) towards sitting in the chair of the patient. This creates compel the costs of the backrest 2 and the shoulder stops 20 (Fig. 1) made in the form of an l-shape curved triangular or trapezoidal plates of Plexiglas, facing the narrow ends 21 down, and wide (oriented horizontally) base 22 (Fig. 1, 2) to the back, above the level of the upper edge of the backrest 2 node 10. You can adjust the distance between the shoulder stops, and between each shoulder rest 20 and the back 2 node 10, as well as the ability to move the whole site 10 up and down along the rod 8.

During patient positioning height of the fixing unit of the shoulders 10 on the rod 8 is adjusted so that facing to the back 2 of the node 10 of the horizontal part 22 of the shoulder stops 20, pressing the upper arm of the patient, provided the maximum abduction of the shoulder joint down. The distance between the shoulder stops are chosen so that the inner edge 23 (Fig. 1) their vertical divisions 20, 21 were located along the anterior axillary line of the patient, and the distance between each shoulder rest 20 and the backrest 2 node 10 is adjusted so that the vertical part of the shoulder stops took the shoulder joints of the patient and posterior them tightly pressed to the back 2 of the node 10.

Lateral pelvic 11 (Fig. 1, 2) made of plexiglass in the form of two parallel to each other and the OS is life edge of each plate moves above the horizontal level of the seat surface, moreover, the plates may be flat or have a thickened upper edge and a vertical section to represent each facing the top down triangle or a trapezoid.

When approaching their inner plates (facing the patient) surface to hold the pelvis of the patient, excluding its lateral displacement. If you are plates with reinforced top edge, then the convergence of the lateral lugs of the upper (more thick) edges of the plates hanging on the wings of the pelvis, pressing the pelvis down and pressing the buttocks of the patient to the seat.

Each arm 6 (Fig. 1, 2) is made in the form of a horizontal rectangular flat (or concave) site 6 (Fig. 1), which still has a concave semi-circular or U-shaped stop 24 (Fig. 2) for the elbow of the patient and is movable along the long axis of the pad vertical pin 25 (Fig. 1).

The design of the armrest and the method of fixation of hand and forearm provide security for the patient, as well as, if necessary, the patient will be able at any moment to release the hand, moving the brush up along the vertical pin 25.

Knee supports 12 (Fig. 1) made in the form of two semicircles connected by a bridge and facing its concave rubber the ti seats and the possibility of their moving along the line, parallel to the anteroposterior axis of symmetry of the seat.

On the upper surface of the platform 26 of the foot 1 (Fig. 1) on which the patient puts feet, has a semi-circular or U-shaped supports for heels of shoes of the patient, as well as the clamps 27, made in the form of two connected by a bridge flat semicircles facing its concave rubber surface to lift the feet of the patient, with the possibility of changing the distance between the clamps 27 and stops for heels, and also with the possibility of changing the distance between the bottom 1 and the support plate 7 of the chair.

Fixation of individual body parts is:

- due to the compression of the articular surfaces or voltage of the soft tissues of the joint or multiple joints;

- due to the immobilization directly the joints (e.g. shoulder) using adjustable clamps;

by successive elimination of physiological gaps ("backlash") in the greatest possible number of articular joints;

- by turning the main load-bearing structure of the body part (e.g., spine) in a pre-strained structure.

Too rigid fixation can be dangerous for the patient, as in freemanii one. It is separated from the medical staff tonnage protective door. Even if the staff (on the screens of television monitors) notice that wrong with the patient, to reach the patient and help him succeed only 2-3 minutes.

Therefore, if the patient during irradiation will lose consciousness and will settle in the chair, he can all the weight of the torso to hang on fixed head and hurt myself cervical spine before the staff will have time to help him.

With fixed head, lifted his chin and stretched his neck unpleasant consequences may cause sudden vomiting (patient may choke on vomit).

In these conditions, for patient safety, greater importance is the ability to quickly, preferably automatic, released his head and hands.

The inventive device seat ensures automatic (with a sudden increase of the load on the chin emphasis) or voluntary (at the request of the patient) unfixing the head and hands of the patient. In this case the patient will not choke on vomit when sudden regurgitation, and an unconscious patient does not "fall out" from the chair and will not receive the complement is aslo mounted on a Medical proton beam LNP OEM (, Dubna) and successfully applied to proton irradiation of cancer of the esophagus. It is reliably ensured rigid and secure fixation of the patient during precision rotary-scanning proton radiation this large, deep-seated tumors in the position of the patient "sitting".

1. The method of fixation of a patient for carrying out a rotational radiotherapy horizontal therapeutic proton beam, concluding that a patient is placed in the chair, containing a seat, foot, backrest, armrests and headrest so that the rear surface of his back firmly against the backrest, thigh lay on the surface of the seat, feet the entire sole stood at the pole, hands and forearms were resting on the armrests, and his head rested on the headrest, with movable locking elements armchairs fix the particular body part of the patient to the appropriate components of the seat, characterized in that that fixation of parts of the body carry out strictly by compression, tension and stretching of the tissues of the joints, through forced displacement of neighbouring parts of the body, bearing articular surfaces of this joint sequentially, to the greatest possible number of articular joints.

3. The method according to PP.1 and 2, characterized in that the first firmly grasp the patient's head and move it up and dosed with effort, and then the shoulder joints of the patient maximally lowered downwards, away back and fix them on the details of the chair, followed by forced lordosis.

4. The method according to PP. 1 to 3, characterized in that at the final stage of fixing ptica, his elbow rested on the existing elbow on the armrest support, after which the patient grasps the hand available on the armrest movable vertical pin, and the operator moves the pin toward the elbow to rest up until the elbow of the patient will not be pressed to the maximum elbow fence and brush, clenched fist around the post, will not SAG in the back side so that the line connecting the vertical axis of the shaft with the center of the elbow-rest, was lying lies lateral to donnica bones of the forearm and locks the pin in this position, then the arm of the chair move back and forth and up and down so that the front surface of the upper arm is located at the level of and along the anterior axillary line, and the humerus was propped up from below the shoulder joint, and fix the arms in this position.

5. Chair for fixing the patient in the position of the irradiation, containing the seat with the side lugs of the pelvis, backrest, armrests and a vertical rod on which they are installed, they can move along it, the device for fastening with brackets, bearing a head and chin rest, with the possibility of their simultaneous movement, and e is the surface of a solid horizontal base plate, which is further provided with a foot, with the possibility of changing the distance between him and the support plate, knee supports are made with the possibility of movement along a line parallel to the anterior-posterior axis of symmetry of the seat, cruel vertical rod upward and rigidly attached to the rear edge of the plate, and the foot and knee supports are attached to the front edge of the plate, the lateral thrust of the pelvis with the possibility of changing the distance between them is attached to the lateral sides, and the arms are rigidly connected with the side lugs of the pelvis and is made with the ability to move each arm parallel to itself up and down and back and forth, parallel to the anterior-posterior axis of symmetry of the seat, while on the vertical rod can move along with the backrest, the fixing unit of the shoulders, and the device for fastening made in the form of device stretching of the spine, all the nodes of the chair is equipped with brakes, locking them into any provisions for them.

6. The chair under item 5, wherein the vertical bar has a rectangular cross-section.

7. The chair on the PP.5 and 6, characterized in that the device is in the distance between them, and with the possibility of their simultaneous movement along a line parallel to the anterior-posterior axis of symmetry of the seat, and chin rest attached to the brackets at two points, one of them with a loop, and the other using a clamp with variable power capture.

8. The chair on the PP.5 to 7, characterized in that one of the backs is configured to move in the direction of sitting in the chair of the patient and from him.

9. The chair on the PP.5 to 8, characterized in that the fixing unit of the shoulders is from the back of the fixing unit and the shoulder lugs, made in the form of an l-shape curved triangular or trapezoidal plates facing narrow end down, and a broad base to the top of the back of the site with the possibility of changing the distance between the shoulder stops, and between each shoulder rest and the back of the node.

10. The chair on the PP.5 to 9, characterized in that the lateral pelvis is made in the form of two removable plates, flat or wedge-shaped, parallel to each other and to the axis of symmetry of the seat, with the possibility of moving the plates toward each other above the surface of the seat.

11. The chair on the PP.5 to 10, characterized in that each arm is made in the form HorizontalAlign along the longitudinal axis of the pad - vertical pin, each armrest is mounted on the same carriage that same side, the emphasis of the pelvis, with the possibility of joint movement in the direction of the patient and from it, with the added ability to move the armrest parallel to itself up and down and back and forth, parallel to the anterior-posterior axis of symmetry of the seat.

12. The chair on the PP.5 to 11, characterized in that the knee stops made in the form of two interconnected jumper semirings, facing its concave rubber surface to the knees of the patient, with the possibility of changing the height of the half-rings relative to the plane of the seat.

13. The chair on the PP.5 to 12, characterized in that the foot has a V-shaped lugs for heels of shoes of the patient and clamps made in the form of two interconnected jumper semirings, facing its concave rubber surface to lift the feet of the patient, with the possibility of changing the distance between the clamps and stops for heels.

14. The chair on the PP.5 to 13, characterized in that the plate side lugs of the pelvis, shoulder rests, head rest, chin rest, backrest made of plexiglass or other hard tissue equivalent material.

 

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SUBSTANCE: invention relates to a method for inhibition of tumor growth using radiation therapy as ionizing radiation with additional administration of mixture of octa-4,5-carboxyphthalocyanine sodium cobalt salt or oxocobalamine with sodium ascorbate in the ratio = (1:10)-(1:30). Method of combined using irradiation and indicated mixture of substances provides enhancing the effectiveness of anti-tumor treatment resulting to 70-100% recovery of experimental animals and reducing radiation loading and toxicity.

EFFECT: improved method for inhibition.

2 tbl, 3 dwg, 3 ex

FIELD: medicine, oncology.

SUBSTANCE: the method deals with applying chemopreparations incubated with autolymph and radiation therapy. Lymph taken out of patient's thoracic duct should be centrifuged for 30 min at 2200 rot./min, lymphatic plasma should be taken and frozen at -40 C, lymphatic formic elements should be incubated in a thermostat at 37 C for 1 h together with chemopreparations by a certain scheme to be reinfused for a patient intravenously by drops according to the given scheme. Then, 2 wk later, one should perform therapy with a split course of distance gammatherapy at single focal dosage (SFD) of 4 Gy. At the first stage one should apply per 2 Gy twice daily at 4-5-h-long interval 5 times weekly, at achieving focal dosage of 28 Gy it is necessary to have a week-long interval. Then radiation therapy should be continued but SFD of 4 Gy should be applied at once. One should fulfill 3 fractions of irradiation per a week, there are 6 fractions during the second stage, totally. Total focal dosage (TFD) per the whole course of irradiation corresponds to 52 Gy. About 4 wk after radiation therapy one should defrost lymphatic plasma to incubate it with the same chemopreparations in a thermostat at 37 C for 1 h to be then reinfused for a patient intravenously by drops. The method enables to decrease tumor volume and tumor process metastasing without any operative interference.

EFFECT: higher efficiency of therapy.

1 ex

FIELD: medicine, oncology.

SUBSTANCE: before irradiation it is necessary to cool the tumor to achieve the temperature of freezing at clinically detectable border between the tumor and healthy tissue to perform irradiation directly after natural tissue defrosting with a single focal dosage (SFD) being 2-2.5 Gy daily for 5 d a week at 2-d-long interval to achieve total focal dosage (TFD) of 60-65 Gy. Moreover, the area of healthy tissue should be protected with a shielding applicator - a lead plate - during irradiation. The present innovation enables to maximally keep anatomical relief and function of local tissues.

EFFECT: higher efficiency of therapy.

1 cl, 4 ex

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