Antianemic and growth-stimulating drug for animals "gambit -"

 

(57) Abstract:

The invention relates to fur farming and animal husbandry. The drug Gambit-S" consists of the following components, wt.%: disodium or dikalova salt Ethylenediamine-N,N'-dinternal acid 15 - 25; iron (III) 3,0 - 5,0; manganese (II) 0,5 - 2,5; copper (II) 0,25-0,5; cobalt (II) 0.1 to 0.3; zinc (II) 0.1 to 1.5; selenium (IV) 0,03 - 0,06; water - the rest. Drug use contributes to the normalization of metabolism, stimulates the growth of animals. The drug is effective in the treatment and prevention of screennote of fur in fur-bearing animals and white-muscle disease in cattle. 1 C.p. f-crystals, 2 tab.

The invention relates to animal breeding and fur farming and can be used in veterinary medicine for the prevention and treatment of iron deficiency anemia and enhance the growth of animals, treatment of specific diseases.

You know the remedy for the prevention and treatment of iron deficiency anemia in fur-bearing animals - gambit (EN, 1702568, A 61 K 31/295, 31/30, 1991). Drug gambit consists of a complex of iron, copper, cobalt and zinc disodium salt Ethylenediamine-N,N'-dinternal acid. The drug reliably renders prophylactic action anaemia in fur-bearing animals, but the lack of it with the IDT also use in veterinary medicine of sodium Selenite (Na2SeO3). The substance has a toxic effect, prevents the development and cures a number of diseases, e.g. toxic liver dystrophy (Worms D. K., Evdokimov, P. D., Wicker A. S., Medicines in veterinary medicine. M., head, 1970, S. 338-339). Sodium Selenite intramuscularly and subcutaneously, due to the high complexity and costs. Aqueous solutions of sodium Selenite for injection is poor, can not withstand boiling, should be used within one day, which causes some difficulties in use.

Also known Antianemic and growth-stimulating drug for animals - gambit-M (EN, 2097045, 27.11.97, bull. N 33, A 61 K 31/295, 33/32). The product includes a complex of iron, manganese, cobalt and zinc in the following ratio, wt.%: disodium or dikalova salt Ethylenediamine-N,N'-dinternal acid 15-25; iron (III) 3,0 - 5,0; manganese (II) 0,5 - 2,5; copper (II) 0,25-0,5: cobalt (II) 0,1 -0,3: zinc (II) 0.1 to 1.5; water the rest.

Drug Gambit-M eliminates the deficiency of trace elements in animals and helps to normalize metabolism. In pigs and poultry normal erythropoiesis and increases energy growth of animals.

However, the drug Hemo is to her as "streetnet hairline", expressed in a sharp decrease in the length of fur in fur-bearing animals, and diseases of young cattle - "white-muscle disease".

The task of the invention to provide an effective drug with optimal ratios of trace elements for the treatment and prevention of specific diseases in animals.

For task preparation on the basis of a complex of iron, manganese, copper, cobalt and zinc disodium or Pikalevo salt Ethylenediamine-N, N'-dinternal acid additionally contains selenium in the following ratio, wt.%: disodium or dikalova salt Ethylenediamine-N, N'-dinternal acid 15-25; iron (III) 3,0 - 5,0; manganese (II) 0,5 - 2,5; copper (II) 0,25 - 0,5; cobalt (II) 0.1 to 0.3; zinc (II) 0.1 to 1.5; selenium (IV) 0,03 - 0,06; water the rest.

As a source of selenium (IV) use selenological sodium or se acid. Getting drug gambit-M that does not contain selenium, as described previously (EN 2097045, 27.11.97, bull. N 33, A 61 K 33/32, 31/295 and THE 9337-005 - 00480141-96).

According to the invention selenological sodium or se acid is added to a known drug gambit-M at the stage of introducing trace elements, pre-dissolved repeat gambit-is a dark brown liquid (pH 6-8, mass fraction of iron 3-5%). Gambit-With infinitely soluble in water and insoluble in organic solvents. The solution should be stored in glass or plastic bottles. Store in containers made of ferrous metals or aluminum is unacceptable because of its corrosiveness. The evaporation of the solution under reduced pressure to obtain the product in paste form (dark brown pasta, pH 6-8, the mass fraction of iron 4-6%) or powder (powder brown, pH 6-8, the mass fraction of iron 6-8%). The drug is in the form of paste or powder is hygroscopic, so it's kept in an airtight container.

Acute toxicity and maximum tolerated dose of the drug for white rats are determined according to the methodological guidelines on the determination of the toxic properties of drugs used in veterinary medicine and animal husbandry, approved by the Ministry of health of the USSR, agricultural Sciences, BS Gosagroprom USSR. Upper level, i.e., the threshold dose was 15 000 mg/kg W.m. LD50= 26250 mg/kg LD16= 22000 mg/kg LD84= 30500 mg/kg According to the accepted classification of the drug belongs to slightly toxic.

In conventional aqueous solutions selenological sodium Oia get semovita With sodium Selenite injected into the solution after adding all of the trace elements, that gives stability to the connection of selenium (IV) in view of the recovery environment solution of a complex of trace elements with the Ethylenediamine-N,N'-dinternal acid.

While the effectiveness of selenium (IV) in complex with ligand and trace elements is increased to 6 months.

Efficacy of the drug gambit-C for the prevention and treatment of diseases of fur-bearing animals "seennot hair" can be illustrated by the following examples.

Example 1.

Fur farming in 1.07. had 31 000 head of young mink, one of them with a violation of mehoopany (cut) -8180 goals. With 20.07. the number of burrows was given with food preparation gambit With daily. After 4 weeks the animals began fouling hair. To 1.11. all the affected livestock overgrown, except for 50 goals. Dynamics of changes in the level of hemoglobin in animals was, g%:

June - 13,5

July - 15,7

August is 16.5

September is 19.5

October - 20,3

Gambit has a positive therapeutic effect on mehoopany young Minks, at the same time improved the physiological condition of the animal.

Example 2.

Research on the effectiveness of drug remove what happened on livestock standard mink. 1 control group received General diet, corresponding to the modern standards of feeding and containing vitamin supplements. 2 control group received gambit in the recommended doses (1 mg of iron per 1 kg W.M.) Experimental group received gambit-With a rate of 1 mg of iron per 1 kg W.m.

Throughout the experiment the experimental mink were clinically healthy, well-eaten food, the safety of all groups was 100%. As a result, at the time of slaughter in the experimental group who received gambit, the average live weight of males exceeded the control by 5.8%, females - 1.7%, which consequently leads to an increase in the size of the skins.

Commission inspection of animals on the course of the autumn and summer moult (August, September, October) in the control groups showed animals with disease seennot hairline (Strigoi) in the following amounts:

at 28.08.

1 rear males and 5.5%

females and 1.1%

2 rear, males and 4.5%

females and 7.1%

on 25.10.

1 rear males 11.1% of

females - 7,7%

2 rear males 10.9% of

females and 8.6%

In the experimental group who received gambit, found no beast with a short-haired fur. Perhaps this is due the

Example 3.

Research on the effectiveness of drug gambit-was conducted on livestock standard mink in the pre-rut, rut, pregnancy, menenia, lactation in females, growth and development of young animals on the background of General diet, corresponding to modern standards of feeding, containing vitamin supplements. Adult females (2nd and 3rd year) supplements received from 25.12., young females (1st year) - 3.08. The control group received food gambit rate of 1 mg of iron per 1 kg W.m.; animals 1 experimental group received gambit, 2 experimental group - gambit-M at the rate of 1 mg of iron per 1 kg W.m. The inclusion of forage preparations were carried out daily, pre-mixing them with water to 10 times its more uniform distribution in the stern. Throughout the experiment, the experimental animals were clinically healthy, well-eaten food, deviations in their behavior compared to the control was not found. Cases of diseases and deaths of animals treated with the drug gambit, was not observed. It should be noted a good clinical state of a female after menenia. The mating, pregnancy and weenie animals developed normally. The results reproduce the data table. 1 and 2, the drug gambit-has a stimulating effect on the reproductive capacity of females, and prolonged use of complex, since rearing, has a more favorable impact - in reproductive performance of young females increased, reaching the level of adult females, and the level of output puppies on the main female is superior to them. Weenie young females 1 experimental group goes active, more quickly. Throughout the period menenia percentage selivshihsya females was higher by 10 to 19% compared with the control. Gambit-helps reduce the fertility of animals increases the number of successfully selivshihsya females by young 9.9%, adults 3.2% and increases fertility.

Drug gambit-can also be used for the treatment and prevention of disease of young cattle - white-muscle disease.

Thus, inclusion in the diet of the animal drug gambit, containing a number of essential micronutrients in the form of a complex with an organic ligand and a balanced composition, eliminates the deficiency of these trace elements in animals, helps to normalize the of Avani animals.

1. Antianemic and growth-stimulating drug for animals, comprising a complex of iron, manganese, copper, cobalt and zinc disodium or Pikalevo salt Ethylenediamine-N,N'-dinternal acid and water, characterized in that it additionally contains selenium in the following ratio, wt.%:

Disodium or dikalova salt Ethylenediamine-N,N'-dinternal acid - 15 - 25

Iron (III) - 3,0 - 5,0

Manganese (II) - 0,5 - 2,5

Copper (II) - 0,25 - 0,5

Cobalt (II) - 0,1 - 0,3

Zinc (II) - 0,1 - 1,5

Selenium (IV) - 0,03 - 0,06

Water - the Rest

2. The drug under item 1, characterized in that as a source of selenium (IV) use selenological sodium or se acid.

 

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