The remedy for the treatment of periodontitis
(57) Abstract:The invention relates to the field of dentistry and concerns antiseptics used for the treatment of periodontitis. Means for therapy of periodontitis contains the antiseptic polydimethyldiallylammonium and water in specific proportions. The tool provides improved therapeutic effect, easy to use, simple to prepare, stable during storage. The invention relates to medicine, in particular to therapeutic dentistry, and concerns antiseptics used for the treatment of periodontitis.As antiseptics for the treatment of periodontitis in clinical practice, using aqueous solutions of hydrogen peroxide, furatsilina, potassium permanganate (USSR Author's certificate N 1168250, class A 61 K 6/00, publ. 23.07.85). These funds have antimicrobial activity and are used in the treatment of periodontitis for antiseptic treatment of the oral cavity, after which further treatment with antibacterial drugs as an anti-inflammatory effect of the above funds is poorly expressed. In addition, in recent years the drug resistant variants of bacteria.The most effective and widely used in the treatment of periodontitis antiseptic is chlorhexidine digluconate, the mechanism of antimicrobial action due to its surface-active properties (USSR Author's certificate N 1391650, class A 61 K 6/00, publ. 30.08.88).However, therapeutic effect of chlorhexidine in the treatment of periodontitis is not enough because it does not penetrate tissue deeply and because of this weak effect on the subgingival microflora, therefore, in the known technical solution, it is used for rehabilitation of the oral cavity in a 0.05% aqueous solution, and then enters into the composition of the products containing the enzyme - profesin. At the same time the treatment of periodontitis is long enough (6 to 12 days).The technical task of the present invention is to provide a tool with an increased therapeutic effect.This task is solved in that the means for the treatment of periodontal disease containing antiseptic and water as an antiseptic use polydimethyldiallylammonium in the following ratio, wt.%:
Polydimethyldiallylammonium - 0,8 - 1,2
Water Up to 100
Polydimethyldiallylammonium (DMDAAC) is pribumi:
< / BR>Domestic industry DMDAAC available under the trade name "Polyelectrolyte water-soluble cationic brand VPK-402" TUU 6-05-2009-81 (25% aqueous solution) and TUU 6-06-002099770-422-91 (solid).Polyelectrolyte VPK-402 is designed for use as a flocculant and in particular, in the medical industry it is used for purification of antibiotics.For the preparation of tools for the treatment of periodontitis can be used VPK-402 as in solid form and in solution.The specified number DMDAAC tool for the treatment of periodontitis are optimal. When using the content DMDAAC below the lower limit of use is impractical.Example 1
For the preparation of tools for the treatment of periodontitis take 4 wt.h. polyelectrolyte VPK-402 25% concentration (TU 6-05-2009-81) and diluted with 96 wt. including water. Get 100 wt.h. an aqueous solution containing 1.0 wt.h. DMDAAC.Example 2
Take to 8.0 wt. hours of polyelectrolyte VPK-402 corresponding to THE 6-06-002099770-422-91 (100%), and dilute with water to 100 wt.h.Example 3
Prepare the medium as in example 2, but take 1,2 wt.h. polyelectrolyte IN WHICH P CLASS="ptx2">Test new means were carried out on white rats, which periodontitis caused by the imposition of silk ligatures at the necks of teeth.Therapy was performed by instillation of periodontal pockets offered a means for the comparison of 0.2% chlorhexidine.In the first group of rats before treatment, the gums look swollen, it was observed mobility of teeth, greenie. If the treatment proposed by means of example 1 complete relief of the inflammatory process in the periodontal happened on the third day of treatment, disappeared tooth mobility. In a parallel group of rats in the treatment of chlorhexidine relief of the inflammatory process occurred on the fifth day, however, the mobility of the teeth remained.The second group of rats gums before treatment looked swollen, cyanotic, has seen pockets depth of 1-2 mm In the treatment tool according to example 2 on the fourth day, the signs of inflammation of the gums and periodontal pockets was gone. In the treatment tool prototype similar pattern was observed on the eighth day of treatment.In the third group of rats on the background of inflamed gums had swelling, redness, bleeding gums. In the treatment tool according to example 3 symptoms battles take place edema, redness and bleeding gums.The results show that the proposed remedy for the treatment of periodontitis better known, simple to prepare, easy to use, resistant to light and does not lose activity during storage, is not exposed to contamination within 60 days. Means for therapy of periodontitis containing antiseptic and water, characterized in that as an antiseptic use polydimethyldiallylammonium in the following ratio, wt.%:
Polydimethyldiallylammonium - 0,8 - 1,2
Water Up To 100
FIELD: agriculture, animal husbandry, organic chemistry.
SUBSTANCE: antiseptic ointment comprises cationic surface-active substance, lower glycols, polyethylene glycols, water and ethylene glycol monophenolic ester and higher polyethylene glycols taken in the definite ratio of components. As cationic surface-active substance ointment comprises N-alkyl-N-alkoxycarbonylmethylhexahydroazipinium chloride or alkyldimethylbenzylammonium chloride, or cetylpyridinium bromide, or cetylpyridinium chloride, or 1,2-ethylenebis-(N-methylcarbdecyloxymethyl)ammonium dichloride, or ethylhexadecyldimethylammonium chloride, or chlorhexidine; as lower glycol ointment comprises 1,2-propylene glycol or polyethylene glycol-300, or polyethylene glycol-400; as higher polyethylene glycol ointment comprises polyethylene glycol-1500 or polyethylene glycol-3000, or polyethylene glycol-4000, or polyethylene glycol-6000. Ointment elicits the high antibacterial activity, broad spectrum of bactericidal effect and low irritating effect with respect to udder skin. Invention can be used for sanitary-hygienic treatment of udder of lactating cows for prophylaxis and rapid healing external damages of udder and nipples (arising cracks), prophylaxis of mastitis, enhancing milk purity by microbiological indices.
EFFECT: valuable antiseptic properties of ointment.
2 cl, 1 tbl, 22 ex