The tool and method century, terentiev treatment of chronic diseases of various etiology

 

(57) Abstract:

The invention relates to the field of medicine. The proposed tool, representing the homogenate tissue parenchymal organ is the pancreas of a dog or pig or eggs Mature dog male. As well as a method of treatment of chronic diseases of various etiologies through the introduction of a specified drug in the subcutaneous fat of the lower part of the anterior abdominal wall, creating in the injection of microcera inflammation, which after maturation infiltrate opens spontaneously. Offer a tissue product with a wide spectrum of actions can be used in the treatment of inflammatory diseases of the gastrointestinal tract, respiratory, urinary system, collagenase and endocrine diseases. The invention provides a wide range of chronic diseases of different etiologies. 2 C. and 14 C.p. f-crystals, 2 tab.

The invention relates to medicine, in particular for the treatment of chronic diseases of different etiologies.

Known and used in medical practice for the treatment of chronic diseases of different etiologies lekarstvennymi drugs include for example, peptides, representing a solution in hydrochloric acid products of the enzymatic hydrolysis of the gastric mucosa of pigs; drug abomin obtained from the gastric mucosa of calves and lambs dairy of age; the drug Pancreatin obtained from the pancreas of slaughtered cattle.

These drugs are used in the treatment of diseases of the gastrointestinal tract (gastritis, gastroenteritis, enterocolitis).

Also known is a method of treatment of chronic diseases of various etiologies. Thus, in the treatment of diseases of the gastrointestinal tract drug use abomin 1 tablet during meals 3 times a day (M. D. Mashkovsky "Drugs", Vilnius, 1993, part 2, pages 54 - 55).

These drugs are primarily used in the treatment of gastrointestinal diseases.

The technical task of the present invention is to create a wide spectrum of action for the treatment of chronic diseases of different etiology, and treatment of these diseases with the help of this drug.

To solve this problem is proposed remedy represents the homogenate tissue parenchymal about the and and the homogenate tissue of the testis puberty dog male.

The tool is stored at a temperature of 0^oC, in a frozen state at a temperature of -10^oC or localityaware form. It is intended for the treatment of inflammatory diseases of the gastrointestinal tract - gastroduodenitis, holetsistopankreatity, hepatitis, enterocolitis; inflammatory diseases of the respiratory system, urinary system; collagenase and endocrine diseases.

Method C., Terentiev treatment of chronic diseases characterized by the fact that in subcutaneous adipose tissue, mainly in the lower part of the anterior abdominal wall, creating microeca inflammation introduction homogenate tissue parenchymal organ is the pancreas of a dog or pig or eggs Mature dog male; after maturation, the abscess opens spontaneously emitting copious quantities of pus brown. The tool is administered at a dose of 0.5 ml, and for children up to 10 years at a dose of 0.3 ml of the Tool with the introduction of defrost and warm to 37^oC. treatment ranged from one to eighteen months. It reuses the homogenate was administered six months after the first injection, and the third injection of twelve months after re-introduction.

aemula treatment and prevention of diseases is to create microcasa anaerobic autoinfective, after overcoming whose body gains the ability to eliminate disease and to prevent diseases caused by autoinfective and other pathogenicity factors.

Microeca create by subcutaneous injection of a homogenate tranxenogen pancreas or eggs in the quantity of 0.2 - 0.5 ml is Preferably introduced into the lower part of the anterior abdominal wall.

Fabric preparation remain frozen after thawing it homogenized mechanically in the homogenizer and incubated for one hour in a thermostat at a temperature of 37^oC. do Not exclude the possibility of saving homogenate in dried form.

Penetration autounion flora injection of tissue preparation, there is reason to believe, is hematogenous neutrophils or macrophages of the intestinal wall, which contain anaerobic bacteria or their derivatives (elementary bodies). After the introduction of the homogenate develops General and local reactions.

The beginning of the General reactions of the established microeca occurs usually after 4-6 hours after administration of the drug. The reaction manifests itself as a rise in body temperature to the chills. The duration of the reaction temperature often from 1.5 to 3.5 hours. After a total reaction becomes more visible local reaction around the site of injection in the form of hyperemia and gradually increasing infiltration. As more local reactions markedly reduced overall. Sometimes, chronic inflammatory processes, the overall reaction is prolonged due to the short-term exacerbation of the underlying disease.

In our proposed method for the treatment of inflammation at the injection of the drug lasts 6-8 days, passing the stage of maturation and resolution. At rest (lying, sitting, standing) it is not painful, the pain is felt while squeezing (flexion, trunk extension) or a push in the nidus. Patients after a day or two can perform a normal operation, except for heavy physical work. Relatively weak pain of infiltration due in part to its localization, i.e. lack of tension in soft tissues of the wall of the abdomen. After maturation, the infiltrate is opened, releasing copious amounts of brown pus. Pus is allocated within 2-3 days, after which the injection heals.

General and local reactions occur in all cases and proceed the same otlichayas the t form of the disease, its duration and age of the patient. Recovery can occur gradually and after a single dose of the drug, but more often after repeated administration (6 months) or even after the third injection (12 months after re).

Positive outcomes in the treatment of various diseases are the result of a significant increase in the overall resistance of the body and mainly from the acquisition of specific immunity to ascogenous microflora and primarily on anaerobic its representatives - bacteriodes and clostridia. They are permanent inhabitants of the gastrointestinal tract, they are characterized by a complex transformation and relationship with the mucous layer, identified the migration of microbes not only in the gut, but also in epithelial cells, the white cells of the intestinal wall. We must assume that immunity to intestinal flora in the body is produced in normal conditions (intestinal barrier), but can only be obtained parenterale in the presence of tissue biofactor, which is the native tissue of the pancreas.

The proposed method of complex microbial tissue immunization promising in the treatment and prevention of many diseases blagodaaaaren immune protection not only from anaerobic autoflora, but from various factors of pathogenicity, which many are formed in the artificially created microcare.

Thanks to these characteristics, the application of the method has shown significant efficacy in the treatment of diseases such as peritonitis, pancreatitis, acute intestinal obstruction, duodenostasis, tuberculosis. Treatment or prevention of such diseases were carried out on dogs, rabbits, rats, cats, Guinea pigs and calves.

Material for preparation of the drug was used homogenate, the pancreas of a dog or pig and testicles Mature dog male.

Significant efficacy of this method in the treatment of human diseases obtained at various intestinal diseases inflammatory nature: organs of the gastrointestinal tract (gastro-duodenitis, cholecysto-pancreatitis, hepatitis, enterocolitis, and others), respiratory system, urinary system organs. Also received positive effect in collagenoses, cancer and endocrine diseases.

The optimal dose is 0.5 ml With further increase of the dose clinical effect is not growing. For children up to 10 years optimum dose sostavlenie on the data source of immunological indexes. The drug is contraindicated in thermal condition of the patient (acute cardiovascular, respiratory, renal failure).

The shelf life when stored in the frozen state (temperature -10^oC) equal to six months. The drug is stored at a temperature of 0^oC remains usable within 24 hours.

therapeutic properties of the drug recovered after warming to a temperature 37,0^oC for 10 minutes.

The proposed tool and method for the treatment of various chronic diseases have been widely tested in clinical practice and received a positive result (see tab. 2).

1. The treatment for chronic diseases of different etiology, characterized in that it represents the homogenate tissue parenchymal organ, xenogenous pancreas or eggs.

2. Means under item 1, characterized in that it contains the homogenate tissue of the pancreas of a dog or pig.

3. Means under item 1, characterized in that it contains the homogenate tissue of the testis of adult dogs male.

4. A tool according to any one of paragraphs.1-3, characterized in that it is stored at 0oWith in six months.

6. A tool according to any one of paragraphs.1-3, characterized in that it is stored in lyophilized form.

7. A tool according to any one of paragraphs.1-3, characterized in that it is intended for the treatment of inflammatory diseases of the gastrointestinal tract, such as gastroduodenitis, holetsistopankreatity, hepatitis, enterocolitis.

8. A tool according to any one of paragraphs.1-3, characterized in that it is intended for the treatment of inflammatory diseases of the respiratory system, urinary system.

9. A tool according to any one of paragraphs.1-3, characterized in that it is intended to ensure collagenase and endocrine diseases.

10. The method of treatment of chronic diseases of different etiology, characterized in that in subcutaneous adipose tissue, mainly in the lower part of the anterior abdominal wall, creating microeca inflammation by injection of a homogenate of tissue parenchymal organ xenogeneic pancreatic gland or testicles after puberty infiltrate it opens spontaneously emitting copious quantities of pus brown.

11. The method according to p. 10, wherein introducing the homogenate tissue of the pancreas of a dog or pig is on the floor.

13. The method according to any of paragraphs.10-12, characterized in that the homogenate was injected at a dose of 0.5 ml.

14. The method according to any of paragraphs.10-13, characterized in that the treatment ranged from one to 18 months, it reuses the homogenate was administered six months after the first injection, and the third injection twelve months after re-introduction.

15. The method according to any of paragraphs.10-12, characterized in that in the treatment of chronic diseases of children under the age of 10 years, the homogenate was injected in a dose of 0.3 ml.

16. The method according to any of paragraphs.10-14, characterized in that the homogenate before the introduction of thawed to 37^oC.