The "didrec for the treatment and prevention of gastrointestinal diseases of farm animals

 

(57) Abstract:

The invention is intended for use in animal husbandry, in particular veterinary medicine, for the treatment and prevention of gastrointestinal diseases of different etiology syndrome of diarrhea in calves and piglets. The "Didrec" includes active substance is a benzimidazole derivatives and accessories - fumaric or maleic acid, hydrochloric acid. The tool further comprises a macro - and micronutrients. Drug, allows prevent and treat gastrointestinal diseases of different etiology with diarrhea syndrome in newborns and older calves and piglets and to restore the intestinal microflora in a short time. 1 C.p. f-crystals.

The invention relates to animal husbandry, in particular for veterinary medicine, and is intended for the treatment and prevention of gastrointestinal diseases of different etiology syndrome of diarrhea in calves and piglets.

Known means used for the treatment of gastrointestinal diseases in animals are antibiotics - antibiotics and sulfonamides; antiseptic - baktisubtil, Interix, antinodes; funds used for R matichenkov actions. These include binders, coating means.

Anti-inflammatories such as indomethacin, which inhibits the synthesis of prostaglandins and arachidonic acid.

Drugs such as clonidine(hamiton, clonidine), psychotropic: amitriptyline, chlorpromazine, codeine, loperamide (Imodium), interrupting the development of transport and biological processes that cause diarrhea (see Mashkovsky M. D. Medicines. - M.: Medicine. - 1993. -T. 1. - S. 41, 86, 366; Reference. Veterinary medicines. - M:VO "Agropromizdat". - 1988. - S. 75-136).

The disadvantage of these drugs is that they suppress the immune system in animals, causing dysbiosis, nausea, vomiting, allergic skin reactions. Can also cause depression, dramatically reduce blood pressure.

Known remedy for the treatment of farm animals diarrhea caused by thermo-labile toxin of E. Coli( -toxin) and similar thermolabile toxins produced by Salmonella, Klebsiella, Yersinia and other bacteria. This connection includes a derivative of benzimidazole-2-(alpha-hydrotherapeutic) benzimidazole(see EN, application 94024359,20.12.96, IPC A 61 K 31/395).

Proizvodietlnosti drugs (N. Demidov.In. The anthelmintic in veterinary medicine. - M.: Kolos, 1982, S. 265-283). This methyl ester 2-benzimidazolecarbamic acid - BMC 2-acetamidobenzoate-acetamido; methyl ester-5(6)-phenylthio-2 benzimidazolecarbamic acid-fenbendazol; methyl ether -5(6)-n-propylthio-2 benzimidazolecarbamic acid - albendazole.

It is known for the treatment and prevention of diseases and conditions, accompanied by vomiting, diarrhea and intoxication, including the active principle, which is used as 2-(phenylmethyl)-1H - benzimidazole hydrochloride, and such accessories as interpolymer complex of poly (methacrylic acid with polyethylene glycol in a molar ratio of 1:1, sucrose and stearate calcium or magnesium.

2-(phenylmethyl))-1H-benzimidazole hydrochloride is a well known drug and is used in medicine as a vasodilator, spasmolytic, hypotensive means in spasm blood vessels of the extremities, ulcers, as well as with residual symptoms of neuritis peripheral nerves in children (see EN, 2071769, 20.01.97, IPC A 61 K 31/41).

The disadvantage of these drugs is low efficiency, because they do not provide LASS="ptx2">

The objective of the invention is to develop medicines devoid of these shortcomings.

The technical result for the solution of this problem may be getting medicines, allows prevent or eliminate the disorder of the gastrointestinal tract with symptoms of diarrhea in calves and piglets and in a short time to restore the intestinal flora.

The problem is solved using a concentrated complex of the drug "Didrec for the treatment and prevention of gastrointestinal diseases of different etiology with syndromes dmarie in farm animals.

The "Didrec" contains as active substance a compound of General formula

< / BR>
where R = CH3, OCH3< / BR>
R1= H; - nS-C3H7;

< / BR>
In the "Didulica" as benzimidazole derivatives include BMC, or acetamido, or fenbendazol, or albendazole, fumaric or maleic acid, hydrochloric acid, which improve the activity of the enzymes of the gastrointestinal tract.

As sources of macro - and microelements as the chlorides of sodium, zinc, calcium, iron, cobalt, sodium iodide or potassium.

Chlorine, in the ways fill in the body of the sick animals that take away them which is diarrhea.

The components are taken in the ratio,%:

Derivatives of benzimidazole - 4,8-5,2

Fumaric or maleic acid - 3,8-3,9

Sodium chloride - 1,67-6,7

Calcium chloride is 0.27-0.67 and

Zinc chloride - 0,067-0,27

Iron douglaston - 0,033-0,4

Cobalt chloride - 0,007-0,053

Potassium iodide or sodium iodide - 0,003-0,033

Hydrochloric acid - 0,067-0.04

Water - the Rest

From the known to the applicant of sources of information not known to the specified set of essential features that allows you to retrieve the specified technical result. Therefore, the claimed invention meets the condition of patentability "novelty."

The applicant is not known products of similar purpose, which would be revealed distinctive features of the claimed invention with getting from using it in any combination of features specified technical result. Therefore, the claimed invention meets the condition of patentability "inventive step".

Proof industrial applicability of the claimed include the following examples.

Example 1. 750 g BMC or acetarsol, or fanband the2, 20 g ZnCl2, 15 g of FeCl23 g of COCl2, 2 g KJ in 10 l of distilled water. Continue to mix at 60-80oC for 2 hours, cooled to room temperature and adjusted with distilled water to 15 l, again stirred for 15-20 min, the resulting suspension concentrate "Didrec" with stirring, poured into containers.

Example 2. 780 g of BMC or acetarsol, or fenbendazol, or albendazole mixed with 390 g of fumaric or maleic acid, 169,3 g of 35% hydrochloric acid, 1000 g of NaCl, 100 g of CaCl2, 40 g ZnCl2, 60 g of FeCl2, 8 g of COCl25 g of potassium iodide or sodium iodide in 10 l of distilled water and then analogously to example 1.

We offer drug experience prophylaxis in newborn calves and piglets and to treat animal having a disorder of the gastrointestinal tract with diarrhea syndrome.

Before use, the suspension is "Didrec" thoroughly shaken, select the required quantity and diluted with hot water (up to 50oC) in a ratio of 1: 25, i.e. 10 ml of the suspension was diluted in 250 ml of water.

Example 3. Ten newborn calves, "Didrec" feeding with colostrum from the first time of feeding once, three days in a row is Olam. One of them fell ill 4, i.e. 40%. Prophylactic efficacy of Didulica" is 100%.

Example 4. Use one litter of newborn piglets, which "Didrec" feeding from teats with milk since the first feeding once, for three consecutive days at a dose of 0.5 ml/kg weight of the animal. Litter other sows were not subjected to treatment. In the piglets that received "Didrec", 't get sick, but out of 11 piglets did not receive this money, ill 7, i.e. 63,6%. Prophylactic efficacy of Didulica" is 100%.

Example 5. Ten calves, sick at 2-3-day diarrhea, twice a day for 3-7 days (until diarrhoea has ceased) together with colostrum or milk drinking "Didrec" in a dose of 0.5-1.0 ml/kg weight of the animal. Of the three untreated calves (control), two Palo, and one was treated "Digicom". Therapeutic efficacy "Didulica" was 100%.

Example 6. Use all piglets from one sow of cases of diarrhoea, which twice a day for 3-7 days (until full recovery) with milk or other liquid food feeding "Didrec" in a dose of 0.5-1.0 ml/kg weight of the animal. Piglets suffering from diarrhea, the other sows treatment is not exposed. As a result of 10 piglets first is rapitinka the tool's efficiency was 100%.

We offer drug, allows prevent and treat gastrointestinal diseases of different etiology with diarrhea syndrome of newborns and older calves and piglets and to restore the intestinal microflora in a short time.

1. For the treatment and prevention of gastrointestinal diseases of different etiology with diarrhea syndrome of farm animals, including active substance is a benzimidazole derivatives and auxiliary components, characterized in that the active substance of the preparation contains the compound of General formula

< / BR>
where R = CH3, OCH3< / BR>
R1= Hi-nS-C3H7;

as auxiliary components - fumaric or maleic acid, hydrochloric acid, and the tool further comprises a macro - and micronutrients: the chlorides of sodium, zinc, calcium, iron, cobalt, sodium iodide or potassium in the following ratio of components, %:

Derivatives of benzimidazole - 4,8 - 5,2

Fumaric or maleic acid - 3,8 - 3,9

Sodium chloride - 1,67 - 6,7

Calcium chloride is 0.27 - 0.67 and

Zinc chloride - 0,067 - 0,27

Iron douglaston - 0,033 - 0,4

Cobalt chloride - 0,007 - 0,053

Potassium Jodis who trichomania fact, as derivatives of benzimidazole it contains methyl ether 2-benzimidazolecarbamic acid, 2-acetamidobenzoate, methyl ester -5(6)-phenylthio-2-benzimidazolecarbamic acid, methyl ester -5(6)-n-propylthio-2-benzimidazolecarbamic acid.

 

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FIELD: medicine, narcology.

SUBSTANCE: one should detect satisfaction insufficiency syndrome due to performing genetic analysis by the presence of, at least, one of the genes coding the exchange of neuromediators being the constituents of human satisfaction system. One should compensate satisfaction insufficiency due to performing, at least, one complex of physical exercises. Moreover, in case of availability of pathological gene allele of dopamine D2 receptor and/or protein gene of reverse dopamine capture in patient one should apply the complex of physical exercises including those to provide sedative effect, and in case of availability of pathological gene allele of dopamine-beta-hydroxylase protein one should apply the complex of physical exercises including those that induce an activating effect. In case of availability of pathological gene allele of dopamine D2 receptor and/or protein gene of reverse dopamine capture one should apply additional food biologically active additives based upon amino acids being the precursors of neuromediators, such as taurine, D-, L-phenylalanine in combination with 5-hydroxytryptophan, hypericin and vitamin B6, and in case of pathological gene allele of dopamine-beta-hydroxylase protein one should additionally apply food biologically active additives based upon amino acids being the precursors of neuromediators, such as: taurine, tyrosine and/or dimethylaminoethanol, lecithin and group B-vitamins. The present innovation enables to take into account pathological disease mechanism.

EFFECT: higher efficiency of prophylaxis.

14 cl, 5 ex

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