The means for increasing comprometimento biological tissue during local hyperthermia of tumors (options)

 

(57) Abstract:

The invention can be used in the treatment of various forms of tumors using local hyperthermia. The means obtained by mixing 50 wt.h. 0.5% solution of novocaine in isotonic NaCl with 50 wt.h isotonic NaCl. Option means obtained by mixing 50 wt.h. 0.5% solution of novocaine in isotonic NaCl with 50 wt.h. gelatinosa. Tools provide a localized hyperthermic effects at high transfer efficiency RF power and the exclusion of damage to healthy tissue surface. 2 S. p. f-crystals.

The invention relates to medicine and can be used in the treatment of various forms of tumors using local hyperthermia.

Known means for radiofrequency thermotherapy methods [1, 2]. These funds represent a suspension, an essential element of which is finely crushed powder of ferrite or magnetic metal, which is achieved amplification and localization of RF heating.

However, the use of such devices may cause complications due to inflammatory reaction and tissue burns in the field of hyperthermia, and hovering is using local hyperthermia of biological tissues RF currents, flowing through the interstitial fluid [3]. However, in this case not achieved the desired uniformity of heating and localization of the temperature in the zone subjected to hyperthermia.

The main task, which is aimed stated remedy is containment hyperthermic effects at high transfer efficiency RF power and the exclusion of damage to healthy tissue surface.

This technical result is achieved due to the proposed use of funds to increase the conductivity of the biological tissue to be entered when performing local hyperthermia of tumors peritumoral in the region of the tumor. The authors studied a variety of options such tools and installed that for relatively short sessions of hyperthermia (lasting less than 90 minutes) is effective tool obtained by mixing 50 wt.h. 0.5% solution of novocaine in isotonic NaCl with 50 wt.h. isotonic NaCl.

The authors also found that the duration of the session local hyperthermia over 90 min, the effect of the introduction of the proposed funds decreases with time due to his RA% solution of novocaine in isotonic NaCl and 50 wt.h. gelatinosa.

Using applied in the claimed tool components known in medicine. However, in the proposed combination they show such property as improving the conductivity of the biological tissue in the desired quantity, and provide the specified localization required for therapeutic effect of temperature during hyperthermia.

Experimental verification of the declared funds were used to treat patients with breast cancer (112 persons) in different clinics. Examples are given in the form of extracts from the histories.

Example 1. Extract from history N 289. Patient R. A. I., 49 years old, was admitted in Nizhny Novgorod city Oncology center 7.02.96 was diagnosed with Cancer of the right breast stage T2N0M0". The patient underwent a course of combined treatment:

1. Performed remote gamma-therapy method medium fraction, the total focal dose of 35 Gy.

2. 15.02.96, under local anesthesia (0.5% solution of novocaine) held a session of local hyperthermia. Patient peritumoral entered the vehicle, obtained by mixing 50 wt.h. 0.5% solution of novocaine in isotonic NaCl with 50 wt. including isotonic NaCl. Then this is oC was achieved in this area through 5.5 min and was maintained for 1.5 h

3. Patient 20.02.96) underwent right radical mastectomy. The postoperative period was uneventful.

4. Histology N 54 from 26.02.96, (abstract). In the pathological focus are pronounced necrotic changes of the 4-th degree beam pathomorphosis.

Example 2. Extract from history N 486. Patient B. L. N., 42, enrolled in Nizhny Novgorod city Oncology center 27.02.96 was diagnosed with breast Cancer stage T2N0M0". The patient underwent a course of combined treatment:

1. Performed remote gamma-therapy method medium fraction, the total focal dose of 35 Gy.

2. 7.03.96, under local anesthesia (0.5% solution of novocaine) held a session of local hyperthermia. Patient peritumoral entered the vehicle, obtained by mixing 50 wt. including a 0.5% solution of novocaine in isotonic NaCl and 50 wt. hours of Gelatines. Then in this region implanted needle-electrodes, the applied RF voltage. Within 2 h was maintained temperature of 43.5-45, 0mmoC.

3. Patient 11.03.96 was done in broad sectoral Rezek

4. Histology N 57 from 14.03.96, the pathological focus are pronounced necrotic changes of the 4-th degree beam pathomorphosis.

Example 3. Patient S. O. L., 42, enrolled in the Moscow scientific research Institute of diagnostics and surgery 2.07.96 was diagnosed with breast Cancer stage T2N0M0". The patient underwent a course of combined treatment:

1. 9.07.96, under local anesthesia conducted the session of local hyperthermia of tumors with the use of the "Volcano-1". Patient peritumoral entered the vehicle, obtained by mixing 50 wt. including a 0.5% solution of novocaine in isotonic NaCl with 50 wt.h. isotonic NaCl. Then in this region implanted needle-electrodes, the applied RF voltage. Within 1.5 h was maintained temperature of 43.5-50oC.

2. 10.07.96, patients received radical mastectomy according to Patey. The postoperative period was uneventful.

3. Histology N 4186/90 from 20.07.96,

In the pathological focus has damaged blood vessels, hemorrhage, degenerative changes in the stroma and tumor cells. The composition of the cells varies: there is a gross destruction, but there malozemelnye elements. When counting 1000 cells is responsible. The stroma around complexes damaged. The degree of therapeutic pathomorphosis regarded as 2A. In other departments of the breast, fibrocystic breast disease with focal disorders of blood circulation and focal infiltration around the vessels. In lymph node metastases of cancer there is.

References

1. U.S. patent N 5128147,1992.

2. PCT (WO) N 90/01939, 1990.

3. Gusev A. N. Thermophysical model hyperthermia of tumors.- Kiev: Naukova Dumka, 1989

1. The means for increasing comprometimento biological tissue during local hyperthermia of tumors, characterized in that it is obtained by mixing 50 wt. including a 0.5% solution of novocaine in isotonic NaCl with 50 wt.h. isotonic NaCl.

2. The means for increasing comprometimento biological tissue during local hyperthermia of tumors, characterized in that it is obtained by mixing 50 wt. including a 0.5% solution of novocaine in isotonic NaCl with 50 wt.h. gelatinosa.

 

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