The way of measuring gerontological values of bioactive substances and compositions, mainly food and cosmetic products

 

(57) Abstract:

The invention relates to gerontology, geriatrics, nutrition. It allows you to assess, in particular, food and cosmetic products from the point of view of the problems of biology and medicine and tasks related to the preservation of health, by improving the quality of life and increase longevity and maintain the beauty of the body. The method includes determining the melting temperature of the investigated supramolecular structure of the samples studied range of products and job reference temperature, the value of which is less than the minimum melting temperature is investigated supramolecular structure of the samples studied range of products. Next, make determination of the specific Gibbs function of formation of supramolecular structures for the samples studied range of products at the specified reference temperature value. Minimum value of the specific Gibbs function of formation of the studied supramolecular structures produce the selection of a reference sample and a comparison of the specific Gibbs function of formation of the studied supramolecular structure of the reference specimens and by defining data relationships Velich is p. f-crystals, 3 tables.

The invention relates to physico-chemical aspects of gerontology, geriatrics, nutrition and allows to estimate food and cosmetic products from the point of view of many of the problems of biology and medicine and tasks related to the preservation of health, to improve the quality of life, increasing its duration, as well as maintain the beauty of the body.

Art

Currently, all known recommendations on slowing the aging process and increase longevity, are formulated only on an experimental basis. The use of many well-known diets and cosmetics to preserve youth and prolonging life is not always justified, since it is impossible to assess the quality featured bioactive substances, compositions, and products from a position of gerontological values. Moreover, there are no techniques to obtain objective information when comparing gerontological properties of bioactive substances in the same category, such as food. In particular, it is impossible to determine gerontological value of vegetable oils, manufactured from the same raw materials, but isolated from plants, prostateanalmoviest values of bioactive substances compositions and products are, as a rule, only with the involvement of empirical experience, and existing tests do not allow us to quantitatively compare the gerontological value bioactive substances, compositions, and products.

The invention

The present invention is to provide a method of gerontological evaluation values of bioactive substances, compositions, and products, allowing a quantitative basis, using the appropriate indicator - GPG (Georgi Pavlovich Gladyshev), to compare the relative gerontological value bioactive substances, compositions, and products and with regard to this comparison to make practical conclusions and to prescribe recommendations.

The solution of this problem can be obtained new results, namely, that allows you to use the obtained values of GPG to solve the problems associated with keeping the body young, beauty body, improve health and prolong life. There is also the opportunity to create a balanced diet and prescribe differentiated recommendations for people of different age.

These results are achieved is o and beauty products includes: definition of the minimum melting temperature is investigated supramolecular structure of the samples studied range of products, task reference temperature, the value of which is less than the minimum melting temperature is investigated supramolecular structure of the samples studied range of products, determination of the specific Gibbs function of formation of the studied supramolecular patterns for the samples studied range of products at the specified reference temperature value, the choice of the minimum value of the specific Gibbs function of formation of the studied supramolecular structure of the reference sample, for which the indicator gerontological value is taken for the unit definition for the sample values of the specific Gibbs function of formation of the studied supramolecular structure at the reference temperature value, a comparison of the specific Gibbs function of formation of supramolecular structures of the reference specimens and by defining the relationship of the data values, the judgment of gerontological values of the investigated sample is a direct proportionality of the value of the above relations.

Distinctive person is similou in absolute value) the value of the specific Gibbs function of formation of the studied supramolecular structure of the product of the studied series with the reference temperature value, however, this value is compared with similar characteristics of other products, also defined at the reference temperature value. As a reference temperature select the temperature, the value of which is less than the value of the melting temperature of the most fusible investigated supramolecular structures of the studied range of products (samples).

It is also advisable to set the reference temperature value temperature value, which is (2-6) degrees less than the minimum melting temperature of the investigated supramolecular structure of the samples studied range of products.

In addition, as the value of the melting temperature, it is preferable to choose the melting point of the lipid and/or protein and/or carbohydrate, and/or nucleotide structures of the samples.

The most valuable results when using the invention can be obtained when comparing gerontological values of similar products, such as tissues of the bodies of plants and animals, natural fats, etc.

The described invention is based on the following premises. The value of the specific Gibbs function of formation, as homogeneous and heterogeneic substances and compositions, in particular foods. Additionally, the value characterizes the degree of evolutionary youth" of these products.

For practical purposes, the value can be accurately calculated using the approximate equation of the Gibbs - Helmholtz:

< / BR>
where the specific enthalpy of formation of supramolecular structures;

specific enthalpy of melting - denaturation supramolecular structure

- the average of the absolute melting point of the i-th structure;

TABOUT- the reference value of the absolute temperature at which the calculated

specific entropy of formation of supramolecular structures.

If you want to perform more accurate calculations should be used and a more accurate equation Gibbs-Helmholtz.

It was also established that the bioactive substance or product is correlated with the chemical composition of tissues, in particular of living organisms, which varies both in phylogeny and ontogeny, i.e., when the aging process. It follows that there is the possibility of estimating the value not only through the use of calorimetric measurement values and data on the chemical composition of biomass.

So, the value of Le is B> in the tissues of plants and animals, either in their supramolecular structures. You can take that higher gerontological value has clean water or saline solution.

However, in order to quantitatively compare the gerontological value of different bioactive substances, compositions, and products, it is not enough to operate on values related to custom TABOUT. In addition, to assess the comparative gerontology value of products required the selection of reference samples for different classes of products and determination for them to reference values

It turned out that the determination of the values for each sample studied range of products should be carried out if the value of TABOUTless than the melting temperature of the investigated supramolecular structure of the most fusible of the sample studied range of products. In this case, the values for each sample are normalized, since they are defined with the same value of TABOUTthat allows quantitative comparison with the reference value. This comparison is performed by determining the relationship between a reference value which selects the minimum (the URS of investigational product series and value of the analyzed sample.

Information confirming the possibility of carrying out the invention

The described method can be illustrated by the following examples.

Example 1. The definition of indicators GPG different fats.

Studied: Triowin (-form), tristearin (-form), fat, cow butter, hydrogenated cottonseed oil, cottonseed oil, peanut oil. Were determined the melting temperature of supramolecular structures of samples of fat. Is there a minimum melting point of supramolecular structure and one of the products of the investigated range of 273 K (peanut butter). However, considering the fact that well-known dietary fats (lipids), having a melting point of order (225 - 230) was assigned a reference value of temperature TABOUT= 223 K. At a given reference temperature value calculated values of the specific Gibbs function of formation of supramolecular structures of all of the above samples.

As a reference sample selected tristearin, in which the value of the specific Gibbs function of formation of supramolecular structures has a minimum value and its index gerontological values adopted for adenalineage value of the specific Gibbs function of formation of supramolecular structures of the reference sample and the samples. Measurements and calculations are shown in table 1.

The data in table 1, allow you to record a series of comparative gerontology values studied fats. This series, written in order of increasing index GPG can be represented in the form: tristearin (1,0) < Triowin (1,4) < hydrogenated cottonseed oil (1,6) < a fat cow butter (3,7) < peanut butter (4,9) < cottonseed oil (5,1). This sequence agrees well with quality medical recommendations, based on extensive empirical experience of medicine and molecular biology.

Example 2. Indicator definition gerontological values of different samples of individual product - the fat of butter.

The measured melting point six samples (from 27oC to 37oC). As the reference temperature selected value of the 25oC (298 K). Defined values at the reference temperature value and the calculated value of GPG. The results are summarized in table 2, the analysis of which shows that the greatest value of GPG (5,85) has sample # 4. It is seen that the lower the melting point of the fat, the more he gerontologically useful.

Example 3. Determine the temperature of melting of supramolecular protein structures of samples of the product (meat) animals of different ages (see table 3). The value of the reference temperature is set to 25oC (298 K). Reference value

Defined values and GPG. The results are shown in table 3, show that a larger value GPG has a product (fabric) younger organisms.

Thus, the described method is applicable for the evaluation of gerontological value of any food (including food additives), biological compositions, medicinal and cosmetic products used by man in his daily life. The method can also be used to assess the gerontological quality animal feed and plant nutrition.

1. The way of measuring gerontological values of bioactive substances and compositions, mainly food and cosmetic products, comprising determining the melting temperature of the investigated supramolecular structure of the samples studied range of products, task reference temperature, the value of which is less than the minimum melting temperature is investigated supramolecular structure of the samples studied range of products, determination of the specific Gibbs function of formation of the studied supramolecular patterns for the samples studied range of products p is of the investigated supramolecular structure of the reference sample, for which the indicator gerontological value is taken for the unit definition for the sample values of the specific Gibbs function of formation of the studied supramolecular structure at the reference temperature value, a comparison of the specific Gibbs function of formation of the studied supramolecular structure of the reference specimens and by defining the relationship of the data values, the judgment of gerontological values of the investigated sample is a direct proportionality of the value of the above relations.

2. The way of measuring gerontological values of bioactive substances and compositions, mainly food and cosmetic products, under item 1, characterized in that as a reference temperature set temperature value, which is 2 to 6 degrees. less than the minimum melting temperature of the investigated supramolecular structure of the samples studied range of products.

3. The way of measuring gerontological values of bioactive substances and compositions, mainly food and cosmetic products, under item 1 or 2, characterized in that the melting temperature of the investigated supramolecular structures choose t is ur samples for which assessment gerontological values.

4. The way of measuring gerontological values of bioactive substances and compositions, mainly food and cosmetic products, under item 1, or 2, or 3, wherein the definition for the sample values of the specific Gibbs function of formation of the studied supramolecular structure at the reference temperature value is done using known calibration curves of functional dependence measuring the concentration of ciwater in the tissues of plants and animals or their supramolecular structures.

 

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