(57) Abstract:The invention can be used in medicine to treat gynecological and proctological diseases. Candles contain as biologically active substances hyaluronidase activity 64-128 UE and the filler in the amount of 1.0 to 1.5, Using the new spark allows you to bring to the sick body of the biologically active substance - hyaluronidase, which increases the efficiency of the administered dose hyaluronidase and avoids complications associated with injection by introducing lidz. The invention relates to medicine, the pharmaceutical industry and relates to the creation of new dosage forms containing hyaluronidase.The closest analogue are candles biological antiseptic containing biologically active substances, such as dry mix bovine plasma and thromboplastin, as well as antiseptic (chloramphenicol) and anesthetic (novocaine and herb extracts) means and the filler, which are used as cocoa butter and castor oil (reference: M. D. Mashkovsky. Medicinal product. Moscow, "Medicine", so 2, 1986, S. 84-85). These candles are used in the presence of a bleeding hemorrhoid at the in and difficult to prepare.The objective of the proposed solutions is the manufacture of candles, where the biologically active substance use hyaluronidase.The technical result, which can be obtained by carrying out the invention, consists in the creation of new highly effective drug for the treatment of gynecological diseases by technology that provides ease of manufacture in comparison with known candles and eliminating mnogokomponentnoi composition. You can also use candles with lidsay in proctology.The essence of the invention lies in the fact that the candle contains hyaluronidase and filler at the following proportions of components:
Lydasum with hyaluronidase activity - 64-128 UE
Filler - 1,0-1,5 gHyaluronidase or "factor distribution causes the breakdown of hyaluronic acid and thus reduces the fundamental biological importance of the latter, as "cementing" the substance of connective tissue. Studies have shown that the optimal ratio of "hyaluronic acid - hyaluronidase" is achieved when the content of hyaluronidase from 64 UE/ml to 128 UE/ml When this ratio is most effectively regulated by the permeability of the fabric.Making candles.Example 1. As filler take a mixture of 97 g of confectionery fat, 15 g of paraffin and 8 g of emulsifier solid T-2. This mixture is sterilized at 0.5 psi for 30 minutes and cooled to 40oC. filler gradually, in small portions with constant stirring injected concentrate lidz in a volume of 30 ml with activity 512 UE/ml, obtained by concentrating the solution lidz by ultrafiltration. Candles form according to the standard technique.Output: 100 candles weighing 1.5 g activity 128 UE in the candle.Obtained candles have torpedo-shaped form, homogeneous shear.Example 2. Take 3.0 g of freeze-dried lidz with total hyaluronidase activity 6400 UE. The filler is a mixture of 99.5 g confectionery fat and 0.5 g of MHD (distilled monoglycerides).The ingredients of the composition in one candle:
Lydasum dried - 64 UE/0.03 g
The filler is 1.0,Lyophilized hyaluronidase before mixing with the filler triturated in a mortar. The resulting powder in two installments at the house.Output: 100 candles weighing 1.0 g activity 64 UE in the candle.In clinical practice proved the efficiency of the claimed candles in the treatment of gynecological diseases (adenomyosis, endometriosis, infertility, spacey process in the pelvis, stimulation of labor activity, and so on).Example 1. Patient S. , aged 26 years. From the anamnesis: in 1992, made surgery for ectopic pregnancy. During the operation revealed spacey process in the pelvis. In February 1995, the patient was admitted with complaints of persistent nagging pain in the lower abdomen, infertility for 4 years.In the treatment of common methods of improving the patient has not come. Then on the background of basic therapy she had undergone treatment candles with lidsay vaginally in 1 suppository 2 times a day for 10 days. The patient's condition has improved. 2 months after discharge ambulatory patients received a second course of treatment lidazoy in the candlelight.Immediately after treatment, no pain in the lower abdomen, after 6 months of pregnancy.Example 2. Patient N., age 31 years. Complaints about the absence of pregnancy within 6 years. Repeatedly treated for infertility.In may and August 1995 was conducted 2 treatment candles with lidsay: 1 suppository 2 times a day vaginally within 10 days on the background of basic therapy, with an interval of 2 months.In November 1995, pregnancy, which saves.Example 3. Patient G., aged 29 years. Was admitted to hospital with a diagnosis of pregnancy is 38 weeks. To prepare the cervix for childbirth instead of the hormones of the prostaglandins were administered vaginally and rectally candles with lidsay 1 candle in the morning and evening for 3 days. Marked by rapid ripening of the cervix and less painful birth.Thus, the invention enables to effectively use the new dosage form based on lidz. Candles containing a biologically active substance and a filler, characterized in that the biologically active substances they contain hyaluronidase in the following ratio of components, g:
Lydasum activity - 64 - 128 UE
The filler is 1.0 to 1.5.
FIELD: medicine, otorhinolaryngological surgery.
SUBSTANCE: one should apply thin layer of "Solcoseryl" gel onto osseous facial walls of frontal and maxillary sinuses at the border with trepanation opening after removing pathological content out of them and before applying a transplant out of flat bone of human fetal cranial arch that exceeds the diameter of trepanation opening by 3-4 mm. Then, one should additionally fix the transplant by affecting with distal edge part of a light guide of semi-conductor laser "ATKUS-15" with contact-type technique at output power of laser radiation being 8 W at constant mode. The method enables to increase fixation density of allobrefobone to osseous walls of sinus along its whole diameter.
EFFECT: higher efficiency of fixation.