A means of encouraging the healing process of wounds

 

(57) Abstract:

The invention relates to medicine, can be used in the production of pharmaceuticals and for the creation of tools for healing of purulent-necrotic wounds of different etiology. The tool gives epithelialization and healing of purulent wounds. The composition of the medicinal product (wt.%): chloramphenicol is 0.65 - 0.75; methyluracil - 0,35-0,45; lavender - of-0.7 to 0.5, glycerin - 10,0-15,0, anhydrous lanolin - 3,0-4,0, butter fat (stone) - 10,0-20,0, distilled monoglycerides - 1,0-2,0; abbasian (stabilizer) is 0.5 - 0.8; nipagin - 0,11-0,12; nipazol - 0,11-0,12 distilled water - the rest. Use accelerates epithelialization and healing of purulent wounds. table 4.

The invention relates to medicine, can be used in the production of pharmaceuticals and applies tools for healing of purulent-actoricesti wounds of different etiology.

It is known that the chloramphenicol /chloramphenicol/ - antibiotic with a broad spectrum of antimicrobial action, effective against major pathogens of purulent infection [1]. Methyluracil, exerting an active influence on tissue metabolism, is widely used to stimulate healing of purulent wounds in CL is well-known: toxic effects on various organs and systems, allergic reactions, drug disease, the appearance of candidiasis, etc. In parenteral and oral administration of anabolic steroids and other agents that affect tissue metabolism /methyluracil, etc./, possible allergic reactions, headaches, dizziness and so on [1, 4].

To avoid these side effects, use ointment composition, allowing for local effects on the wound simultaneously affect pathogens and stimulate the healing process. In surgical practice, widely used such ointments: domestic drug to polietilenoksidnoy basis /PEO/ the vegetable "levomekol, of foreign drugs "Trogoderma" /production company "Pharmacia & decision Upjohn, USA/.

The aim of the invention is to develop tools to accelerate epithelialization and healing of purulent wounds. To achieve this goal in the drug entered the complex of active components, such as chloramphenicol, methyluracil, lavender, glycerin emulsion of oil and water stabilized by abbasides, monoglycerides distillirovanna in the following ratio, wt.%:

Chloramphenicol is 0.65 - 0.75

Methyluracil - 0,35-0,45

20,0

Distilled monoglycerides - 1,0-2,0

Abbasian (stabilizer) - 0,5-0,8

Nipagin - 0,11-0,12

Nipazol - 0,11-0,12

Distilled water - Rest

The inventive tool is a low-toxic, highly effective drug for healing of purulent wounds, the tool was prepared as follows.

According to the composition of the inventive recipe N 2 /table 1/ beat drug substance chloramphenicol, methyluracil, emulsifiers - abbasian, distilled monoglycerides, butter fat, butter lavender, nipagin, nipazol /preservatives/, glycerin, lanolin, and distilled water. In a porcelain Cup in a measured amount of distilled water make abbasian and leave for swelling /about 40 minutes. After swelling aubazidan in the same glass placed glycerin, nipagin, chloramphenicol, methyluracil in a water bath with constant stirring, heated to complete dissolution of aubazidan /at a temperature of about 50oC/. In the second porcelain glass alloys distilled monoglycerides, lanolin oil fatty. In the resulting alloy is dissolved nipazol. In the solution of aubazidan with glycerin and medicinal substances injected when the mixer gradually masou emulsion is cooled at a low speed mixer /60-100 rpm /min to ambient temperature /20oC/.

The resulting cream is an emulsion system type "oil-water" on the basis of a polysaccharide gentle creamy consistency, which is very stable during the whole observation period /24 months/.

To install changes at different storage conditions cream kept at temperatures 40oC, 20oC and 4oC. condition of the studied emulsion system before laying and during storage was determined by the following indicators: colloidal stability, dispersibility, the quantitative content of medicinal substances and antimicrobial activity of preservatives, as well as viscous properties of the system as freshly prepared, and in the process of storing /24 months/. Investigation of rheological properties and the main physico-chemical parameters of the system allow us to conclude that the claimed product is a structured colloidal systems and has high stability /tables 2, 3/.

Research on the effectiveness of the use of funds was carried out in the treatment of purulent wounds in animals. The experiment was performed on a 64 outbred rats-males that were razdelannogo bag /M. I. Verai et al., 1985/. Animals of the 1st, 2nd and 3rd groups were made appliques ointment drugs on wound at a dose of 0.5 g/cm2daily until complete wound healing: in the 1st group - ointment the vegetable "levomekol, in the 2nd group - ointment "Trogoderma", in the 3rd group - the claimed means. In the 4th group application of ointments was not made /control/.

Control over the course of the wound process was carried out visually with photography, evaluating the quality and speed of granulation and epithelization and cytological method of wound prints" by M. P. intercession and M. S. Makarov modification D. M. Steinberg [6]. Microbiological study of wound was performed 1 time per 7 days by standard procedures. In addition, controlled hematological parameters and blood histamine /table 4/.

Macroscopic examination after the start of the applications already for 2-3 days showed a "revival" of granulations. They became brighter, disappeared plaque fibrin, appeared easy, contact bleeding. On the periphery of the RAS intensified the process of epithelialization. However, already in the second week of applying the ointment the vegetable "levomekol was marked negative effect of "drying out" granulating wounds /group 1 animals/, ctivity was not observed. In the 3rd group was marked by more rapid in comparison with the 1-St and 2-nd groups granulation of wounds, as well as a more active regional and islet epithelialization.

Cytological studies "wound fingerprints" in the modification D. M. Steinberg showed that baseline measurements of animals in all groups were dominated by 1 type of cytogram: cellular elements presented in the imprint of the number of neutrophils and a single histiocytes with vacuolation cytoplasm, indicating a low resistance to infection, the inhibition of immune resistance and regeneration processes. Further, when the daily application of creams, as wound healing, smears appeared connective tissue elements at different stages of development and differentiation, epithelial cells in large quantities, first, young, later young and orogovevshie. This picture was intermediate between the 3rd and 4th types of cytograms. At this stage of treatment in the first two groups, compared to the 3rd, was relatively less number of elements of the connective tissue, a little earlier appeared orogovevshi epithelium on the background of relatively smaller content of young epieimeria drugs percentage of sterile crops was higher in animals of the 3rd group /61.7% of/ as compared with other groups /1-I - 51,6%, 2-I - 46,2%, 4th - 31,2%/.

Apparently, these experimental studies, differences between the macroscopic and cytological characteristics healing of purulent wounds in the second and third phases of the wound healing process in animals treated with combination products the vegetable "levomekol, "Trogoderma" and claimed means, associated with different properties of the media /base/ medicinal drugs in ointments. The bearer of the proposed drug is an emulsion of the "oil-water", which has the property to reduce skin dryness, improve softness and elasticity, to maintain normal water balance of the skin, reduce inflammation. Abbasian, a polysaccharide of natural origin, included in the emulsion base of the proposed drug, as has already been established [7], enhance and prolong the activity of antibiotics, and also increases the resistance of the organism [8] . Polysaccharide based, as a carrier of drugs in the inventive tool, contributes to a more powerful regenerative-stimulating activity and methyluracil, which is part of the tools.

Thus, the proposed tool has an impact on wound microflora stimulates

1. Drugs in Russia. On the main page. -M.: 1997, 1504 S.

2. Wounds and wound infection /edited by M. I. Kuzin, B. M. Kostuchenko. -M.: 1981, 688 S.

2. Pods of C. I., Postyshev C. K., Pods Y. C. Guide purulent surgery. -M.: 1984, 512 S.

4. Radbill O. S. Pharmacotherapy in gastroenterology. The Handbook. - M.: 1981, 688 S.

5. Medicines used in medical practice in the USSR. Reference book /Ed. by M. A. Klyuyev. -M.: Medicine, 1989.

6. Fencin K. M. wound Healing. -Kiev. 1979, 168 S.

7. Ageeva O. N., Arkadiev, E. Aksenov, O. A. and other Study interference and antiviral activity of yeast polysaccharides of different chemical structure. In the book: Mater. the scientific. proc. Len. chem.-farm, in-TA. -L.: 1976, S. 13-15.

8. Elin N. P. Microbial polysaccharides and their physiological activity. In kN. : Research-thematic. proc. on Probl.: Medicinal cf-VA and biological. active. prophetic. -L.: 1964, S. 31 and 32.

A means of encouraging the healing process of wounds containing chloramphenicol, methyluracil, characterized in that the base emulsion of the type oil-in-water stable abbasides, monoglycerides distillirovanna and additionally includes lavender, gli

Methyluracil - 0,35 - 0,45

Lavender - 0,5 - 0,7

Glycerin - 10,0 - 15,0

Anhydrous lanolin - 3,0 - 4,0

Oil fatty (stone) - 10,0 - 20,0

Abbasian (stabilizer) - 0,5 - 0,8

Nipagin - 0,11 - 0,12

Nipazol - 0,11 - 0,12

Distilled water - the Rest

 

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