Method and device for spraying fluid

 

(57) Abstract:

Method of atomization ensures the availability of a given quantity of fluid between the first surface and the second surface, spaced from each other. Move these two surfaces from each other up until the first surface along its entire length will not come in contact with the second surface, and with such speed that the fluid medium between the two surfaces is pushed outward along the periphery of the surface at a rate sufficient to atomize the fluid. Both surfaces have complementary shape. The fluid is fed through the discharge outlet, which is open at one surface and is preferably in its center. Both surfaces are alternately moved to a position in which they are separated from each other, and in the position in which they are in contact with each other. The device comprises a first clamping means having a first surface and a second clamping means having a second surface. The clamping surface means facing each other. The device also has a tool drive for alternately moving one of the clamping means in communication with the source in order to reap the fixed and movable clamping means. The tool actuator is a solenoid actuator that contains a floating magnetic or electrically conductive core for impact on movable clamping means and rigidly mounted a winding surrounding the core, the annular gap between them. Winding zapityvat energy from the power source mode interruptible supply. The core still attached to the movable clamping means, one surface of which is slightly concave for education acting County region and is made of elastic material. With clamping means are connected by means of focus to determine the minimum gap between their surfaces. The invention allows to avoid large quantities of fluid, because only a limited amount of fluid between the surfaces subjected to compression. In addition, using the device you can get the spray fluid with a droplet size of about 10 microns or less. 2 S. and 9 C.p. f-crystals, 5 Il.

The invention relates to a method of atomizing fluid and the device for implementing this method.

From the patent literature there are several known devices and nozzles for fine u is the fluid through a small orifice under high pressure.

Further, in EP-A1-0520571 disclosed nozzle for receiving the aerosol droplets containing a nozzle having a locking element that is moved between a position in which it locks the nozzle, and a position spaced from it to form the gap. Under the influence of pressurized fluid locking element is displaced relative to the nozzle, forming a gap through which the film of fluid flows through the gap and destroyed with the formation of drops.

Furthermore, from WO 92/19383 known spraying flow fluid into droplets by collision flow with the body placed in the path of the release thread with great speed.

And finally, in EP-A2-0387179 disclosed spraying device, in which under the pressure of the fluid released through the vibrant nozzle containing a saddle portion having a discharge hole, and the locking element, the decline in the locking position by a spring and locking in this position the outlet. By using the Electromechanical actuator can create fluctuations locking element between the closed and open position relative to the saddle parts, through which pressurized fluid medium will produce the pharmaceutical field known application of a solution or suspension of the drug, introduced as a fine spray through the nose or mouth. For inhalation is necessary to apply so small droplet size of about 10 microns or less that they can carry with them the air you breathe, and they thus reached its destination, i.e. at the alveoli in the lungs.

In order to obtain a sufficiently small drops, in practice, for many years the solution or suspension of the drug was sprayed using a propellant, usually type gas freon. Due to the impact on the environment and the physiological effects it is desirable to avoid the use of more or less inert propellants.

The technical problem of the invention is to develop a method and apparatus for fine atomization fluid, in particular, medicines in the form of a solution or suspension in a medium such as water, to using such a device you could get spray fluid with a droplet size of about 10 microns or less.

In accordance with the invention, a method of spraying a fluid medium is characterized by the fact that provide a specified quantity of a fluid medium between the first surface of the pores, while the first surface is essentially along its entire length will not come in contact with the second surface, and with such speed that the fluid medium between the two surfaces is pushed outward along the periphery of the surface at a rate sufficient to atomize the fluid.

Thus, the invention is based on the knowledge of the fact that you can get a very fine atomization of the fluid, if the two surfaces between which there is some dose of fluid to move toward each other at a rate sufficient to spray a thin film of fluid out on the edge surfaces. After this film the fluid becomes unstable and splits into thin streams of fluid, which are broken into droplets, whose diameter is smaller than the original film thickness of the fluid obtained under the influence of the surface tension of the fluid. Compared with the principles of the spray without the use of propellants using the present invention it is possible in this way to avoid compression of large quantities of fluid, as essentially only a limited amount of fluid between the surfaces subjected to compression. In particular, for example, the so-called inhaler.

In accordance with the invention, both surfaces may have essentially complementary shape. This variant embodiment of the invention at present preferred.

In addition, in accordance with the invention, the fluid can be fed through the outlet channel, which opens in one surface and which is preferably in its center.

Finally, in accordance with the invention can alternately move the two surfaces between the position in which they are separated from each other, and a position in which they are essentially in contact with each other, preferably with a frequency of 10-100 Hz. In this variant embodiment of the invention the alternating movement get essentially continuous fine spray of fluid. In relation to the inhaler, the time interval may be 2 C.

The term "substantive contact between two surfaces" is used here to indicate that the two surfaces are not necessarily in direct contact, and may slightly defend from each other, namely, at a distance corresponding to the half, thirds or smaller proportion is microns can result in this way the surface of the end position, when will they defend each other, for example, 5 μm, and due to this it will be possible to get the corresponding effect atomization. This is in particular significant when the spray suspension, and the surface should not be close to a distance less than the particle size of the suspension, because otherwise there will be a compression of these particles and possibly sticking them to one of the surfaces. Naturally, when spraying solutions of the surface can come into direct contact with each other.

The proposed device for the implementation of the proposed method differs in that it includes a first clamping means having a first surface and a second clamping means having a second surface, and the clamping surface means facing each other, the tool actuator for alternately moving one of the clamping means between a position in which the surface of the clamping means are separated from each other, and the position in which these surfaces are essentially in contact with each other along its entire length; the outlet for the fluid, opening in the region between the two clamping means and communicates with Istoki delivers a specified amount of fluid in the region between the two clamping means through the outlet, when these funds are separated from each other.

Therefore, as described earlier in connection with the proposed method, the specified amount of fluid located between the holding means is pressed out, and a thin film of fluid is broken into small droplets, when the surface of the clamping means are moved towards each other.

In accordance with the invention, the device may include fixed and movable clamping means. This variant embodiment of the invention at present preferred.

In addition, in accordance with the invention, the tool drive can be by means of an electromagnetic drive that contains the roaming electromagnetic or elektroprivodnye core for impact on movable clamping means and rigidly mounted a winding surrounding the core, the annular gap between them, and the winding zapityvat energy from the power source mode interruptible supply. The tool drive can be purely mechanical or piezoelectric type.

The core may have a discontinuous effect on the movable clamping means to enter its surface in the cue, in which its surface is separated from the surface of the second clamping means return an item, such as a spring, deflector movable clamping the tool to the specified position. Instead of deflecting means such as a spring, can provide movement of the clamp, and the core can provide the movement of the clamp due to the supply of power to the coil.

In connection with the above variant embodiment of the invention, it should be noted that the core can still be connected with a movable clamping means. As a result of this you can alter the polarity of the supplied power, and thus by the power supply, you can move the movable clamping means in a position in which the surfaces of the two clamping means are in contact with each other, as well as in the position in which these surfaces are separated from each other. In addition, the mobile facility can also be moved into a position of contact with the deflecting means such as a spring, as mentioned above.

Further, in accordance with the invention, the surface of both clamping means can be essentially complementary Fortescue or spherical.

In addition, in accordance with the invention, one surface of the clamping means may be slightly concave to education speaker circuit region and being made of elastic material. When the movement of both clamping means toward each other to their first surface form a closed compartment containing a quantity of fluid. With the constant movement of clamping means fluid is compressed and squeezed the district edge, which is thus deformed.

In addition, in connection with the above variant embodiment of the invention, it should be noted that the protruding circumferential edge can effectively adhere to the surface of the second clamping means in a position in which surfaces are separated from each other. Consequently, there is a guarantee that the metered quantity of fluid is securely fastened between the two surfaces until then, until they begin to move towards each other.

Finally, in accordance with the invention, the tool stops may be connected with the clamping means for determining the minimum gap between two surfaces. In this regard, it should be noted that the tool stop is formed by at least poverhnosti other clamping means. The availability of emphasis is advantageous, in particular, when spraying suspensions, because the tool stop prevents direct contact of the surfaces of the clamping means with each other, and hence the compression of the suspension particles. When the tool actuator is a magnetic or electrically conductive core surrounded by an electric coil, the tool stops may contain electric control system, accurately determining the position of the contact clamping means.

Below the invention is described in more detail with reference to the accompanying drawings, in which:

Fig. 1 is a schematic axial section of a first variant embodiment of the device;

Fig. 2 is a schematic axial section of a second variant embodiment of the device;

Fig. 3 is an axial section of the interacting fields of another variant embodiment of the clamping means of the device;

Fig. 4 is an axial section of the interacting fields of another variant embodiment of the clamping means of the device; and

Fig. 5 - image of the third variant embodiment of the device made in the form of an inhaler.

The best way to implement the tool 1, made in the form of movable clamping node and the second clamping means 2, which is located coaxially with the first clamping means and in the form of a fixed clamping of the node.

On the upper end of the stationary clamping node 2 is provided by the camera 3, which placed small package 4 with the drug. The chamber is closed by a cover 5. The form of the camera 3 is complementary to the shape of a small package 4 of the medicinal product placed in the camera with the possibility of axial movement. Small packing 4 drugs move through the activate button 6, passing through the cover 5.

In addition, the fixed node 2 has an axial outlet channel 7, an opening in the lower clamping surface 8 through the outlet opening 9. The outlet 9 passes through the ledge 10 in an enlarged hole 11 that is designed to place him in the discharge tube 12 injection valve 13 of a known type, located at the mouth of a small package with the medication.

Through a piston 14 small package 4 drugs are divided into the upper pressure chamber 15 containing the drug in the form of the solution is STU offset in the housing 17 and is continuously supplied fluid medium from the feed chamber 16 by means of a spring 18, located between the end wall 19 of the housing 17 and the belt 20 of the discharge tube 12, is rejected in its closed position, shown in Fig. 1. In the closed position, the radial hole 21 in the outlet pipe is closed by a seal 22, fixed to the body 17 of the valve. When the discharge tube slip inside, the radial hole 21 is out of contact with the seal and forms a fluid communication between the camera feed 16 and the inner part of the discharge tube 12, through which the fluid medium flows through the pipe. Fluid communication and flow of fluid is achieved by pressing an activating button b, and hence due to pressure on a small package, with the exception of the discharge tube 12.

The lower movable clamping the node 1 has a flat upper clamping surface 23 located opposite the clamping surface 8 of the stationary clamping node 2. Of the clamping surface 23 at its center stands a conical spout 24. The spout 24 is designed to communicate with the outlet 9 of the fixed node. By means of a spring 25 mobile node 1 deviates to a stationary node 2 in the position in which both clamping surfaces 8, 23 are adjacent to each other. E-the material predetermined, moreover, the winding 26 zapityvat mode interruptible supply negative and positive pulses from the power source. Positive impulses cause the movable clamping node 1 to move toward the stationary clamping node 2, and this movement contributes to the force of the spring 18, while the negative pulses cause the movable clamping node 1 to move from the stationary clamping node 2 in the direction opposite to the direction of the action of a spring force. Instead, interruptible supply can be submitted only negative pulses, so that the force of the spring 18 causes the movable clamping node 1 to move toward the stationary clamping node 2.

The device operates as follows.

In the initial position of clamping clamping surfaces of both nodes are adjacent to each other, and the outlet of the stationary clamping host closed as tapered nose 24 of the rolling presses site is in locking contact with the hole. When pressing the trigger button 6 small package 4 medicines offset relative to its discharge tube 12, through which pressurized fluid is within the power source movable clamping the node is moved to the intermittent mode of displacement from the fixed clamping node 2 and to this site. During the move, the mobile unit 1 from a fixed site, a small amount of fluid between the clamping surfaces of the nodes is compressed between them and popped out on the periphery of the clamping surfaces. The film of fluid is unstable and forms a thin trickle of fluid, which is then broken into small drops.

During the subsequent downward movements of the rolling presses node 1 a small amount of fluid again produced on the holding surface 23 of this node. As indicated above, this amount of fluid is caught out in a thin film, when a mobile node 1 then comes in contact with the stationary clamping unit. When the button b is released and stop power to the coil 26, the release of fluid stops, and a mobile node remains in contact with a fixed node.

Experience has shown that a film of fluid must have a speed of 5-10 m/s, to ensure the formation of small droplets when the gap. Calculations showed that if the film of fluid thickness of 20 μm is placed on the press surface with a diameter of 8 mm film of the fluid acquires a speed of about 10 m/s, provided that prize the water is about 1 microliter to stroke, i.e. to release the total number of fluid 50 microlitres, which is the usual number, produced by medical inhalers, take 50 strokes. Therefore, if you have to provide the output for 2 seconds, the frequency of strokes is 25 Hz.

A variant embodiment of the spray device corresponding to the invention, shown in Fig. 2, contains a movable clamping the node 31 and the fixed clamping the node 32. Fixed node 32 shown in the drawing as the lower node has a cavity forming a chamber supply 33 of the produced fluid. The fluid can be fed into this chamber through a blocked hole (not shown). Fixed node 32 has a top wall 34, the upper surface of which forms a clamping surface 38. The cylinder 40 passes through the center through the top wall 34 and has a lower open end submerged in the fluid in the chamber 33, and the upper end, the speaker for the clamping surface 38. Directly above the clamping surface in the cylinder, a plurality of exhaust holes 39. The cylinder 40 has an end wall 36 through which passes the piston rod 41 of the piston sealed by seals 44. At its lower end strgen single valve 43, allowing fluid to flow from the lower surface to the upper surface of the piston 42 and preventing the flow of fluid in the opposite direction. At its upper end the rod 41 of the piston has a flange 45 adjacent to the end surface 49 of the mobile node 31 in the position shown. In addition, around the stem 41 of the piston is a compression spring 48, compressible between the upper surface of the piston and the bottom surface of the seal 44 and is intended to bring the flange into contact with the end surface 49.

Movable clamping the node 31 has a first small axial hole 46 in which the stem 41 of the piston, passing into a large axial hole 47 through the ledge 35, and in this big hole 47 is the protruding portion of the cylinder 40. At its bottom end a mobile node 31 has a flat clamping surface 53. By means of compression springs 55 mobile node 31 is deflected into the position in which the ledge 35 is adjacent to the upper surface of the end wall 36 of the cylinder 40. In this position (the position of the clamp) clamping surface 53 of the mobile node 31 is separated from the holding surface 39 of the fixed node 32 to a few micrometers.

And finally the wire. Electrical coil 56 can be powered mode interruptible supply the positive and negative pulses from the power source. When applying a positive pulse coil 56 carries a mobile node up in the direction opposite to the direction of action of the force of the spring 55, to the position shown in the drawing. When applying a negative pulse, the impact of which contributes to the force of the spring 55, the mobile node 31 moves down until its ledge 35 no abuts the end wall 36 of the cylinder 40 and the clamping surface 53 will not be a little distant from the clamping surface 38 of the lower stationary node 32.

The device shown in Fig. 2, operates as follows.

By supplying a positive pulse to the coil 56 of the mobile node 31 is moved upward, so that the piston 42 attached to the lower end of the rod 41 of the piston also moves up. After a certain amount of fluid is produced on the clamping surface 38 of the lower node 32 through the exhaust hole 39 in the cylinder wall. By supplying a negative pulse to the coil 56 or instead simply by blocking the positive pulse mobile node 31 peremeshautsa environment is compressed between the clamping surfaces 53, 38 and extrudes on the periphery of these surfaces with a gap of a thin film of fluid into droplets as described above. Because the ledge 35 abuts against the end wall 36 of the cylinder 40, the two clamping surfaces 38, 53 do not come into direct contact with each other, which is beneficial when issuing suspensions, since it avoids compression of particle suspensions and sticking them to the clamping surfaces. During the clamping stroke and the subsequent period between pulses spring 48 causes the flange 45 into contact with the ledge, whereupon fluid flows through the one-way valve 43.

In connection with the alternative embodiment depicted in Fig. 1, it should be noted that in Fig. 3 shows another variant of the clamping surfaces of the nodes. In this embodiment, the upper clamping the node 62 has a flat clamping surface 68, while the lower clamping the node 61 has a slightly concave clamping surface 63, ending the County edge 64 and is made of elastic material. When both nodes are in contact with each other, clamping surface 63 of the lower node 61 is deformed due to its elasticity and a certain amount of fluid initially With continuous movement of the two clamping surfaces toward each other clamping surface 63 of the lower node 61 is deformed, and fluid is pushed out in the form of a thin film due to the deformation of the edge part of the lower node 61. When the compression of the conical spout 65, extending from the clamping surface 63 of the lower node 61, closes the exhaust hole 69 in the upper node 62.

As shown by the dotted lines in Fig. 3, the upper clamping the node 62 may have a convex clamping surface having a shape complementary to the shape of the clamping surface 63 of the lower clamping node 61. In this embodiment, the clamping surface 63 of the lower node 61 may be made of unyielding material.

In connection with the alternative embodiment depicted in Fig. 1, it should be noted that in Fig. 4 shows another variant embodiment of the clamping means. In addition to the modifications shown in the drawing (and described in detail below), should indicate that the upper clamping tool is made corresponding lower clamping means opened above in connection with Fig. 1. Since the ledge 74, which forms the base for installation of the discharge tube 75 small packaging of the medicinal product, the discharge channel 73 fixed clamping means 72 provided with a first section 76, the plot is similar to the camera 77, adjacent and having a large opening in the clamping surface 79 of the stationary clamping means 72.

Movable clamping means 71 provided with a plate element 80 is facing upward clamping surface 81 that is located opposite the clamping surface 79 of the stationary clamping means 72. The Central rod 82 moves in the center upward from the clamping surface 81 and is equipped with a number of radial ribs 83, each of which is provided with a protruding radial protrusion 84. The Central rod passes through the section 78 of small diameter in camerabody section 77 of the stationary clamping means 72. The outer lateral surface of the radial ribs is in contact with the inner surface 78 of small diameter to guide the movable clamping means 71 relative to the stationary clamping means 72. The protrusions 84 of the radial ribs 83 are camaroptera section 77 and through the spring 86 fastened to the ledge 85 between cameraphones section 77 and section 78 of small diameter. In the position shown in the drawing, the holding surface 81 of the movable clamping means 71 is separated from the holding surface 79 of the stationary clamping means 72 to form a gap for receiving a quantity of fluid released from a small package lekarstvennaya, the gap has a locking effect on the released fluid environment which adheres to the clamping surfaces 79, 81. To get additional warranty commit a certain amount of fluid, the holding surface 81 of the movable clamping means 71 can be provided protruding circumferential edge 88 (shown by dashed lines) made of elastic material. Circumferential edge 88 ensures that a certain amount of fluid that is released into the space between the clamping surfaces 79, 81, is fixed, and may rest against a clamping surface 79 of the stationary clamping means 72 when the clamping surfaces are separated from each other, to achieve a full guarantee that a certain amount of fluid is fixed, up until the clamping surface starts to move towards each other. By moving clamping surfaces to each other, fluid is squeezed out when the deformation of the circumferential edge 88 movable clamping means 71.

Lower movable clamping means 71 is the tool actuator 87, intended to influence movable clamping means 71 to move its clamping surface 81 to prize testuya between the clamping surfaces, in a thin film fluid, torn into droplets.

As shown in the drawing, the tool drive can be made in the form of a core with a magnetic or electrically conductive part which is surrounded by an electric coil. Alternately feeding to the coil positive and negative pulses from the power source, it is possible to provide a variable effect of the core on the movable clamping means 71. Due to the force of the spring 86, movable clamping means 71 is returned to its original position shown in the drawing, when it is not exposed to the means of the actuator 87. In the depicted construction, the core drive means 87 has a speed, when it acts on the movable clamping means 71, such that achieved great acceleration movable clamping means 71, which is advantageous, in particular, to achieve high-speed compression of the fluid, and hence extrusion film of fluid.

In Fig. 5 shows a variant implementation of the proposed spray device made in the form of an inhaler for the inhalation of drugs in the form of fluid. The device comprises a hollow cylindrical inhalation node 101 and the filter inhalational node 101 is coaxially located stationary clamping the node 106, connected with the wall 108 inhalation node via a connecting rod 107.

Stationary clamping the node 106 provided with an axial bore containing the guide section 109 and the channel 110, the diameter of which is larger than the diameter of the guide section 109. Through the guide section and the channel 110 of the fixed node 106 is held slidable and providing seals the piston rod 111 of the rolling presses node 112. At its opening, the outer end of the rod has a head 113 having a clamping surface 114 facing the clamping surface 115 of the fixed node 106, which opens the channel 110. At the opposite end of the rod 111 includes a core 116 of larger diameter. Between the core 116 and the end surface 117 of the fixed node 106, opposite clamping surface, is a compression spring acting on the clamping surface for the purpose of pressing them to each other and enter into contact with each other. Around the core 116 of the mobile unit 112 is an electric coil 118, the so-called solenoid winding. The winding 118 is connected with the wall 108 through the connecting rods 132. The electrical winding 118 is connected to the power source 120 through with the sliding lid 122.

Inside the inhalation of node 101 between the filter 102 and the winding 108 is rotatable small thin leaf or blade 124. This sash is provided with micromagnets intended to influence the relay 125 which is connected to the control system 119, when a thin flap is rotated.

The depicted device is also equipped with a camera 126 designed to be able to put slidable small packing 127 medicines as it has been described in connection with a variant of the embodiment shown in Fig. 1. Small package 127 medicinal product is the packaging of the same type as the packaging stated above in connection with Fig. 1, and for this reason her work is not described in detail. The camera 126 is designed and made so that the discharge tube 129 small packaging of the medicinal product passes in a radial direction relative to the axis of the stationary clamping node 106. Fixed node 106 is provided with radial hole 129, passing in the channel 110 and intended for a presence of the outer end of the discharge tube 128 resting on a ledge in the hole 129.

The device shown in Fig. 5, operates as follows.

Due to hit the shutting down of the discharge tube 120) is moved down, whereupon fluid from the interior of the package flows out into the discharge tube 128 and the channel 110. Since the channel with the outer end closed, clamping surface clamping nodes are in contact with each other due to the influence of the force of the spring 123.

Inhalation on the end section 132 inhalation node 101 causes the air stream to flow through the filter 102. The air flow causes a thin flap 124 with micromagnets be rotated and thereby close the relay contacts reading 125, which in turn activates the control system 119, powered by voltage from the power source 120. As described above, the control system 119 causes alternating the flow of positive and negative pulses to the coil 118. These pulses cause the core 116 to move back and forth, alternately introducing clamping surface of the head 113 in contact with the clamping surface 115 of the stationary clamping node and outputting the surfaces of contact. When the opening movement of a small quantity of fluid flows on the clamping surface 115 of the fixed node and stick to it. At the subsequent closing movement of the specified amount of fluid quickly vydavlivaete, usually about 2 seconds, the control system interrupts the current supply to the coil 118 and release a spray of fluid is stopped, the spring 123 causes the nodes densely adjoin to each other.

1. Method of atomization fluid, characterized in that it provides a certain amount of fluid between the first surface and the second surface, spaced from each other, and then move these two surfaces from each other up until the first surface, essentially along its entire length will not come in contact with the second surface, and with such speed that the fluid medium between the two surfaces is pushed outward along the periphery of the surface at a rate sufficient to atomize the fluid.

2. The method according to p. 1, characterized in that both surfaces are essentially complementary shape.

3. The method according to p. 1, characterized in that the fluid is fed through the discharge outlet, which is open at one surface and is preferably in its center.

4. The method according to p. 1, characterized in that both surfaces are alternately moved to a position in which they are separated from the La implementation of the method according to p. 1, characterized in that it contains the first clamping means having a first surface and a second clamping means having a second surface, and the clamping surface means facing each other, the tool actuator for moving the clamping means between a position in which the surface of the clamping means are separated from each other, and the position in which these surfaces are essentially in contact with each other along its entire length, an outlet for the fluid opening in the region between the two clamping means and in communication with the source of fluid and means of dosing through the flow channel of the fluid, moreover, the tool dosing delivers a specified amount of fluid in the region between the two clamping means through the discharge outlet when said means are separated from each other.

6. The device under item 5, characterized in that it contains a fixed and movable clamping means.

7. The device under item 5 or 6, characterized in that the tool actuator is a solenoid actuator that contains a floating magnetic or electrically conductive core for environmenta what Azor between them, moreover, the winding zapityvat energy from the power source mode interruptible supply.

8. The device according to p. 7, characterized in that the core is fixed to movable clamping means.

9. Device according to one or more paragraphs.5 to 8, characterized in that one surface of the clamping means is slightly concave for education acting County region and is made of elastic material.

10. The device according to p. 9, characterized in that a protruding circumferential edge, essentially, is adjacent to the surface of the second clamping means in a position in which surfaces are separated from each other.

11. The device under item 5, characterized in that the holding means are connected by means of focus to determine the minimum gap between their surfaces.

 

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