Method for the treatment of stress lesions of the nervous system

 

(57) Abstract:

The invention relates to medicine and can be used in the treatment of stress lesions of the nervous system in combustionengines, traumatic, neurological and surgical clinics. Simultaneously with syndromic treatment of the underlying disease are correction mediator currency analogues or precursors major neurotrophic mediators of acetylcholine and noradrenaline. Support trophic processes in glial cell has drugs gammalinolenic acid, antihypoxants pentabasic sugars. They also provide medication M-cholinolytics Central action, the Central adrenalectomy, blockers, brake mediators and blockers of calcium channels. The method allows to reduce the recovery time and reduce mortality and to prevent the development of late effects in various fields of medicine. 2 C.p. f-crystals, 1 table.

The present invention relates to medicine, and more specifically relates to a method of treatment of stress lesions of the nervous system.

This invention can be used in various medical fields, e.g. Jovovich, traumatic, toxic, postoperative), combustionengines, trauma, neurological, surgical clinics, as well as for prevention and treatment of stress lesions of the nervous system caused by exposure to chronic and/or intensive psychogenic somatic stress factors in mental health, substance abuse, therapeutic clinics, in the practice of sports and preventive medicine.

There is a method of treatment of stress lesions of the nervous system ("Actual questions of pharmacology neurotropic drugs", Riga, 1981, S. 65-67, Denisenko, p. P. "issues in the pharmacotherapy of extreme States"), namely, that provide syndromic treatment of the underlying disease that causes stress lesions of the nervous system, such as shock, myocardial infarction, overload, Hypo - and hyperthermia, hypokinesia, intoxication. This pharmacological effect means on the nervous and endocrine (metabolic) mechanisms for the development and maintenance of the underlying disease. Also, this method involves the application of M-cholinolytics Central action and antihypoxants.

However, this method does not take into account the development of history is citypulse option hipotecarias reaction, in which the introduction of M-cholinolytics Central action is contraindicated. In the method are not clear indications for use of this group of drugs, i.e., applying only to hyperstructures the reaction centers of regulation. In addition, in the described method is not used actually a complex effect on the system neuron-glia for the treatment of lesions of the nervous system and maintain the trophic function of the Central nervous system does not restore the adaptive capabilities of the nervous system. All of the above is not possible in this way to reduce the rehabilitation period under the stress lesions of the nervous system and reduce mortality in different areas of medicine and to prevent the development of late effects associated with stress lesions of the nervous system.

The basis of the invention is to provide a method of treatment of stress lesions of the nervous system, which due to the complex impact on the system neuron-glia and recovery adaptive capabilities of the nervous system by reducing the period of rehabilitation in the stress lesions of the nervous system, reducing mortality in various fields of medicine and before the

The problem is solved in that in the method of treatment of stress lesions of the nervous system, namely, that provide syndromic treatment of the underlying disease that causes stress lesions of the nervous system, carry out the application of M-cholinolytics Central action and antihypoxants, according to the invention simultaneously with syndromic treatment of the underlying disease provide drug exposure in mediator doses analogues or precursors major neurotrophic mediators of acetylcholine and noradrenaline, also using drugs gammalinolenic acid, antihypoxants, pentabasic sugar to maintain the trophic processes of glial cell has, while in the presence of hyperstructures the reaction centers regulation also carry out medical effects of M-cholinolytics Central action, Central adrenalectomy, selective peripheral-blockers, brake mediators and blockers of calcium channels.

It is advisable as M-cholinolytics Central action to use amizil, pentity, as the Central adrenolytic to use clonidine, as reselect peptide D-sleep, dalargin, as well as calcium channel blockers to apply phenoptin, isoptin.

Preferably drug exposure analogues main neurotrophic mediators of acetylcholine and noradrenaline be done with life-threatening conditions through them intravenous.

This method of treatment of stress lesions of the nervous system is a comprehensive method for the treatment of stress lesions of the nervous system of different etiology and different clinical manifestations. Its use in intensive-care hospital with severe burns, traumatic, toxic lesions, postoperative States can significantly reduce mortality among patients, to reduce the rehabilitation period and to prevent the development of late effects associated with lesions of the nervous system (encephalopathy). The use of this invention in psychiatric and narcological practice improves the efficiency of treatment of mental and behavioral disorders psychogenic and organic nature, it is more efficient to stop the withdrawal syndrome and to deal with symptoms of alcohol and drug addiction that ceremoniesthe. Also, this invention allows in sports medicine to shorten the period of recovery of athletes after competition and to achieve a more sustainable achieve their athletic performance. In the practice of preventive medicine this way on the stages of psycho-physiological disorders allows the prevention of the development of nosological forms of diseases and disabilities that can have significant economic importance.

The invention is further explained with specific examples of implementation.

Method for the treatment of stress lesions of the nervous system lies in the fact that provide syndromic treatment of the underlying disease that causes stress lesions of the nervous system. At the same time with syndromic treatment of the underlying disease provide drug exposure in mediator doses analogues or precursors major neurotrophic mediators of acetylcholine and noradrenaline. Also the patient prescribed drugs gammalinolenic acid, antihypoxants, pentabasic sugar to maintain the trophic processes of glial cell has. And if hyperstructures the reaction centers regulation also made the and-blockers, brake mediators, calcium channel blockers. At the same time as M-cholinolytics Central action can be used amizil, pentity, as the Central adrenalitis can be used clonidine, as a non-selective peripheral --blocker - obzidan as brake mediators - peptide D-sleep, dalargin, as blockers of calcium channels, phenoptin, isoptin. Medication analogues main neurotrophic mediators of acetylcholine and noradrenaline in life-threatening conditions is carried out by intravenous injection. The following is a more detailed description of the method for the treatment of stress lesions of the nervous system.

Under stress lesions of the nervous system, you should understand the effects of any emotional, physical or exogenous (mechanical, chemical) factors on the body, which, being realized through the mechanisms of mental or physical stress, directly or indirectly, have a damaging effect on the Central and peripheral structures of the nervous system. The function of the neurons is inextricably linked with the activity of surrounding cells glial cell has, i.e. the correct Gavotte increase the functional activity of neurons under certain influences their opportunities are being rapidly depleted, as these highly specialized cells do not contain significant reserves of energy material (e.g., glycogen). Especially fast function of neurons depleted in extreme situations in hypoxia, which is one of the reasons for their damage. Glial cells are significantly more resistant to such situations due to the peculiarities of its functional biochemistry. To understand the essence of therapeutic interventions, it is important to note the peculiarities of the metabolism of glial cells, which differ fundamentally from those of the neurons. One of them, in comparison with neurons, is the prevalence of enzymes hexosaminidase shunt. This way the oxidation of glucose (pentony cycle) is very effective for providing synthetic processes in the cells of the pentose and reduced forms of NAD (nicotineinduced). In addition, glial cells are much more active neurons absorb amino acids, indicating intense synthetic processes. There are also differences in fat metabolism. In the experiment, the selection of certain types of lipids and determination of radioactivity showed that the rate of incorporation of label in neutral lipids is much higher in glial fractions, and ate cells play a mediator in the exchange. So, it has been shown that glial cells are an efficient uptake system for choline neural origin in the breakdown of acetylcholine. A significant role in the metabolism of brain tissue plays norepinephrine, which Poreba its action through adenylyl cyclase system, is an important regulator of metabolic processes, in particular carbohydrate metabolism. It is assumed that the noradrenergic system may innerbeauty glial cells and regulate thus metabolic and trophic functions of glia. This may be a key mechanism of action noradrenaline system adaptive capabilities of the nervous system. In addition, as was shown in experiments, norepinephrine increased the inhibition of spontaneous spike activity of neurons, called gammaaminobutyric acid. Facilitating GABA-ergicheskoe braking under the influence of norepinephrine is associated with activation of b-adrenergic receptors and the subsequent stimulation of adenylate-cyclase activity with increasing formation of cyclic adenosine monophosphate. This is particularly important for understanding approaches to the treatment of increased seizure activity with encephalopathy. With the depletion adrenergically system that often limitacia adaptation activity of the sympathetic nervous system, leads to an increase in the content of nucleic acids in glial cell has. Thus, the adrenaline, not acting as a specific activator of neurons, contributes to the improvement of their specific activities. Besides the participation in the activities of the major neurotransmitter systems acetylcholine, adrenaline, noradrenaline cells glia participate in the exchange gammalinolenic acid, glutamate, regulate intracellular ion concentration. An important aspect of glial cell has is its relation to hormonal influences. Studies have shown that the hypothalamus is the most sensitive to corticosteroid balance of the nervous system, with adrenalectomy content of nucleic acids in glial cells supraopticus kernel has been clearly reduced. Introduction adrenalectomised animals hydrocortisone completely normalized the content of nucleic acids in glial cell has hypothalamus. The data obtained allow us to raise the question of glial cell has as main place of application of hormonal influences on the metabolism of the nervous system. Due to these peculiarities of metabolism in extreme conditions or chronic long-term stress exposure, when the function Neureichenau communication to convey plastic material (ribonucleic acid, proteins, even ribosomes) neurons to maintain the function of the latter. The efficiency of the system neuron-glia depends on the level of the main trophic mediators, acetylcholine and noradrenaline. The degree of decrease in the content of their blood and brain tissue is directly related to the severity and duration of stress exposure. The most important point adaptation (or recovery) of the nervous system to the stress of the situation is the state of the higher centers in the regulation of metabolism - the anterior and posterior regions of the hypothalamus. They are the Central parts of, respectively, cholinergic and catecholaminergic neurotransmitter systems (as well as the parasympathetic and sympathetic divisions of the nervous system) and simultaneously the first links of the arc of somatic stress, have a direct beneficial or damaging effect on the trophic nerve tissue. Only when the adaptive level of activity of the higher centers in the regulation of the metabolism of the termination of the damaging stress action on the nervous tissue and restore normal functional activity system neuron-glia. If you achieve adaptive level of functioning must be achieved in extreme situations, when a stump interaction of the sympathetic and parasympathetic systems, without explicit prevalence of certain influences. Functional abnormalities can be identified easily using the well-known variational method pulsometry by R. M. Baevsky (see Baevsky R. M. and other Mathematical analysis of changes in cardiac rhythm during stress. - M.: Nauka, 1984, S. 221). In extreme situations, the boundaries of the adaptive response form: heart rate should not go beyond 95-120 per minute, the optimal values are the values of the pulse from 105 to 115 of heart contractions per minute. In children, the heart rate should not exceed the sum of: age norm +45 (50) and be less than 30 beats per minute from the maximum values. Daily consumption should not exceed 2 to 2.5 levels of basal metabolic rate and fundamentally should correspond to the estimated design parameters and should not be less than 1.25 - 1.5 levels. Reducing daily energy consumption to normal values when saving large wounds demonstrates hypometabolism and beyond adaptive responses. Monitoring of metabolism should be based on the changes in nitrogen balance.

The table shows the fundamentally there are two types of twisted R is shown data it is easy enough to develop the concept of treatment of lesions of the nervous system in extreme conditions. It should include the following main directions:

1. Correction of water-electrolyte balance.

2. Correction of metabolic disorders at the organism level, including enteral and parenteral energy and plastic materials under controlled nitrogen balance. It is important to follow the known ratio between the components of the power supply. So, the ratio of proteins, fats, carbohydrates caloric content should be equal to, respectively, 1: 1:2, and for every 100 "total" calories should be 1 g of nitrogen.

3. Correction mediator of exchange implies the introduction with the aim of substitution analogues or precursors most "spent" neurotransmitters acetylcholine and norepinephrine.

4. The introduction of drugs specifically affecting the metabolism of glial cells. Such preparations are:

- the dicarboxylic amenability. Aspartic and glutamic acids play an important role in the synthesis of purine and pyrimidine nucleotides, amino acid transport. In addition, she serves as a donor of acetyl groups for the synthetic is iticheskie dose);

- pentabasic sugar ribose, xylitol up to 2 - 3 g/kg They are precursors of nucleotides, intermediates pentoses cycle, and have strong anti-catabolic properties.

5. The use of brain protectors - antihypoxants, of which the most widely barbiturates (phenobarbital sredneterapevticheskih doses).

6. The use of drugs that improve blood circulation in the brain (Cinnarizine, stugeron).

In addition to specific therapy aimed at the elimination of metabolic disorders of the nervous system, it is necessary to korrigirovat activities mediator trophic systems to return the organism in the direction of adaptive reactions. The impact should be in the first place stressrelated system - cholinergic and monoaminergic systems. Taking into account the above information schematic diagram of pathogenetic therapy of stress lesions of the nervous system can be represented as follows.

(I) the Principal therapeutic scheme at any variants of stress lesions of the nervous system.

1. A balanced diet.

2. The complex of vitamins (C, B1, B2, Venelin or L-DOPA (tyrosine).

6. Acetylcholine or food with high content of choline (Overact), a decoction of the herb shepherd's purse, containing acetylcholine and dolinopodobnymi substances.

7.Antihypoxants.

II). When hyperstructures reactions, in addition to using the base schema, you must constantly keeping the heart rate at a level not exceeding 115 - 120 beats per minute. For this purpose, the Central M-cholinolytics (amizil, pentity), Central sympatholytic (clonidine), --blockers (obzidan), kamakshipalya acid and other brake mediators. When the state of psychomotor excitation, accompanied by a pronounced tachycardia (sympathetic crisis) shows the introduction of barbiturates from 150 - 200 mg Tipitapa sodium or its analogues with morphine (therapeutic dose).

III). When hipotecarias reactions, in addition to using the base schema, if necessary, is hormone therapy sredneterapevticheskih dose: prednisone (up to 20-25 mg/day) followed by cancel. Under extreme conditions, it is necessary modeling adaptive response, which is achieved by the intravenous injection of noradrenaline and adrenaline in mediator doses, i.e. doses, is not able to provide the temporarily should be conducted oral substitution therapy predecessors key mediators: L - Dov - up to 2 g/day, tyrosine to 3 g/day of choline to 1 g/day.

Methodology for intravenous substitution mediator therapy is presented below.

Dry substance (acetylcholine chloride, 0.1 or 0.2 g) is diluted in 100 to 150 ml of a 5% glucose solution and slowly for 10 - 12 min, taking into account the effects on the heart, under the control pulse is injected into a vein. To carry out the introduction of a solution of acetylcholine better through a peripheral vein or through a catheter placed in the femoral Vienna, i.e. perhaps more anatomically from the heart. At the end of the introduction acetylcholine is injected 125 mg of hydrocortisone. A similar procedure may be performed up to 2 - 3 times a day. Intravenous adrenaline should simulate the adaptive reaction of the organism. In this regard, the speed of intravenous epinephrine (1 - 2 ml of 0.1% solution of epinephrine hydrochloride, dissolved in 400 ml of 5% glucose solution or saline solution) is determined by the achievement of the heart rate corresponding to the area of adaptive reactions.

This method of treatment of stress lesions of the nervous system has been tested in a clinical setting. It was used to treat patients with various diseases, in particular institutions, postoperative and others.

Example 1. Patient B-N. Yu, R. 1985 (8 years), history 35955 transferred to the clinic of thermal lesions of the Military Medical Academy of the district hospital after removal of the shock on the third day after injury 25.10.93. Diagnosis: Subtotal flame burn 85% (80%) / II-IV century, inhalation defeat. Gradually, 27.10.93 and 29.10.93 were performed radial on how agressively to debride the area, respectively, 40 and 20% of the body surface. The wound was closed auto - and allografts in various combinations. Further as the recovery of donor sites and purification from the formation of new areas of the wounds were made piecemeal restore the skin. The period of burn disease was regarded as extremely difficult, however, in addition to development of the syndrome disseminirovannogo intravascular coagulation (7.11.93), which could be controlled, and other dangerous complications for a long time was not observed. Weight loss before 10.13.93 did not exceed 10% of the body surface. By this time the patient developed an intolerance to food (received the protein inpit), accompanied by severe diarrheal illness. Only seven days later was able to restore the function of the gastro-intestinal trawl 20% of initial body weight. From this moment began the destabilization of the patient manifested a constant tendency to tachycardia (hypersecretory reaction), increased catabolism, Hypo - and dysproteinemia, slow epithelialization in wounds, severe intractable episodes of hyperthermia. 4.01.94 the patient developed septic arthritis of the ankle joint, and soon right elbow. Burn disease took septic course. At this point, the remaining area of burn wounds did not exceed 15% of the body surface. Despite adequate treatment of purulent foci of the patient's condition continued to deteriorate: increased lethargy, weakness. With 4.02.94 marked bradycardia (60 heartbeats per minute), i.e., on the background of the depletion of the adaptive capabilities of the organism evolved Hipotecaria reaction. With 10.02.94 marked hypertonicity of the muscles of the face, impaired swallowing, signs of mental inadequacy. The change in traditional therapy of sepsis, increased antibiotic therapy has not led to an improvement in the patient's condition. 12.02.94 the patient developed severe nekupiruemy drug seizures with breathing disorders. Produced tracheal intubation, translated on artificial lung ventilation in rainsystem regulation (Hipotecaria reaction), the tendency to hypovolemia, metabolic disorders, was assigned to combination therapy, comprising,

- infusion-transfusion therapy (albumin, plasma, blood, glucose solutions and amino acids, fat emulsions, solutions of electrolytes);

probe power (soy-based) to cover the needs of metabolism together with parenteral nutrition and correctable by nitrogen balance;

- drug therapy: heparin with antiplatelet agents (nicotinic acid), norepinephrine intravenous drip mediator doses of acetylcholine with oral probe power, hydrocortisone (125 mg/day), a full range of vitamins, adrenaline mediator doses (the speed was determined by the achievement heart rate 100-105 per minute), xylitol (50 g/day), phenobarbital, gentamicin (80 mg/day), phenibut, aspartic and glutamic acid;

sedative and symptomatic therapy.

After a few days there was a positive trend in the condition of the patient, improved mental status, disappeared bradycardia, decreased significantly the severity of seizures and their frequency. 24.02.94 transfer mode auxiliary ventilation "SIMV". In further noted gradual the hydrometeorological status. There were single seizures from two to four per day, which was easily stopped by the introduction of seduksen. At the same time was marked by some weight gain. Against this background, the continued phased autodermoplasty remaining wounds. 12.03.94 patient excubitor, translated into spontaneous breathing. Further there were single in a few days episodes of increased seizure activity, which was easily stopped by the introduction of seduksen (Relanium). To 20.05.94 skin recovered completely, cropped purulent processes in the ankle and elbow joints, the patient is maximized. 6.06.94 in satisfactory condition discharged home. Approximately one month after discharge the patient on the background of persistent phenomena psychasthenia was marked irritability, propensity to develop hysteroid States, the tendency to tachycardia, as well as the appearance of convulsive contractions of facial muscles, and extremities to two or three times a day, quickly stopping the introduction of intramuscular seduksen (Relanium). Treatment included obzidan (up to 1/4 tab. with increasing heart rate over 100-105 per minute, phenobarbital, phenibut, glutamic acid (detskogo tools with increasing seizure activity was administered Relanium. After ten days of treatment showed a significant improvement in the condition: normalized sleep, significantly decreased excitability, the number of bouts of increased seizure activity decreased to once within one to two weeks. It was noted long-term remission. In the future this condition developed less and were much weaker than expressed. Treatment remained fundamentally the same.

Example 2. Patient D., history 36112), 12 years old, was admitted to the clinic of thermal lesions of the Military Medical Academy 19.10.92 with granulating wounds on the area about 18% of the body surface. Burns received 26.09.92 from burning glue. Treated in General hospitals, where on the thirteenth day the victim was executed necrectomy. After excision of the scab of the wound was not closed, as, apparently, and was due to rapid loss of body weight, accompanied by a progressive deterioration. Only at the twenty-third day after injury, the boy was transferred to a specialized medical institution. Upon admission to the hospital General condition was regarded as serious. The body weight deficit amounted to this point, 30% of the original. The patient was conscious, one is almost completely absent. Among laboratory parameters was noticed severe anemia (b - 65 g/l) and hypoproteinemia (total protein 45 g/l). The clinical examination revealed a clear tendency to tachycardia (pulse 125 - 130 heart rate and higher), indicating that hyperstructures reaction centers regulation. The victim was assigned to standard treatment, including infusion-transfusion, antibiotics and supportive therapy, tube feeding. As a result of treatment have achieved a certain stabilization of the patient and in three stages to 5.11.92 fully restore the skin. Despite this patient's condition continued to deteriorate, there was a growing shortage of body weight, which by the end of the eighth week after injury (four weeks in the clinic) has reached 40%. Remained tachycardia, increased catabolism. Against the background of progressive burn depletion in a patient developed astheno-dynamic and intellectual-mnestic disorders, reaching full intellectual degradation. Productive contact with the patient was almost impossible. The patient chewed sheets, pulled off the bandage, defecated. Staff and relatives did not recognize. Since 5.12.92 periodically been identified Oganezov not detected). There were signs of polyneuritis. 14.12.92 developed arthritis of the right ankle joint, synovial fluid and blood began to do it Staphylococcus aureus. Antibiotic therapy has been strengthened. In addition, against the background of strengthening food with high content of choline patient was assigned amizil via a stomach tube to 0.25 mg/kg 3-4 times a day. therapy was a success, the patient's condition began to stabilize, there is a tendency to normalize heartbeat. The boy was more than adequate, active, appetite. 4.02.93 restored skin on the sacrum in place of a bed sore. By this time it was noted explicit regression phenomena polyradiculoneuritis and encephalopathy. The further course of the disease is smooth. He was discharged 19.02.94 in satisfactory condition.

Example 3. Patient-C., 52 years old. Examined on an outpatient basis. For more than 20 years, suffering from chronic alcoholism. Previously noted binges for 3-5 days, tolerance to 1 liter of vodka. It was noted spontaneous remission for up to 6 months. In the last 2 years he drinks almost daily, there is a notable trend toward lower tolerance. In the past, twice sought treatment for the first time 10 years ago, when within the TLD is the treatment remission within 2 months. Re-turned 4 years ago when the home was conducted mild withdrawal syndrome, and then out of the held session psychotherapeutic treatment ("encoding"), noted a two-year remission. In the last 3 months drinking daily, fractional doses up to 0.5 liters of vodka per day. One month prior to examination by a psychiatrist in a state of alcoholic intoxication suffered a traumatic brain injury with brief loss of consciousness, to the doctor did not address. The last 1.5 weeks was on sick leave, issued by therapist territorial polyclinics, the diagnosis of exacerbation of chronic cholecystitis". Sick for many years working as a technician vacuum machines at the factory, has a reputation as a good specialist. However, in the last 6 months it became harder for him to cope with the work, appeared absent-mindedness, forgetfulness, decreased productivity, increased absenteeism. After the fault of the patient has failed one of vacuum machines, the administration of the enterprise, the question was raised about his dismissal or transfer to a less skilled job. According to his wife the last time the patient was markedly changed, became lethargic, apathetic, weak physically, stopped Noah dose of alcohol. Two days before the inspection was interrupted by the alcoholism. During the last night he slept restlessly, he jumped up, walked around the house, vaguely talked to himself, stated that the apartment is his cousin who came to visit him, fell asleep for a short time only in the morning, taking 50 grams of vodka. During the day preceding the examination, drank 200 g of vodka.

Objective: Physical state. Pale skin, thick, mucous membranes pale pink tongue coated whitish bloom. Breath the smell of alcohol. Heart sounds deaf, pulse 80 beats per minute, a/D 130/90 mm Od. The liver is 1 cm from the edge of the costal arch, light pain on deep palpation in the right upper quadrant. Neurological condition. Marked tremor of the hands, the instability in the Romberg position. On the feet - some reduction in sensitivity type "socks". Mental state. Patient ascension, listless. Complains of headaches, which appeared after suffering a traumatic brain injury, poor health, manifested in the feeling of weakness, weakness, lack of appetite, feeling of inner restlessness, anxiety, which at some time passes after taking a regular dose of alcohol. Says that over on the face. The events of the last night remembers vaguely says that with closed eyes appeared bright images of awesome content, saw a moving figure in a geometric pattern wall carpet, "seemed to come relative" long time no see. Understands the pain of his condition, expresses the installation of treatment and total abstinence from alcohol, asks, unable to stop alcoholism. Concerned about the state of his health, worried that you may lose your job, says that "the administration gave him one last chance", the fear of further deterioration of family relationships. At the time of inspection of any psychotic disorders (delirium, hallucinations) is not marked.

Diagnosis: Chronic alcoholism II-III, initial signs of alcoholic encephalopathy and alcoholic polyneuritis, withdrawal syndrome with psychotic episodes.

From hospitalization in a psychiatric or substance abuse hospitalization, the patient and his relatives refused. After psychotherapeutic interviews patients received detoxification and sedation: 400 ml of physiological solution and 400 ml gemodeza drip, intravenous in the day: night slept without revivals, health in General has improved, complaints to severe weakness, dizziness. On the background of sedatives (sonapax 30 mg/day; zoloft 37.5 mg/day) and politicomilitary appointed the following complex treatment:

1. The decoction of the herb shepherd's purse (containing acetylcholine and molinietalia substances).

2. L-DOPA 0.5 g/day (the precursor of noradrenaline).

3. Phenibut 0.75 g/day (the drug group gammaaminobutyric acid).

4. Xylitol 150 g/day (pentabasic sugar).

5. Phenobarbital 0.03 g/day (antihypoxic drug).

After 3 days: feeling much better and withdrawal phenomena were stopped completely, restored appetite, normalized sleep, decreased headaches. Remain astenizirovannah, lethargy. After 12 days of therapy in the home showed a significant improvement: the headaches stopped, the patient became more cheerful, active, began to show interest in reading Newspapers, TV, housework, says about the lack of traction to alcohol consumption, expressed firm installation of sobriety. Was held a session of emotional stress psychotherapy, aimed at the achievement of full sobriety. The recommended course is of 1 times in 3 months.

Continued: inspected after 6 months. Feel good, do not drink alcohol, works at the same place, work very well.

Example 4. Sick Of Yu , 42 years. Examined on an outpatient basis. Patient education teacher, occupies an important position in the system of secondary education, in parallel, has a great public duty. In the past year was very busy, very tired, often have enough sleep. Three months ago, after serious trouble at work (student fell from the window), there was an unpleasant sensation in the heart area ("felt heart now stop"), accompanied by acute fear of death. Since then, appeared anxious waiting for cardiac arrest, accompanied by a subjective sense of disruption and a feeling of prolonged pauses between strikes, accompanied by fear of death. Along with this disturbed sleep, began to grow phenomena of weakness, exhaustion, became difficult to cope with their duties. Underwent preoperative examination, serious violations in the activity of cardiac muscle were not identified, was diagnosed: "Vegeto-vascular dystonia on cardial type" and was recommended to consult psychon the český to alkoholitarbimist, but it brought only temporary relief.

Objective: the Pulse of 90 beats per minute, BP 140/100 mm Od.

Mental state. At the reception a few bound, at the same time, recounts his experiences. Complaints about headaches compressive nature, a feeling of weakness, fatigue, poor sleep, a sense of disruption in the region of the heart. Understands that "time the doctors found nothing" serious pathology of the heart in him probably not, at the same time says that it can not cope with the disturbing happenings. Feelings of disruption and heart the fear of death arise occasionally, usually after a nervous stress and negative emotions. By nature he thinks he is ambitious, secretive, mandatory, honest. The background of reduced mood, concerned about the state of his health, however, understands that it is linked to nervous stress at work and negative experiences.

Diagnosis: Asthenic syndrome. Cardiophobia.

Treatment: rational psychotherapy. Conducted 10 sessions of autogenic training (in a group). Medication: coaxil 12.5 mg x 3 times a day. On the background of psychotropic drugs and politicalinterests.

2. L-DOPA 0.5 g/day.

3. Phenibut 0.75 g/day.

4. Xylitol 100 g/day.

5. Phenobarbital 0.01 g/day.

6. Obzidan 0.03 g/day (non-selective peripheral -- adrenergic).

After 3 weeks showed a significant improvement. Gone are the headaches, normalized sleep, improved mood, increased efficiency, ceased to bother unpleasant sensations in the heart area and anxious fears, the fear of death.

The follow-up. Viewed through 5 months. After treatment and leave feeling good, job, unpleasant sensations in the heart area not to be disturbed.

Example 5. Patient G. , 8 years old, was admitted to the clinic of cardiovascular surgery 10.05.94 with a diagnosis of ventricular septal defect. 19.05.94 operation: suturing of the defect in terms extracoronary circulation. In the early postoperative period, the patient showed postperfusion encephalopathy, manifested in the form of deep brain coma in the face of moderate tachycardia and relatively stable hemodynamics. On the background of therapy: infusion-transfusion, cardiac symptomatic patient was assigned specificto 2-3 g/day, aspartic and glutamic acid (sredneterapevticheskih doses). As antihypoxic drug used pedifen (up to 10 mg/day), phenobarbital (0.1 g/day). In the complex therapy was noted positive dynamics of the nervous system. 4 days observed full recovery of consciousness in satisfactory condition discharged home 3 weeks after surgery.

Thus, the test in clinical conditions of the present invention allows to make a conclusion that this method of treatment of stress lesions of the nervous system due to the complex impact on the system neuron-glia and restore the adaptive capacities of the Central nervous system reduced mortality in patients with severe disorders of homeostasis in various fields of medicine, reducing the period of rehabilitation at various stress lesions of the nervous system and prevention of the development of their remote consequences.

1. Method for the treatment of stress lesions of the nervous system, including syndromic treatment of the underlying disease, the use of M-cholinolytics Central action and antihypoxants, characterized in that simultaneously carry out the corre and norepinephrine, support trophic processes in glial cell has drugs gammalinolenic acid, pentabasic sugars and implement medication Central adrenalectomy, selective peripheral blockers, brake mediators and blockers of calcium channels.

2. The method according to p. 1, characterized in that as M-cholinolytics Central actions use amizil, pentity, as the Central adrenalitis - clonidine, as a non-selective peripheral-blocker - obsidian as brake mediators use the peptide D-sleep, dalargin, and as blockers of calcium channels use phenoptin, isoptin.

3. The method according to p. 1 or 2, characterized in that the medication analogues main neurotrophic mediators of acetylcholine and noradrenaline in life-threatening conditions is carried out by intravenous injection.

 

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The invention relates to new biologically active compounds, specifically, the peptides of General formula: Trp-X-Gly-Gly-Asp-R, where X is the residue of the hydroxyl - containing amino acids L-or D-configuration, R-Ala-Ser-Gly-Glu or Ala-Ser-Gly or Ala-Ser, or Ala; and their pharmaceutically acceptable salts having anti-stress, anticonvulsant and neuroprotective action

The invention relates to medicine, in particular to the experimental therapy, and for the prevention and treatment of atherosclerosis

The invention relates to new compounds of formula I Nu-O-Fa, where O is oxygen, Nu is a nucleoside or nucleoside analogue, including such nitrogen base, as adenine, Esenin, cytosine, uracil, thymine; Fa - acyl monounsaturated C18YPD C20-9-fatty acids, which fatty acid etherification hydroxyl group in 5-position of the sugar portion of the nucleoside or nucleoside analog, or a hydroxyl group, an acyclic chain of an analogue of the nucleoside

The invention relates to medicine

The invention relates to the field of pharmacy and concerns receiving means having a radioprotective effect
The invention relates to Oncology

The invention relates to medicine and relates to means for treatment of a dysbacteriosis

Antiviral agent // 2123339
The invention relates to medicine and pharmacology, and relates to means for the treatment of herpetic infections
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