Liniment "fusel" drug that has anti-inflammatory, wound healing and regenerative effect, and method thereof

 

(57) Abstract:

The invention relates to medicine and pharmaceutical industries and can be used in gynecological practice. The essence is that the liniment is prepared by mixing the components of the plants, salicylic acid, Aerosil and metronidazole at 18 - 25oC for 40-60 minutes Use of this liniment does not cause local irritation, allergic or other reactions. 2 S. and 4 C.p. f-crystals, 1 table.

The invention relates to medicine and pharmaceutical industry and for the creation of new medicines for external use, for example for the treatment of wounds, sores, abrasions and other skin damage, and for internal use, for example in gynecology for the treatment of genital organs.

Famous liniment drug, possess wound healing properties, containing stearic acid, glycerin, triethanolamine, ml, chloramphenicol, benzocaine, boric acid, sea buckthorn oil, propellant and distilled water in the following ratio, wt.%:

stearic acid - 2,8 - 5,6

glycerin - 1,6 - 9,3

triethanolamine - 0,5 - 4,0

the oil - 3,0 -12,0

propellant - 7,0 - 20,0

distilled water - 51,0 - 70,0

(see the description of the invention to the author's certificate of the USSR N 884189, IPC A 61 K 9/12, publication 23.02.85 year).

Popular liniment inherent disadvantages due to firstly, the presence of propellant, which negatively affects the environmental factor, and also causes side effects on the human body; secondly, the presence of lanolin causes the softness of the composition and does not provide sufficient emulsification; thirdly, not all the amount of water in the composition tools, emulsified, which causes stratification of liniment.

A method of obtaining liniment by mixing the oil with a solution of the emulsifier in the apparatus with stirring (see the description of the invention to the author's certificate of the USSR N 363511, IPC B 01 F 3/08, publication, 13.11.73).

In a known way to get a coarse mixture, resulting in a liniment is not sustainable.

A method of obtaining liniment by circulating ingredients through the mixer, which is periodically empty, and the processed mass move through the dispersing device in additional capacity, from which the mass return is as dispersing device in a known way using a rotary pulsation apparatus (see description of the invention to the author's certificate of the USSR N 965490, IPC B 01 F 3/00 A 61 K 9/06, publication 15.10.82 year).

The known method is difficult to use and long production cycle.

Famous liniment methyluracil for external use, having wound healing properties, containing ointment based on castor oil, Aerosil as emulsifier (thickener) and Supplement the active substance in the form of form methyluracil (description to the patent of Russian Federation N 2007997, IPC A 61 K 9/05, publication 28.02.94 year).

When using the famous liniment methyluracil possible in patients with allergic reactions, such as Wattana rash, headache, dizziness. Famous liniment is contraindicated in acute and chronic malignant diseases of the blood and bone marrow, in connection with which this liniment has limitations in use for the treatment of diseases of the female genital organs.

Also known is a method of obtaining this famous liniment methyluracil, comprising mixing the aerosol with the addition of the active substance, adding parts to the mixture of castor oil and a thorough kneading until smooth (see the description of the invention to patsatsia by mixing the components manually in laboratory tanks, which allows the liniment availability of various sizes of inclusions and the result is a coarse grain emulsion with a lack of stability.

Obtained in a known manner liniment storage thickens and becomes unsuitable for tampons. In addition, in the known method of obtaining liniment using mortar for grinding powders and ointments lengthens the cooking process liniment.

The problem to which this invention is directed, is to create a simple and effective liniment drug with a wide range of applications. Thus, the preparation should be free of negative side effects, and its use should not be contraindications. The ointment should be accessible and easy to use. Furthermore, the method of obtaining liniment should be high-performance and secure storage duration liniment - at least two years.

The invention consists in the following. The task that liniment drug that has anti-inflammatory, wound healing and regenerative action containing ointment base of plant origin, Aerosil and Supplement existing vases as an additive to the active substance it contains at least one component from the group of dry extract of licorice, the oil from pumpkin seeds, thick concentrate, sea buckthorn oil, salicylic acid, metronidazole, sea buckthorn oil in the following ratio, wt.%:

the residue oil of pumpkin seeds is 50.3 - 99,0

Aerosil - 0,9 - 2,5

at least one component from the group:

dry extract of licorice - 6,0 - 14,0

the oil from pumpkin seeds is 0.1 to 18.6

thick concentrate, sea buckthorn oil - 2,0 - 4,0

salicylic acid - 0,4 - 0,6

metronidazole - 2,9 - 3,1

sea buckthorn oil - 10,0 - 18,0

Liniment drug obtained according to this invention is simple and effective, has a wide range of applications, stable at low and high temperatures, devoid of negative side effects, its use has no contraindications. Storage duration liniment - at least two years.

One of the preferred embodiments of the invention can be liniment drug that has anti-inflammatory, wound healing and regenerative effect, which as an additive to the active substance contains dry extract of licorice root, oil of pumpkin seeds, salicylic acid and metronidazole at the following component ratio is ar - 6,0 - 10,0

the oil from pumpkin seeds - 10,0 - 18,0

salicylic acid - 0,4 - 0,6

metronidazole - 2,9 - 3,1

The proposed liniment is recommended for use in gynecological practice and is designed for a wide range of patients with acute and chronic inflammation of the sexual organs in women and after electrocoagulation, laser and radiation therapy and after operations on the vagina, cervix, shivani fistula.

Another preferred example may be liniment drug that has anti-inflammatory, wound healing and regenerative effect, which as an additive to the active substance contains dry extract of licorice root, oil of pumpkin seeds and salicylic acid in the following ratio, wt%:

sludge oil pumpkin seeds - 62 - 79,8

Aerosil - 0,9 - 1,1

dry extract of licorice - 8,9 - 13,1

the oil from pumpkin seeds - 10,0 - 18,0

salicylic acid - 0,4 - 0,6

This liniment is recommended for use in gynecological practice for a group of patients with no infection protozoa infections, in particular, Trichomonas.

A third preferred example may be the liniment Lakers is as an additive to the active substance contains dry extract of licorice, the oil from pumpkin seeds and metronidazole at the following ratio, wt.%:

the residue oil of pumpkin seeds is 67.2 - 79,8

Aerosil - 0,9 - 1,1

dry extract of licorice - 6.0 - 10.0v

the oil from pumpkin seeds - 10,4 - 18,6

metronidazole - 2,9 - 3,1

This liniment is recommended for use in gynecological practice for a group of patients with severe inflammatory process accompanied by copious secretions and in the presence of Trichomonas.

The fourth preferred example may be liniment drug that has anti-inflammatory, wound healing and regenerative effect, which as an additive to the active substance containing oil from pumpkin seeds, salicylic acid and metronidazole at the following ratio, wt.%:

sludge oil pumpkin seeds for 77.2 - 85,8

Aerosil - 0,9 - 1,1

the oil from pumpkin seeds - 10,0 - 18,0

salicylic acid - 0,4 - 0,6

metronidazole - 2,9 - 3,1

This liniment is recommended for use in gynecological practice for a group of patients with well-developed immune system.

The problem is solved also by the fact that in the method of producing liniment drug, possess the very foundations of plant origin, Aerosil and additives to the active substance, as ointment bases using sediment vegetable oil, for example, sludge oil, pumpkin seeds, and as an additive to the active substance using at least one component from the group:

dry licorice root extract, oil of pumpkin seeds, a thick concentrate, sea buckthorn oil, salicylic acid, metronidazole, sea buckthorn oil, mixing components liniment is carried out in a rotary pulsation apparatus at a temperature of 18-25oC for 40-60 minutes, and the components of liniment taken in the following ratio, wt.%:

the residue oil of pumpkin seeds is 50.3 - 99,0

Aerosil - 0,9 - 2,5

at least one component from the group:

dry extract of licorice - 6,0 - 14,0

the oil from pumpkin seeds is 0.1 to 18.6

thick concentrate, sea buckthorn oil - 2,0 - 4,0

salicylic acid - 0,4 - 0,6

metronidazole - 2,9 - 3,1

sea buckthorn oil - 10,0 - 18,0

The method of obtaining liniment drug that has anti-inflammatory, wound healing and regenerative effect, according to this invention is a high-performance and provides storage duration is not less than two years.

Swedeagree the present invention is effective in the treatment of many diseases, different types of wounds, sores, abrasions and other skin damage both topical and internal use, for example in gynecological practice for the treatment of female genital organs.

The effectiveness of liniment is ensured by appropriate selection of the components constituting the active part, and their number. In particular, liniment drug recommended in gynecological practice, improves blood circulation in the tissues of contact. Liniment normalizes the pH inside the vagina and the vaginal environment, has anti-inflammatory properties, promotes the healing of wounds, and stimulates the glands of the vagina, has a high reparative properties, with long-term use (more than two weeks) stimulates the body's structures. The use of ointment bases of vegetable origin, containing a residue of vegetable oil, such as sludge oil pumpkin seeds, enriches liniment by a complex of biologically active substances, protein, amino acids, including essential, a mixture of fatty acids, vitamins and trace elements.

Studies to determine thermal stability of States is s almost not divided into solid and liquid phases, does not separate into individual fractions.

Dry extract of licorice powder obtained by freeze-drying an aqueous extract of the roots and rhizomes of licorice, which contains glycosidation compounds containing potassium and calcium salts, and flavonoid compounds and amino acids that stimulate the activity of nonspecific and specific factors of humoral and cellular immunity, which increases resistance of the organism in persons with weakened immune systems.

The oil from pumpkin seeds, oily liquid, obtained by cold pressing the seeds of the pumpkin, a positive effect on the processes of inflammation and regeneration, delays the development of connective tissue, improve microcirculation. Part of liniment oil from pumpkin seeds is introduced in order to create the desired consistency characteristic of liniment.

Salicylic acid is a crystalline powder, sparingly soluble in vegetable oil has an antiseptic effect.

Metronidazole (trichopol) - crystalline powder, has a broad spectrum of action against anaerobic protozoa infections.

Thick concentrate, sea buckthorn oil or Biologicheskie active substances, the effects of their membrane-stabilizing, correcting lipid metabolism, regulating the metabolism of the skin. Sea buckthorn oil is a natural concentrate of such biologically active substances, such as carotene, tocopherol, phylloquinone, polyunsaturated fatty acids, coumarins, serotinin, calciferol, flavonoids, pectin, ursolic acid, beta-sitosterol, thiamin, Niacin, Inositol, possess versatile medicinal properties.

Thick concentrate, sea buckthorn oil contains no solvent. Thick concentrate obtained by freeze drying natural juice of the fruit of the sea buckthorn to the content of moisture not more than 30%. In conventional concentrate the moisture content to 60% (see GOST 18078-72). Conventional concentrate is produced by boiling sea-buckthorn juice at temperatures up to 100oC, which leads to loss of useful properties of the substances contained in sea buckthorn, in particular carotene and vitamin C, and the decrease of its biological value. For this reason, in this invention the usual concentrate, sea buckthorn oil GOST 18078-72 not used.

Thus, the complex, the combined use of the components of the claimed liniment containing a large number of diverse active substances, with its regenerative effect, put in the basis of its wide use in the treatment of many diseases. This liniment contains components in such amounts that provide joint use most pronounced therapeutic effect, and used the ointment base of plant origin facilitates the efficient release of active substances and their quick absorption. While adverse effects and contraindications are absent.

Introduction into medical practice of the new liniment drug allows to expand the range of drugs that have anti-inflammatory, wound healing and regenerative effect.

Get liniment drug by mixing its components: ointment bases, Aerosil and additives to the active substance, taken in the right quantities, for example, as indicated in the table for examples 1-20, and the components are mixed liniment is carried out in a rotary pulsation apparatus at a temperature of 18-25oC for 40-60 minutes.

In the proposed method, the time of receipt (produced) liniment significantly less than the method described in the prototype for the patent of Russia No. e, and allows storage duration liniment more than 2 years.

Apply liniment drug as follows. Received liniment is used externally in the outpatient setting, which lubricate them sick foci or enter tampons impregnated with liniment in the cavity organs to be treated, for example in the vagina of the female sexual organ. The application of this liniment drug does not cause local irritation, allergic or other adverse reactions. Proposed according to this invention liniment has a wide range of applications.

1. Liniment drug that has anti-inflammatory, wound healing and regenerative action containing ointment base of plant origin, Aerosil and Supplement the active substance, characterized in that as ointment bases it contains the residue of vegetable oil, such as sludge oil, pumpkin seeds, and as the active substance it contains at least one from the group of dry licorice root extract, oil of pumpkin seeds, a thick concentrate, sea buckthorn oil, salicylic acid, metronidazole, sea buckthorn oil the next time she least one component from the group:

Dry concentrate licorice - 6,0 - 14,0

The oil from pumpkin seeds is 0.1 to 18.6

Thick concentrate, sea buckthorn oil - 2,0 - 4,0

Salicylic acid - 0,4 - 0,6

Metronidazole - 2,9 - 3,1

Sea buckthorn oil - 10,0 - 18,0

2. Liniment under item 1, characterized in that the additive of the active substance it contains dry extract of licorice root, oil of pumpkin seeds, salicylic acid and metronidazole at the following ratio, wt.%:

The residue oil of pumpkin seeds is 67.2 - 79,8

Aerosil - 0,9 - 1,1

Dry extract of licorice - 6,0 - 10,0

The oil from pumpkin seeds - 10,0 - 18,0

Salicylic acid - 0,4 - 0,6

Metronidazole - 2,9 - 3,1

3. Liniment under item 1, characterized in that the additive of the active substance it contains dry extract of licorice root, oil of pumpkin seeds and salicylic acid in the following ratio, wt.%:

The residue oil of pumpkin seeds is 67.2 - 79,8

Aerosil - 0,9 - 1,1

Dry extract of licorice - 8,9 - 13,1

The oil from pumpkin seeds - 10,0 - 18,0

Salicylic acid - 0,4 - 0,6

4. Liniment under item 1, characterized in that the additive of the active substance it contains dry extract of licorice, maqui - 67,2 - 79,8

Aerosil - 0,9 - 1,1

Dry extract of licorice - 6,0 - 10,0

The oil from pumpkin seeds - 10,4 - 18,6

Metronidazole - 2,9 - 3,1

5. Liniment under item 1, characterized in that the additive of the active substance it contains the oil from pumpkin seeds, salicylic acid and metronidazole at the following ratio, wt.%:

Sludge oil pumpkin seeds - 77,1 - 85,8

Aerosil - 0,9 - 1,1

The oil from pumpkin seeds - 10,0 - 18,0

Salicylic acid - 0,4 - 0,6

Metronidazole - 1,9 - 3,1

6. The method of obtaining liniment drug that has anti-inflammatory, wound healing and regenerative action, including mixing ointment bases of vegetable origin, Aerosil and additives to the active substance, characterized in that as ointment bases use residue of vegetable oil, such as sludge oil, pumpkin seeds, and as an additive to the active substance using at least one component from the group of dry licorice root extract, oil of pumpkin seeds, a thick concentrate, sea buckthorn oil, salicylic acid, metronidazole, sea buckthorn oil, the mixing of components is carried out in a rotary machine pulsating at 18 - 25
Aerosil - 0,9 - 2,5

At least one component from the group:

Dry extract of licorice - 6,0 - 14,0

The oil from pumpkin seeds is 0.1 to 18.6

Thick concentrate, sea buckthorn oil - 2,0 - 4,0

Salicylic acid - 0,4 - 0,6

Metronidazole - 2,9 - 3,1

Sea buckthorn oil - 10,0 - 18,0

 

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FIELD: medicine, cardiology, phytotherapy, pharmacy.

SUBSTANCE: invention relates to the field in development of an agent of vegetable origin used for improvement of the functional state and prophylaxis of organic alterations in cardiovascular system, in particular, atherosclerosis. The biologically active supplement used for prophylaxis of cardiovascular diseases, in particular, atherosclerosis comprises clover dry extract, haw-thorn flowers powder, ascorbic and nicotinic acids, and accessory substances taken in the definite ratio. The biologically active supplement is made in the form of tablet or capsule. No adverse responses observed in intake of the supplement. The blood cholesterol level was reduced to the normal value in 68% of patients and reducing morbidity with acute respiratory-viral infections has been noticed. In patients with ischemic heart disease with cholesterolemia the improvement of the state is noted on the background of conventional therapy: the moderate reducing the arterial pressure value in its elevation, improved in the state of health, enhanced working capacity, reduced retrosternal pains, ear noise, vertigo, headache.

EFFECT: valuable medicinal properties of supplement.

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