A method for predicting non-specific adaptive response is activated on exposure to infrared laser radiation on the patient's body

 

(57) Abstract:

The method can be used in medicine, namely in laser therapy. In the first, third and fifth sessions of laser therapy compute the index of influence. Compare it with the normalized reaction activation value. When registering a stable reduction of the specified index to the value of 0.85 or its steady increase to a value of 1.35 predict the transition to response training in the first case, or the reaction of stress in the second case. When the observation of occasional deviations within the boundaries of these values predict a stabilization of the activation reaction. The method reduces the execution time of the forecast. 3 tab., 4 Il.

The invention can be used in medicine, namely in laser therapy. It allows us to predict the nature of the adaptive response of the patient in subsequent sessions, the degree of deviation from the activation reaction, objectively to cancel or continue the course of treatment.

The creation of such a forecast can be useful to reduce the inflammatory potential with a view to its improvement, for example, when chronic inflammation (chronic gastritis, colitis, adnexitis, post-traumatic arthrosis and others who aldeasa pronounced leukopenia); when mental illness (manic-depressive psychosis). To achieve the desired effect in such cases, you must call and steadfastly maintain the reaction activation.

The essence of the method is that in the first, third and fifth sessions calculates the index effect, compare it with the normalized value, and if you register a stable decrease of the impact to the value of 0.85 or increase to a value of 1.35, then predict the training reaction in the first case, or stress reactions in the second and cancel laser therapy.

Known methods of forecasting the response of the body to laser exposure, chosen as analogues. They are characterized by the following disadvantages: the duration of the formation of the forecast, as it is necessary to perform 6-8 sessions of laser therapy, and each of the second session to conduct clinical and laboratory examination of the patient; there are no objective criteria that allow to conclude about the feasibility of cessation laser therapy.

The prototype of the present invention is selected publication, which presents the normalized values of the index of influence corresponding to the reactions of the training, activation and stress. The prototype also svoistvennoi the probability of the forecast due to the lack of quantitative criteria boundary values, indicating the transition to activation reactions or reaction training, or reaction to stress.

In the proposed invention solved the problem of reducing the execution time of the forecast tactics of laser therapy and objectification criteria deviations from activation reactions, which make the conclusion about the appropriateness of the treatment laser radiation.

This problem is solved in that in the first, third and fifth sessions of laser therapy compute the index effect, compare it with the normalized reaction activation value, and if you are registering a steady decrease in the specified index to the value of 0.85 or stable increase to a value of 1.35, we predict a transition to response training in the first case, or the reaction of stress in the second case, and in both cases overturned laser procedures; if there are one-time deviation index of influence defined by the boundaries of named values, and a return to normalized to its value in subsequent sessions, then predict the stabilization of the activation reaction and carry out a course of laser therapy.

List of drawings:

Fig. 1 - this in the prototype graph of the correlation dependence of the index of the effect of the pilot found the numerical values of the index of influence, characterizing two transitions adaptive reactions: activation of stress or activation - training;

Fig. 3 is a graphical depiction of a prognostic index value effect, which determine the nature of the transition from activation reactions to reactions workout;

Fig. 4 is a graphical representation of the index change impact at the transition from activation reactions reaction to stress.

Indicate on drawings:

figure 1 characterizes the magnitude of the boundary values of the index of influence for predicting the transition from activation reactions reaction to stress;

figure 2 characterizes the magnitude of the boundary values of the index of influence for predicting the transition from activation reactions to reactions workout;

figure 3 pattern of transition from activation reactions reaction training, found experimentally;

graph 4 - the pattern of transition from activation reactions reaction to stress, determined by experimental observations and statistical processing of the obtained results.

In the prototype found the normalized index value impact for the three adaptive reactions (Fig. 1): the workout - I; activation - II; stress - III. These normalized values indec is reneseme in the present description. The solution of the problem, namely, to induce and sustain a reaction activation in the process of forecasting, planning and execution of therapy in patients with reduced inflammatory potential applicants propose to do by controlling the deviation of the index of influence in the first sessions of laser therapy compared with normalized values defined in table. 1 (group II - reaction activation) and Fig. 1 (graph II).

The second part of the task control adaptive reactions of the patient based on the fact that the rapid transition from activation reactions to other adaptive reactions under such conditions the body requires cancellation of laser therapy. Clinical as indicators of the transition from activation reactions to other adaptive reactions appear with delay, comparable to the duration of the course of laser therapy.

Known methods of ascertaining the fact of the transition from one adaptive response to another performed by evaluating the results of laboratory tests in each session, no algorithm for numerical evaluation of the dynamics of the reaction to laser treatment. These laboratory methods require at least 6-C. It is difficult to cancel laser therapy.

Experimentally-based execution and aggregation 450 observations (200 observations of the transition from activation reactions to reactions of stress and 250 observations on the reaction of activation for reaction training) were reliably established the boundary values of the index of influence in the transition from activation reactions other reactions.

The transition from activation reactions reaction training determined experimentally and confirmed statistically. In this case, the observed strong decrease of influence, register reduced to values less than 0,85 already in the first sessions of laser therapy. In Fig. 2 experimental set edge index value effect, equal to 0.85, indicated by schedule 2. Mounted on this boundary value of the index of the influence of the fact of the transition from activation reactions reaction training confirmed that appears in subsequent sessions, changes in clinical laboratory data and fixation reaction training relevant laboratory tests.

The transition from activation reactions to the stress response is characterized by a persistent increase in the index of influence, as well as the steady increase in the numerical value of the top is the act of the stress response in subsequent sessions confirmed by tests made on the basis of clinical and laboratory studies and with a certain delay in comparison with the readings of the index of influence, each patient was cancelled a course of laser therapy.

In table. 2 presents a table. 1 index values influence only the second group, the corresponding normalized indicators of this index for the activation reaction, the forecast violations which have the problem solved in the invention.

In table. 3 shows comparative data of the prototype and the proposed method of treatment.

A detailed description of the complete method.

The method is performed in the following sequence. In the first, third and fifth sessions of laser therapy compute the index of influence. Compare it with that found in the prototype are given in table. 2 description normalized to response activation values. If the value of the specified index of more than 0.85, then conclude that maintained the reaction activation. If you are registering a steady decrease of influence (table. 2 and Fig. 3, graph 3) to the value of 0.85 or less, then predict the transition from activation reactions reaction training, and after the fifth session cancel treatment of low-intensity laser radiation. SNAT ensuing reaction training therefore, cancel treatment after the third session.

If you are registering a steady increase in the index of influence (table. 2 and Fig. 4, figure 4) to the value not exceeding 1,35, then make a conclusion about saving activation reactions. It is found experimentally that if the index of influence in the first, third and fifth sessions of laser therapy increases and exceeds the value of 1.35, we predict a transition to a reaction of stress, and after the fifth session cancel the treatment laser radiation. The index value of the influence in the first and third sessions over 1.35 indicates the presence of tension adaptive response. In this case, predict the reaction of stress, and after the third session is scheduled laser therapy overturned.

If the first, third and fifth sessions record numerical index value effect, alternately varying from 0.85 to 1.35 without a clear trend towards the exit in a given interval, the predicted stabilization of the activation reaction. Continue the assigned course of laser therapy.

Clinical examples.

Example 1. The patient s A. D., 39 years. Diagnosis: left post-traumatic coxarthrosis II stage, II degree. The patient should receive laser therapy. Potstone equal 0,86; 0,80; 0,78. Compare the observed values of the index of influence with the normalized values are given in table. 2 and in Fig. 3, graph 3. Register a steady decrease observed during treatment of the patient index values influence their transition below the cutoff value equal to 0.85. Predict the transition to response training and supersede laser therapy.

Example 2. Patient a-WA K. H., 38 years. About post-traumatic gonarthrosis II stage, II degree spend 5 sessions of laser therapy. The magnitude of the power indices in the first, third and fifth sessions were observed, respectively 1,37; 1,42; 1,49. Compared with the normalized values of this index (table. 2 and in Fig. 4, figure 4). Register a steady increase in values of observed indices of influence and crossing the boundary value of 1.35. Predict the transition from activation reactions reaction to stress. Laser therapy has been cancelled in order to avoid exacerbation of gonarthrosis.

Example 3. The patient P-th D. P., 40 years for the treatment of chronic bronchitis spend infrared low-level laser therapy. Determine the index value of the influence in the first, third and fifth sessions that have values 1,14; 0,98; 1,05 respectively. Compared to normalized the Oia inflammatory potential of the organism. Predict persistent response activation and continue laser therapy.

The effectiveness of the invention.

The proposed invention allows to reduce the duration of the forecast results of laser therapy in patients with reduced inflammatory potential with a view to its improvement, for example, in chronic gastritis, post-traumatic arthritis, hypotonia, etc.

In the invention this forecast is produced on the basis of the analysis of the dynamics of the index of influence and its values have objective data on activation reactions, necessary for the treatment of patients with reduced inflammatory potential, can later be used to cancel a course of laser therapy. This forecast get before there are changes in clinical and laboratory research and clinical status of the patient.

The invention allows to make a prediction of the normal flow of treated process by calculating the index of influence and confirm persistent activation reactions in the first and subsequent treatments of the effects of low-intensity laser radiation on the organism of the patient.

A method for predicting the total nonspecific adaptive reactions of activation of the n elements of the white blood cells, characterized in that the first, third and fifth sessions of laser therapy compute the index effect, compare it with the normalized reaction activation value and, if you are registering a steady decrease in the specified index to the value of 0.85 or stable increase to a value of 1.35, predict the transition to response training in the first case, or the reaction of stress in the second case, and in both cases overturned laser procedures, if see one deviation index of influence defined by the boundaries of named values, and a return to normalized to its value in subsequent sessions, predict the stabilization of the activation reaction and carry out a course of laser therapy.

 

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