The method of normalization of physiological state on levin

 

(57) Abstract:

The invention relates to medicine, more specifically to a method of normalizing the physiological state by drug therapy and physiotherapy, and can be used for the prevention and treatment of a wide range of diseases. To normalize the physiological state use drugs, medicinal plants and physiotherapeutic effect, stimulating the interstitial humoral transport and functions of the lymphatic system, in combination with hepatotropic means, means, normalizing the activity of the stomach and intestines, chelators, vitamins and trace elements. Method is a system of endoecological rehabilitation, capable of detoxification of the body, starting from the intercellular space to the excretory organs, inclusive. Effect: method allows for detoxification at the cellular level, to strengthen the function of the excretory organs, to optimize the functions of the lymphatic system and to accelerate the mobilization of the immune system. 7 C.p. f-crystals, 6 ill., 22 table.

The invention relates to medicine, more specifically to a method of normalizing the physiological state by l is of deseases.

Currently, the problem of normalization of the physiological state of the organism in practical medicine is solved either by a direct effect on the pathological process using etiopathogenetic and symptomatic remedies, either by enhancing the protective functions of the organism, for example, using immunomodulators (M. D. Mashkovsky, "Drugs" M, Medicine, 1993; Fr N 2624019, EP N 0068042, US N 4521407, DE N 2804457, WO N 9106307, SU N 1168253, SU N 1168253, SU N 1816217). When for a number of diseases good therapeutic effect is the use of chelators ("Enterosorption", Ed. N.A. Belyaev, L., 1991) and (EP N 0172018, EP N0132534, SU N 1468858, SU N 1560219). It is also known successful use for these purposes of human growth hormone (US N 4816439).

Optimal use of medicines in combination with physiotherapy impacts, thus achieving more stable therapeutic effect ("Physical methods of treatment in otolaryngology" V. P. Nikolaev, M., "Medicine", 1989; "Interstitial electrophoresis Essentiale and kontrikala in the treatment of patients with chronic hepatitis and chronic pancreatitis", Fayez R. I., Diss. K. M. N., Minsk, 1990).

However, the known l is s, give unstable therapeutic effect or are ineffective. Also, at this time appeared the so-called "environmental" disease, pathological therapy which has never been developed.

Therefore there is an urgent need for effective therapeutic method, with which you can influence specific pathology and normalize the parameters of homeostasis.

The essence of the invention.

According to the invention created a fundamentally new way to normalize the physiological state through management of interstitial humoral transport (HDE) and drainage functions of the lymphatic system (BOS) in General pathology. This method allows you to optimize drug therapy, to perform the correction of immunity to obtain a therapeutic effect when a previously known methods are ineffective.

Held earlier experimental studies and clinical observations ("Practical lymphology", Baku, Y. M. Levin, 1982; "foundations of medical lymphology", M. Y. M. Levin, 1996, and.with. SU N 293609, and.with. SU N 452343, and.with. SU N 825079, and.with. SU N 939005, and.with. SU N 1217376, and.with. SU N 1273051) showed that humoral transport and lymphatic system are involved in almost all pathologist its movement in the extracellular (extravascular space and lymph outflow 5 - 10 or more times. It was found that the acceleration of the humoral transport links of blood capillary ---> the interstitium (inflow) ---> the interstitium (outflow) ---> lymphatic capillary ---> lymphatic vessel allows you to delete accumulated in interstingly medium and macromolecular education, including Exo - and endotoxins, and thereby to contribute to the normalization of cell function and homeostasis.

The basis of the invention is a new therapeutic approach to resolve violations of the HDE and functions of drugs through rehabilitation direct "ecological" space cells, affecting drainage and detoxification potency lymphatic structures. This approach, called us endoecological rehabilitation includes the means and methods of influence on various parts of HDE and lymphatic drainage (LD), primarily for the purpose of detoxification extravascular environment direct habitat cells that has a pronounced therapeutic and ozdorovitelny effect, under normal and proper endocrine diseases and weakened body.

We applied a fundamentally new methods that allow the selective and comprehensively strengthen the barrier, transportowe LD are formed therapeutic areas - the clinical lymphology and humorology.

Applying stimulation of HDE and LD in inflammatory processes of various etiology and localization, sepsis, peritonitis, meningitis, mastitis, abscesses, phlegmon, cholecystitis, allows a 30 - 70% of cases are cured without surgery, whereas in a particular group, the figure is no more than 15 - 20%. When turning on the way in the complex treatment of obliterating diseases of lower extremities is possible to avoid amputation of legs 76% of patients.

Claimed in the invention the method is comprehensive, stimulating the detoxification processes at different levels: from the extracellular space to the excretory organs, which provides clearing the entire body of endo - and exotoxins, leads to normalization of parameters of homeostasis.

According to the invention, is combined or sequential stimulation of HDE and LD various types of impact, including impact on subsequent stages of removal of Exo - and endotoxins from organisms. Preferred are methods and tools, selected from among:

1) electrophisiotherapeutic procedures,

2) chemo - and phytotherapeutic funds,

3) different types mehanicheskogo and Wellness importance atraumatic variant of such stimulation.

For endoecological rehabilitation used as drugs and medicinal plants, electrophisiotherapeutic, water, thermal and other effects and their combinations that stimulate the HDE drainage, barrier, transport, metabolic, immune and other functions of drugs.

In the complex of endoecological rehabilitation are known and noninvasive methods of detoxification, also known as a means to normalize the function of the body.

The method showed a therapeutic effect in the treatment of various diseases associated local or General intoxication.

We first established that the ability to influence the processes of HDE and LD have some known drugs, and that they have the effect of detoxification on a cellular level. In the previous literature on these drugs, such information is not available.

Thus, urea causes a dose-dependent sympohony effect appearing after 3 - 5 minutes after injection and lasts for 30 to 100 minutes. The biological toxicity of tissue fluid in the area of the pathological lesion is reduced to 1.5 to 5 times.

Mannitol stimulate the pathological processes and conditions.

Beta-adrenostimulyator alupent increases education and lymph transport in 3 - 4 times, and the alkaloid ergotamine and alpha-adrenergic - tropafen - 10 times. Us has detoxification effect infotemplate, playing with these drugs.

Increase of HDE and LD and detoxify at the cellular level drugs with protivosvertawati properties. It has been established that such parameters include sodium salicylate, nicotinic acid, streptase, turrilites. Pronounced protivosvertavatmi property, combined with sympohony detoxifying tissue effect has combined application of sodium salicylate and nicotinic acid. Thus, in experiments on animals their joint introduction extended clotting time of the lymph of the thoracic duct during the day of observation. Increased time rekaltsifikatsii, thrombin time, the content of free heparin; 1.5 - 2-times fell tolerance to heparin; decreased fibrinogen concentration. Against this background, 20 - 70% accelerated destruction of previously entered the medium and macromolecular labels from interstice.

Has shown the ability to enhance the HDE, LD and tissue detoxification immunomodulators, in particular, the adjuvant, tachipirina. Some of them can affect different mechanisms of formation and transport lymph, and thus magnified lymphatic drainage.

Discovered that the medicine, enhances hydrodynamics in one of the bodies might not have this effect in another. Moreover, along with medicines, which revealed the ability to stimulate LD, established drugs that have the opposite effect. So, no-Spa, platifillina hydrotartrate, papaverine hydrochloride slow lymphatic drainage by 20 - 40%. At the same time removing the medium and macromolecular metabolites from the extracellular space.

It should be noted open us the ability of some medicinal plants, in addition to the described in the literature properties, stimulate HDE, LD and removal of toxic metabolites of habitat cells. The use of such plants for cellular detoxification is preferred over other methods because of safety such medicinal plants proved centuries-old experience of their use for other purposes.

According to the invention it is possible to use plants separately or in the form of fees from mutual the action in the HDE and LD of individual organs. For example, infusion of parsley root has this effect mainly in the heart and the uterus, the infusion of rosehips in the lymph nodes, infusion of leaves of plantain in the intestinal wall.

In the presence of such a preferential orientation, medicinal plants affect several pathological links. Therefore, the collection is selected so that your plants have expanded the range of pharmacological actions.

Part of the fees can be included currant leaf, leaf bergenia, wild rose hips, bilberry leaf, Radiola rose, immortelle, Java, buckthorn bark, grass, peppermint leaf, spring Adonis, origanum, corn silk, European wild ginger, larch sponge, the mother-and-stepmother, marigold drug, oats ordinary, curly parsley, plantain.

For example, according to the invention, preferred charges the following composition, g:

collection N 1

1. Leaf currant - 100,

2. Leaf bergenia - 100,

3. Rose hips - 100,

4. Bilberry leaf - 100,

5. Rhodiola rosea - 100,

6. Immortelle - 100,

7. Java - 100,

8. Buckthorn bark - 100.

collection N 2

1. Leaf currant - 130,

2. L is Piwnica - 260,

collection N 3

1. Bilberry leaf - 50,0

2. The nettle - 20,0

3. Rosehips - 20,0

4. Lawsee - 50,0

5. Sex-sex - 50,0

6. Root buckthorn - 100,0

7. Siberian ginseng root - 50,0

Receiving infusion or decoction of plant materials is carried out by the conventional technology, taking into account dosage: one tablespoon, top, collection, fill in brought to the boil 0.5 liters of water, leave for 30 - 40 minutes, drain, add to taste 1 to 2 tablespoons of honey. Apply in the form of heat by two-thirds Cup 3 times a day 30 minutes before meals (children - 1 times a day).

We found that stimulation of the HDE, LD and detoxification at the cellular level can be implemented by using electrophisiotherapeutic and physiotherapy treatment: high-frequency and laser radiation, ultrasound therapy and phonophoresis, pulsed currents, galvanization, magnetic fields, "lymphatic" mechanical and underwater massage, total dry sauna and wet (steam) temperature effects.

The ability to enhance the HDE, LD and tissue detoxification previously known methods have been disclosed and shown us how a previously unknown mechanism of their action, or achieved PU is mA steps requires the creation of settings and applications.

The electrophoresis. Has been very effective medicinal electrophoresis, for example, a proteolytic enzyme of fungal nature - terrintino.

According to the invention iontophoresis with terrintino carried out in a dose of 200 PE. Order effects on the entire body two positive electrode attached to the pads placed on the surface of the tibia of both legs, two negative electrode - strips are placed on the cervical-collar zone. With the purpose of obtaining a regional effect, the electrodes are arranged so that the pathologic lesion was in interpolation space.

Soaked terrintino strip is applied: when neurovegetative dystonia - cervical-Voroncova zone, diseases of the cardiovascular system to the chest at the sternum, diseases of the lung to the chest from behind, when liver disease is on the region of the right hypochondrium, kidney disease lumbar region, when vascular lesions of the lower extremity on the area of the inguinal lymph node. Regional infotemplate alternates with a total limphostimulating.

Forces who is seven procedures "regional" stimulation and three procedures General stimulation. However, in some patients for a positive effect is sufficient and fewer procedures.

Magnetic therapy is therapeutic use of DC or low frequency AC magnetic field. Peripheral vascular system responds to the magnetic field expansion of the arteries of the muscular type, the arterioles, the disclosure of non-functioning collaterals, precapillary sphincter, the recovery of microcirculation, dilatation of venules and veins. Significantly increases the capacity of blood vessels, decreases the amount of extravascular tissue fluid. Inside the vessel passes over the induced EMF, which helps to streamline laminar flow of blood due to the orientation of the formed elements in a magnetic field, to improve the rheological properties of blood, increase the content of heparin, fibrinolytic activity, reducing the aggregation ability of the cells. As determined by us in experiments, under the influence of a constant magnetic field induction 10 - 40 MT, and the use of circular inductors from 5 to 20 MT (exposure time 10 - 30 minutes) is the activation of HDE, LD. Identified aftereffect to 3 to 5 days. The mechanism of the discovered effect may be associated with a lower viscosity and short is ructure body, increases the permeability of cell membranes. In the mechanism of the physiological and therapeutic action of the magnetic fields involved, apparently, and the so-called effect of "magnetised water".

Laser therapy. Stimulation of humoral transport of low-intensity coherent radiation wavelength = 0,8 - 1,3 μm. The use of laser radiation for detoxification stimulation of HDE and LD based on the previously obtained data about its lymphangiomatosis action. In experiments on animals was injected intravenously quartz electrode. It was found that when creating on the end of the electrode capacity of 0.8 - 1.0 μm for 10 - 20 minutes then reduced frictional properties lymph falls coagulation. It was shown that such part of the irradiation of blood involves the creation of conditions that accelerate the flow of fluid in the tissues.

Ultrasound therapy and phonophoresis of drugs. Ultrasound therapy is the use for therapeutic purposes mechanical vibrations of an elastic medium with a frequency above 16 kHz, in particular, from 20 kHz to 3000 kHz. The method used ultrasound therapy the frequency of ULTRASONIC vibrations 800 - 900 kHz. Most commercially available therapeutic devices work n is ebony (22 - 44 kHz) in pulsed mode for impacts on the deep organs and tissues, in particular, in gynecology, arthrology, diseases of vessels of the bottom extremities. The use of this frequency range allows the ULTRASONIC penetration to a depth of 6 cm, which provides end-to-end voice and actively influence of HDE and LD. National physiotherapy practice has a series of portable ultrasound devices", such as" and "Gamma", which operate at a frequency of 880 kHz and is specialized in various areas: intravenous disease, neurology, gynecology, dentistry, urology and proctology, ophthalmology, otolaryngology and has design features emitters for each area. This allows you to add effects directly to the pathological focus, which certainly improves the efficiency of treatment.

Therapeutic efficacy can be enhanced by phonophoresis drugs. For phonophoresis most preferably the use of drugs whose action or potentiates the effect of phonophoresis, or exhibits a synergistic effect when combined with the influence.

the th power UHF 30, UHF 2M, UHF-62, Miniterm (up to 5 watts), sometimes medium power UHF-4, UHF-66 or universal UHF unit-80-01 - Undeterm" (from 3 to 80 watts, 27,12 MHz). Children usually use the power of impact from 10 to 40 watts.

Justified the use of DC layering on it pulses exponential form 50 - 100 Hz separately and collectively in various combinations of frequency and time steps, which results in 8 kinds of current. Experience therapeutic effects associated with exposure to frequencies in the range from 0 to 150 Hz.

Galvanization. Galvanization leads to normalization violations of arterial and venous blood flow (atherosclerosis of the brain and lower extremities, hypertension, coronary heart disease, angina, varicose veins, poor venous drainage of the brain) and the normalization of impaired trophic tissues and diseases of internal organs (acute myocardial infarction, arthritis, abnormal lipid metabolism, acute toxicity, gastric ulcer disease, and kidney disease - scleroderma, atopic dermatitis). Our experiments showed that exposure of DC voltage of 80 volts and low power - up to 50 mA, input s was used galvanization in doses average density: 0,03 - of 0.08 mA/sq. see

Sauna's effect on the body. Sauna significantly affects metallicheskie processes in the body, and because sweating is primarily on water-salt metabolism. Redistributed fluid in the body, changes the viscosity of the blood and decreases platelet aggregation, is weight loss. Inhibited urination. Dosed stay in the sauna promotes normalization processes in the Central nervous system develops a calming effect, achieve mental relaxation. Simultaneously celebrated and training of the autonomic nervous system. Most researchers say about the activation of both its departments (sympathetic and parasympathetic), which ultimately increases the adaptive capacity of the organism. In our study, it is shown that the warming of the body contributes to the HDE and LD.

Similar in effect the action has a bath.

Taking bath with therapeutic and prophylactic purposes, you must create temperature. In the baths with high relative humidity (90%) temperature should not exceed 60oC (for the elderly and the sick - 55oC) at a humidity of 30 - 35% of the temperature may rise up to 70 who have during the bathing process, we recommend you to drink a little liquid (tea, brew, juice, alkaline mineral water). The total number of the received liquid should be approximately 50 - 60% of the lost weight after the procedure.

In the claimed invention to normalize the physiological state were also used drugs that enhance the detoxification function of the liver, because it is known that the liver delivers up to 80% of the lymph of the thoracic duct. It was found that the drugs known as bile and improves metabolic and detoxifying function of the liver, have sympohony effect in the body. In turn, increased lymphoblastoma of the liver accompanied by the improvement of its detoxifying function. The latter are cytomedines. A clear effect showed dalargin. Can be used known drugs of natural bile of animals: allohol, halogen, holenzim, Khalezin, liabil. For example, in the complex of endoecological rehabilitation used for the specified purpose allaha 2 tablets 3 times a day after meal for the entire course.

It should be emphasized that the strengthening of detoxification functions as the liver and kidneys taken into account in the layout used fees laquana of tubage, held according to the following scheme.

In the morning on an empty stomach after an evening and a morning cleansing enema, the patient takes oral stimulus, contributing to the contraction of the gall bladder and disclosure of the sphincter of Oddi and go for 1.5 - 2 hours on the right side with the heating pad on the area of the right hypochondrium. As stimulus can be used:

5 g of magnesium sulfate dissolved in 200 ml of warmed up to 40 degrees water;

5 g of sorbitol or xylitol in 200 ml of warm water;

5 g of Carlsbad salt in 200 ml of warm water;

3 egg yolks;

30 - 50 grams of warmed olive or olive oil;

100 grams of sugar, or glucose, dissolved in 200 ml of warm water.

When poor tolerability of listed indirect stimuli duodenal intubation can be accomplished by using only mineral water. To this end it is recommended that mineral water containing sulfates of sodium, causing choleretic effect, and sulfates of magnesium, defining halucinations effect - Essentuki 17 and 4, Jermuk, Izhevsk, Naftusya, Arzni, Smirnovskaya, Slovjanovskaja etc. When conducting tubage give the patient to drink 250 ml of mineral water. Pre-to open a bottle of the

A full course of endoecological rehabilitation involves the use of chelators, which themselves, without stimulating the humoral transport, only indirectly, through the detoxification of blood helps cleanse the environmental space of the cells. To reduce reverse suction" received in the intestines of toxic substances, primarily components of bile and related specific metabolites, used drugs, adsorbing bile acids. These medications include anion-exchange resin Cholestyramine or its analogs, which assign 1 teaspoon 30 minutes after a meal. The use of selective ion exchange resins combined with nonspecific enterosorption. As selective chelators, depending on the objectives and the individual characteristics of the patient, is used per 1 kg of patient's weight: enterosorbent SUMS-1, in a daily dose of 1 gram, divided into 3 - 4 admission; politeam in a daily dose of 0.5 to 1.0 grams, divided into 3 - 4 admission; enterosgel - 1 tablespoon 3 times a day.

Chelators take between meals and medicinal substances within 10 - 14 days. Depending on your zadachi macromolecular toxins (politeam SUMS-1), and in the second turn - taking medication, absorbing mainly of low molecular weight toxins (enterosgel). If the patient's pathology on the part of the stomach chelators are combined.

To prevent possible negative consequences of enterosorption course of endoecological rehabilitation provides for the introduction of multivitamins and minerals, as well as preparations containing vegetative forms of intestinal microflora. Medications are selected taking into account age features biocenose intestine. Children up to 10 years in recommended products containing lactic acid bacteria (Bifidumbacterin and Lactobacterin). Older - prescribed drugs, containing lactic acid bacteria and Escherichia coli (bifocal or a combination of the application of colibacterin with bifidumbakterin). Children over 10 years of prescribed drugs, containing only E. coli (colibacterin).

Because most patients who have undergone a course of endoecological rehabilitation, were observed normalization of all parameters of immunity to specific means of stimulating phagocytes, cellular and humoral immunity, should only be done while maintaining immunological n the sa endoecological rehabilitation appoint vitamins, micronutrients and nutritional supplements. The drug is selected individually depending on facing medical challenges. The most commonly used are the following drugs: pectin, spirulina, Mitrovic, ausib, Vetoron, Cell-Guard, fibromy, tykveol, Elton, smectite, adelivered, preserved in honey Royal jelly.

Claimed according to the invention, the method of normalization of the physiological state by using the system of endoecological rehabilitation is a number of selection methods, depending on the environment in which it is applied. Of particular practical importance is atraumatic variant of such stimulation (without injection and outside the hospital), which has shown its therapeutic efficacy.

A preferred variant of the method atraumatic endoecological rehabilitation includes the following techniques:

1) phase of preparation of the patient before, including separate power supply for 2 - 3 days and a cleansing enema before going to sleep;

2) cleansing tissues and cells gather medicinal plants N 1 or N2 according to the testimony;

3) hepatotropic funds (allohol 2 tablets 3 times a day 1 to day 10 of treatment or ursodeoxycholic acid for 1 x plants N 1 or N 2;

5) electrophisiotherapeutic introduction of terrilian dose of 200 PE;

6) enterosorption: "selective" (cholesterin - 1 tea spoon 3 times a day 30 minutes after meals and at 1 - 1.5 hours before meals and medication) and "non-selective" or SUM-1 (in the first two days 0.5 grams to 1 kilogram, then 1 gram per 1 kg of body weight), or politeam according to the same scheme 10 days;

7) the normalization of the activity of the stomach and intestines. Children under 16 years of age take Bifidumbacterin or Lactobacterin. Persons in the age limits 17 - 50 years of age take bificol. Persons older than 50 years of age take colibacterin: 5 doses dissolve in water and drink on an empty stomach 1 time per day;

8) as vitamins and minerals bee "Royal jelly in honey. Take 20 days in parallel with vitamins, 1 package (15 grams) 2 times a day for 40 minutes before a meal, holding in the mouth, it is desirable to maximize suction.

The system of endoecological rehabilitation, especially its noninvasive option allows detoxification at the cellular level, to strengthen the function of the excretory organs and excretion of toxic metabolites, strengthen the function of the lymph nodes, block lymphogenous metastasis microorganis scariati mobilization of the immune system.

Thus the system of endoecological rehabilitation gives the doctor a number of "selection methods", depending on the conditions in which it is applied, does not require scarce drugs, sophisticated equipment and vysokorentabelno.

After a detailed presentation of the preferred variant of the present invention for professionals will become obvious modifications and improvements within the framework of the present invention.

Information confirming the possibility of use of the invention.

Example 1.

Offers the results of the proposed system endoecological rehabilitation for the rehabilitation of children, adolescents and adults.

Since 1991 in the city of Bratsk Endoecological the Center conducts rehabilitation of the adult and child population in the claimed method. From September 1993 to February 1996 recovery passed 14570 children and 870 adult residents of the city. Adapted to the conditions of the city's environmental emergency method of endoecological rehabilitation includes the following modifications:

I. 1. Herbs: endoecological collection N 1.

2. Allaha.

3. Enterosorbent polifan

4. Tea with vitamins.

II. 1.SS="ptx2">

III. 1. Herbs: endoecological collection N 3.

2. Enterosorbent SUMS.

3. Multivitamins.

The results of tests conducted 2 times per year course length 2 weeks, showed a decrease in exacerbations of various diseases (excluding diseases of the gastrointestinal tract) by 47%, decrease exacerbations of diseases of the gastrointestinal tract by 75% and reduce the number of missed classes in children by 25% (Fig. 1).

Since 1993 in the city of Anapa, in sanatoria Deluc spend the improvement in the claimed method. In the analysed indicators of immunity 600 children aged 6 to 16 years, coming from ecologically unfavorable regions of Russia and Belarus, including those affected by the Chernobyl accident. The method of endoecological rehabilitation includes the following modifications:

Endoecological collection of N 2 or N 3 (if necessary).

Allohol - 1 tablet morning and evening after meals for 10 days

Politeam: dose (per day) is calculated based on the weight of the patient. The first two days - 1/4 gram per 1 kg of body weight of the patient, then 0.5 grams per 1 kg

After completion of phase enterosorption bifidum bacterin - 5 doses, dissolved in water on an empty stomach 1 time per day.

Results: among children is decreasing (Fig. 2).

Example 3.

Available results of clinical trials of the claimed system endoecological rehabilitation at health resort treatment of children with chronic bronchopulmonary pathology.

Under supervision there were 440 children, among them 220 (first group) suffering from recurrent bronchitis and 220 children (second group) suffering from chronic pneumonia. Ages 4 to 6 years was 240, and from 7 to 14 years - 200 children. According to anamnesis 50% of children in both groups were sick for the first time at the age of 1 year, the other at the age of 2 - 3 years. The recurrence rate was 1 to 2 times per year in 80% of patients of the first group and up to 3 times in 70% of patients of the second group. Remission during the year, periodically occurred in 60% of patients of the first group and 49% in the second group.

Ophthalmic test intoxication showed contamination in 100% of examined children. Symptoms of intoxication, characterized by fatigue, weakness, loss of appetite, pale skin, were expressed in 40% of children in the first group and in 70% of the second group. The severity of subjective and objective clinical symptoms in children of the second group was higher than the first (P<0,05). The muting tones the heart and Sisto is cadeverous bronchitis) cough had 77% of children dry rales in 44%, shortness of breath during physical activity - 15% of children. In the second group (with chronic pneumonia cough was in 93% of patients, of whom half - wet, with sputum. In 32% of patients had pulmonary heart disease the first degree. Auscultation against the hard breathing to listen dry rales in all children, and moist rales in 53% of cases.

At the beginning and at the end of the treatment performed ophthalmologically test intoxication, anthropometric measurements, spirography, pneumotonometry electrocardiogram in 12 standard dimensions. A set of laboratory parameters included the determination of C-reactive protein, protein fractions of blood serum sialic acid according to Hess, the catalase activity in erythrocytes and catalase index of blood (Kylie), the activity of hyaluronidase on Berezovskaya (1967), activity myeloperoxidase neutrophils (M, Subic, 1967), the content of the complement 50% increase hemolysis (Reznikova, 1967), as well as the content of immunoglobulin serum (Mancini) using monospecific sera.

The study was complex and consisted of the application of individualized variants of the claimed system endoecological rehab the day;

allaha 2 tablets 3 times a day 1 to day 10 of treatment;

electrophisiotherapeutic introduction of terrilian dose of 200 PE;

enterosorbent cholesterin - 1 teaspoon 3 times a day 30 minutes after meals and at 1 - 1.5 hours before eating;

Bifidumbacterin - 5 doses dissolved in water and drink on an empty stomach 1 times a day, multivitamin.

The second variant of the inventive system endoecological rehabilitation:

within 2 - 3 days a cleansing enema before going to sleep;

the collection of medicinal plants N 2: 0.5 cups of broth, 2 times a day;

ursodeoxycholic acid 1 tablet 3 times a day;

enterosorbent of politeam - 10 days to 1 teaspoon 3 times a day 30 minutes after meals and at 1 - 1.5 hours before eating; Bifidumbacterin - 5 doses dissolved in water and drink on an empty stomach 1 time per day.

pectin, vitamins, bee "Royal jelly in honey.

Under the influence of endoecological rehabilitation showed improvement of subjective and objective data. Had the dynamics of a physical data: observed the disappearance of wheezing, increased clarity and sonority of tone heart. The positive dynamics of respiratory function was characterized by increased lung capacity 6 - 2,8%. Minute Elny analysis neapolitanum showed improved pulmonary hemodynamics in 55% of children. It was noted positive dynamics of biochemical indices: normalized content of the complement, disappeared C-reactive protein. There was a trend toward reduction of sialic acids, the normalization of the serum protein fractions of the blood, reducing the activity of hyaluronidase. Showed normalization catalase activity in erythrocytes, activity myeloperoxidase, alkaline phosphatase neutrophils. Special attention should be achieved normalization of immunological parameters. Clearly revealed immunomodulatory action method similar to that specified in example 2. Thus, clinical improvement was confirmed by positive dynamics of immunological and biochemical parameters.

Example 4.

Available results of clinical trials of the claimed system endoecological rehabilitation sanatorium-resort treatment of diseases of the gastrointestinal tract.

In 1995 the goal of the claimed method in the sanatorium was treated 1940 person. 44 of them suffering from diseases of the gastrointestinal tract, were placed under special observation. Another 30 patients with similar disorders, but receiving only traditional sanatorium solution served as the control.


the collection of medicinal plants N 2: 0.5 cups of broth, 2 times a day;

ursodeoxycholic acid 1 tablet 3 times a day;

tubage: within three days, in the morning, on an empty stomach after an evening and a morning cleansing enema the patient took oral stimulus, contributing to the contraction of the gall bladder and disclosure of the sphincter of Oddi and lays down for 1.5 - 2 hours for the right unit with the heating pad on the area of the right hypochondrium. As the stimulus used 5 g of magnesium sulfate dissolved in 200 ml of warmed up to 40 degrees plain or mineral water;

enterosorbent of politeam - 10 days to 1 teaspoon 3 times a day 30 minutes after meals and at 1 - 1.5 hours before eating;

at the end of the cycle of endoecological rehabilitation - Bifidumbacterin - 5 doses, dissolved in water. Drink on an empty stomach 1 time per day.

pectin, vitamins, bee "Royal jelly in honey.

The use of endoecological rehabilitation was significantly accelerated and improved therapeutic effect. This is especially noticeable in cases where traditional methods are not effective enough. For example, such echographic signs of pathology of the gallbladder, as the increase and thickening of the walls, were identified in 27 patients the main girgenti 1.2 - 2 times faster (p<0,1) than in the control group. Moreover, in the main group by the end of the period of stay in the sanatorium these symptoms completely disappeared in 9 persons (33%) in the control group - 4 (23,5%).

Example 5.

Available results of clinical trials of the claimed system endoecological rehabilitation sanatorium treatment of allergies and allergic.

Found that 86.5% of applicants to the Allergy Department of the sanatorium "Russia" patients suffering from allergies-allergic, simultaneously suffer from disorders of the stomach and intestines. Bronchial asthma 59,5% of cases correlates with respiratory allergies of the upper respiratory tract, 46% of those with skin disorders. Asthma and obstructive bronchitis in 23% of cases are accompanied ENT diseases. The latter often precedes asthma and obstructive bronchitis. Allergic dermatoses in 33% of cases combined with respiratory allergies and 97% of those with a pathology gastrointestinal tract (45% - diseases of the liver and gall bladder, 52% - a dysbacteriosis). Scheme of endoecological rehabilitation included:

separate meals;

the collection of medicinal plants N 1 0.5 cups of the mini-introduction of terrilian dose of 200 PE;

enterosorbent cholesterin - 1 teaspoon 3 times a day 30 minutes after meals and at 1 - 1.5 hours before eating;

from the second half of the course is SUM-1;

Bifidumbacterin - 5 doses dissolved in water and drink on an empty stomach 1 time per day;

multivitamins.

The positive effect of the upper respiratory tract are registered in 92% of patients, which exceeds the results of treatment in the control group. The positive effect of the gastro-intestinal tract in the study group achieved in 100% of patients in the control only 11%. However, in 69% of cases the main group result was achieved in the second week and was expressed in the reduction of the liver to normal size, improve appetite, normalization of stool, disappearance or significant reduction in itching and rashes, etc., In 31% of cases a decrease in liver size was only after connecting holinolitikov and extend the deadline of the sorbents.

Example 6.

Available results of clinical trials of the claimed system endoecological rehabilitation at sanatorium treatment of gynecological pathology.

Selected group of 34 women with chronic adnexitis. Gynecological examination opavia single or multiple follicular cysts ranging in size from 2 to 5, see

Treatment was carried out according to the method adapted by the specified disease. Additionally stimulated HDE and LD and carried out endoecological rehabilitation electrophoresis of terrilian, taking SUMS-1. The course of electrophoresis of terrilian was 8 - 18 days, 30 minutes every day. The first 3 days electrodes superimposed on the femur and tibia, then 5 procedures for inguinal region. At this time, other types of physiotherapy (water, mud, etc. were not applied.

All women after treatment stopped the pain in the lower abdomen, disappeared a feeling of heaviness, decreased in size of the ovaries. In 12 patients cystic formations disappeared, 20 - their sizes decreased significantly. This result in end effect, the time and economic costs significantly exceed the results of traditional treatment.

Selected group of 30 women suffering from obesity. In the implementation of the method compared with the results of standard treatment control group of 30 people. The results are shown in table 22 presents (PL. 1 - 22 see the end of the description).

Example # 7. Available results of clinical trials of the claimed system endoecological rehabilitation at sanatorium laciniaria "Rus" was treated according to the stated procedure 88 patients from Murmansk, Belgorod, Kemerovo, Perm oblasts in age from 20 to 60 years with diseases of the musculoskeletal system (46) and with neurocirculatory dystonia (42 patients). The effectiveness of treatment of patients, including, in contrast to the control group, the stimulation of HDE LD magnetotherapy. Used circular inductors - 7 - 8 sessions - within 10 MT (exposure time 10 - 15 minutes and elements detox cleansing enemas, tubage and taking Politeama, the Efficiency was 75% of patients were discharged with significant improvement, a 24% improvement.

Example N 8.

The proposed evaluation of the effectiveness of the method in the treatment of myocardial infarction. Analyzed the treatment of myocardial infarction in 123 people. Of them: men 70 women - 53, age from 40 to 70 years. Stimulation of HDE and LD attack was carried out by ionophoresis of terrilian and concomitant introduction of sodium salicylate and nicotinic acid. In patients with increased time rekaltsifikatsii, thrombin time, the content of free heparin; 1.5 - 2 times padapa tolerance to heparin; decreased fibrinogen concentration. These impacts was conducted in conjunction with conventional 78 patients (the first group). In the control group (II) included micescu therapy. The patients were evaluated clinically, the analysis of electrocardiograms recorded in standard and thoracic otwedeniah, the definition of the dynamics of enzyme activity of creatine kinase (ck) and lactate dehydrogenase (LDH).

Patients of the first group indicated a more rapid positive changes in the electrocardiogram in the conventional 12 leads. Of the 78 patients from the first group in 14 patients (5%), despite treatment, the positive dynamics according to 35 precordial holes electrocardiogram was absent. Of the 45 patients of the second group in 19 (42%) - there was a positive dynamics of the electrocardiogram. (P<0,01). The study showed a trend towards a higher normalization of the levels of the enzymes ck and DLG membership card up patients of the first group (P<0,05). Marked positive effect in terms of pain relief, reduce signs of heart failure. Positive correlation of clinical effect from the time of the beginning of treatment, which was even more pronounced than before the treatment started the claimed method.

In the measurement of Central venous pressure in patients of the first group mentioned his demotion in case the original high performance. Patients of the first group marked ardia, atrial premature beats and transient A-V block first degree with increasing interval PQ to 0.22 - 0,23 seconds). The analysis showed a decrease in the occurrence of persistent arrhythmia 1.5 times, edema 1.6 times, postinfarction aneurysm - 1.7 times. Available results of clinical trials of the claimed system endoecological rehabilitation in the treatment of patients with atherosclerosis and pulmonary insufficiency.

The observations were carried out in stationary conditions on 150 patients suffering from atherosclerosis and symptoms of coronary insufficiency and pulmonary pathology. Patients of the control group (60 patients) received conventional therapy. Patients of the main group (90 patients) advanced system were endoecological rehabilitation. It included:

1) preparation of the patient before, including a cleansing enema before bedtime for 2 to 3 days;

2) collection of medicinal plants N 1;

3) hepatotropic funds (allohol 2 tablets 3 times a day 1 to day 10 of treatment or ursodeoxycholic acid 1 tablet 3 times a day);

4) electrophisiotherapeutic introduction of terrilian dose of 200 PE;

5) enterosorption: "selective" (cholesterol - 1 chineseamericna" - polifan (in the first two days 0.5 grams to 1 kilogram, then 1 gram per 1 kg of body weight) for 10 days;

6) colibacterin: 5 doses dissolve in water and drink on an empty stomach 1 time per day;

7) a multivitamin.

Registered significant positive clinical effect. Endoecological rehabilitation has a positive effect on the number of neutrophils in the blood and their phagocytic activity.

Thus, in patients with COPD who passed on the traditional treatment course EARL, reduction in peripheral blood in the number of leukocytes and neutrophils occurred only in cases when they are adequate or elevated baseline, whereas patients who received only conventional treatment, a larger percentage of cases there is a reduction of these indicators, even when reduced to their original level. The increase in the percentage faguoqitirute neutrophils, absolute phagocytic index and the index of completeness of phagocytosis after a course of EARL as in patients with COPD and in patients with atherosclerosis, occurs most frequently in patients with low baseline values of the indicators listed above. Patients with higher initial values of the frequent lack of response of these on the re-analysis of the number of active phagocytes and absolute phagocytic index (Fig. 3, example 9, PL. 1 - 21, Fig. 4 - 6),

The rate of stimulation of the humoral transport by electrophoresis of terrilian in patients with atherosclerosis has mainly a stimulating effect on the number of leukocytes, neutrophils and blood of their phagocytic activity. Similar action has both the first and the last treatment EF of terrilian.

The data obtained indicate that endoecological rehabilitation contributes to a more efficient functioning of neutrophils blood in the implementation of phagocytosis. It should be noted that this effect with the same frequency is achieved as in chronic nonspecific lung diseases, the pathogenesis of which is a greater role for violations of the nonspecific defense factors, and atherosclerosis, the disease that traditionally are not directly communicating with immunological disorders. The course EARLE leads to more appropriate changes phagocytose, depending on the initial level of indicators characterizing it, than a stand-alone course electrophoresis of terrilian.

Example 10.

Patient P. , aged 34, was admitted with a diagnosis of right salpingoophoritis. History of secondary misplacements eight iontophoresis under our observation 6.IV.1984 one dose of 200 PE. Soaked terrintino strip superimposed on the lower part of the abdomen on the right, the second strip - the area of the inguinal lymph node. The current is 10 mA. The duration of the 1st session of 15 minutes, with a gradual extension of 5 minutes to 25 minutes. The course was seven procedures. Temperature returned to normal after the second treatment, the pain disappeared after the third. There was a significant decrease in palpable infiltration, ceased to be after the fourth. The patient was discharged with recovery.

Example 11.

Patient K., 38 years old, was admitted with a diagnosis of bilateral inflammation of the uterine appendages. History of frequent and prolonged recurrence of the disease. On the background of standard therapy with the aim of enhancing HDE and LD in inflammation, the patient performed four times a day, bilateral puncture of the round ligament of the uterus through the inguinal canal with the introduction of 20 mg of trypsin and 500 thousand units of penicillin per side in area, adjacent to the ovaries. Pain and temperature decreased after the first puncture, disappeared after a second. Infiltration is completely resorbed, the white blood cell count returned to normal after the third puncture, has changed the character of pain. After the fourth puncture the patient practices the years the patient clinically healthy.

Example 12.

Patient T. , 39 years old, was admitted in the state of moderate severity with complaints of severe headache, pain in the left gluteal region. Consciousness is confused with signs of General intoxication. Body temperature galloping, with rises to 41 degrees. Blood test: Hb - 140 g/l, leucocytes - 20,3 x x 10 9 /l, stab - 18%, segmented - 52%, lymphocytes - 8%, monocytes - 14%, ESR - 48 mm/hour. Urinalysis - no change. In the outer upper quadrant of the left gluteal region dense painful infiltrate size 10 x 8 see 9 days before admission the patient was injected intramuscularly sulphate of magnesia. Taken a blood on definition of microflora. Data seeding: Staphylococcus aureus, sensitive to ampicillin, lincomycin, oxacillin. Diagnosis: postinjection abscess of the left gluteal region, pyosepticemia.

Produced the opening and drainage of purulent cavity gauze cloth with hypertonic solution. Appointed indirect endolymphatic therapy with gentamicin at a dose of 80 mg once daily. The next day the body temperature ranged from 37.5 to 38.4 degrees. The patient's condition has not improved. Further appointed intestines washing, iontophoresis of terrilian, enterosorbent polite yadernye - 8%, segmented - 52%, lymphocytes - 28%, monocytes - 4%, ESR - 8 mm/hour. Aureus from blood is not planted. Subsequently, the wound healed by secondary intention. On the 10th day the patient was discharged to outpatient treatment with superficial wounds in the granulation phase.

1. Way to normalize physiological condition, comprising the introduction into the body of the chemo drugs, drugs from medicinal plants and physiotherapeutic effect, characterized in that the use of drugs, medicinal plants and physiotherapeutic effect, stimulating the interstitial humoral transport and functions of the lymphatic system, and the introduction of drugs and fizioterapevticheskoe effects combine with hepatotropic means, means, normalizing the activity of the stomach and intestines, chelators, vitamins and trace elements.

2. The method according to p. 1, characterized in that the quality of medicinal plants used collection, including currant leaf, leaf bergenia, wild rose hips, bilberry leaf.

3. The method according to p. 1, characterized in that the quality of medicinal plants used collection, including currant leaf, bilberry leaf, herb, peppermint, Java.

4. SP is 2">

5. The method according to p. 1, characterized in that as enterosorbents use polifan.

6. The method according to p. 1, characterized in that as a means of normalizing the activity of the stomach and intestines, use bificol, colibacterin, Lactobacterin, Bifidumbacterin, pectin.

7. The method according to p. 1, characterized in that the quality of vitamins and minerals used canned honey Royal jelly.

8. The method according to p. 1, characterized in that as a physiotherapy treatment using electrophoresis, magnetic field, laser radiation.

 

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